MX9703192A - Nucleosidos modificados en el azucar y su uso para la sintesis de oligonucleosidos. - Google Patents
Nucleosidos modificados en el azucar y su uso para la sintesis de oligonucleosidos.Info
- Publication number
- MX9703192A MX9703192A MX9703192A MX9703192A MX9703192A MX 9703192 A MX9703192 A MX 9703192A MX 9703192 A MX9703192 A MX 9703192A MX 9703192 A MX9703192 A MX 9703192A MX 9703192 A MX9703192 A MX 9703192A
- Authority
- MX
- Mexico
- Prior art keywords
- oligonucleotides
- modified
- synthesis
- modified nucleosides
- nucleosides
- Prior art date
Links
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title abstract 3
- 125000003835 nucleoside group Chemical group 0.000 title abstract 3
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 239000002777 nucleoside Substances 0.000 abstract 2
- 150000008300 phosphoramidites Chemical class 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical group OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical group OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 1
- 101710163270 Nuclease Proteins 0.000 abstract 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Chemical group OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Chemical group OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 1
- 230000000692 anti-sense effect Effects 0.000 abstract 1
- 230000004700 cellular uptake Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Se describen muchos nucleosidos modificados compuestos de las porciones de azucar modificadas, las cuales contienen los sustituyentes en las posiciones C1 y C4, o los sustituyentes ramificados en las posiciones C3 y C5 de la desoxiribosa o ribosa. Cada nucleosido se convierte a o se protege adecuadamente y los convierte a las fosforamiditas correspondientes. Estas fosforamiditas se utilizan para ensamblar oligonucleotidos, en los cuales hay por lo menos uno de los nucleosidos mencionados en lo anterior. Estos oligonucleotidos modificados en el azucar tienen el potencial de ser utilizados como terapias antisentido, ya que se espera que aumenten la resistencia a la nucleasa y la incorporacion celular, mientras que mantienen especificidad de la secuencia y afinidad a los ácidos nucleicos objetivo in vitro o in vivo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/333,545 US5681940A (en) | 1994-11-02 | 1994-11-02 | Sugar modified nucleosides and oligonucleotides |
PCT/US1995/014600 WO1996014329A1 (en) | 1994-11-02 | 1995-11-02 | Sugar modified nucleosides and their use for synthesis of oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9703192A true MX9703192A (es) | 1997-12-31 |
Family
ID=23303253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9703192A MX9703192A (es) | 1994-11-02 | 1995-11-02 | Nucleosidos modificados en el azucar y su uso para la sintesis de oligonucleosidos. |
Country Status (17)
Country | Link |
---|---|
US (3) | US5681940A (es) |
EP (1) | EP0789706A4 (es) |
JP (1) | JP3633626B2 (es) |
KR (1) | KR100274331B1 (es) |
CN (1) | CN1122040C (es) |
AU (1) | AU690394B2 (es) |
CA (2) | CA2202280C (es) |
CZ (1) | CZ293731B6 (es) |
HK (1) | HK1007881A1 (es) |
HU (1) | HUT77516A (es) |
MX (1) | MX9703192A (es) |
PL (1) | PL184378B1 (es) |
RU (1) | RU2145964C1 (es) |
SI (1) | SI9520113A (es) |
SK (1) | SK54897A3 (es) |
UA (1) | UA45362C2 (es) |
WO (1) | WO1996014329A1 (es) |
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1994
- 1994-11-02 US US08/333,545 patent/US5681940A/en not_active Expired - Lifetime
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1995
- 1995-11-02 WO PCT/US1995/014600 patent/WO1996014329A1/en not_active Application Discontinuation
- 1995-11-02 KR KR1019970702924A patent/KR100274331B1/ko not_active IP Right Cessation
- 1995-11-02 UA UA97041994A patent/UA45362C2/uk unknown
- 1995-11-02 MX MX9703192A patent/MX9703192A/es unknown
- 1995-11-02 PL PL95319944A patent/PL184378B1/pl not_active IP Right Cessation
- 1995-11-02 US US08/552,363 patent/US5712378A/en not_active Expired - Fee Related
- 1995-11-02 SK SK548-97A patent/SK54897A3/sk unknown
- 1995-11-02 CA CA002202280A patent/CA2202280C/en not_active Expired - Fee Related
- 1995-11-02 AU AU41525/96A patent/AU690394B2/en not_active Ceased
- 1995-11-02 SI SI9520113A patent/SI9520113A/sl unknown
- 1995-11-02 EP EP95939864A patent/EP0789706A4/en not_active Withdrawn
- 1995-11-02 JP JP51551996A patent/JP3633626B2/ja not_active Expired - Fee Related
- 1995-11-02 CZ CZ19971291A patent/CZ293731B6/cs not_active IP Right Cessation
- 1995-11-02 RU RU97108591/04A patent/RU2145964C1/ru not_active IP Right Cessation
- 1995-11-02 HU HU9702445A patent/HUT77516A/hu unknown
- 1995-11-02 CN CN95196962A patent/CN1122040C/zh not_active Expired - Fee Related
- 1995-11-02 CA CA002307311A patent/CA2307311A1/en not_active Abandoned
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1996
- 1996-12-16 US US08/766,991 patent/US6191266B1/en not_active Expired - Fee Related
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1998
- 1998-07-09 HK HK98109044A patent/HK1007881A1/xx not_active IP Right Cessation
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CZ129197A3 (en) | 1997-10-15 |
HUT77516A (hu) | 1998-05-28 |
JP3633626B2 (ja) | 2005-03-30 |
AU4152596A (en) | 1996-05-31 |
RU2145964C1 (ru) | 2000-02-27 |
PL319944A1 (en) | 1997-09-01 |
JPH10506915A (ja) | 1998-07-07 |
US5681940A (en) | 1997-10-28 |
KR100274331B1 (ko) | 2000-12-15 |
CZ293731B6 (cs) | 2004-07-14 |
AU690394B2 (en) | 1998-04-23 |
HK1007881A1 (en) | 1999-04-30 |
EP0789706A1 (en) | 1997-08-20 |
PL184378B1 (pl) | 2002-10-31 |
CA2202280C (en) | 2000-08-15 |
CN1122040C (zh) | 2003-09-24 |
US6191266B1 (en) | 2001-02-20 |
WO1996014329A1 (en) | 1996-05-17 |
SK54897A3 (en) | 1997-09-10 |
EP0789706A4 (en) | 1999-08-11 |
US5712378A (en) | 1998-01-27 |
CN1170412A (zh) | 1998-01-14 |
CA2202280A1 (en) | 1996-05-17 |
UA45362C2 (uk) | 2002-04-15 |
SI9520113A (sl) | 1998-06-30 |
CA2307311A1 (en) | 1996-05-17 |
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