HK1035490A1 - Targeted liposome gene delivery. - Google Patents

Targeted liposome gene delivery.

Info

Publication number
HK1035490A1
HK1035490A1 HK01106017A HK01106017A HK1035490A1 HK 1035490 A1 HK1035490 A1 HK 1035490A1 HK 01106017 A HK01106017 A HK 01106017A HK 01106017 A HK01106017 A HK 01106017A HK 1035490 A1 HK1035490 A1 HK 1035490A1
Authority
HK
Hong Kong
Prior art keywords
gene delivery
targeted liposome
liposome gene
virus
targeted
Prior art date
Application number
HK01106017A
Other languages
English (en)
Inventor
Esther H Chang
Liang Xu
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of HK1035490A1 publication Critical patent/HK1035490A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Plant Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
HK01106017A 1997-11-19 2001-08-27 Targeted liposome gene delivery. HK1035490A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27
PCT/US1998/024657 WO1999025320A1 (en) 1997-11-19 1998-11-19 Targeted liposome gene delivery

Publications (1)

Publication Number Publication Date
HK1035490A1 true HK1035490A1 (en) 2001-11-30

Family

ID=26746455

Family Applications (3)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Country Status (12)

Country Link
EP (2) EP1166775B1 (zh)
JP (2) JP2001522871A (zh)
CN (3) CN1616665B (zh)
AT (2) ATE459340T1 (zh)
AU (1) AU759164C (zh)
CA (1) CA2308584C (zh)
DE (2) DE69841536D1 (zh)
DK (1) DK1166775T3 (zh)
ES (1) ES2339421T3 (zh)
HK (3) HK1035490A1 (zh)
PT (1) PT1166775E (zh)
WO (1) WO1999025320A1 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4799736B2 (ja) 1999-02-22 2011-10-26 ジョージタウン・ユニバーシティ 全身性遺伝子送達のための抗体フラグメント標的化イムノリポソーム
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
EP1595142A4 (en) * 2003-01-28 2006-08-23 Univ Georgetown METHOD FOR EVALUATING THE EFFECTIVENESS OF CERTAIN CANCER TREATMENTS
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
PL1633327T3 (pl) * 2003-06-04 2011-02-28 Univ Georgetown Sposób poprawienia stabilności i okresu trwałości kompleksów liposomowych
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
JP5102630B2 (ja) * 2005-11-24 2012-12-19 ジェノミディア株式会社 改変パラミクソウイルスおよびその作製方法
WO2007142781A1 (en) 2006-05-15 2007-12-13 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
CA2857604A1 (en) 2011-12-22 2013-06-27 Nuvo Research Gmbh Liposomal chlorite or chlorate compositions
EP2711000B1 (en) 2012-09-19 2019-04-03 Georgetown University Targeted Liposomes
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
EP2968598B1 (en) 2013-03-14 2020-05-27 Georgetown University Treatment for exposure to nerve agent
EP3359197B1 (en) 2015-10-08 2021-03-10 University of Utah Research Foundation Methods and compositions for preventing or treating cancer
EP3538546A1 (en) 2016-11-14 2019-09-18 Novartis AG Compositions, methods, and therapeutic uses related to fusogenic protein minion

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
BR9508951A (pt) * 1994-09-13 1999-04-06 Theratech Inc Liberação intracelular de agentes químicos para um tipo específico de célula
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
EP0904100B1 (en) * 1996-02-09 2006-07-26 Pi-Wan Cheng Cationic lipid and receptor ligand-facilitated delivery of biologically active molecules
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
EP1032369B1 (en) 2005-05-18
HK1045641A1 (en) 2002-12-06
ATE295722T1 (de) 2005-06-15
AU759164B2 (en) 2003-04-10
JP2010263920A (ja) 2010-11-25
CN1904055A (zh) 2007-01-31
AU1464299A (en) 1999-06-07
DK1166775T3 (da) 2010-05-03
DE69830249D1 (de) 2005-06-23
HK1045641B (zh) 2010-10-29
CN1616665A (zh) 2005-05-18
ATE459340T1 (de) 2010-03-15
CA2308584A1 (en) 1999-05-27
WO1999025320A1 (en) 1999-05-27
CA2308584C (en) 2011-07-19
JP2001522871A (ja) 2001-11-20
DE69830249T2 (de) 2006-05-04
EP1166775A3 (en) 2003-06-25
AU759164C (en) 2007-03-29
CN1191094C (zh) 2005-03-02
DE69841536D1 (de) 2010-04-15
HK1078608A1 (en) 2006-03-17
CN1286630A (zh) 2001-03-07
ES2339421T3 (es) 2010-05-20
PT1166775E (pt) 2010-04-16
EP1032369A1 (en) 2000-09-06
EP1166775A2 (en) 2002-01-02
CN1616665B (zh) 2010-10-06
EP1166775B1 (en) 2010-03-03

Similar Documents

Publication Publication Date Title
HK1078608A1 (en) Targeted liposome gene delivery
AU9676198A (en) Drug delivery and gene therapy delivery system
WO1997038010A3 (en) Fusogenic liposomes
ZA200105505B (en) Small particle liposome aerosols for delivery of anti cancer drugs.
WO1999010014A3 (en) Receptor-mediated gene delivery using bacteriophage vectors
EP0633943A4 (en) GENTHERAPY USING TARGETED VIRAL VECTORS.
AU6140598A (en) Multipathway electronically-controlled drug delivery system
BR9801027B1 (pt) sistema de distribuiÇço de medicamentos.
AU6535096A (en) Methods and means for targeted gene delivery
AU2905199A (en) Combined therapy with a chemotherapeutic agent and an oncolytic virus for killing tumor cells in a subject
IL153853A0 (en) Bifunctional molecules and vectors complexed therewith for targeted gene delivery
WO1998030709A3 (en) Non-immunogenic prodrugs and selectable markers for use in gene therapy
MY138257A (en) Compositions and methods for enhancing delivery of therapeutic agents to cells
EP0911397A4 (en) TUMORANTANT PROTEINS, THEIR GENES, AND TUMORANTANT PEPTIDES
AU5846598A (en) Promoter of the CDC25B gene, its preparation and use
AU4089899A (en) Stable envelope proteins for retroviral, viral and liposome vectors and use in gene and drug therapy
NZ510154A (en) A tumour antigen protein and gene therefor, tumour antigen peptides and derivatives thereof in medicaments and prophylactics
AU9269898A (en) Artificial viruses derived from papillomavirus, and their uses, in particular gene therapy
DE69704269D1 (de) Dendritische, lysinhaltige Polypeptide zur gezielten Arzneimittelabreichung
AU6987696A (en) The use of the wap of mmtv regulatory sequences for targeted expression of linked heterologous genes in human mammary cells, including human mammary carcinoma cells
EP1041146A4 (en) TUMOR ANTIGEN PROTEIN, ITS GENE AND ITS USE
NZ516777A (en) Method for delivery of therapeutic agents, particularly nucleic acids, using a solution of dextrin
AU2000273645A1 (en) Drug target isogenes: polymorphisms in the uncoupling protein 3 (mitochondrial, proton carrier) gene
Gillespie The Dynamics of Museum Representation:: An invesigation into the Exhibitions of the Japanese Garden and Cultural Centre, Cowra
徐美和 et al. General Surface Reconstruction From a Set of Planar Contours

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171119