FI970983A0 - Molekyylien siirto solujen sytoplasmaan - Google Patents

Molekyylien siirto solujen sytoplasmaan

Info

Publication number
FI970983A0
FI970983A0 FI970983A FI970983A FI970983A0 FI 970983 A0 FI970983 A0 FI 970983A0 FI 970983 A FI970983 A FI 970983A FI 970983 A FI970983 A FI 970983A FI 970983 A0 FI970983 A0 FI 970983A0
Authority
FI
Finland
Prior art keywords
cells
molecules
cytoplasm
transfer
photodynamic treatment
Prior art date
Application number
FI970983A
Other languages
English (en)
Swedish (sv)
Other versions
FI121328B (fi
FI970983A (fi
Inventor
Kristian Berg
Kirsten Sandvik
Johan Moan
Original Assignee
Photocure As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Photocure As filed Critical Photocure As
Publication of FI970983A0 publication Critical patent/FI970983A0/fi
Publication of FI970983A publication Critical patent/FI970983A/fi
Application granted granted Critical
Publication of FI121328B publication Critical patent/FI121328B/fi

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Catalysts (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI970983A 1994-09-08 1997-03-07 Molekyylien siirto solujen sytosoliin FI121328B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
NO943327 1994-09-08
NO943327A NO180167C (no) 1994-09-08 1994-09-08 Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
PCT/NO1995/000149 WO1996007432A1 (en) 1994-09-08 1995-09-04 Transfer of molecules into the cytosol of cells
NO9500149 1995-09-04

Publications (3)

Publication Number Publication Date
FI970983A0 true FI970983A0 (fi) 1997-03-07
FI970983A FI970983A (fi) 1997-03-07
FI121328B FI121328B (fi) 2010-10-15

Family

ID=19897382

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970983A FI121328B (fi) 1994-09-08 1997-03-07 Molekyylien siirto solujen sytosoliin

Country Status (20)

Country Link
US (3) US5876989A (fi)
EP (1) EP0783323B1 (fi)
JP (1) JP4148328B2 (fi)
KR (2) KR100395615B1 (fi)
CN (1) CN1222309C (fi)
AT (1) ATE209507T1 (fi)
AU (1) AU700797B2 (fi)
BR (1) BRPI9508825B8 (fi)
CA (1) CA2199290C (fi)
CZ (1) CZ65897A3 (fi)
DE (1) DE69524238T2 (fi)
ES (1) ES2163527T3 (fi)
FI (1) FI121328B (fi)
HK (1) HK1004110A1 (fi)
HU (1) HU222984B1 (fi)
MX (1) MX9701676A (fi)
NO (1) NO180167C (fi)
NZ (2) NZ509519A (fi)
PT (1) PT783323E (fi)
WO (1) WO1996007432A1 (fi)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US6210356B1 (en) * 1998-08-05 2001-04-03 Ekos Corporation Ultrasound assembly for use with a catheter
US6176842B1 (en) * 1995-03-08 2001-01-23 Ekos Corporation Ultrasound assembly for use with light activated drugs
EP1003429B1 (en) * 1997-03-19 2008-09-24 Lucid, Inc. Cellular surgery utilizing confocal microscopy
US6676626B1 (en) 1998-05-01 2004-01-13 Ekos Corporation Ultrasound assembly with increased efficacy
US6582392B1 (en) * 1998-05-01 2003-06-24 Ekos Corporation Ultrasound assembly for use with a catheter
CA2317549C (en) * 1998-01-05 2006-04-11 University Of Washington Composition for enhancing transport through lipid-containing membranes, and uses thereof
US6399769B1 (en) * 1998-01-20 2002-06-04 Kimberly-Clark Worldwide, Inc. Method of making sulfanatophenyl substituted porphines
GB9905911D0 (en) * 1999-03-15 1999-05-05 Photocure As Method
US7320885B1 (en) * 1999-09-09 2008-01-22 Toudai Tlo, Ltd. Method of perforating membrane and apparatus therefor
US20040220100A1 (en) * 2000-07-21 2004-11-04 Essentia Biosystems, Inc. Multi-component biological transport systems
WO2002007773A2 (en) * 2000-07-21 2002-01-31 Essentia Biosystems, Inc. Multi-component biological transport systems
EP1346059B1 (en) * 2000-11-29 2012-05-23 PCI Biotech AS Photochemical internalization for delivery of molecules into the cytosol
ES2445579T3 (es) * 2000-11-29 2014-03-04 Pci Biotech As Internalización fotoquímica para el suministro de moléculas mediado por virus en el citosol
US20020098472A1 (en) * 2000-11-30 2002-07-25 Erlach Julian Van Method for inserting a microdevice or a nanodevice into a body fluid stream
US20020137901A1 (en) * 2001-01-22 2002-09-26 Cavanaugh Philip Gerard Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin
AU2002250034A1 (en) * 2001-02-08 2002-08-19 Sequitur, Inc. Methods of light activated release 0f ligands from endosomes
DK1407787T3 (da) * 2001-06-20 2009-06-02 Dainippon Sumitomo Pharma Co Fremgangsmåde til fremme af nukleinsyreoverförsel
GB0121023D0 (en) * 2001-08-30 2001-10-24 Norwegian Radium Hospital Res Compound
US7220239B2 (en) 2001-12-03 2007-05-22 Ekos Corporation Catheter with multiple ultrasound radiating members
US7141044B2 (en) 2001-12-11 2006-11-28 Ekos Corporation Alternate site gene therapy
DK2128248T4 (en) 2002-02-01 2017-03-13 Life Technologies Corp Oligonucleotide compositions with increased efficiency
EP1572902B1 (en) * 2002-02-01 2014-06-11 Life Technologies Corporation HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES
US20060009409A1 (en) 2002-02-01 2006-01-12 Woolf Tod M Double-stranded oligonucleotides
US8226629B1 (en) 2002-04-01 2012-07-24 Ekos Corporation Ultrasonic catheter power control
US20040248094A1 (en) * 2002-06-12 2004-12-09 Ford Lance P. Methods and compositions relating to labeled RNA molecules that reduce gene expression
GB0215534D0 (en) * 2002-07-04 2002-08-14 Ecole Polytech Selective photochemotherapy using oligonucleotide targeting agents
US20040029275A1 (en) * 2002-08-10 2004-02-12 David Brown Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs
US6921371B2 (en) * 2002-10-14 2005-07-26 Ekos Corporation Ultrasound radiating members for catheter
US20040176282A1 (en) * 2003-01-09 2004-09-09 Brian Dalby Cellular delivery and activation of polypeptide-nucleic acid complexes
US7332477B2 (en) * 2003-07-10 2008-02-19 Nitto Denko Corporation Photocleavable DNA transfer agent
DE602004026747D1 (de) * 2003-09-29 2010-06-02 Nitto Denko Corp Biologisch abbaubare polyacetale für die in-vivo-abgabe von polynucleotiden
US20080318319A1 (en) * 2003-12-19 2008-12-25 Yoshiko Minakuchi Novel Method of Nucleic Acid Transfer
DK1729821T3 (da) * 2004-03-03 2013-10-28 Revance Therapeutics Inc Sammensætninger og fremgangsmåder til topisk påføring og transdermal afgivelse af botulinumtoksiner
MXPA06009897A (es) * 2004-03-03 2008-02-07 Revance Therapeutics Inc Composiciones y metodos para el diagnostico topico y el transporte terapeutico.
US9211248B2 (en) 2004-03-03 2015-12-15 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
US20060094781A1 (en) * 2004-11-04 2006-05-04 Syneron Medical Ltd. Method of treating extracellular matrix
FR2877943B1 (fr) * 2004-11-16 2008-09-05 Univ De Coimbra Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique
US9180081B2 (en) * 2005-03-03 2015-11-10 Revance Therapeutics, Inc. Compositions and methods for topical application and transdermal delivery of botulinum toxins
JP2008531725A (ja) * 2005-03-03 2008-08-14 ルバンス セラピュティックス インク． オリゴペプチドの局所適用及び経皮送達のための組成物及び方法
US7674452B2 (en) * 2005-03-16 2010-03-09 Nitto Denko Corporation Polymer coating of cells
BRPI0501037B8 (pt) * 2005-03-18 2021-07-27 Fund De Amparo A Pesquisa Do Estado De Sao Paulo uso de crotamina e composição
EP1948230A4 (en) * 2005-11-17 2010-03-10 Revance Therapeutics Inc COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL ADMINISTRATION OF BOTULINUM TOXIN CONTAINING LESS NON-TOXIC PROTEINS
WO2007109584A1 (en) * 2006-03-16 2007-09-27 University Of Washington Temperature-and ph-responsive polymer compositions
GB0613753D0 (en) 2006-07-11 2006-08-23 Norwegian Radium Hospital Res Method
EP2099496A2 (en) * 2006-12-08 2009-09-16 Massachusetts Institute of Technology Delivery of nanoparticles and/or agents to cells
CA2672886C (en) * 2006-12-29 2015-02-10 Revance Therapeutics, Inc. Transport molecules using reverse sequence hiv-tat polypeptides
KR20090096735A (ko) * 2006-12-29 2009-09-14 레반스 테라퓨틱스, 아이엔씨. Ｈｉｖ-ｔａｔ로부터 유래된 폴리펩티드 단편에 의해 안정화된 보툴리눔 독소의 국소 적용 및 경피 전달용 조성물 및 방법
US10182833B2 (en) 2007-01-08 2019-01-22 Ekos Corporation Power parameters for ultrasonic catheter
US7981688B2 (en) 2007-03-08 2011-07-19 University Of Washington Stimuli-responsive magnetic nanoparticles and related methods
EP2494932B1 (en) 2007-06-22 2020-05-20 Ekos Corporation Apparatus for treatment of intracranial hemorrhages
EP2231024A4 (en) * 2007-12-14 2015-03-18 Ekos Corp ULTRASOUND PULSE SHAPING
GB0811955D0 (en) 2008-06-30 2008-07-30 Pci Biotech As Method
US8426214B2 (en) * 2009-06-12 2013-04-23 University Of Washington System and method for magnetically concentrating and detecting biomarkers
GB0914286D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Method
GB0914287D0 (en) 2009-08-14 2009-09-30 Pci Biotech As Compositions
US20110117668A1 (en) * 2009-11-09 2011-05-19 University Of Washington Through Its Center For Commercialization Self-powered smart diagnostic devices
US9080933B2 (en) 2009-11-09 2015-07-14 University Of Washington Through Its Center For Commercialization Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates
GB201208548D0 (en) 2012-05-15 2012-06-27 Pci Biotech As Compound and method
CA2906279A1 (en) 2013-03-15 2014-09-18 Pci Biotech As A method of generating antigen presenting cells using photochemical internalisation
CA2922320C (en) 2013-08-28 2022-11-22 Pci Biotech As Enhanced photochemical internalisation using a tlr ligand
GB2517707B (en) * 2013-08-28 2020-09-02 Pci Biotech As A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen
EP3129045B1 (en) 2014-04-11 2022-03-02 PCI Biotech AS Method of treating melanoma
BR112017003486A2 (pt) 2014-08-28 2018-01-16 Pci Biotech As métodos para expressar uma molécula antigênica ou uma parte da mesma e gerar uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e molécula antigênica, molécula antigênica, agente fotossensibilizante e citocina, produto, e, kit
GB201503776D0 (en) 2015-03-05 2015-04-22 Pci Biotech As Compound and method
WO2016201136A1 (en) 2015-06-10 2016-12-15 Ekos Corporation Ultrasound catheter
EP3525783B1 (en) 2016-10-14 2020-12-16 PCI Biotech AS Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine
GB201718631D0 (en) * 2017-11-10 2017-12-27 Pci Biotech As Method
GB201801169D0 (en) * 2018-01-24 2018-03-07 Pci Biotech As Method
CA3104833A1 (en) 2018-07-16 2020-01-23 Dcprime B.V. A combination product for use in tumor vaccination.
CA3133410A1 (en) 2019-04-25 2020-10-29 Dcprime B.V. Methods of tumor vaccination
CN110711249B (zh) * 2019-09-19 2020-10-27 北京化工大学 一种溶酶体膜包覆纳米颗粒的制备方法
CN115916963A (zh) 2020-03-27 2023-04-04 门德斯有限公司 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途
AU2021244937A1 (en) 2020-03-27 2022-11-03 Mendus B.V. In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy
CN114163508B (zh) * 2020-09-11 2024-07-16 王月志 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用
JP2023547520A (ja) 2020-11-05 2023-11-10 メンドゥス・ベスローテン・フェンノートシャップ 免疫療法における腫瘍非依存性抗原の使用
GB202101726D0 (en) 2021-02-08 2021-03-24 Pci Biotech As Method
WO2022190058A1 (en) 2021-03-12 2022-09-15 Dcprime B.V. Methods of vaccination and use of cd47 blockade
GB202115451D0 (en) 2021-10-27 2021-12-08 Pci Biotech As Method
WO2024068795A1 (en) 2022-09-27 2024-04-04 Pci Biotech As Method for releasing viral vectors
GB202301312D0 (en) 2023-01-30 2023-03-15 Pci Biotech As Method and product
GB202404168D0 (en) 2024-03-22 2024-05-08 Pci Biotech As Method

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU563827B2 (en) 1982-07-01 1987-07-23 Millipore Corp. Filtration apparatus
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4704255A (en) 1983-07-15 1987-11-03 Pandex Laboratories, Inc. Assay cartridge
US5066274A (en) * 1985-04-30 1991-11-19 Nippon Petrochemicals Company, Ltd. Tetrapyrrole therapeutic agents
US5076950A (en) 1985-12-20 1991-12-31 Syntex (U.S.A.) Inc. Magnetic composition for particle separation
US4895706A (en) 1986-10-28 1990-01-23 Costar Corporation Multi-well filter strip and composite assemblies
US5095030A (en) * 1987-01-20 1992-03-10 University Of British Columbia Wavelength-specific cytotoxic agents
HU204856B (en) 1987-08-12 1992-02-28 Orszagos Mueszaki Fejlesztesi Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates
NO891491L (no) * 1987-08-12 1989-04-11 Peter Nemeth Prosedyre for befrielse av celleblandinger og vev for uoenskede populasjoner.
GB8721108D0 (en) * 1987-09-08 1987-10-14 Salford University Of Liposomes
US5284647A (en) * 1988-03-18 1994-02-08 Schering Aktiengesellschaft Mesotetraphenylporphyrin complex compounds, process for their production and pharmaceutical agents containing them
US5256532A (en) 1988-05-02 1993-10-26 Zynaxis Technologies, Inc. Methods, reagents and test kits for determination of subpopulations of biological entities
US4925736A (en) * 1988-07-06 1990-05-15 Long Island Jewish Medical Center Topical hematoporphyrin
GB8905001D0 (en) 1989-03-04 1989-04-19 Univ Leicester Screening for natural products of microbial metabolism
US5567687A (en) * 1989-03-06 1996-10-22 University Of Texas Texaphyrins and uses thereof
US4935498A (en) * 1989-03-06 1990-06-19 Board Of Regents, The University Of Texas System Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles
US5328470A (en) * 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5059619A (en) * 1989-06-14 1991-10-22 Quadra Logic Technologies, Inc. Stable freeze-dried polyhematoporphyrin ether/ester
DE3919873A1 (de) 1989-06-19 1990-12-20 Behringwerke Ag Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung
GB8916859D0 (en) 1989-07-24 1989-09-06 Dynal As Hapten linking
GB8929297D0 (en) 1989-12-29 1990-02-28 Dynal As Method of separation
US5200084A (en) 1990-09-26 1993-04-06 Immunicon Corporation Apparatus and methods for magnetic separation
US5491068A (en) 1991-02-14 1996-02-13 Vicam, L.P. Assay method for detecting the presence of bacteria
US5179120A (en) * 1991-06-28 1993-01-12 Cytopharm, Inc. Porphycene compounds for photodynamic therapy
PL165249B1 (pl) * 1991-10-29 1994-11-30 Wojskowa Akad Tech Sposób otrzymywania soli kompleksowych hematoporfiryny i jej pochodnych PL PL PL PL PL PL PL
US5376546A (en) * 1991-11-04 1994-12-27 Xoma Corporation Analogs of ribosome-inactivating proteins
US5258453A (en) * 1992-01-21 1993-11-02 University Of Utah Drug delivery system for the simultaneous delivery of drugs activatable by enzymes and light
ATE212063T1 (de) * 1992-03-16 2002-02-15 Isis Pharmaceuticals Inc Oligonukleotide modulation von protein kinase c
CA2131090A1 (en) 1992-03-20 1993-09-21 Peter Leonard Grant Method and apparatus for the analysis of biological material
WO1993022443A1 (en) * 1992-04-24 1993-11-11 Sri International In vivo homologous sequence targeting in eukaryotic cells
WO1994007138A1 (en) 1992-09-14 1994-03-31 Fodstad Oystein Detection of specific target cells in specialized or mixed cell population and solutions containing mixed cell populations
EP0672133B1 (en) * 1992-11-03 2004-06-16 Gene Shears Pty Limited TNF-alpha RIBOZYMES AND DEGRADATION RESISTANT mRNA DERIVATIVES LINKED TO TNF-alpha RIBOZYMES
FR2700010B1 (fr) 1992-12-24 1995-03-17 Rocher Yves Biolog Vegetale Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits.
US5374531A (en) 1993-03-22 1994-12-20 Zynaxis, Inc. Immunoassay for determination of cells
US5861310A (en) * 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
US5491084A (en) * 1993-09-10 1996-02-13 The Trustees Of Columbia University In The City Of New York Uses of green-fluorescent protein
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
US5514340A (en) 1994-01-24 1996-05-07 Magnetix Biotechnology, Inc. Device for separating magnetically labelled cells
NO180658C (no) 1994-03-10 1997-05-21 Oeystein Fodstad Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner
NO180167C (no) 1994-09-08 1997-02-26 Photocure As Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol
US5872007A (en) * 1995-02-17 1999-02-16 Hybridon, Inc. CAPL-specific oligonucleotides and methods of inhibiting metastatic cancer

Also Published As

Publication number Publication date
AU3534795A (en) 1996-03-27
US20020155099A1 (en) 2002-10-24
JP4148328B2 (ja) 2008-09-10
KR100395615B1 (ko) 2003-12-31
NO943327D0 (no) 1994-09-08
EP0783323A1 (en) 1997-07-16
PT783323E (pt) 2002-03-28
CA2199290C (en) 2010-10-26
NZ509519A (en) 2004-10-29
CN1222309C (zh) 2005-10-12
CN1164829A (zh) 1997-11-12
WO1996007432A1 (en) 1996-03-14
DE69524238T2 (de) 2002-07-18
EP0783323B1 (en) 2001-11-28
NO180167B (no) 1996-11-18
NO943327L (no) 1996-03-11
FI121328B (fi) 2010-10-15
HU222984B1 (hu) 2004-01-28
BR9508825A (pt) 1998-01-06
FI970983A (fi) 1997-03-07
US5876989A (en) 1999-03-02
ATE209507T1 (de) 2001-12-15
JPH10508295A (ja) 1998-08-18
AU700797B2 (en) 1999-01-14
KR20040004402A (ko) 2004-01-13
CZ65897A3 (en) 1997-10-15
MX9701676A (es) 1998-04-30
US6680301B2 (en) 2004-01-20
NZ293008A (en) 2001-04-27
KR970705415A (ko) 1997-10-09
CA2199290A1 (en) 1996-03-14
ES2163527T3 (es) 2002-02-01
DE69524238D1 (de) 2002-01-10
US20030134813A1 (en) 2003-07-17
BRPI9508825B8 (pt) 2021-07-06
BRPI9508825B1 (pt) 2020-12-22
KR100529967B1 (ko) 2005-11-22
NO180167C (no) 1997-02-26
HUT77469A (hu) 1998-05-28
HK1004110A1 (en) 1998-11-20

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