HK1040926B - 回腸膽汁酸輸送抑制物與纖維酸衍生物的組合作心血管病指徵 - Google Patents
回腸膽汁酸輸送抑制物與纖維酸衍生物的組合作心血管病指徵Info
- Publication number
- HK1040926B HK1040926B HK02102722.9A HK02102722A HK1040926B HK 1040926 B HK1040926 B HK 1040926B HK 02102722 A HK02102722 A HK 02102722A HK 1040926 B HK1040926 B HK 1040926B
- Authority
- HK
- Hong Kong
- Prior art keywords
- combinations
- transport inhibitors
- ileal bile
- cardiovascular indications
- acid derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11395598P | 1998-12-23 | 1998-12-23 | |
| US14260399P | 1999-07-07 | 1999-07-07 | |
| PCT/US1999/027948 WO2000038727A1 (en) | 1998-12-23 | 1999-12-17 | Combinations of ileal bile acid transport inhibitors and fibric acid derivatives for cardiovascular indications |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HK1040926A1 HK1040926A1 (en) | 2002-06-28 |
| HK1040926B true HK1040926B (zh) | 2003-10-17 |
Family
ID=26811676
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02102722.9A HK1040926B (zh) | 1998-12-23 | 2002-04-10 | 回腸膽汁酸輸送抑制物與纖維酸衍生物的組合作心血管病指徵 |
| HK02106673.9A HK1045114A1 (zh) | 1998-12-23 | 2002-09-11 | 適用於心血管疾病的回腸胆汁酸轉運抑制劑和貝酸衍生物的組合 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK02106673.9A HK1045114A1 (zh) | 1998-12-23 | 2002-09-11 | 適用於心血管疾病的回腸胆汁酸轉運抑制劑和貝酸衍生物的組合 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6638969B1 (zh) |
| EP (2) | EP1140189B1 (zh) |
| JP (1) | JP2002533413A (zh) |
| KR (1) | KR20010102964A (zh) |
| CN (1) | CN1342090A (zh) |
| AR (1) | AR022023A1 (zh) |
| AT (1) | ATE240120T1 (zh) |
| AU (1) | AU776658B2 (zh) |
| BR (1) | BR9916565A (zh) |
| CA (1) | CA2356607A1 (zh) |
| CZ (1) | CZ20012342A3 (zh) |
| DE (1) | DE69907960T2 (zh) |
| DK (1) | DK1140189T3 (zh) |
| EA (1) | EA200100707A1 (zh) |
| ES (1) | ES2200588T3 (zh) |
| HK (2) | HK1040926B (zh) |
| HU (1) | HUP0104793A2 (zh) |
| IL (1) | IL143947A0 (zh) |
| MX (1) | MXPA01006472A (zh) |
| NO (1) | NO20013162L (zh) |
| NZ (1) | NZ512537A (zh) |
| PL (1) | PL348580A1 (zh) |
| PT (1) | PT1140189E (zh) |
| WO (1) | WO2000038727A1 (zh) |
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| SE0000772D0 (sv) | 2000-03-08 | 2000-03-08 | Astrazeneca Ab | Chemical compounds |
| EG26979A (en) | 2000-12-21 | 2015-03-01 | Astrazeneca Ab | Chemical compounds |
| EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| GB0121337D0 (en) | 2001-09-04 | 2001-10-24 | Astrazeneca Ab | Chemical compounds |
| GB0121622D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| GB0121621D0 (en) | 2001-09-07 | 2001-10-31 | Astrazeneca Ab | Chemical compounds |
| ATE349214T1 (de) | 2001-09-08 | 2007-01-15 | Astrazeneca Ab | Benzothiazepin und benzothiadiazepin derivative mit hemmender wirkung auf den säuretransport in den gallengängen zur behandlung von hyperlipidaemia |
| GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
| GB0213669D0 (en) | 2002-06-14 | 2002-07-24 | Astrazeneca Ab | Chemical compounds |
| GB0304194D0 (en) | 2003-02-25 | 2003-03-26 | Astrazeneca Ab | Chemical compounds |
| GB0307918D0 (en) | 2003-04-05 | 2003-05-14 | Astrazeneca Ab | Therapeutic use |
| EP1918000A2 (en) | 2003-11-05 | 2008-05-07 | Schering Corporation | Combinations of lipid modulating agents and substituted azetidinones and treatments for vascular conditions |
| AU2005217318B2 (en) * | 2004-02-27 | 2010-07-01 | Asahi Kasei Pharma Corporation | Novel benzothiazepine and benzothiepine compounds |
| KR101351209B1 (ko) | 2004-12-03 | 2014-02-06 | 머크 샤프 앤드 돔 코포레이션 | Ｃｂ1 길항제로서 치환된 피페라진 |
| US7897601B2 (en) | 2006-01-18 | 2011-03-01 | Intervet, Inc. | Cannabinoid receptor modulators |
| US20090318496A1 (en) | 2006-08-04 | 2009-12-24 | Aska Pharmaceutical Co., Ltd. | Preparation containing fibrate agent and process for producing the same |
| CA2703203C (en) | 2007-10-22 | 2015-12-15 | Schering Corporation | Bicyclic heterocycle derivatives and methods of use thereof |
| WO2009143049A1 (en) | 2008-05-19 | 2009-11-26 | Schering Corporation | Bicyclic heterocycle derivatives and use thereof as gpr119 modulators |
| MX2011000664A (es) | 2008-07-16 | 2011-02-24 | Schering Corp | Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119. |
| US20110245209A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Pyridopyrimidine derivatives and methods of use thereof |
| US20110243940A1 (en) | 2008-12-16 | 2011-10-06 | Schering Corporation | Bicyclic pyranone derivatives and methods of use thereof |
| JP2012513469A (ja) | 2008-12-23 | 2012-06-14 | シェーリング コーポレイション | ピリミジン誘導体及びその使用法 |
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| AU2009330208A1 (en) | 2008-12-23 | 2011-08-04 | Merck Sharp & Dohme Corp. | Bicyclic heterocycle derivatives and methods of use thereof |
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| AR076024A1 (es) | 2009-04-03 | 2011-05-11 | Schering Corp | Derivados de heterociclos biciclicos puenteados y metodos de uso de los mismos |
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| KR20230152818A (ko) | 2013-03-15 | 2023-11-03 | 샤이어 휴먼 지네틱 테라피즈 인크. | 원발성 담관염 및 염증성 장 질환 치료용 담즙산 재순환 억제제 |
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| US10793534B2 (en) | 2018-06-05 | 2020-10-06 | Albireo Ab | Benzothia(di)azepine compounds and their use as bile acid modulators |
| JOP20200297A1 (ar) | 2018-06-20 | 2020-11-22 | Albireo Ab | تعديلات بلورية للأوديفيكسيبات |
| US11801226B2 (en) | 2018-06-20 | 2023-10-31 | Albireo Ab | Pharmaceutical formulation of odevixibat |
| US11007142B2 (en) | 2018-08-09 | 2021-05-18 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| US11549878B2 (en) | 2018-08-09 | 2023-01-10 | Albireo Ab | In vitro method for determining the adsorbing capacity of an insoluble adsorbant |
| US10722457B2 (en) | 2018-08-09 | 2020-07-28 | Albireo Ab | Oral cholestyramine formulation and use thereof |
| PL3921028T3 (pl) | 2019-02-06 | 2023-02-13 | Albireo Ab | Związki benzotiadiazepinowe i ich zastosowanie jako modulatory kwasów żółciowych |
| US10941127B2 (en) | 2019-02-06 | 2021-03-09 | Albireo Ab | Benzothiadiazepine compounds and their use as bile acid modulators |
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| US10975045B2 (en) | 2019-02-06 | 2021-04-13 | Aibireo AB | Benzothiazepine compounds and their use as bile acid modulators |
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-
1999
- 1999-12-17 MX MXPA01006472A patent/MXPA01006472A/es unknown
- 1999-12-17 IL IL14394799A patent/IL143947A0/xx unknown
- 1999-12-17 AT AT99965903T patent/ATE240120T1/de not_active IP Right Cessation
- 1999-12-17 JP JP2000590678A patent/JP2002533413A/ja active Pending
- 1999-12-17 HU HU0104793A patent/HUP0104793A2/hu unknown
- 1999-12-17 KR KR1020017008084A patent/KR20010102964A/ko not_active Application Discontinuation
- 1999-12-17 NZ NZ512537A patent/NZ512537A/en unknown
- 1999-12-17 US US09/465,642 patent/US6638969B1/en not_active Expired - Fee Related
- 1999-12-17 PL PL99348580A patent/PL348580A1/xx not_active Application Discontinuation
- 1999-12-17 WO PCT/US1999/027948 patent/WO2000038727A1/en not_active Application Discontinuation
- 1999-12-17 CZ CZ20012342A patent/CZ20012342A3/cs unknown
- 1999-12-17 CN CN99816270A patent/CN1342090A/zh active Pending
- 1999-12-17 DK DK99965903T patent/DK1140189T3/da active
- 1999-12-17 BR BR9916565-1A patent/BR9916565A/pt not_active IP Right Cessation
- 1999-12-17 EA EA200100707A patent/EA200100707A1/ru unknown
- 1999-12-17 ES ES99965903T patent/ES2200588T3/es not_active Expired - Lifetime
- 1999-12-17 CA CA002356607A patent/CA2356607A1/en not_active Abandoned
- 1999-12-17 AU AU21579/00A patent/AU776658B2/en not_active Ceased
- 1999-12-17 EP EP99965903A patent/EP1140189B1/en not_active Revoked
- 1999-12-17 EP EP03009706A patent/EP1336413A1/en not_active Withdrawn
- 1999-12-17 PT PT99965903T patent/PT1140189E/pt unknown
- 1999-12-17 DE DE69907960T patent/DE69907960T2/de not_active Expired - Fee Related
- 1999-12-23 AR ARP990106754A patent/AR022023A1/es not_active Application Discontinuation
-
2001
- 2001-06-22 NO NO20013162A patent/NO20013162L/no not_active Application Discontinuation
-
2002
- 2002-04-10 HK HK02102722.9A patent/HK1040926B/zh not_active IP Right Cessation
- 2002-09-11 HK HK02106673.9A patent/HK1045114A1/zh unknown
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2003
- 2003-09-02 US US10/652,306 patent/US20040048846A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2157900A (en) | 2000-07-31 |
| AR022023A1 (es) | 2002-09-04 |
| US6638969B1 (en) | 2003-10-28 |
| HK1045114A1 (zh) | 2002-11-15 |
| ES2200588T3 (es) | 2004-03-01 |
| ATE240120T1 (de) | 2003-05-15 |
| CZ20012342A3 (cs) | 2001-12-12 |
| JP2002533413A (ja) | 2002-10-08 |
| BR9916565A (pt) | 2002-01-29 |
| DE69907960D1 (de) | 2003-06-18 |
| CA2356607A1 (en) | 2000-07-06 |
| PT1140189E (pt) | 2003-09-30 |
| US20040048846A1 (en) | 2004-03-11 |
| EP1336413A1 (en) | 2003-08-20 |
| HK1040926A1 (en) | 2002-06-28 |
| IL143947A0 (en) | 2002-04-21 |
| CN1342090A (zh) | 2002-03-27 |
| DE69907960T2 (de) | 2004-02-26 |
| EP1140189A1 (en) | 2001-10-10 |
| NO20013162D0 (no) | 2001-06-22 |
| DK1140189T3 (da) | 2003-09-15 |
| EA200100707A1 (ru) | 2001-12-24 |
| PL348580A1 (en) | 2002-06-03 |
| EP1140189B1 (en) | 2003-05-14 |
| MXPA01006472A (es) | 2004-03-10 |
| NO20013162L (no) | 2001-08-21 |
| WO2000038727A1 (en) | 2000-07-06 |
| NZ512537A (en) | 2003-11-28 |
| AU776658B2 (en) | 2004-09-16 |
| KR20010102964A (ko) | 2001-11-17 |
| HUP0104793A2 (en) | 2002-06-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PF | Patent in force | ||
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20061217 |