FI970983A0 - Molekyylien siirto solujen sytoplasmaan - Google Patents
Molekyylien siirto solujen sytoplasmaanInfo
- Publication number
- FI970983A0 FI970983A0 FI970983A FI970983A FI970983A0 FI 970983 A0 FI970983 A0 FI 970983A0 FI 970983 A FI970983 A FI 970983A FI 970983 A FI970983 A FI 970983A FI 970983 A0 FI970983 A0 FI 970983A0
- Authority
- FI
- Finland
- Prior art keywords
- cells
- molecules
- cytoplasm
- transfer
- photodynamic treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Catalysts (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NO943327 | 1994-09-08 | ||
NO943327A NO180167C (no) | 1994-09-08 | 1994-09-08 | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
PCT/NO1995/000149 WO1996007432A1 (en) | 1994-09-08 | 1995-09-04 | Transfer of molecules into the cytosol of cells |
NO9500149 | 1995-09-04 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI970983A0 true FI970983A0 (fi) | 1997-03-07 |
FI970983A FI970983A (fi) | 1997-03-07 |
FI121328B FI121328B (fi) | 2010-10-15 |
Family
ID=19897382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI970983A FI121328B (fi) | 1994-09-08 | 1997-03-07 | Molekyylien siirto solujen sytosoliin |
Country Status (20)
Country | Link |
---|---|
US (3) | US5876989A (fi) |
EP (1) | EP0783323B1 (fi) |
JP (1) | JP4148328B2 (fi) |
KR (2) | KR100395615B1 (fi) |
CN (1) | CN1222309C (fi) |
AT (1) | ATE209507T1 (fi) |
AU (1) | AU700797B2 (fi) |
BR (1) | BRPI9508825B8 (fi) |
CA (1) | CA2199290C (fi) |
CZ (1) | CZ65897A3 (fi) |
DE (1) | DE69524238T2 (fi) |
ES (1) | ES2163527T3 (fi) |
FI (1) | FI121328B (fi) |
HK (1) | HK1004110A1 (fi) |
HU (1) | HU222984B1 (fi) |
MX (1) | MX9701676A (fi) |
NO (1) | NO180167C (fi) |
NZ (2) | NZ509519A (fi) |
PT (1) | PT783323E (fi) |
WO (1) | WO1996007432A1 (fi) |
Families Citing this family (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
US6210356B1 (en) * | 1998-08-05 | 2001-04-03 | Ekos Corporation | Ultrasound assembly for use with a catheter |
US6176842B1 (en) * | 1995-03-08 | 2001-01-23 | Ekos Corporation | Ultrasound assembly for use with light activated drugs |
EP1003429B1 (en) * | 1997-03-19 | 2008-09-24 | Lucid, Inc. | Cellular surgery utilizing confocal microscopy |
US6676626B1 (en) | 1998-05-01 | 2004-01-13 | Ekos Corporation | Ultrasound assembly with increased efficacy |
US6582392B1 (en) * | 1998-05-01 | 2003-06-24 | Ekos Corporation | Ultrasound assembly for use with a catheter |
CA2317549C (en) * | 1998-01-05 | 2006-04-11 | University Of Washington | Composition for enhancing transport through lipid-containing membranes, and uses thereof |
US6399769B1 (en) * | 1998-01-20 | 2002-06-04 | Kimberly-Clark Worldwide, Inc. | Method of making sulfanatophenyl substituted porphines |
GB9905911D0 (en) * | 1999-03-15 | 1999-05-05 | Photocure As | Method |
US7320885B1 (en) * | 1999-09-09 | 2008-01-22 | Toudai Tlo, Ltd. | Method of perforating membrane and apparatus therefor |
US20040220100A1 (en) * | 2000-07-21 | 2004-11-04 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
WO2002007773A2 (en) * | 2000-07-21 | 2002-01-31 | Essentia Biosystems, Inc. | Multi-component biological transport systems |
EP1346059B1 (en) * | 2000-11-29 | 2012-05-23 | PCI Biotech AS | Photochemical internalization for delivery of molecules into the cytosol |
ES2445579T3 (es) * | 2000-11-29 | 2014-03-04 | Pci Biotech As | Internalización fotoquímica para el suministro de moléculas mediado por virus en el citosol |
US20020098472A1 (en) * | 2000-11-30 | 2002-07-25 | Erlach Julian Van | Method for inserting a microdevice or a nanodevice into a body fluid stream |
US20020137901A1 (en) * | 2001-01-22 | 2002-09-26 | Cavanaugh Philip Gerard | Synthesis, and photodynamic therapy-mediated anti-cancer, and other uses of chlorin e6-transferrin |
AU2002250034A1 (en) * | 2001-02-08 | 2002-08-19 | Sequitur, Inc. | Methods of light activated release 0f ligands from endosomes |
DK1407787T3 (da) * | 2001-06-20 | 2009-06-02 | Dainippon Sumitomo Pharma Co | Fremgangsmåde til fremme af nukleinsyreoverförsel |
GB0121023D0 (en) * | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
US7220239B2 (en) | 2001-12-03 | 2007-05-22 | Ekos Corporation | Catheter with multiple ultrasound radiating members |
US7141044B2 (en) | 2001-12-11 | 2006-11-28 | Ekos Corporation | Alternate site gene therapy |
DK2128248T4 (en) | 2002-02-01 | 2017-03-13 | Life Technologies Corp | Oligonucleotide compositions with increased efficiency |
EP1572902B1 (en) * | 2002-02-01 | 2014-06-11 | Life Technologies Corporation | HIGH POTENCY siRNAS FOR REDUCING THE EXPRESSION OF TARGET GENES |
US20060009409A1 (en) | 2002-02-01 | 2006-01-12 | Woolf Tod M | Double-stranded oligonucleotides |
US8226629B1 (en) | 2002-04-01 | 2012-07-24 | Ekos Corporation | Ultrasonic catheter power control |
US20040248094A1 (en) * | 2002-06-12 | 2004-12-09 | Ford Lance P. | Methods and compositions relating to labeled RNA molecules that reduce gene expression |
GB0215534D0 (en) * | 2002-07-04 | 2002-08-14 | Ecole Polytech | Selective photochemotherapy using oligonucleotide targeting agents |
US20040029275A1 (en) * | 2002-08-10 | 2004-02-12 | David Brown | Methods and compositions for reducing target gene expression using cocktails of siRNAs or constructs expressing siRNAs |
US6921371B2 (en) * | 2002-10-14 | 2005-07-26 | Ekos Corporation | Ultrasound radiating members for catheter |
US20040176282A1 (en) * | 2003-01-09 | 2004-09-09 | Brian Dalby | Cellular delivery and activation of polypeptide-nucleic acid complexes |
US7332477B2 (en) * | 2003-07-10 | 2008-02-19 | Nitto Denko Corporation | Photocleavable DNA transfer agent |
DE602004026747D1 (de) * | 2003-09-29 | 2010-06-02 | Nitto Denko Corp | Biologisch abbaubare polyacetale für die in-vivo-abgabe von polynucleotiden |
US20080318319A1 (en) * | 2003-12-19 | 2008-12-25 | Yoshiko Minakuchi | Novel Method of Nucleic Acid Transfer |
DK1729821T3 (da) * | 2004-03-03 | 2013-10-28 | Revance Therapeutics Inc | Sammensætninger og fremgangsmåder til topisk påføring og transdermal afgivelse af botulinumtoksiner |
MXPA06009897A (es) * | 2004-03-03 | 2008-02-07 | Revance Therapeutics Inc | Composiciones y metodos para el diagnostico topico y el transporte terapeutico. |
US9211248B2 (en) | 2004-03-03 | 2015-12-15 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
GB0415263D0 (en) * | 2004-07-07 | 2004-08-11 | Norwegian Radium Hospital Res | Method |
US20060094781A1 (en) * | 2004-11-04 | 2006-05-04 | Syneron Medical Ltd. | Method of treating extracellular matrix |
FR2877943B1 (fr) * | 2004-11-16 | 2008-09-05 | Univ De Coimbra | Nouveaux derives de porphyrine, notamment chlorines et/ou bacteriochlorine, et leurs applications en therapie photodynamique |
US9180081B2 (en) * | 2005-03-03 | 2015-11-10 | Revance Therapeutics, Inc. | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
JP2008531725A (ja) * | 2005-03-03 | 2008-08-14 | ルバンス セラピュティックス インク. | オリゴペプチドの局所適用及び経皮送達のための組成物及び方法 |
US7674452B2 (en) * | 2005-03-16 | 2010-03-09 | Nitto Denko Corporation | Polymer coating of cells |
BRPI0501037B8 (pt) * | 2005-03-18 | 2021-07-27 | Fund De Amparo A Pesquisa Do Estado De Sao Paulo | uso de crotamina e composição |
EP1948230A4 (en) * | 2005-11-17 | 2010-03-10 | Revance Therapeutics Inc | COMPOSITIONS AND METHODS FOR TOPICAL APPLICATION AND TRANSDERMAL ADMINISTRATION OF BOTULINUM TOXIN CONTAINING LESS NON-TOXIC PROTEINS |
WO2007109584A1 (en) * | 2006-03-16 | 2007-09-27 | University Of Washington | Temperature-and ph-responsive polymer compositions |
GB0613753D0 (en) | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
EP2099496A2 (en) * | 2006-12-08 | 2009-09-16 | Massachusetts Institute of Technology | Delivery of nanoparticles and/or agents to cells |
CA2672886C (en) * | 2006-12-29 | 2015-02-10 | Revance Therapeutics, Inc. | Transport molecules using reverse sequence hiv-tat polypeptides |
KR20090096735A (ko) * | 2006-12-29 | 2009-09-14 | 레반스 테라퓨틱스, 아이엔씨. | Hiv-tat로부터 유래된 폴리펩티드 단편에 의해 안정화된 보툴리눔 독소의 국소 적용 및 경피 전달용 조성물 및 방법 |
US10182833B2 (en) | 2007-01-08 | 2019-01-22 | Ekos Corporation | Power parameters for ultrasonic catheter |
US7981688B2 (en) | 2007-03-08 | 2011-07-19 | University Of Washington | Stimuli-responsive magnetic nanoparticles and related methods |
EP2494932B1 (en) | 2007-06-22 | 2020-05-20 | Ekos Corporation | Apparatus for treatment of intracranial hemorrhages |
EP2231024A4 (en) * | 2007-12-14 | 2015-03-18 | Ekos Corp | ULTRASOUND PULSE SHAPING |
GB0811955D0 (en) | 2008-06-30 | 2008-07-30 | Pci Biotech As | Method |
US8426214B2 (en) * | 2009-06-12 | 2013-04-23 | University Of Washington | System and method for magnetically concentrating and detecting biomarkers |
GB0914286D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
US20110117668A1 (en) * | 2009-11-09 | 2011-05-19 | University Of Washington Through Its Center For Commercialization | Self-powered smart diagnostic devices |
US9080933B2 (en) | 2009-11-09 | 2015-07-14 | University Of Washington Through Its Center For Commercialization | Stimuli-responsive polymer diagnostic assay comprising magnetic nanoparticles and capture conjugates |
GB201208548D0 (en) | 2012-05-15 | 2012-06-27 | Pci Biotech As | Compound and method |
CA2906279A1 (en) | 2013-03-15 | 2014-09-18 | Pci Biotech As | A method of generating antigen presenting cells using photochemical internalisation |
CA2922320C (en) | 2013-08-28 | 2022-11-22 | Pci Biotech As | Enhanced photochemical internalisation using a tlr ligand |
GB2517707B (en) * | 2013-08-28 | 2020-09-02 | Pci Biotech As | A device for light-induced rupture of endocytic vesicles to effect the delivery of an antigen |
EP3129045B1 (en) | 2014-04-11 | 2022-03-02 | PCI Biotech AS | Method of treating melanoma |
BR112017003486A2 (pt) | 2014-08-28 | 2018-01-16 | Pci Biotech As | métodos para expressar uma molécula antigênica ou uma parte da mesma e gerar uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e molécula antigênica, molécula antigênica, agente fotossensibilizante e citocina, produto, e, kit |
GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
WO2016201136A1 (en) | 2015-06-10 | 2016-12-15 | Ekos Corporation | Ultrasound catheter |
EP3525783B1 (en) | 2016-10-14 | 2020-12-16 | PCI Biotech AS | Treatment of cholangiocarcinoma with tpcs-2a induced photochemical internalisation of gemcitabine |
GB201718631D0 (en) * | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
GB201801169D0 (en) * | 2018-01-24 | 2018-03-07 | Pci Biotech As | Method |
CA3104833A1 (en) | 2018-07-16 | 2020-01-23 | Dcprime B.V. | A combination product for use in tumor vaccination. |
CA3133410A1 (en) | 2019-04-25 | 2020-10-29 | Dcprime B.V. | Methods of tumor vaccination |
CN110711249B (zh) * | 2019-09-19 | 2020-10-27 | 北京化工大学 | 一种溶酶体膜包覆纳米颗粒的制备方法 |
CN115916963A (zh) | 2020-03-27 | 2023-04-04 | 门德斯有限公司 | 白血病来源的经修饰细胞用于增强过继性细胞治疗的效力的离体用途 |
AU2021244937A1 (en) | 2020-03-27 | 2022-11-03 | Mendus B.V. | In vivo use of modified cells of leukemic origin for enhancing the efficacy of adoptive cell therapy |
CN114163508B (zh) * | 2020-09-11 | 2024-07-16 | 王月志 | 能破坏细胞的氨基酸序列及相关核苷酸序列和相关的应用 |
JP2023547520A (ja) | 2020-11-05 | 2023-11-10 | メンドゥス・ベスローテン・フェンノートシャップ | 免疫療法における腫瘍非依存性抗原の使用 |
GB202101726D0 (en) | 2021-02-08 | 2021-03-24 | Pci Biotech As | Method |
WO2022190058A1 (en) | 2021-03-12 | 2022-09-15 | Dcprime B.V. | Methods of vaccination and use of cd47 blockade |
GB202115451D0 (en) | 2021-10-27 | 2021-12-08 | Pci Biotech As | Method |
WO2024068795A1 (en) | 2022-09-27 | 2024-04-04 | Pci Biotech As | Method for releasing viral vectors |
GB202301312D0 (en) | 2023-01-30 | 2023-03-15 | Pci Biotech As | Method and product |
GB202404168D0 (en) | 2024-03-22 | 2024-05-08 | Pci Biotech As | Method |
Family Cites Families (41)
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AU563827B2 (en) | 1982-07-01 | 1987-07-23 | Millipore Corp. | Filtration apparatus |
US4649151A (en) * | 1982-09-27 | 1987-03-10 | Health Research, Inc. | Drugs comprising porphyrins |
US4704255A (en) | 1983-07-15 | 1987-11-03 | Pandex Laboratories, Inc. | Assay cartridge |
US5066274A (en) * | 1985-04-30 | 1991-11-19 | Nippon Petrochemicals Company, Ltd. | Tetrapyrrole therapeutic agents |
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US5095030A (en) * | 1987-01-20 | 1992-03-10 | University Of British Columbia | Wavelength-specific cytotoxic agents |
HU204856B (en) | 1987-08-12 | 1992-02-28 | Orszagos Mueszaki Fejlesztesi | Process for releasing cell mixtures and tissues from undesired populations and for producing monoclonal antibody - hematoporphyrin conjugates |
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US4935498A (en) * | 1989-03-06 | 1990-06-19 | Board Of Regents, The University Of Texas System | Expanded porphyrins: large porphyrin-like tripyrroledimethine-derived macrocycles |
US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
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DE3919873A1 (de) | 1989-06-19 | 1990-12-20 | Behringwerke Ag | Magnetische protein-konjugate, verfahren zu ihrer herstellung und ihre verwendung |
GB8916859D0 (en) | 1989-07-24 | 1989-09-06 | Dynal As | Hapten linking |
GB8929297D0 (en) | 1989-12-29 | 1990-02-28 | Dynal As | Method of separation |
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ATE212063T1 (de) * | 1992-03-16 | 2002-02-15 | Isis Pharmaceuticals Inc | Oligonukleotide modulation von protein kinase c |
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FR2700010B1 (fr) | 1992-12-24 | 1995-03-17 | Rocher Yves Biolog Vegetale | Méthode et dispositif pour tester la réactivité de cellules à l'égard de produits. |
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US5491084A (en) * | 1993-09-10 | 1996-02-13 | The Trustees Of Columbia University In The City Of New York | Uses of green-fluorescent protein |
US6015897A (en) * | 1993-12-07 | 2000-01-18 | Neorx Corporation | Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota |
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NO180658C (no) | 1994-03-10 | 1997-05-21 | Oeystein Fodstad | Fremgangsmåte og anordning for deteksjon av spesifikke målceller i spesialiserte eller blandede cellepopulasjoner og opplösninger som inneholder blandede cellepopulasjoner |
NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
US5872007A (en) * | 1995-02-17 | 1999-02-16 | Hybridon, Inc. | CAPL-specific oligonucleotides and methods of inhibiting metastatic cancer |
-
1994
- 1994-09-08 NO NO943327A patent/NO180167C/no not_active IP Right Cessation
-
1995
- 1995-09-04 ES ES95932244T patent/ES2163527T3/es not_active Expired - Lifetime
- 1995-09-04 CZ CZ97658A patent/CZ65897A3/cs unknown
- 1995-09-04 US US08/793,794 patent/US5876989A/en not_active Expired - Lifetime
- 1995-09-04 HU HU9800153A patent/HU222984B1/hu active IP Right Grant
- 1995-09-04 NZ NZ509519A patent/NZ509519A/en not_active IP Right Cessation
- 1995-09-04 DE DE69524238T patent/DE69524238T2/de not_active Expired - Lifetime
- 1995-09-04 JP JP50940496A patent/JP4148328B2/ja not_active Expired - Fee Related
- 1995-09-04 NZ NZ293008A patent/NZ293008A/en not_active IP Right Cessation
- 1995-09-04 WO PCT/NO1995/000149 patent/WO1996007432A1/en not_active Application Discontinuation
- 1995-09-04 EP EP95932244A patent/EP0783323B1/en not_active Expired - Lifetime
- 1995-09-04 CN CNB951960652A patent/CN1222309C/zh not_active Expired - Lifetime
- 1995-09-04 PT PT95932244T patent/PT783323E/pt unknown
- 1995-09-04 BR BRPI9508825A patent/BRPI9508825B8/pt not_active IP Right Cessation
- 1995-09-04 MX MX9701676A patent/MX9701676A/es unknown
- 1995-09-04 AU AU35347/95A patent/AU700797B2/en not_active Expired
- 1995-09-04 CA CA2199290A patent/CA2199290C/en not_active Expired - Lifetime
- 1995-09-04 AT AT95932244T patent/ATE209507T1/de active
- 1995-09-14 KR KR1019970701520A patent/KR100395615B1/ko active IP Right Grant
- 1995-09-14 KR KR10-2003-7005142A patent/KR100529967B1/ko not_active IP Right Cessation
-
1997
- 1997-03-07 FI FI970983A patent/FI121328B/fi not_active IP Right Cessation
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1998
- 1998-04-24 HK HK98103468A patent/HK1004110A1/xx not_active IP Right Cessation
- 1998-09-01 US US09/144,750 patent/US6680301B2/en not_active Expired - Fee Related
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2002
- 2002-11-01 US US10/286,632 patent/US20030134813A1/en not_active Abandoned
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