HK1032782A1 - Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic. - Google Patents

Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic.

Info

Publication number
HK1032782A1
HK1032782A1 HK01103502A HK01103502A HK1032782A1 HK 1032782 A1 HK1032782 A1 HK 1032782A1 HK 01103502 A HK01103502 A HK 01103502A HK 01103502 A HK01103502 A HK 01103502A HK 1032782 A1 HK1032782 A1 HK 1032782A1
Authority
HK
Hong Kong
Prior art keywords
antiallergic
same
alkyl
chem
alkoxy
Prior art date
Application number
HK01103502A
Other languages
English (en)
Inventor
Yasuo Ohtsuka
Toshio Nishizuka
Sohjiro Shiokawa
Seiji Tsutsumi
Mami Kawaguchi
Hideo Kitagawa
Hiromi Takata
Takashi Shishikura
Toyoaki Ishikura
Kenichi Fushihara
Yumiko Okada
Sachiko Miyamoto
Maki Shiobara
Original Assignee
Meiji Seika Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha filed Critical Meiji Seika Kaisha
Publication of HK1032782A1 publication Critical patent/HK1032782A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
HK01103502A 1997-09-29 2001-05-22 Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic. HK1032782A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP26461197 1997-09-29
JP5206398 1998-03-04
PCT/JP1998/004363 WO1999016770A1 (fr) 1997-09-29 1998-09-29 Derives de triazolobenzazepine tricyclique, leur procede de production et antiallergique

Publications (1)

Publication Number Publication Date
HK1032782A1 true HK1032782A1 (en) 2002-08-30

Family

ID=26392670

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01103502A HK1032782A1 (en) 1997-09-29 2001-05-22 Tricyclic triazolobenzazepine derivatives, processfor producing the same, and antiallergic.

Country Status (25)

Country Link
US (3) US6372735B1 (zh)
EP (1) EP1026167B1 (zh)
JP (1) JP3188482B2 (zh)
KR (1) KR100389140B1 (zh)
CN (2) CN1312135C (zh)
AT (1) ATE233764T1 (zh)
AU (1) AU744636B2 (zh)
BR (1) BR9814055B1 (zh)
CA (1) CA2305307C (zh)
DE (1) DE69811930T2 (zh)
DK (1) DK1026167T3 (zh)
ES (1) ES2191963T3 (zh)
HK (1) HK1032782A1 (zh)
HU (1) HUP0004020A3 (zh)
ID (1) ID24101A (zh)
IL (1) IL135303A0 (zh)
NO (2) NO319542B1 (zh)
NZ (1) NZ503601A (zh)
PL (1) PL339544A1 (zh)
PT (1) PT1026167E (zh)
RU (1) RU2198885C2 (zh)
SK (1) SK283869B6 (zh)
TR (1) TR200000808T2 (zh)
TW (1) TW510902B (zh)
WO (1) WO1999016770A1 (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002367110A1 (en) 2001-12-26 2003-07-15 Meiji Seika Kaisha, Ltd. Amorphous substance of tricyclic triazolobenzazepine derivative
DE60313124T2 (de) 2002-02-01 2007-08-23 Meiji Seika Kaisha Ltd. Verfahren zur herstellung einer 1,2,3-triazolverbindung
PL375230A1 (en) 2002-07-09 2005-11-28 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
PL374860A1 (en) 2002-07-09 2005-11-14 Bristol-Myers Squibb Company Substituted heterocyclic derivatives useful as antidiabetic and antiobesity agents and method
WO2004113343A1 (ja) * 2003-06-19 2004-12-29 Meiji Seika Kaisha, Ltd. 三環性トリアゾロベンゾアゼピン誘導体の新規結晶性物質
JP4391475B2 (ja) * 2003-06-20 2009-12-24 明治製菓株式会社 難水溶性物質と水溶性高分子との共沈物の製造方法
MXPA06013042A (es) 2004-05-14 2007-02-12 Millennium Pharm Inc Compuestos y m??todos para inhibir la progresion mit??tica.
KR20080110760A (ko) 2006-03-02 2008-12-19 메이지 세이카 가부시키가이샤 삼환성 트리아졸로벤즈아제핀 유도체를 포함하는 알레르기성 안질환 또는 알레르기성 비질환용 예방 또는 치료제
JP5588172B2 (ja) * 2006-09-25 2014-09-10 フォルシュングフェアブント ベルリン エー．ファウ． プロリンが豊富なペプチドの構造的模倣薬およびその医薬用途
CL2007003244A1 (es) 2006-11-16 2008-04-04 Millennium Pharm Inc Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer.
PL2123277T3 (pl) 2007-12-18 2011-08-31 Meiji Seika Pharma Co Ltd Środek zapobiegawczy lub terapeutyczny do leczenia choroby zapalnej jelit
JP5738196B2 (ja) 2008-12-22 2015-06-17 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． オーロラキナーゼ阻害剤および抗ｃｄ２０抗体の併用
JO3635B1 (ar) 2009-05-18 2020-08-27 Millennium Pharm Inc مركبات صيدلانية صلبة وطرق لانتاجها
EP2521545B1 (en) * 2010-01-07 2019-11-27 Alkermes Pharma Ireland Limited Prodrugs of heteroaromatic compounds
CN102770024A (zh) 2010-02-19 2012-11-07 米伦纽姆医药公司 4-{[9-氯-7-(2-氟-6-甲氧基苯基)-5h-嘧啶并[5,4-d][2]苯并氮杂卓-2基]氨基}-2-甲氧基苯甲酸钠的结晶形式
US20130303519A1 (en) 2012-03-20 2013-11-14 Millennium Pharmaceuticals, Inc. Methods of treating cancer using aurora kinase inhibitors
WO2014153509A1 (en) 2013-03-22 2014-09-25 Millennium Pharmaceuticals, Inc. Combination of catalytic mtorc 1/2 inhibitors and selective inhibitors of aurora a kinase

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995018130A1 (fr) * 1993-12-28 1995-07-06 Meiji Seika Kabushiki Kaisha Derives tricycliques de benzazepine et benzothiazepine
US6093714A (en) * 1995-06-15 2000-07-25 Meiji Seika Kaisha, Ltd. Tricyclic benzazepine compounds
IL126095A0 (en) * 1996-03-08 1999-05-09 Zeneca Ltd Azolobenzazepine derivatives as neurogically active agents
US20070059533A1 (en) * 2005-09-12 2007-03-15 Burdette Steven R Thermal reflow of glass and fused silica body

Also Published As

Publication number Publication date
US7022860B2 (en) 2006-04-04
US20060074074A1 (en) 2006-04-06
RU2198885C2 (ru) 2003-02-20
KR100389140B1 (ko) 2003-06-25
PL339544A1 (en) 2000-12-18
KR20010030784A (ko) 2001-04-16
NZ503601A (en) 2002-02-01
BR9814055A (pt) 2000-09-26
ID24101A (id) 2000-07-06
AU9186998A (en) 1999-04-23
DE69811930D1 (de) 2003-04-10
CN1155599C (zh) 2004-06-30
US20020137739A1 (en) 2002-09-26
ATE233764T1 (de) 2003-03-15
NO20001500L (no) 2000-05-18
EP1026167A1 (en) 2000-08-09
BR9814055B1 (pt) 2009-05-05
CN1523019A (zh) 2004-08-25
SK283869B6 (sk) 2004-03-02
DE69811930T2 (de) 2003-12-18
JP3188482B2 (ja) 2001-07-16
NO20043765L (no) 2000-05-18
US7238812B2 (en) 2007-07-03
SK4252000A3 (en) 2000-10-09
NO319542B1 (no) 2005-08-29
DK1026167T3 (da) 2003-05-26
CN1312135C (zh) 2007-04-25
HUP0004020A3 (en) 2002-12-28
NO20001500D0 (no) 2000-03-23
IL135303A0 (en) 2001-05-20
TR200000808T2 (tr) 2000-08-21
CA2305307A1 (en) 1999-04-08
CA2305307C (en) 2004-11-30
CN1278262A (zh) 2000-12-27
ES2191963T3 (es) 2003-09-16
EP1026167B1 (en) 2003-03-05
AU744636B2 (en) 2002-02-28
EP1026167A4 (en) 2001-07-11
HUP0004020A2 (hu) 2001-09-28
US6372735B1 (en) 2002-04-16
PT1026167E (pt) 2003-07-31
TW510902B (en) 2002-11-21
WO1999016770A1 (fr) 1999-04-08

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20140929