HK1005728A1 - Piperidyloxy-and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use - Google Patents

Piperidyloxy-and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use Download PDF

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Publication number
HK1005728A1
HK1005728A1 HK98104828A HK98104828A HK1005728A1 HK 1005728 A1 HK1005728 A1 HK 1005728A1 HK 98104828 A HK98104828 A HK 98104828A HK 98104828 A HK98104828 A HK 98104828A HK 1005728 A1 HK1005728 A1 HK 1005728A1
Authority
HK
Hong Kong
Prior art keywords
group
formula
carbon atoms
compound
substituted
Prior art date
Application number
HK98104828A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1005728B (en
Inventor
Nagano Mitsuo
Sakai Junichi
Kobayashi Takeo
Kozuka Masao
Iwata Nobuyoshi
Kubo Yoshiko
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of HK1005728B publication Critical patent/HK1005728B/en
Publication of HK1005728A1 publication Critical patent/HK1005728A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Psychiatry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK98104828A 1990-05-11 1998-06-03 Piperidyloxy-and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use HK1005728A1 (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP11975490 1990-05-11
JP02119754 1990-05-11
JP02216519 1990-08-17
JP21651990 1990-08-17
JP02278489 1990-10-17
JP27848990 1990-10-17

Publications (2)

Publication Number Publication Date
HK1005728B HK1005728B (en) 1999-01-22
HK1005728A1 true HK1005728A1 (en) 1999-01-22

Family

ID=27313898

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98104828A HK1005728A1 (en) 1990-05-11 1998-06-03 Piperidyloxy-and quinuclidinyloxy- isoxazole derivatives, their preparation and their therapeutic use

Country Status (15)

Country Link
US (1) US5643923A (cs)
EP (1) EP0456519B1 (cs)
JP (1) JPH0747585B2 (cs)
KR (1) KR0178369B1 (cs)
CN (1) CN1042225C (cs)
AT (1) ATE108448T1 (cs)
CA (1) CA2042336A1 (cs)
CZ (1) CZ284343B6 (cs)
DE (1) DE69102816T2 (cs)
DK (1) DK0456519T3 (cs)
ES (1) ES2060303T3 (cs)
HK (1) HK1005728A1 (cs)
HU (2) HU215832B (cs)
IE (1) IE65997B1 (cs)
PT (1) PT97637B (cs)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE124865T1 (de) * 1986-12-17 1995-07-15 Glaxo Group Ltd Verwendung von heterocyclischen verbindungen zur behandlung von bewusstseinsstörungen.
EP0492020A1 (en) * 1990-12-21 1992-07-01 Merrell Dow Pharmaceuticals Inc. Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
GB9226573D0 (en) * 1992-12-21 1993-02-17 Ici Plc Heterocyclic compounds
DK124393D0 (da) * 1993-11-03 1993-11-03 Lundbeck & Co As H Compounds
US5821371A (en) * 1994-10-24 1998-10-13 Eli Lilly And Comany Heterocyclic compounds and their preparation and use
US6040442A (en) * 1995-06-01 2000-03-21 Eli Lilly And Company Process for preparing 1,2,5-thiadiazole containing ethers
KR19990087339A (ko) * 1996-02-27 1999-12-27 가와무라 요시부미 이속사졸 유도체
UA52698C2 (uk) 1996-10-04 2003-01-15 Х. Луннбек А/С Похідні (3-алкоксіізоксазол-4-іл)заміщеної 2-амінокарбонової кислоти та їх сірковмісні аналоги, фармацевтична композиція на їх основі
ATE315033T1 (de) 1998-08-07 2006-02-15 Chiron Corp Subtituierte isoxazole derivate als estrogen rezeptor modulatore
US7655657B2 (en) 2003-12-22 2010-02-02 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
US7160876B2 (en) 2003-12-22 2007-01-09 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
AR079493A1 (es) 2009-12-21 2012-02-01 Nippon Soda Co Compuesto de amina ciclica y acaricida
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
HU230649B1 (hu) 2013-01-24 2017-05-29 Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság Javított eljárás prasugrel gyógyszeripari hatóanyag és az 1-ciklopropil-2-(2-fluorofenil)-etanon intermedier előállítására

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3290301A (en) * 1963-12-02 1966-12-06 Shionogi & Co Certain 3-aminoalkyl-5-alkylisoxazoles
AT254868B (de) * 1964-02-13 1967-06-12 Shionogi & Co Verfahren zur Herstellung von neuen disubstituierten Isoxazolverbindungen
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
US5321037A (en) * 1986-12-26 1994-06-14 Sankyo Company, Limited Isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants
ZA879631B (en) * 1986-12-26 1989-08-30 Sankyo Co Centrally-acting muscle relaxants
CA1307790C (en) * 1987-08-04 1992-09-22 Ian Anthony Cliffe Ethers
CA1329128C (en) * 1988-03-24 1994-05-03 Nobuyoshi Iwata Isoxazolinones as cerebro-active drugs
IE62276B1 (en) * 1988-03-30 1995-01-25 Sankyo Co "New isoxazole derivatives for use as cerebro-active drugs and central muscle relaxants"
US5116839A (en) * 1989-06-26 1992-05-26 Sankyo Company, Limited Use of isoxazolin-3-one derivatives as antidepressants
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni

Also Published As

Publication number Publication date
US5643923A (en) 1997-07-01
CN1042225C (zh) 1999-02-24
IE911598A1 (en) 1991-11-20
CN1057259A (zh) 1991-12-25
HU211875A9 (en) 1995-12-28
ATE108448T1 (de) 1994-07-15
JPH0747585B2 (ja) 1995-05-24
JPH04225977A (ja) 1992-08-14
IE65997B1 (en) 1995-11-29
DE69102816T2 (de) 1995-03-16
PT97637A (pt) 1992-02-28
KR0178369B1 (ko) 1999-03-20
HUT60735A (en) 1992-10-28
ES2060303T3 (es) 1994-11-16
CA2042336A1 (en) 1991-11-12
EP0456519B1 (en) 1994-07-13
DE69102816D1 (de) 1994-08-18
HU215832B (hu) 1999-04-28
EP0456519A1 (en) 1991-11-13
KR910019988A (ko) 1991-12-19
PT97637B (pt) 1998-08-31
DK0456519T3 (da) 1994-11-07
CS138591A3 (en) 1992-03-18
CZ284343B6 (cs) 1998-10-14
HU911568D0 (en) 1991-11-28

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)