HK1007881A1 - Sugar modified nucleosides and their use for synthesis of oligonucleotides - Google Patents

Sugar modified nucleosides and their use for synthesis of oligonucleotides

Info

Publication number
HK1007881A1
HK1007881A1 HK98109044A HK98109044A HK1007881A1 HK 1007881 A1 HK1007881 A1 HK 1007881A1 HK 98109044 A HK98109044 A HK 98109044A HK 98109044 A HK98109044 A HK 98109044A HK 1007881 A1 HK1007881 A1 HK 1007881A1
Authority
HK
Hong Kong
Prior art keywords
oligonucleotides
synthesis
modified nucleosides
sugar modified
sugar
Prior art date
Application number
HK98109044A
Other languages
English (en)
Inventor
Guangyi Wang
Kandasamy Ramasamy
Wilfried Seifert
Original Assignee
Icn Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icn Pharmaceuticals filed Critical Icn Pharmaceuticals
Publication of HK1007881A1 publication Critical patent/HK1007881A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK98109044A 1994-11-02 1998-07-09 Sugar modified nucleosides and their use for synthesis of oligonucleotides HK1007881A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/333,545 US5681940A (en) 1994-11-02 1994-11-02 Sugar modified nucleosides and oligonucleotides
PCT/US1995/014600 WO1996014329A1 (fr) 1994-11-02 1995-11-02 Nucleosides modifies au niveau du groupe sucre et leur utilisation pour la synthese d'oligonucleotides

Publications (1)

Publication Number Publication Date
HK1007881A1 true HK1007881A1 (en) 1999-04-30

Family

ID=23303253

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98109044A HK1007881A1 (en) 1994-11-02 1998-07-09 Sugar modified nucleosides and their use for synthesis of oligonucleotides

Country Status (17)

Country Link
US (3) US5681940A (fr)
EP (1) EP0789706A4 (fr)
JP (1) JP3633626B2 (fr)
KR (1) KR100274331B1 (fr)
CN (1) CN1122040C (fr)
AU (1) AU690394B2 (fr)
CA (2) CA2307311A1 (fr)
CZ (1) CZ293731B6 (fr)
HK (1) HK1007881A1 (fr)
HU (1) HUT77516A (fr)
MX (1) MX9703192A (fr)
PL (1) PL184378B1 (fr)
RU (1) RU2145964C1 (fr)
SI (1) SI9520113A (fr)
SK (1) SK54897A3 (fr)
UA (1) UA45362C2 (fr)
WO (1) WO1996014329A1 (fr)

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US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US20040161777A1 (en) * 1996-06-06 2004-08-19 Baker Brenda F. Modified oligonucleotides for use in RNA interference
US20040171032A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Non-phosphorous-linked oligomeric compounds and their use in gene modulation
US20040171030A1 (en) * 1996-06-06 2004-09-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to cytosine and uracil or thymine and their use in gene modulation
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US20050118605A9 (en) * 1996-06-06 2005-06-02 Baker Brenda F. Oligomeric compounds having modified bases for binding to adenine and guanine and their use in gene modulation
US6210707B1 (en) * 1996-11-12 2001-04-03 The Regents Of The University Of California Methods of forming protein-linked lipidic microparticles, and compositions thereof
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Also Published As

Publication number Publication date
PL319944A1 (en) 1997-09-01
US6191266B1 (en) 2001-02-20
US5681940A (en) 1997-10-28
PL184378B1 (pl) 2002-10-31
JP3633626B2 (ja) 2005-03-30
EP0789706A4 (fr) 1999-08-11
UA45362C2 (uk) 2002-04-15
CA2307311A1 (fr) 1996-05-17
JPH10506915A (ja) 1998-07-07
AU4152596A (en) 1996-05-31
US5712378A (en) 1998-01-27
CZ293731B6 (cs) 2004-07-14
CN1122040C (zh) 2003-09-24
WO1996014329A1 (fr) 1996-05-17
CN1170412A (zh) 1998-01-14
MX9703192A (es) 1997-12-31
EP0789706A1 (fr) 1997-08-20
AU690394B2 (en) 1998-04-23
CA2202280A1 (fr) 1996-05-17
RU2145964C1 (ru) 2000-02-27
SK54897A3 (en) 1997-09-10
KR100274331B1 (ko) 2000-12-15
CA2202280C (fr) 2000-08-15
CZ129197A3 (en) 1997-10-15
HUT77516A (hu) 1998-05-28
SI9520113A (sl) 1998-06-30

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