HK1078608A1 - Targeted liposome gene delivery - Google Patents

Targeted liposome gene delivery

Info

Publication number
HK1078608A1
HK1078608A1 HK05110310.7A HK05110310A HK1078608A1 HK 1078608 A1 HK1078608 A1 HK 1078608A1 HK 05110310 A HK05110310 A HK 05110310A HK 1078608 A1 HK1078608 A1 HK 1078608A1
Authority
HK
Hong Kong
Prior art keywords
gene delivery
targeted liposome
liposome gene
virus
targeted
Prior art date
Application number
HK05110310.7A
Other languages
English (en)
Inventor
Esther H Chang
Liang Xu
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of HK1078608A1 publication Critical patent/HK1078608A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
HK05110310.7A 1997-11-19 2005-11-17 Targeted liposome gene delivery HK1078608A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27

Publications (1)

Publication Number Publication Date
HK1078608A1 true HK1078608A1 (en) 2006-03-17

Family

ID=26746455

Family Applications (3)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送

Country Status (12)

Country Link
EP (2) EP1166775B1 (xx)
JP (2) JP2001522871A (xx)
CN (3) CN1904055A (xx)
AT (2) ATE459340T1 (xx)
AU (1) AU759164C (xx)
CA (1) CA2308584C (xx)
DE (2) DE69830249T2 (xx)
DK (1) DK1166775T3 (xx)
ES (1) ES2339421T3 (xx)
HK (3) HK1035490A1 (xx)
PT (1) PT1166775E (xx)
WO (1) WO1999025320A1 (xx)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1811036E (pt) 1999-02-22 2011-07-11 Univ Georgetown Imunolipossomas dirigidos por fragmento de anticorpo para distribuição sistémica de genes
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
US20040241088A1 (en) * 2003-01-28 2004-12-02 Georgetown University Method for evaluating the efficacy of certain cancer treatments
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
PT1633327E (pt) * 2003-06-04 2010-11-08 Univ Georgetown Método para melhoramento da estabilidade e duração de armazenamento de complexos lipossomais
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
US7858356B2 (en) * 2005-11-24 2010-12-28 Genomidea, Inc. Mutant paramyxovirus and method for production thereof
JP2009537526A (ja) 2006-05-15 2009-10-29 ジョージタウン・ユニバーシティ 治療もしくは診断剤の全身投与のための抗体もしくは抗体断片標的化免疫リポソームの製造およびその使用
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
IN2014DN05866A (xx) 2011-12-22 2015-05-22 Nuvo Res Gmbh
EP2711000B1 (en) 2012-09-19 2019-04-03 Georgetown University Targeted Liposomes
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
AU2014244339B2 (en) 2013-03-14 2020-03-05 Georgetown University Treatment for exposure to nerve agent
EP3359197B1 (en) 2015-10-08 2021-03-10 University of Utah Research Foundation Methods and compositions for preventing or treating cancer
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
KR970705404A (ko) * 1994-09-13 1997-10-09 찰스 디.에버트 특정 세포형에 화학 물질의 세포내 수송(intracellular delivery of chemical agents to a specific cell type)
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
WO1997028817A1 (en) * 1996-02-09 1997-08-14 Cheng Pi Wan Receptor ligand-facilitated delivery of biologically active molecules
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
AU759164B2 (en) 2003-04-10
DK1166775T3 (da) 2010-05-03
EP1166775A3 (en) 2003-06-25
CA2308584A1 (en) 1999-05-27
CN1191094C (zh) 2005-03-02
CN1616665A (zh) 2005-05-18
EP1032369A1 (en) 2000-09-06
EP1032369B1 (en) 2005-05-18
HK1035490A1 (en) 2001-11-30
AU759164C (en) 2007-03-29
DE69841536D1 (de) 2010-04-15
HK1045641B (zh) 2010-10-29
DE69830249D1 (de) 2005-06-23
CA2308584C (en) 2011-07-19
CN1904055A (zh) 2007-01-31
DE69830249T2 (de) 2006-05-04
CN1286630A (zh) 2001-03-07
JP2001522871A (ja) 2001-11-20
CN1616665B (zh) 2010-10-06
ES2339421T3 (es) 2010-05-20
ATE459340T1 (de) 2010-03-15
WO1999025320A1 (en) 1999-05-27
AU1464299A (en) 1999-06-07
PT1166775E (pt) 2010-04-16
EP1166775A2 (en) 2002-01-02
HK1045641A1 (en) 2002-12-06
EP1166775B1 (en) 2010-03-03
ATE295722T1 (de) 2005-06-15
JP2010263920A (ja) 2010-11-25

Similar Documents

Publication Publication Date Title
HK1078608A1 (en) Targeted liposome gene delivery
AU2284697A (en) Fusogenic liposomes
ZA200105505B (en) Small particle liposome aerosols for delivery of anti cancer drugs.
WO1999010014A3 (en) Receptor-mediated gene delivery using bacteriophage vectors
EP0633943A4 (en) GENTHERAPY USING TARGETED VIRAL VECTORS.
AU6140598A (en) Multipathway electronically-controlled drug delivery system
AU6535096A (en) Methods and means for targeted gene delivery
AU5700094A (en) Modified cutinases, dna, vector and host
WO1998030709A3 (en) Non-immunogenic prodrugs and selectable markers for use in gene therapy
FI961666A0 (fi) Restenosiksen geeniterapia, jossa käytetään adenovirusvektoria
MY138257A (en) Compositions and methods for enhancing delivery of therapeutic agents to cells
EP0911397A4 (en) TUMORANTANT PROTEINS, THEIR GENES, AND TUMORANTANT PEPTIDES
WO1998010750A3 (en) Nucleic acid particle delivery
AU5846598A (en) Promoter of the CDC25B gene, its preparation and use
NZ510154A (en) A tumour antigen protein and gene therefor, tumour antigen peptides and derivatives thereof in medicaments and prophylactics
AU9269898A (en) Artificial viruses derived from papillomavirus, and their uses, in particular gene therapy
AU6987696A (en) The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
AU3133799A (en) Seed-coat promoters, genes and gene products
AP2006003504A0 (en) Outer surface proteins, their genes, and their use.
EP1041146A4 (en) TUMOR ANTIGEN PROTEIN, ITS GENE AND ITS USE
NZ516777A (en) Method for delivery of therapeutic agents, particularly nucleic acids, using a solution of dextrin
MXPA01012500A (es) Productos para terapia de gen.
AU1598200A (en) Systemic delivery of gene products via skin
EP1033402A4 (en) P16 BINDING PROTEINS, GENE OF SUCH PROTEINS AND ANTIBODIES AGAINST THESE PROTEINS
AU2000273645A1 (en) Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171119