HK1021815A1 - Preparation of cyclohexene carboxylate derivatives - Google Patents

Preparation of cyclohexene carboxylate derivatives

Info

Publication number
HK1021815A1
HK1021815A1 HK99105821A HK99105821A HK1021815A1 HK 1021815 A1 HK1021815 A1 HK 1021815A1 HK 99105821 A HK99105821 A HK 99105821A HK 99105821 A HK99105821 A HK 99105821A HK 1021815 A1 HK1021815 A1 HK 1021815A1
Authority
HK
Hong Kong
Prior art keywords
preparation
carboxylate derivatives
cyclohexene carboxylate
useful
formulas
Prior art date
Application number
HK99105821A
Other languages
English (en)
Inventor
Kenneth M Kent
Choung U Kim
Lawrence R Mcgee
John D Munger
Ernest J Prisbe
Michael J Postich
John C Rohloff
Daphne E Kelly
Matthew A Williams
Lijun Zhang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/701,942 external-priority patent/US5859284A/en
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1021815A1 publication Critical patent/HK1021815A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D203/00—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D203/26—Heterocyclic compounds containing three-membered rings with one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C07C227/08—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid by reaction of ammonia or amines with acids containing functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D303/40—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals by ester radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK99105821A 1996-08-23 1999-12-09 Preparation of cyclohexene carboxylate derivatives HK1021815A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2412296P 1996-08-23 1996-08-23
US08/701,942 US5859284A (en) 1996-08-23 1996-08-23 Preparation of carbocyclic compounds
PCT/US1997/014813 WO1998007685A1 (en) 1996-08-23 1997-08-22 Preparation of cyclohexene carboxylate derivatives

Publications (1)

Publication Number Publication Date
HK1021815A1 true HK1021815A1 (en) 2000-10-05

Family

ID=26698076

Family Applications (1)

Application Number Title Priority Date Filing Date
HK99105821A HK1021815A1 (en) 1996-08-23 1999-12-09 Preparation of cyclohexene carboxylate derivatives

Country Status (12)

Country Link
EP (1) EP0920410B1 (xx)
JP (3) JP3622983B2 (xx)
AT (1) ATE215062T1 (xx)
AU (1) AU738577C (xx)
DE (1) DE69711395T2 (xx)
DK (1) DK0920410T3 (xx)
ES (1) ES2173480T3 (xx)
HK (1) HK1021815A1 (xx)
MX (1) MXPA99001697A (xx)
NZ (2) NZ507106A (xx)
PT (1) PT920410E (xx)
WO (1) WO1998007685A1 (xx)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69607704T2 (de) 1995-02-27 2000-12-28 Gilead Sciences Inc Neue selektive inhibitoren viraler oder bakterieller neuraminidasen
US6518438B2 (en) 1996-08-23 2003-02-11 Gilead Sciences, Inc. Preparation of cyclohexene carboxylate derivatives
US5859284A (en) 1996-08-23 1999-01-12 Gilead Sciences, Inc. Preparation of carbocyclic compounds
US5994377A (en) 1996-10-21 1999-11-30 Gilead Sciences, Inc. Piperidine compounds
NZ502988A (en) * 1997-09-17 2002-08-28 Gilead Sciences Inc 5-Acetamido-4-amino-2-propionyloxy-6-isopropoxy-1-cyclohexene useful for treating influenza
US6455571B1 (en) 1998-04-23 2002-09-24 Abbott Laboratories Inhibitors of neuraminidases
US6518305B1 (en) 1998-04-23 2003-02-11 Abbott Laboratories Five-membered carbocyclic and heterocyclic inhibitors of neuraminidases
ATE209621T1 (de) * 1998-05-13 2001-12-15 Hoffmann La Roche Verfahren zur herstellung von shikiminsäure und deren derivate
EP1059283B1 (en) * 1999-06-11 2003-05-28 F. Hoffmann-La Roche Ag Process for preparing neuraminidase inhibitor ro-64-0796
US6593314B1 (en) 1999-10-19 2003-07-15 Abbott Laboratories Neuraminidase inhibitors
AU2039301A (en) * 1999-10-19 2001-04-30 Abbott Laboratories Neuraminidase inhibitors
JP2001131144A (ja) 1999-11-02 2001-05-15 Sagami Chem Res Center ７−アザビシクロ［４．１．０］ヘプト−３−エン−３−カルボン酸エステル類の製造方法
US6462226B1 (en) 1999-12-03 2002-10-08 Hoffmann-La Roche Inc. Process for the preparation of 4,5-diamino shikimic acid derivatives
US6797832B1 (en) 1999-12-27 2004-09-28 Sagami Chemical Research Center Process for the production of 5-oxy-7-oxabicyclo [4.1.0] hept-3-ene-3-carboxylic acid esters
US6403824B2 (en) 2000-02-22 2002-06-11 Hoffmann-La Roche Inc. Process for the preparation for 4,5-diamino shikimic acid derivatives
US6518048B2 (en) 2000-04-10 2003-02-11 Hoffmann-La Roche Inc. Stereo-specific synthesis of shimikic acid derivatives with improved efficiency
US7122684B2 (en) 2003-03-13 2006-10-17 Roche Colorado Corporation Process for preparing 1,2-diamino compounds
RS51073B (sr) 2003-12-23 2010-10-31 Tibotec Pharmaceuticals Ltd. Proces za pripremanje (3r,3as,6ar)-heksahidrofuro│2,3-b│ furan-3-il (1s,2r)-3-││(4-aminofenil) sulfonil│(izobutil) amino │-1-benzil-2-hidroksipropilkarbamata
MX2007002316A (es) 2004-09-02 2007-04-17 Hoffmann La Roche Proceso para preparacion de acido 4,5-diamino shikimico.
PL1951654T3 (pl) * 2005-11-25 2011-11-30 Hetero Drugs Ltd Ulepszony sposób wytwarzania fosforanu oseltamiwiru
EP2178819A2 (en) 2005-12-28 2010-04-28 F.Hoffmann-La Roche Ag Epoxide intermediate in the tamiflu synthesis
US7732632B2 (en) 2006-01-02 2010-06-08 Hetero Drugs Limited Process for obtaining pure oseltamivir
EP1987825B1 (en) 2006-02-20 2018-09-05 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition comprising oseltamivir phosphate
JP2008050336A (ja) * 2006-07-28 2008-03-06 Univ Of Tokyo イソキヌクリジン誘導体およびこれを利用した１−シクロヘキセン−１−カルボン酸誘導体の製法
WO2009037137A2 (en) 2007-09-18 2009-03-26 F. Hoffmann-La Roche Ag Process from shikimic acid to oseltamivir phosphate
US8334319B2 (en) * 2008-01-04 2012-12-18 Roche Palo Alto Llc Polymorphic forms of oseltamivir phosphate
TWI482775B (zh) 2008-09-01 2015-05-01 Tibotec Pharm Ltd 用於製備（３ｒ，３ａｓ，６ａｒ）－六氫呋喃并〔２，３－ｂ〕呋喃－３－基（１ｓ，２ｒ）－３－〔〔（４－胺基苯基）磺醯基〕（異丁基）胺基〕－１－苯甲基－２－羥基丙基胺基甲酸酯之方法
JP5698128B2 (ja) 2009-06-09 2015-04-08 国立大学法人 岡山大学 ジヒドロキシヘキセン酸エステル及びその製造方法
JP4496351B1 (ja) * 2009-09-01 2010-07-07 国立大学法人 岡山大学 １，３−ジオキソラン化合物及びその製造方法
SK288218B6 (sk) 2010-05-05 2014-08-05 Synkola, S.R.O. Spôsob prípravy 1-nitro-4-oxobutanylamidov a ich opačných enantiomérov
JP5039236B1 (ja) 2011-04-27 2012-10-03 学校法人東邦大学 抗不整脈剤及び心房細動抑制剤
WO2014208753A1 (ja) * 2013-06-28 2014-12-31 富士フイルム株式会社 シキミ酸誘導体の製造法および中間体
TWI481600B (zh) * 2013-07-24 2015-04-21 Nat Applied Res Laboratories 一種奎尼酸衍生物、其製程及其用途
CN105439884A (zh) * 2015-10-27 2016-03-30 沈阳药科大学 一种奥司他韦的制备方法
CN110272381A (zh) * 2019-06-19 2019-09-24 五邑大学 含吡啶片段的奥司他韦类似物及其应用
JP7475578B2 (ja) 2020-07-01 2024-04-30 信越化学工業株式会社 １，３－ジヒドロキシ－１，１，３，３－テトラ－ｔｅｒｔ－ブトキシジシロキサンの製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69607704T2 (de) * 1995-02-27 2000-12-28 Gilead Sciences Inc Neue selektive inhibitoren viraler oder bakterieller neuraminidasen

Also Published As

Publication number Publication date
NZ507106A (en) 2003-01-31
JP2003002888A (ja) 2003-01-08
WO1998007685A1 (en) 1998-02-26
DE69711395D1 (de) 2002-05-02
AU4157997A (en) 1998-03-06
DK0920410T3 (da) 2002-06-10
MXPA99001697A (es) 2004-04-05
EP0920410B1 (en) 2002-03-27
JP2000517306A (ja) 2000-12-26
PT920410E (pt) 2002-07-31
ES2173480T3 (es) 2002-10-16
NZ522535A (en) 2004-07-30
ATE215062T1 (de) 2002-04-15
JP2009167210A (ja) 2009-07-30
JP3622983B2 (ja) 2005-02-23
AU738577B2 (en) 2001-09-20
AU738577C (en) 2002-04-11
EP0920410A1 (en) 1999-06-09
DE69711395T2 (de) 2002-11-07

Similar Documents

Publication Publication Date Title
HK1021815A1 (en) Preparation of cyclohexene carboxylate derivatives
MXPA96003822A (es) Aislamiento de material celular bajo visualizacional microscopio.
CA2263136A1 (en) Preparation of cyclohexene carboxylate derivatives
BG103485A (en) Ketobanzamides as calpain inhibitors
AU2002319814A1 (en) Substituted 1h-dihydropyrazoles, their preparation and use
BG102071A (en) Minor molecule inhibitors of rotamase enzymic activity
MX9703564A (es) Inhibidores de proteasa multicatalitica.
AU7725596A (en) Antithrombotic diamines
GEP20084461B (en) New derivative of 3,3- diphenyl-propylamine
DE69401204D1 (de) Gonadotropin enthaltende gefriergetrocknete troepfen
ES2136037A1 (es) Inhibidores de sulfamida-metaloproteasa
BG103310A (en) Benzonaphthyridins as bronchial therapeutical means
HRP20020330A2 (en) Novel oligosaccharides, preparation method and pharmaceutical compositions containing same
MY118828A (en) Substituted amino compounds and their use as substances having an analgesic effect
MX9801987A (es) Nuevos derivados de aminoacido, su obtencion y su uso.
CA2160961A1 (fr) Nouveaux composes amides tricycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
NZ331875A (en) Asymmetric synthesis of R-alpha-propyl-piperonyl amine and its analogs
IL117209A (en) 1-aryl-2-acylamino-ethane compounds and pharmaceutical compositions containing them
MY120683A (en) New phenylamidine derivatives, processes for their preparation and their use as pharmaceuticals.
MY120550A (en) Substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-ols, processes for preparing them and their use as pharmaceutical compositions.
ATE305771T1 (de) Verfahren zur herstellung von vitaminpulvern
GEP20074226B (en) Novel selective inhibitors of viral or bacterial neuraminidases
MD502G2 (ro) Derivaţi noi ai adenozinei, procedee de preparare a lor, compoziţii farmaceutice ce le conţin
MY127474A (en) Naphthyl compounds, intermediates, compositions, and methods of use
BG102213A (en) Endoparasiticidic composition based on didepsipeptides, new didepsipeptides and method for their preparation

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20170821