HK1028020A1 - Alpha-aminoamide derivatives useful as analgesic agents - Google Patents

Alpha-aminoamide derivatives useful as analgesic agents

Info

Publication number
HK1028020A1
HK1028020A1 HK00107398A HK00107398A HK1028020A1 HK 1028020 A1 HK1028020 A1 HK 1028020A1 HK 00107398 A HK00107398 A HK 00107398A HK 00107398 A HK00107398 A HK 00107398A HK 1028020 A1 HK1028020 A1 HK 1028020A1
Authority
HK
Hong Kong
Prior art keywords
sub
hydrogen
alkyl
integer
present
Prior art date
Application number
HK00107398A
Other languages
English (en)
Inventor
Paolo Pevarello
Mario Varasi
Patricia Salvati
Claes Post
Original Assignee
Newron Pharm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10824342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1028020(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Newron Pharm Spa filed Critical Newron Pharm Spa
Publication of HK1028020A1 publication Critical patent/HK1028020A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/54—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and etherified hydroxy groups bound to the carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
HK00107398A 1997-12-31 2000-11-20 Alpha-aminoamide derivatives useful as analgesic agents HK1028020A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9727523.4A GB9727523D0 (en) 1997-12-31 1997-12-31 Alpha-aminoamide derivatives useful as analgesic agents
PCT/EP1998/008157 WO1999035125A1 (fr) 1997-12-31 1998-12-12 Derives alpha-aminoamides utiles en tant qu'agents analgesiques

Publications (1)

Publication Number Publication Date
HK1028020A1 true HK1028020A1 (en) 2001-02-02

Family

ID=10824342

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00107398A HK1028020A1 (en) 1997-12-31 2000-11-20 Alpha-aminoamide derivatives useful as analgesic agents

Country Status (19)

Country Link
US (2) US6306903B1 (fr)
EP (1) EP1045830B1 (fr)
JP (1) JP4410930B2 (fr)
KR (1) KR100525587B1 (fr)
AT (1) ATE238273T1 (fr)
BR (1) BR9814548A (fr)
CA (1) CA2316902C (fr)
DE (1) DE69813896T2 (fr)
DK (1) DK1045830T3 (fr)
EA (1) EA002763B1 (fr)
ES (1) ES2194392T3 (fr)
GB (1) GB9727523D0 (fr)
HK (1) HK1028020A1 (fr)
HU (1) HU228995B1 (fr)
IL (2) IL136734A0 (fr)
NO (1) NO327453B1 (fr)
NZ (1) NZ505440A (fr)
PT (1) PT1045830E (fr)
WO (1) WO1999035125A1 (fr)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL136044A (en) 1997-11-21 2005-08-31 Euro Celtique Sa 2-aminoacetamide derivatives and pharmaceutical compositions containing the same
WO2002048114A1 (fr) * 2000-11-27 2002-06-20 Pharmacia Italia S.P.A. Derives phenylacetamido-pyrazole et leur utilisation comme agents antitumoraux
ES2253579T3 (es) 2001-09-03 2006-06-01 Newron Pharmaceuticals S.P.A. Composicion farmaceutica que comprende gabapentina o un analogo suyo y una alfa-aminoamida y su uso analgesico.
US6476068B1 (en) 2001-12-06 2002-11-05 Pharmacia Italia, S.P.A. Platinum derivative pharmaceutical formulations
EP1438956A1 (fr) * 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Dérivés alpha-aminoamides en tant qu'agents antimigraine
WO2004087125A1 (fr) * 2003-04-02 2004-10-14 Ionix Pharmaceuticals Limited Derives d'acides amines en tant qu'inhibiteurs des canaux sodiques de mammiferes
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
WO2005000309A2 (fr) * 2003-06-27 2005-01-06 Ionix Pharmaceuticals Limited Composes chimiques
AU2004266494B2 (en) * 2003-08-25 2010-04-08 Newron Pharmaceuticals, Spa Alpha-aminoamide derivatives useful as anti-inflammatory agents
EP1524267A1 (fr) * 2003-10-15 2005-04-20 Newron Pharmaceuticals S.p.A. Heterocycles benzyleaminoalkylene substitues
EP1533298A1 (fr) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Dérivés de 3-aminopyrrolidone
EP1533302A1 (fr) * 2003-11-21 2005-05-25 Newron Pharmaceuticals S.p.A. Dérivés de l'histidine
EP1533295A1 (fr) * 2003-11-24 2005-05-25 Newron Pharmaceuticals S.p.A. Dérivés de cyclopentyle
EP1535908A1 (fr) * 2003-11-24 2005-06-01 Newron Pharmaceuticals S.p.A. Derives de N-acyl-N-benzylalkylendiamine
EP1557166A1 (fr) * 2004-01-21 2005-07-27 Newron Pharmaceuticals S.p.A. Derives d'alpha-aminoamides pour le traitement des désordres de l'appareil urinaire inférieur
EP1588704A1 (fr) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Dérivés d'alpha-aminoamides utiles dans le traitement de l'acroparesthésie nocturne et des troubles de toxicomanie
CN101018546B (zh) * 2004-09-10 2013-06-12 纽朗制药有限公司 作为钠和/或钙通道选择性调节剂的(卤代苄氧基)苄氨基-丙酰胺类
JP5139307B2 (ja) * 2005-10-10 2013-02-06 グラクソ グループ リミテッド ナトリウムチャネルモジュレーターとしてのプロリンアミド誘導体
TW200728258A (en) 2005-10-10 2007-08-01 Glaxo Group Ltd Novel compounds
TW200730494A (en) 2005-10-10 2007-08-16 Glaxo Group Ltd Novel compounds
BRPI0620239B8 (pt) * 2005-12-22 2021-05-25 Newron Pharm Spa derivados de 2-feniletilamino.
EP1870097A1 (fr) * 2006-06-15 2007-12-26 Newron Pharmaceuticals S.p.A. Dérivés d'alpha-aminoamide pour le traitement de troubles cognitifs
AU2007263328C1 (en) 2006-06-19 2012-09-06 Newron Pharmaceuticals S.P.A. Process for the production of 2- [4 - ( 3- and 2-fluorobenzyloxy) benzylamino] propan amides
LT2155663T (lt) 2007-06-15 2018-02-12 Newron Pharmaceuticals S.P.A. Pakeisti 2-[2-(fenil)etilamino]alkanamidų dariniai ir jų, kaip natrio ir (arba) kalcio kanalų moduliatorių, panaudojimas
EP2229351B1 (fr) 2007-12-11 2017-11-08 Newron Pharmaceuticals S.p.A. Procédé pour la fabrication de 2-[4-(3- or 2-fluorobenzyloxy)benzylamino]propanamides de grande pureté
EP2314569A1 (fr) 2009-10-22 2011-04-27 Merck Patent GmbH Nouvelles formules polymorphiques de sel de mesylate (S)-2-[4-(3-Fluoro-benzyloxy)-benzylamino]-propionamide, et son procédé de fabrication
HUE030504T2 (en) 2010-04-27 2017-05-29 Newron Pharm Spa Process for the preparation of ralfinamide methanesulfonate salts or their R-enantiomers
EA201590384A1 (ru) 2012-09-10 2015-10-30 Ф. Хоффманн-Ля Рош Аг 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
WO2015102390A1 (fr) * 2013-12-30 2015-07-09 이화여자대학교 산학협력단 Nouveau dérivé d'amide ou sel pharmaceutiquement acceptable de celui-ci, procédé de préparation de celui-ci, et composition pharmaceutique pour prévenir ou traiter la douleur, le contenant
ES2912881T3 (es) 2014-12-23 2022-05-30 Convergence Pharmaceuticals Procedimiento para preparar derivados de alfa-carboxamida pirrolidina
CN107522654B (zh) * 2016-06-21 2020-09-01 中国人民解放军军事医学科学院毒物药物研究所 新的α-氨基酰胺衍生物及其医药用途
SG10202112966SA (en) 2017-10-05 2021-12-30 Biogen Inc Process for preparing αlpha-carboxamide pyrrolidine derivatives

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1140748A (en) 1966-06-23 1969-01-22 Ici Ltd New carboxylic acid derivatives
US3658967A (en) 1966-06-23 1972-04-25 Ici Ltd Carboxylic acid derivatives for lowering the concentration of triglycerides in the blood
CH480308A (de) 1966-08-11 1969-10-31 Ciba Geigy Verfahren zur Herstellung von Thiosemicarbazid-Verbindungen
US4049663A (en) * 1972-06-06 1977-09-20 Allen & Hanburys Limited Ethylene diamine derivatives
US4311853A (en) 1979-02-06 1982-01-19 The Radiochemical Centre Limited Selenium derivatives of thyroxine and tri-iodothyronine
DE3050800C2 (fr) 1979-03-22 1989-06-22 Continental Pharma Inc., Bruessel/Bruxelles, Be
US4267354A (en) 1979-04-25 1981-05-12 E. R. Squibb & Sons, Inc. Substituted amides having antiinflammatory activity and intermediates
ZA805476B (en) 1979-09-26 1981-11-25 Robins Co Inc A H 2-amino-3-benzoyl-phenylacetamides and cyclic homologues
FR2480747A1 (fr) 1980-04-17 1981-10-23 Roques Bernard Derives d'acides amines et leur application therapeutique
EP0144853B1 (fr) 1983-11-21 1990-09-26 Fujisawa Pharmaceutical Co., Ltd. Dérivés semicarbazides, procédé pour leur préparation et compositions pharmaceutiques les contenant
US4631287A (en) 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
GB8714901D0 (en) 1986-07-23 1987-07-29 Ici Plc Amide derivatives
GB2216515A (en) 1988-03-04 1989-10-11 Nippon Shinyaku Co Ltd Acylphenol derivatives
IL94466A (en) * 1989-05-25 1995-01-24 Erba Carlo Spa Pharmaceutical preparations containing the history of A-amino carboxamide N-phenylalkyl are converted into such new compounds and their preparation
US5153226A (en) 1989-08-31 1992-10-06 Warner-Lambert Company Acat inhibitors for treating hypocholesterolemia
EP0525360B1 (fr) 1991-07-30 1998-03-25 Korea Research Institute Of Chemical Technology Nouveau dérivés de phénylacetamide et procédé pour leur préparation
US5498610A (en) 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
GB9306899D0 (en) 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylalkylaminobenzyl) aminopropionamide derivatives and process for their preparation
GB9306886D0 (en) * 1993-04-01 1993-05-26 Erba Carlo Spa Substituted (arylakoxybenzyl) aminopropanamide derivatives and process for their preparation
US5475007A (en) 1993-05-28 1995-12-12 The Regents Of The University Of California 1,2,3,4-tetrahydroquinoline-2,3,4-trione-3 or 4-oximes and the use thereof
US5482964A (en) 1994-10-11 1996-01-09 Warner-Lambert Company Substituted phenoxyhydroxypropyl amines as central nervous system agents
US5541204A (en) 1994-12-02 1996-07-30 Bristol-Myers Squibb Company Aryloxypropanolamine β 3 adrenergic agonists
KR0147963B1 (ko) 1995-01-10 1998-08-17 강박광 엔-아릴알킬페닐아세트아미드 유도체와 그의 제조방법
US5849737A (en) 1995-04-14 1998-12-15 The Regents Of The University Of California Compositions and methods for treating pain
US5741818A (en) 1995-06-07 1998-04-21 University Of Saskatchewan Semicarbazones having CNS activity and pharmaceutical preparations containing same
GB9515412D0 (en) * 1995-07-27 1995-09-27 Pharmacia Spa 2-(4-substituted)-benzylamino-2-methyl-propanamide derivatives
GB9515411D0 (en) 1995-07-27 1995-09-27 Pharmacia Spa N-(4-substituted-benzyl)-2-aminolactam derivatives
US5688830A (en) 1996-01-25 1997-11-18 Syntex (U.S.A.) Inc. Treatment of neuropathic pain
TW492957B (en) 1996-11-07 2002-07-01 Novartis Ag N-substituted 2-cyanopyrrolidnes
GB9706730D0 (en) 1997-04-03 1997-05-21 Pharmacia & Upjohn Spa 2-[(3-substituted)-5-Isoxazolymethylaminojalkanamid derivatives
BR9809288A (pt) 1997-04-22 2001-08-07 Cocensys Inc Semicarbazonas e tiosemicarbazonas substituìdas carbocìclicas e heterocìclicas e utilização das mesmas
IL136044A (en) 1997-11-21 2005-08-31 Euro Celtique Sa 2-aminoacetamide derivatives and pharmaceutical compositions containing the same
GB9727521D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Substituted 2-benzylamino-2-phenyl-acetamide compounds
MXPA00007585A (es) 1998-02-04 2002-10-17 Euro Celtique Sa Semicarbazidas substituidas y el uso de las mismas.
US6281211B1 (en) 1999-02-04 2001-08-28 Euro-Celtique S.A. Substituted semicarbazides and the use thereof
ES2253579T3 (es) 2001-09-03 2006-06-01 Newron Pharmaceuticals S.P.A. Composicion farmaceutica que comprende gabapentina o un analogo suyo y una alfa-aminoamida y su uso analgesico.
EP1438956A1 (fr) 2003-01-16 2004-07-21 Newron Pharmaceuticals S.p.A. Dérivés alpha-aminoamides en tant qu'agents antimigraine
AR044007A1 (es) 2003-04-11 2005-08-24 Newron Pharmaceuticals Inc Metodos para el tratamiento de la enfermedad de parkinson
EP1588704A1 (fr) 2004-04-22 2005-10-26 Newron Pharmaceuticals S.p.A. Dérivés d'alpha-aminoamides utiles dans le traitement de l'acroparesthésie nocturne et des troubles de toxicomanie

Also Published As

Publication number Publication date
CA2316902C (fr) 2006-06-06
BR9814548A (pt) 2000-10-10
WO1999035125A1 (fr) 1999-07-15
EP1045830B1 (fr) 2003-04-23
HUP0100870A2 (hu) 2001-07-30
DK1045830T3 (da) 2003-08-04
HU228995B1 (en) 2013-07-29
EA002763B1 (ru) 2002-08-29
IL136734A (en) 2007-03-08
HUP0100870A3 (en) 2002-11-28
DE69813896D1 (de) 2003-05-28
NZ505440A (en) 2002-02-01
KR20010033706A (ko) 2001-04-25
EA200000731A1 (ru) 2001-02-26
IL136734A0 (en) 2001-06-14
ES2194392T3 (es) 2003-11-16
NO327453B1 (no) 2009-07-06
US6306903B1 (en) 2001-10-23
NO20003399D0 (no) 2000-06-29
ATE238273T1 (de) 2003-05-15
JP4410930B2 (ja) 2010-02-10
JP2002508302A (ja) 2002-03-19
NO20003399L (no) 2000-08-02
CA2316902A1 (fr) 1999-07-15
PT1045830E (pt) 2003-08-29
KR100525587B1 (ko) 2005-11-03
USRE40259E1 (en) 2008-04-22
DE69813896T2 (de) 2003-11-06
GB9727523D0 (en) 1998-02-25
EP1045830A1 (fr) 2000-10-25

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Effective date: 20181211