HK1032538A1 - Pharmaceutical formulation of a didemnin compound - Google Patents

Pharmaceutical formulation of a didemnin compound

Info

Publication number
HK1032538A1
HK1032538A1 HK01103194A HK01103194A HK1032538A1 HK 1032538 A1 HK1032538 A1 HK 1032538A1 HK 01103194 A HK01103194 A HK 01103194A HK 01103194 A HK01103194 A HK 01103194A HK 1032538 A1 HK1032538 A1 HK 1032538A1
Authority
HK
Hong Kong
Prior art keywords
didemnin
pharmaceutical formulation
compound
didemnin compound
lyophilized
Prior art date
Application number
HK01103194A
Other languages
English (en)
Inventor
Jacob Hendrik Beijnen
Bastiaan Nuyen
Roland E C Henrar
Andres Gomez
Jose Jimeno
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10827213&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1032538(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of HK1032538A1 publication Critical patent/HK1032538A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK01103194A 1998-02-18 2001-05-07 Pharmaceutical formulation of a didemnin compound HK1032538A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9803448.1A GB9803448D0 (en) 1998-02-18 1998-02-18 Pharmaceutical formulation
PCT/GB1999/000511 WO1999042125A1 (fr) 1998-02-18 1999-02-18 Formulation pharmaceutique d'un compose de didemnine

Publications (1)

Publication Number Publication Date
HK1032538A1 true HK1032538A1 (en) 2001-07-27

Family

ID=10827213

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01103194A HK1032538A1 (en) 1998-02-18 2001-05-07 Pharmaceutical formulation of a didemnin compound

Country Status (17)

Country Link
US (1) US8420130B1 (fr)
EP (1) EP1054686B1 (fr)
JP (2) JP4536255B2 (fr)
KR (1) KR100595597B1 (fr)
CN (1) CN1170586C (fr)
AT (1) ATE217532T1 (fr)
AU (1) AU754073B2 (fr)
BR (1) BRPI9908088C1 (fr)
CA (1) CA2321116C (fr)
DE (1) DE69901487T2 (fr)
DK (1) DK1054686T3 (fr)
ES (1) ES2175940T3 (fr)
GB (1) GB9803448D0 (fr)
HK (1) HK1032538A1 (fr)
IL (1) IL137911A (fr)
PT (1) PT1054686E (fr)
WO (1) WO1999042125A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030148933A1 (en) 1990-10-01 2003-08-07 Pharma Mar S.A. Derivatives of dehydrodidemnin B
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
GB0002952D0 (en) 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
DE10008128A1 (de) * 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
BR0114604A (pt) 2000-10-12 2003-10-14 Pharma Mar Sa Tratamento de c‰nceres
US7473681B2 (en) * 2000-10-31 2009-01-06 Pharma Mar, S.A. Kahalalide F
GB0304367D0 (en) 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
US7381703B2 (en) * 2003-03-12 2008-06-03 Dana-Faber Cancer Institute, Inc. Aplidine for multiple myeloma treatment
AU2004220451B2 (en) 2003-03-12 2010-01-21 Pharma Mar, S.A. Improved antitumoral treatments
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
CN100335495C (zh) * 2006-01-23 2007-09-05 南方医科大学 一种海鞘多肽及其制备方法
EP2029155B1 (fr) 2006-02-28 2016-04-13 Pharma Mar S.A. L'amélioration du traitement du myélome multiple
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
BR112013020383A2 (pt) * 2011-02-09 2017-06-13 Glaxosmithkline Llc formulações liofilizadas.
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CA3169544A1 (fr) 2020-03-02 2021-09-10 Pablo Aviles Marin Composes destines a etre utilises en conditions inflammatoires
CA3169528A1 (fr) 2020-03-02 2021-09-10 Pharma Mar, S.A.U. Pld s'utilisant en combinaison dans le traitement de coronavirus
US20230158104A1 (en) 2020-03-02 2023-05-25 Pharma Mar, S.A. Compounds for use in autoimmune conditions
AU2021232534A1 (en) 2020-03-02 2022-10-06 Pharma Mar, S.A. Compounds for use in the treatment of coronavirus infection
CN114085272B (zh) * 2022-01-10 2022-06-10 中山大学 一种isaridin类环酯肽衍生物及其制备方法和应用

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342744A (en) * 1979-07-19 1982-08-03 Lever Brothers Company Hair treatment products
DE3161556D1 (en) * 1980-09-12 1984-01-05 Univ Illinois Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them
US4493796A (en) 1980-09-12 1985-01-15 Board Of Trustees, Univ. Of Ill. Didemnins A, B, C, and derivatives thereof, as antiviral agents
US4950649A (en) * 1980-09-12 1990-08-21 University Of Illinois Didemnins and nordidemnins
JPS5781413A (en) * 1980-09-12 1982-05-21 Univ Illinois Didemnin antibiotic
IT1153974B (it) 1982-09-23 1987-01-21 Erba Farmitalia Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento
US4948791A (en) 1989-04-10 1990-08-14 The Board Of Trustees Of The University Of Illinois Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum
GB8922026D0 (en) 1989-09-29 1989-11-15 Pharma Mar Sa Novel anti-viral and cytotoxic agent
DE4120327A1 (de) 1991-06-20 1992-12-24 Basf Ag Neue peptide, ihre herstellung und verwendung
FR2698543B1 (fr) * 1992-12-02 1994-12-30 Rhone Poulenc Rorer Sa Nouvelles compositions à base de taxoides.
IL109350A (en) * 1993-05-12 2001-01-28 Genentech Inc Stable liquid preparations of gamma interferon
US5462726A (en) * 1993-12-17 1995-10-31 Bristol-Myers Squibb Company Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents
CA2180260A1 (fr) * 1993-12-29 1995-07-06 Dennis M. Brown Procedes et compositions utilises dans le traitement d'un hote affecte par une maladie a proliferation cellulaire
US5861439A (en) * 1994-11-14 1999-01-19 Alza Corporation Method for enhanced electrotransport agent delivery
ES2102322B1 (es) 1995-07-13 1998-03-01 Pharma Mar Sa Procedimiento de preparacion de didemnina a.
US6365597B1 (en) * 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US20020077461A1 (en) * 1996-04-24 2002-06-20 Soren Bjorn Pharmaceutical formulation
DK0914116T3 (da) 1996-05-22 2000-11-20 Protarga Inc Kompositstoffer omfattende konjugater af cis-docosahexaensyre og Taxotere
US6156724A (en) 1996-06-07 2000-12-05 Rinehart; Kenneth L. Uses of didemnins as immunomodulating agents
GB2331744B (en) 1996-07-03 2000-07-26 Mckechnie Uk Ltd Container
US6380156B1 (en) 1996-10-24 2002-04-30 The Board Of Trustees Of The University Of Illnois Total synthesis of the amino hip analogue of didemnin A
WO1998017275A1 (fr) 1996-10-24 1998-04-30 The Board Of Trustees Of The University Of Illinois Procedes semi-synthetiques de preparation d'analogues de didemnine
US6034058A (en) 1997-04-15 2000-03-07 Rinehart; Kenneth L. Semi-synthetic alanyl dilemnin analogs
JP4327260B2 (ja) 1997-05-07 2009-09-09 フアルマ・マル・エセ・ア Ｌ型カルシウムチャンネルエンハンサーとしてのアプリジン
GB9803448D0 (en) 1998-02-18 1998-04-15 Pharma Mar Sa Pharmaceutical formulation
EP1100589B1 (fr) 1998-07-30 2005-01-19 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Utilisation de propionyle l-carnitine et d'acetyl l-carnitine dans la preparation de medicaments a action anticancereuse
US20010021380A1 (en) 1999-04-19 2001-09-13 Pluenneke John D. Soluble tumor necrosis factor receptor treatment of medical disorders
WO2000071135A1 (fr) 1999-05-25 2000-11-30 Point Therapeutics, Inc. Agents anti-tumorales contenant des composes de boroproline
US6890904B1 (en) 1999-05-25 2005-05-10 Point Therapeutics, Inc. Anti-tumor agents
CN1423564A (zh) 1999-11-15 2003-06-11 法马马有限公司 癌症的aplidine治疗
US6509315B1 (en) 2000-04-07 2003-01-21 The Trustees Of The University Of Pennsylvania Didemnin analogs and fragments and methods of making and using them
PL358579A1 (en) 2000-04-07 2004-08-09 The Trustees Of The University Of Pennsylvania Tamandarin and didemnin analogs and methods of making and using them
UA76718C2 (uk) 2000-06-30 2006-09-15 Фарма Мар, С.А. Протипухлинні похідні аплідину
CA2423462A1 (fr) 2000-10-05 2002-04-11 Immunex Corporation Polypeptides de nectine, polynucleotides, procedes de fabrication et utilisation
CA2424823A1 (fr) 2000-10-12 2002-04-18 Pharma Mar, S.A. Traitement de cancers
AU2002224417A1 (en) 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
PT1435991E (pt) 2001-10-19 2009-01-16 Pharma Mar Sa Utilização de aplidina para o tratamento de cancro pancreático
AU2004220451B2 (en) 2003-03-12 2010-01-21 Pharma Mar, S.A. Improved antitumoral treatments

Also Published As

Publication number Publication date
AU2538999A (en) 1999-09-06
DE69901487T2 (de) 2002-12-19
IL137911A (en) 2006-04-10
GB9803448D0 (en) 1998-04-15
ES2175940T3 (es) 2002-11-16
DE69901487D1 (de) 2002-06-20
CA2321116A1 (fr) 1999-08-26
US8420130B1 (en) 2013-04-16
BRPI9908088C1 (pt) 2021-05-25
EP1054686A1 (fr) 2000-11-29
KR100595597B1 (ko) 2006-07-03
CN1330551A (zh) 2002-01-09
IL137911A0 (en) 2001-10-31
JP2002503704A (ja) 2002-02-05
PT1054686E (pt) 2002-09-30
DK1054686T3 (da) 2002-06-17
CA2321116C (fr) 2009-10-06
ATE217532T1 (de) 2002-06-15
AU754073B2 (en) 2002-11-07
WO1999042125A1 (fr) 1999-08-26
CN1170586C (zh) 2004-10-13
BR9908088B1 (pt) 2013-05-21
EP1054686B1 (fr) 2002-05-15
JP2010163443A (ja) 2010-07-29
BR9908088A (pt) 2000-10-31
BRPI9908088B8 (pt) 2017-03-07
KR20010040993A (ko) 2001-05-15
JP4536255B2 (ja) 2010-09-01

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Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20190217