HK1024689A1 - Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles - Google Patents

Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles

Info

Publication number
HK1024689A1
HK1024689A1 HK00103861A HK00103861A HK1024689A1 HK 1024689 A1 HK1024689 A1 HK 1024689A1 HK 00103861 A HK00103861 A HK 00103861A HK 00103861 A HK00103861 A HK 00103861A HK 1024689 A1 HK1024689 A1 HK 1024689A1
Authority
HK
Hong Kong
Prior art keywords
6alkyloxy
6alkyl
hydrogen
halo
cyano
Prior art date
Application number
HK00103861A
Other languages
English (en)
Inventor
Marc Gaston Venet
Patrick Rene Angibaud
Yannick Aime Eddy Ligny
Virginie Sophie Poncelet
Gerard Charles Sanz
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1024689A1 publication Critical patent/HK1024689A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
HK00103861A 1997-03-10 2000-06-27 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles HK1024689A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97200708 1997-03-10
EP97200709 1997-03-10
PCT/EP1998/001296 WO1998040383A1 (en) 1997-03-10 1998-03-03 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles

Publications (1)

Publication Number Publication Date
HK1024689A1 true HK1024689A1 (en) 2000-10-20

Family

ID=26146222

Family Applications (1)

Application Number Title Priority Date Filing Date
HK00103861A HK1024689A1 (en) 1997-03-10 2000-06-27 Farnesyl transferase inhibiting 1,8-annelated quinolinone derivatives substituted with n- or c-linked imidazoles

Country Status (22)

Country Link
US (2) US6187786B1 (xx)
EP (1) EP0970079B1 (xx)
JP (1) JP4272262B2 (xx)
KR (1) KR100549096B1 (xx)
CN (1) CN1128797C (xx)
AT (1) ATE251159T1 (xx)
AU (1) AU748702B2 (xx)
BR (1) BR9808843A (xx)
CA (1) CA2283587C (xx)
DE (1) DE69818649T2 (xx)
ES (1) ES2209127T3 (xx)
HK (1) HK1024689A1 (xx)
HU (1) HUP0001498A3 (xx)
IL (1) IL130362A (xx)
NO (1) NO313143B1 (xx)
NZ (1) NZ336234A (xx)
PL (1) PL191564B1 (xx)
RU (1) RU2204553C2 (xx)
SK (1) SK283927B6 (xx)
TR (1) TR199902203T2 (xx)
TW (1) TW591030B (xx)
WO (1) WO1998040383A1 (xx)

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KR100549096B1 (ko) 2006-02-06
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AU748702B2 (en) 2002-06-13
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HUP0001498A2 (hu) 2000-11-28
CA2283587A1 (en) 1998-09-17
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AU7031898A (en) 1998-09-29
ATE251159T1 (de) 2003-10-15
EP0970079B1 (en) 2003-10-01
NZ336234A (en) 2000-10-27
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EP0970079A1 (en) 2000-01-12
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DE69818649T2 (de) 2004-07-01
IL130362A0 (en) 2000-06-01
RU2204553C2 (ru) 2003-05-20
SK283927B6 (sk) 2004-05-04
SK121799A3 (en) 2000-05-16
BR9808843A (pt) 2000-07-04
NO994268D0 (no) 1999-09-02
US6187786B1 (en) 2001-02-13
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US20020049327A1 (en) 2002-04-25
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