ATE459340T1 - Zielgerichtete liposomen zur verabreichung von genen - Google Patents

Zielgerichtete liposomen zur verabreichung von genen

Info

Publication number
ATE459340T1
ATE459340T1 AT01123562T AT01123562T ATE459340T1 AT E459340 T1 ATE459340 T1 AT E459340T1 AT 01123562 T AT01123562 T AT 01123562T AT 01123562 T AT01123562 T AT 01123562T AT E459340 T1 ATE459340 T1 AT E459340T1
Authority
AT
Austria
Prior art keywords
targeted liposomes
gene administration
virus
gene
administration
Prior art date
Application number
AT01123562T
Other languages
English (en)
Inventor
Esther H Chang
Liang Xu
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Application granted granted Critical
Publication of ATE459340T1 publication Critical patent/ATE459340T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
AT01123562T 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen ATE459340T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27

Publications (1)

Publication Number Publication Date
ATE459340T1 true ATE459340T1 (de) 2010-03-15

Family

ID=26746455

Family Applications (2)

Application Number Title Priority Date Filing Date
AT01123562T ATE459340T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen
AT98958643T ATE295722T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT98958643T ATE295722T1 (de) 1997-11-19 1998-11-19 Zielgerichtete liposomen zur verabreichung von genen

Country Status (12)

Country Link
EP (2) EP1166775B1 (de)
JP (2) JP2001522871A (de)
CN (3) CN1191094C (de)
AT (2) ATE459340T1 (de)
AU (1) AU759164C (de)
CA (1) CA2308584C (de)
DE (2) DE69841536D1 (de)
DK (1) DK1166775T3 (de)
ES (1) ES2339421T3 (de)
HK (3) HK1035490A1 (de)
PT (1) PT1166775E (de)
WO (1) WO1999025320A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
ATE511543T1 (de) 1999-02-22 2011-06-15 Univ Georgetown Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
JP2006517032A (ja) * 2003-01-28 2006-07-13 ジョージタウン・ユニバーシティ ある種の癌治療の有効性を評価するための方法
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
PL1633327T3 (pl) * 2003-06-04 2011-02-28 Univ Georgetown Sposób poprawienia stabilności i okresu trwałości kompleksów liposomowych
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
EP1947181A4 (de) * 2005-11-24 2010-09-22 Genomidea Inc Mutantes paramyxovirus und verfahren zur herstellung davon
CA2652222A1 (en) 2006-05-15 2007-12-13 Georgetown University Preparation of antibody- or antibody-fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
BR112014015333A2 (pt) 2011-12-22 2017-06-13 Nuvo Res Gmbh composições lipossomais de clorito ou clorato
BR102013004109A2 (pt) 2012-09-19 2015-06-23 Univ Georgetown Lipossomas direcionados
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
US9878055B2 (en) 2013-03-14 2018-01-30 Georgetown University Treatment for exposure to nerve agent
ES2863773T3 (es) * 2015-10-08 2021-10-11 Univ Utah Res Found Métodos y composiciones para prevenir o tratar el cáncer
CN109996809A (zh) 2016-11-14 2019-07-09 诺华股份有限公司 与促融合蛋白minion相关的组合物、方法和治疗用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
CN1157570A (zh) * 1994-09-13 1997-08-20 瑟拉技术有限公司 化学药物向特定细胞的细胞内载运
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
US6077834A (en) * 1996-02-09 2000-06-20 Cheng; Pi-Wan Receptor ligand-facilitated delivery of biologically active molecules
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
DK1166775T3 (da) 2010-05-03
DE69830249T2 (de) 2006-05-04
WO1999025320A1 (en) 1999-05-27
CN1616665B (zh) 2010-10-06
HK1078608A1 (en) 2006-03-17
CN1904055A (zh) 2007-01-31
EP1032369B1 (de) 2005-05-18
HK1045641A1 (en) 2002-12-06
EP1166775A3 (de) 2003-06-25
PT1166775E (pt) 2010-04-16
AU1464299A (en) 1999-06-07
CN1191094C (zh) 2005-03-02
CA2308584A1 (en) 1999-05-27
CA2308584C (en) 2011-07-19
CN1286630A (zh) 2001-03-07
AU759164C (en) 2007-03-29
ATE295722T1 (de) 2005-06-15
HK1035490A1 (en) 2001-11-30
EP1166775B1 (de) 2010-03-03
JP2001522871A (ja) 2001-11-20
CN1616665A (zh) 2005-05-18
DE69830249D1 (de) 2005-06-23
JP2010263920A (ja) 2010-11-25
EP1032369A1 (de) 2000-09-06
ES2339421T3 (es) 2010-05-20
HK1045641B (zh) 2010-10-29
AU759164B2 (en) 2003-04-10
EP1166775A2 (de) 2002-01-02
DE69841536D1 (de) 2010-04-15

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