HK1004110A1 - Transfer of molecules into the cytosol of cells - Google Patents

Transfer of molecules into the cytosol of cells

Info

Publication number
HK1004110A1
HK1004110A1 HK98103468A HK98103468A HK1004110A1 HK 1004110 A1 HK1004110 A1 HK 1004110A1 HK 98103468 A HK98103468 A HK 98103468A HK 98103468 A HK98103468 A HK 98103468A HK 1004110 A1 HK1004110 A1 HK 1004110A1
Authority
HK
Hong Kong
Prior art keywords
cells
molecules
cytosol
transfer
photodynamic treatment
Prior art date
Application number
HK98103468A
Other languages
English (en)
Inventor
Kristian Berg
Kirsten Sandvik
Johan Moan
Original Assignee
Photocure As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure As filed Critical Photocure As
Publication of HK1004110A1 publication Critical patent/HK1004110A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Catalysts (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
HK98103468A 1994-09-08 1998-04-24 Transfer of molecules into the cytosol of cells HK1004110A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO943327A NO180167C (no) 1994-09-08 1994-09-08 Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
PCT/NO1995/000149 WO1996007432A1 (en) 1994-09-08 1995-09-04 Transfer of molecules into the cytosol of cells

Publications (1)

Publication Number Publication Date
HK1004110A1 true HK1004110A1 (en) 1998-11-20

Family

ID=19897382

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98103468A HK1004110A1 (en) 1994-09-08 1998-04-24 Transfer of molecules into the cytosol of cells

Country Status (20)

Country Link
US (3) US5876989A (pt)
EP (1) EP0783323B1 (pt)
JP (1) JP4148328B2 (pt)
KR (2) KR100395615B1 (pt)
CN (1) CN1222309C (pt)
AT (1) ATE209507T1 (pt)
AU (1) AU700797B2 (pt)
BR (1) BRPI9508825B8 (pt)
CA (1) CA2199290C (pt)
CZ (1) CZ65897A3 (pt)
DE (1) DE69524238T2 (pt)
ES (1) ES2163527T3 (pt)
FI (1) FI121328B (pt)
HK (1) HK1004110A1 (pt)
HU (1) HU222984B1 (pt)
MX (1) MX9701676A (pt)
NO (1) NO180167C (pt)
NZ (2) NZ293008A (pt)
PT (1) PT783323E (pt)
WO (1) WO1996007432A1 (pt)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
JP4383545B2 (ja) * 1997-03-19 2009-12-16 ルーシド インコーポレーテッド 共焦点顕微鏡使用法を利用する細胞手術
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
EP2138191A1 (en) 1998-01-05 2009-12-30 University Of Washington Enhanced transport using membrane disruptive agents
US6399769B1 (en) * 1998-01-20 2002-06-04 Kimberly-Clark Worldwide, Inc. Method of making sulfanatophenyl substituted porphines
GB9905911D0 (en) * 1999-03-15 1999-05-05 Photocure As Method
AU6871800A (en) * 1999-09-09 2001-04-17 Center For Advanced Science And Technology Incubation, Ltd. Method of piercing membrane and apparatus therefor
IL154044A0 (en) * 2000-07-21 2003-07-31 Essentia Biosystems Inc Multi-component pharmaceutical compositions containing a complex of a positively charged backbone and a negatively charged backbone and methods for the preparation thereof
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
KR100980153B1 (ko) * 2000-11-29 2010-09-03 피씨아이 바이오테크 에이에스 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행
KR101180548B1 (ko) * 2000-11-29 2012-09-06 피씨아이 바이오테크 에이에스 사이토졸 내로의 바이러스 매개된 분자 전달을 위한 광화학적 내부이행
US20020098472A1 (en) * 2000-11-30 2002-07-25 Erlach Julian Van Method for inserting a microdevice or a nanodevice into a body fluid stream
US20020137901A1 (en) * 2001-01-22 2002-09-26 Cavanaugh Philip Gerard Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin
US20030031655A1 (en) * 2001-02-08 2003-02-13 Sequitur, Inc. Methods of light activated release of ligands from endosomes
DK1407787T3 (da) * 2001-06-20 2009-06-02 Dainippon Sumitomo Pharma Co Fremgangsmåde til fremme af nukleinsyreoverförsel
GB0121023D0 (en) 2001-08-30 2001-10-24 Norwegian Radium Hospital Res Compound
ATE319378T1 (de) 2001-12-03 2006-03-15 Ekos Corp Katheter mit mehreren ultraschall-abstrahlenden teilen
US7141044B2 (en) * 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
WO2003064625A2 (en) 2002-02-01 2003-08-07 Sequitur, Inc. Oligonucleotide compositions with enhanced efficiency
US20060009409A1 (en) * 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US20030166282A1 (en) * 2002-02-01 2003-09-04 David Brown High potency siRNAS for reducing the expression of target genes
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
GB0215534D0 (en) * 2002-07-04 2002-08-14 Ecole Polytech Selective photochemotherapy using oligonucleotide targeting agents
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US6921371B2 (en) * 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
JP2006517790A (ja) * 2003-01-09 2006-08-03 インヴィトロジェン コーポレーション ポリペプチド−核酸複合体の細胞の送達および活性化
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
EP1667732B1 (en) * 2003-09-29 2010-04-21 Nitto Denko Corporation Biodegradable polyacetals for in vivo polynucleotide delivery
US20080318319A1 (en) * 2003-12-19 2008-12-25 Yoshiko Minakuchi Novel Method of Nucleic Acid Transfer
CA3031270A1 (en) 2004-03-03 2005-12-22 Revance Therapeutics, Inc. Compositions and methods for topical diagnostic and therapeutic transport
EP1729821B1 (en) * 2004-03-03 2013-07-17 ReVance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
US20060094781A1 (en) * 2004-11-04 2006-05-04 Syneron Medical Ltd. Method of treating extracellular matrix
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
RU2007136616A (ru) 2005-03-03 2009-04-10 Риванс Терапьютикс, Инк. (Us) Композиция и способ для местного применения и чрескожного введения ботулинового токсина
SG160358A1 (en) * 2005-03-03 2010-04-29 Revance Therapeutics Inc Compositions and methods for topical application and transdermal delivery of an oligopeptide
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
BRPI0501037B8 (pt) * 2005-03-18 2021-07-27 Fund De Amparo A Pesquisa Do Estado De Sao Paulo uso de crotamina e composição
US8518414B2 (en) * 2005-11-17 2013-08-27 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins with reduced non-toxin proteins
WO2007109584A1 (en) * 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
GB0613753D0 (en) * 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
EP2099496A2 (en) * 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
AU2007340162B2 (en) * 2006-12-29 2013-08-01 Revance Therapeutics, Inc. Compositions and methods of topical application and transdermal delivery of botulinum toxins stabilized with polypeptide fragments derived from HIV-TAT
CN101583274A (zh) * 2006-12-29 2009-11-18 雷文斯治疗公司 使用反向序列hiv-tat多肽的运输分子
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
PL2170181T3 (pl) 2007-06-22 2014-08-29 Ekos Corp Sposób i aparat do leczenia wylewów wewnątrzczaszkowych
WO2009079415A1 (en) * 2007-12-14 2009-06-25 Ekos Corporation Ultrasound pulse shaping
GB0811955D0 (en) 2008-06-30 2008-07-30 Pci Biotech As Method
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
GB0914286D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Method
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
GB201208548D0 (en) 2012-05-15 2012-06-27 Pci Biotech As Compound and method
CA2906279A1 (en) 2013-03-15 2014-09-18 Pci Biotech As A method of generating antigen presenting cells using photochemical internalisation
GB2517707B (en) 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
JP6684215B2 (ja) 2013-08-28 2020-04-22 ピーシーアイ バイオテック エイエス 予防接種用化合物および免疫化用化合物、ならびに予防接種方法および免疫化方法
AU2014390262B2 (en) 2014-04-11 2020-11-26 Pci Biotech As Method of treating melanoma
NZ729408A (en) 2014-08-28 2021-12-24 Pci Biotech As A method of photochemical internalization (pci) utilizing a antigenic molecule, a photosensitizing agent, and a cytokine
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2016201136A1 (en) 2015-06-10 2016-12-15 Ekos Corporation Ultrasound catheter
WO2018069536A1 (en) 2016-10-14 2018-04-19 Pci Biotech As Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine
GB201718631D0 (en) * 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) * 2018-01-24 2018-03-07 Pci Biotech As Method
EP3823668A1 (en) 2018-07-16 2021-05-26 DCPrime B.V. A combination product for use in tumor vaccination
CA3133410A1 (en) 2019-04-25 2020-10-29 Dcprime B.V. Methods of tumor vaccination
CN110711249B (zh) * 2019-09-19 2020-10-27 北京化工大学 一种溶酶体膜包覆纳米颗粒的制备方法
AU2021244937A1 (en) 2020-03-27 2022-11-03 Mendus B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
EP4127139A1 (en) 2020-03-27 2023-02-08 Mendus B.V. Ex vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CN114163508A (zh) * 2020-09-11 2022-03-11 王月志 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用
US20220168407A1 (en) 2020-11-05 2022-06-02 Dcprime B.V. Use of tumor-independent antigens in immunotherapies
GB202101726D0 (en) 2021-02-08 2021-03-24 Pci Biotech As Method
AU2022235341A1 (en) 2021-03-12 2023-09-21 Mendus B.V. Methods of vaccination and use of cd47 blockade
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method
WO2024068795A1 (en) 2022-09-27 2024-04-04 Pci Biotech As Method for releasing viral vectors
GB202404168D0 (en) 2024-03-22 2024-05-08 Pci Biotech As Method

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563827B2 (en) 1982-07-01 1987-07-23 Millipore Corp. Filtration apparatus
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4704255A (en) 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US5066274A (en) * 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US5076950A (en) 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US4895706A (en) 1986-10-28 1990-01-23 Costar Corporation Multi-well filter strip and composite assemblies
US5095030A (en) * 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
NO891491D0 (no) * 1987-08-12 1989-04-11 Peter Nemeth Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner.
GB8721108D0 (en) * 1987-09-08 1987-10-14 Salford University Of Liposomes
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5256532A (en) 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US4925736A (en) * 1988-07-06 1990-05-15 Long Island Jewish Medical Center Topical hematoporphyrin
GB8905001D0 (en) 1989-03-04 1989-04-19 Univ Leicester Screening for natural products of microbial metabolism
US5567687A (en) * 1989-03-06 1996-10-22 University Of Texas Texaphyrins and uses thereof
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5059619A (en) * 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
DE3919873A1 (de) 1989-06-19 1990-12-20 Behringwerke Ag Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung
GB8916859D0 (en) 1989-07-24 1989-09-06 Dynal As Hapten linking
GB8929297D0 (en) 1989-12-29 1990-02-28 Dynal As Method of separation
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5491068A (en) 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
PL165249B1 (pl) * 1991-10-29 1994-11-30 Wojskowa Akad Tech Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL
US5376546A (en) * 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
US5258453A (en) * 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
CA2132094A1 (en) * 1992-03-16 1993-09-30 C. Frank Bennett Oligonucleotide modulation of protein kinase c
WO1993019199A1 (en) 1992-03-20 1993-09-30 Celsis Limited Method and apparatus for the analysis of biological material
CA2118513A1 (en) * 1992-04-24 1993-11-11 David A. Zarling In vivo homologous sequence targeting in eukaryotic cells
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
IL107480A0 (en) * 1992-11-03 1994-02-27 Gene Shears Pty Ltd Tnf-x ribozymes and degradation resistant mrna derivatives linked to tnf-x ribozymes
FR2700010B1 (fr) 1992-12-24 1995-03-17 Rocher Yves Biolog Vegetale Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits.
US5374531A (en) 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
US5861310A (en) * 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5872007A (en) * 1995-02-17 1999-02-16 Hybridon, Inc. CAPL-specific oligonucleotides and methods of inhibiting metastatic cancer

Also Published As

Publication number Publication date
HU222984B1 (hu) 2004-01-28
NO180167B (no) 1996-11-18
PT783323E (pt) 2002-03-28
JPH10508295A (ja) 1998-08-18
BR9508825A (pt) 1998-01-06
ES2163527T3 (es) 2002-02-01
DE69524238T2 (de) 2002-07-18
NZ293008A (en) 2001-04-27
ATE209507T1 (de) 2001-12-15
AU3534795A (en) 1996-03-27
NO180167C (no) 1997-02-26
US20020155099A1 (en) 2002-10-24
KR20040004402A (ko) 2004-01-13
EP0783323A1 (en) 1997-07-16
NO943327D0 (no) 1994-09-08
FI121328B (fi) 2010-10-15
KR100529967B1 (ko) 2005-11-22
KR970705415A (ko) 1997-10-09
FI970983A (fi) 1997-03-07
NO943327L (no) 1996-03-11
CN1222309C (zh) 2005-10-12
AU700797B2 (en) 1999-01-14
JP4148328B2 (ja) 2008-09-10
CA2199290A1 (en) 1996-03-14
DE69524238D1 (de) 2002-01-10
EP0783323B1 (en) 2001-11-28
CN1164829A (zh) 1997-11-12
US5876989A (en) 1999-03-02
BRPI9508825B8 (pt) 2021-07-06
BRPI9508825B1 (pt) 2020-12-22
CZ65897A3 (en) 1997-10-15
CA2199290C (en) 2010-10-26
HUT77469A (hu) 1998-05-28
FI970983A0 (fi) 1997-03-07
KR100395615B1 (ko) 2003-12-31
MX9701676A (es) 1998-04-30
US20030134813A1 (en) 2003-07-17
US6680301B2 (en) 2004-01-20
WO1996007432A1 (en) 1996-03-14
NZ509519A (en) 2004-10-29

Similar Documents

Publication Publication Date Title
HK1004110A1 (en) Transfer of molecules into the cytosol of cells
EP0827410A4 (en) METHOD FOR INTRODUCING AND EXPRESSING GENES IN ANIMAL CELLS
AU1059399A (en) Method for electro-permeabilisation of individual cellular and organellar structures and use thereof
HK1047129A1 (en) Sequence-specific dna recombination in eukaryotic cells
MX9605716A (es) Metodos y composiciones para el tratamiento de restenosis y cancer usando ribozimas.
AU2001290706A1 (en) Antisense modulation of clusterin expression
EP0752874A4 (en) A STRENGTHENED VIRUS-TRANSFERED DNA TRANSFER
EP0883344A4 (en) THERAPEUTIC MOLECULES OBTAINED BY TRANS-SPLITTING
NO970049D0 (no) Nukleinsyre holdt i preparat, dets fremstilling og anvendelse
EP1686181A3 (en) Methods for enhanced virus-mediated DNA transfer using molecules with virus-and cell-binding domains
GB0208591D0 (en) Isolation of dna molecules
WO2001029175A3 (en) Antisense modulation of fra-1 expression
AU2672099A (en) Compositions and methods for wound healing
WO1998031786A3 (en) Novel microorganisms
AU6028898A (en) Methods for cultivating cells and propagating viruses
AU2001264317A1 (en) Preparations for oligonucleotide transfer
EP1165145A4 (en) ANTISENSE REGULATION OF MDMX EXPRESSION
WO2001025398A3 (en) Process for inducing functional tolerance to gene transfer products
IL131436A0 (en) Compositions for treatment of disorders involving programmed cell death
WO2001012798A3 (en) Male sterile plants
EP1094115A4 (en) NEGATIVE STRENGTH RNA VIRUS VECTOR
EP1257669A4 (en) ANTISENSE MODULATION OF THE E2F TRANSCRIPTION FACTOR 3 EXPRESSION
DK0980379T3 (da) Chimære oligonucleotider og deres anvendelse
HUP0202722A2 (hu) Szekvencia-specifikus DNS-rekombináció eukarióta sejtekben
WO2002066620A3 (de) Pigmentepithelzelle des auges, ihre herstellung und verwendung in der therapie einer augen- oder zns-erkrankung

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20150903