|
US4749576A
(en)
*
|
1984-05-10 |
1988-06-07 |
Ciba-Geigy Corporation |
Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentration gradient for improved constant release, their manufacture and use
|
|
JPS61218517A
(ja)
*
|
1985-03-25 |
1986-09-29 |
Bio Materiaru Yunibaasu:Kk |
経皮吸収製剤
|
|
FR2585246A1
(fr)
*
|
1985-07-26 |
1987-01-30 |
Cortial |
Procede d'obtention de formes pharmaceutiques solides a liberation prolongee
|
|
US4794002A
(en)
*
|
1985-11-01 |
1988-12-27 |
Monsanto Company |
Modified polymeric surfaces and process for preparing same
|
|
JPH0643851B2
(ja)
*
|
1986-03-13 |
1994-06-08 |
大同メタル工業株式会社 |
軸受ユニット
|
|
US4983400A
(en)
*
|
1986-06-16 |
1991-01-08 |
Merck & Co., Inc. |
Controlled release combination of carbidopa/levodopa
|
|
US4780236A
(en)
*
|
1986-06-20 |
1988-10-25 |
Kiwi Brands, Inc. |
Lavoratory cleansing block containing polyethylene gycol disteatrate, guar gum and sodium chloride
|
|
US4743248A
(en)
*
|
1986-08-11 |
1988-05-10 |
Alza Corporation |
Dosage form for delivering acid sensitive beneficial agent
|
|
GB8620845D0
(en)
*
|
1986-08-28 |
1986-10-08 |
Reckitt & Colmann Prod Ltd |
Treatment of textile surfaces
|
|
EP0297650A1
(en)
*
|
1987-06-26 |
1989-01-04 |
Duphar International Research B.V |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US5219575A
(en)
*
|
1987-06-26 |
1993-06-15 |
Duphar International Research B.V. |
Compositions with controlled zero-order delivery rate and method of preparing these compositions
|
|
US4910015A
(en)
*
|
1987-10-19 |
1990-03-20 |
Massachusetts Institute Of Technology |
Surface-active polysiloxanes and drug releasing materials thereof
|
|
GB8801863D0
(en)
*
|
1988-01-28 |
1988-02-24 |
Fulmer Yarsley Ltd |
Pharmaceutical formulations with controlled drug release
|
|
US6440457B1
(en)
*
|
1993-05-27 |
2002-08-27 |
Alza Corporation |
Method of administering antidepressant dosage form
|
|
EP0808153B1
(en)
|
1995-02-10 |
1999-08-04 |
Medtronic, Inc. |
Method and device for administering analgesics
|
|
US5945125A
(en)
*
|
1995-02-28 |
1999-08-31 |
Temple University |
Controlled release tablet
|
|
US20030203036A1
(en)
|
2000-03-17 |
2003-10-30 |
Gordon Marc S. |
Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients
|
|
GB9703673D0
(en)
*
|
1997-02-21 |
1997-04-09 |
Bradford Particle Design Ltd |
Method and apparatus for the formation of particles
|
|
US6039968A
(en)
*
|
1997-06-24 |
2000-03-21 |
Hoechst Marion Roussel |
Intravaginal drug delivery device
|
|
DE19843903A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit copolymerem Bindemittel
|
|
DE19843904A1
(de)
*
|
1998-09-24 |
2000-03-30 |
Basf Ag |
Feste Dosierungsform mit polymerem Bindemittel
|
|
US6706283B1
(en)
|
1999-02-10 |
2004-03-16 |
Pfizer Inc |
Controlled release by extrusion of solid amorphous dispersions of drugs
|
|
US7943162B2
(en)
*
|
1999-10-21 |
2011-05-17 |
Alcon, Inc. |
Drug delivery device
|
|
EP1967185A1
(en)
*
|
1999-12-23 |
2008-09-10 |
Pfizer Products Inc. |
Hydrogel-driven drug dosage form
|
|
US20030086972A1
(en)
*
|
2000-08-09 |
2003-05-08 |
Appel Leah E. |
Hydrogel-driven drug dosage form
|
|
GB0027357D0
(en)
*
|
2000-11-09 |
2000-12-27 |
Bradford Particle Design Plc |
Particle formation methods and their products
|
|
DK1385452T3
(da)
*
|
2001-07-23 |
2007-01-15 |
Alcon Inc |
Anordning til tilförsel af et ophthalmisk medikament
|
|
EP1409065B1
(en)
|
2001-07-23 |
2007-01-17 |
Alcon, Inc. |
Ophthalmic drug delivery device
|
|
EP1441703B1
(en)
*
|
2001-10-29 |
2018-01-03 |
Massachusetts Institute of Technology |
Zero-order release profile dosage form manufactured by three-dimensional printing
|
|
GB0216562D0
(en)
|
2002-04-25 |
2002-08-28 |
Bradford Particle Design Ltd |
Particulate materials
|
|
US9339459B2
(en)
|
2003-04-24 |
2016-05-17 |
Nektar Therapeutics |
Particulate materials
|
|
GB0310636D0
(en)
*
|
2003-05-08 |
2003-06-11 |
Nektar Therapeutics Uk Ltd |
Particulate materials
|
|
KR20060015587A
(ko)
|
2003-05-08 |
2006-02-17 |
넥타 쎄라퓨틱스 유케이 리미티드 |
미립물
|
|
JP2007526019A
(ja)
*
|
2003-07-10 |
2007-09-13 |
アルコン，インコーポレイティド |
眼科用薬物送達デバイス
|
|
US20060246109A1
(en)
*
|
2005-04-29 |
2006-11-02 |
Hossainy Syed F |
Concentration gradient profiles for control of agent release rates from polymer matrices
|
|
EP1933852B1
(en)
|
2005-09-27 |
2018-12-19 |
TissueTech, Inc. |
Amniotic membrane preparations and purified compositions and methods of use
|
|
US8187639B2
(en)
|
2005-09-27 |
2012-05-29 |
Tissue Tech, Inc. |
Amniotic membrane preparations and purified compositions and anti-angiogenesis treatment
|
|
KR101415329B1
(ko)
|
2005-11-28 |
2014-07-04 |
마리누스 파마슈티컬스 |
ｇａｎａｘｏｌｏｎｅ 제형, 이의 제조방법 및 용도
|
|
US8246973B2
(en)
|
2006-06-21 |
2012-08-21 |
Advanced Cardiovascular Systems, Inc. |
Freeze-thaw method for modifying stent coating
|
|
CN101528830A
(zh)
|
2006-07-10 |
2009-09-09 |
麦德医像公司 |
超弹性环氧水凝胶
|
|
US20080090897A1
(en)
|
2006-08-11 |
2008-04-17 |
The Johns Hopkins University |
Compositions and methods for neuroprotectin
|
|
ES2585902T3
(es)
|
2006-09-22 |
2016-10-10 |
Pharmacyclics Llc |
Inhibidores de tirosina cinasa de Bruton
|
|
WO2009035818A1
(en)
|
2007-09-10 |
2009-03-19 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
US9995295B2
(en)
|
2007-12-03 |
2018-06-12 |
Medipacs, Inc. |
Fluid metering device
|
|
BRPI0917719A2
(pt)
|
2008-08-27 |
2019-11-19 |
Calcimedica Inc |
compostos que modulam cálcio intracelular
|
|
ES2559029T3
(es)
|
2009-04-24 |
2016-02-10 |
Tissue Tech, Inc. |
Composiciones que contienen al complejo HC.HA y metodos de uso de las mismas
|
|
WO2011032011A1
(en)
|
2009-09-10 |
2011-03-17 |
Medipacs, Inc. |
Low profile actuator and improved method of caregiver controlled administration of therapeutics
|
|
US7718662B1
(en)
|
2009-10-12 |
2010-05-18 |
Pharmacyclics, Inc. |
Pyrazolo-pyrimidine inhibitors of bruton's tyrosine kinase
|
|
US9500186B2
(en)
|
2010-02-01 |
2016-11-22 |
Medipacs, Inc. |
High surface area polymer actuator with gas mitigating components
|
|
WO2011130689A1
(en)
|
2010-04-15 |
2011-10-20 |
Tracon Pharmaceuticals, Inc. |
Potentiation of anti-cancer activity through combination therapy with ber pathway inhibitors
|
|
HUE029570T2
(en)
|
2010-04-27 |
2017-03-28 |
Calcimedica Inc |
Intracellular calcium modifying compounds
|
|
JP2013525448A
(ja)
|
2010-04-27 |
2013-06-20 |
カルシメディカ，インク． |
細胞内カルシウムを調節する化合物
|
|
SG10201809111XA
(en)
|
2010-06-03 |
2018-11-29 |
Pharmacyclics Llc |
The use of inhibitors of bruton's tyrosine kinase (btk)
|
|
AU2011293201B2
(en)
|
2010-08-27 |
2015-11-05 |
Calcimedica Inc. |
Compounds that modulate intracellular calcium
|
|
WO2012061556A1
(en)
|
2010-11-03 |
2012-05-10 |
Flugen, Inc. |
Wearable drug delivery device having spring drive and sliding actuation mechanism
|
|
CA2767773C
(en)
|
2011-02-11 |
2015-11-24 |
Grain Processing Corporation |
Composition comprising a salt and a crystallization interrupter
|
|
US9526770B2
(en)
|
2011-04-28 |
2016-12-27 |
Tissuetech, Inc. |
Methods of modulating bone remodeling
|
|
US9682044B2
(en)
|
2011-06-10 |
2017-06-20 |
Tissuetech, Inc. |
Methods of processing fetal support tissues, fetal support tissue powder products, and uses thereof
|
|
US9492423B2
(en)
|
2011-09-13 |
2016-11-15 |
Pharmacyclics Llc |
Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
|
|
US8377946B1
(en)
|
2011-12-30 |
2013-02-19 |
Pharmacyclics, Inc. |
Pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine compounds as kinase inhibitors
|
|
ES2982694T3
(es)
|
2012-01-06 |
2024-10-17 |
H Lundbeck As |
Compuestos de carbamato para su uso en tratamiento
|
|
HK1206374A1
(en)
|
2012-03-14 |
2016-01-08 |
麦德医像公司 |
Smart polymer materials with excess reactive molecules
|
|
MX348290B
(es)
|
2012-06-04 |
2017-06-05 |
Pharmacyclics Llc |
Formas cristalinas de un inhibidor de tirosina quinasa de bruton.
|
|
ES2846789T3
(es)
|
2012-07-11 |
2021-07-29 |
Tissuetech Inc |
Composiciones que contienen complejos HC-HA/PTX3 y métodos de uso de los mismos
|
|
CA2885828C
(en)
|
2012-09-28 |
2021-04-27 |
University Of Washington Through Its Center For Commercialization |
Ureido-thiophenyl derivatives, compositions thereof and methods for preventing, treating and/or protecting against sensory hair cell death
|
|
US9512116B2
(en)
|
2012-10-12 |
2016-12-06 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
WO2015054283A1
(en)
|
2013-10-08 |
2015-04-16 |
Calcimedica, Inc. |
Compounds that modulate intracellular calcium
|
|
CA2932609A1
(en)
|
2013-12-05 |
2015-06-11 |
Pharmacyclics Llc |
Inhibitors of bruton's tyrosine kinase
|
|
EP3134418A4
(en)
|
2014-04-23 |
2018-01-03 |
The Research Foundation for The State University of New York |
A rapid and efficient bioorthogonal ligation reaction and boron-containing heterocycles useful in conjuction therewith
|
|
TW201603818A
(zh)
|
2014-06-03 |
2016-02-01 |
組織科技股份有限公司 |
組成物及方法
|
|
US10080877B2
(en)
|
2014-07-25 |
2018-09-25 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a drug cartridge
|
|
US9775978B2
(en)
|
2014-07-25 |
2017-10-03 |
Warsaw Orthopedic, Inc. |
Drug delivery device and methods having a retaining member
|
|
US9839644B2
(en)
|
2014-09-09 |
2017-12-12 |
ARKAY Therapeutics, LLC |
Formulations and methods for treatment of metabolic syndrome
|
|
US9359316B1
(en)
|
2014-11-25 |
2016-06-07 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic TRPV1 agonists
|
|
KR102557184B1
(ko)
|
2015-02-06 |
2023-07-18 |
유니버시티 오브 워싱톤 |
감각 유모 세포 사멸을 예방 또는 치료하기 위한 화합물 및 방법
|
|
US10227333B2
(en)
|
2015-02-11 |
2019-03-12 |
Curtana Pharmaceuticals, Inc. |
Inhibition of OLIG2 activity
|
|
WO2016138025A2
(en)
|
2015-02-23 |
2016-09-01 |
Tissuetech, Inc. |
Apparatuses and methods for treating ophthalmic diseases and disorders
|
|
BR112017018198A2
(pt)
|
2015-02-27 |
2018-04-10 |
Curtana Pharmaceuticals Inc |
inibição da atividade de olig2
|
|
IL315294A
(en)
|
2015-03-03 |
2024-10-01 |
Pharmacyclics Llc |
Pharmaceutical formulations of bruton's tyrosine kinase inhibitor
|
|
MA41827A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Formes solvatées d'un inhibiteur de la tyrosine kinase de bruton
|
|
MA41828A
(fr)
|
2015-03-27 |
2018-01-30 |
Pharmacyclics Llc |
Co-cristaux d'un inhibiteur de la tyrosine kinase de bruton
|
|
KR20180004263A
(ko)
|
2015-05-11 |
2018-01-10 |
어바이드 테라퓨틱스, 인크. |
염증 또는 신경병성 통증의 치료 방법
|
|
CA2984443A1
(en)
|
2015-05-20 |
2016-11-24 |
Tissuetech, Inc. |
Compositions and methods for preventing the proliferation and epithelial-mesenchymal transition of epithelial cells
|
|
HK1257338A1
(zh)
|
2015-08-31 |
2019-10-18 |
Pharmacyclics Llc |
用於治疗多发性骨髓瘤的btk抑制剂组合
|
|
US10076650B2
(en)
|
2015-11-23 |
2018-09-18 |
Warsaw Orthopedic, Inc. |
Enhanced stylet for drug depot injector
|
|
ES2952064T3
(es)
|
2015-12-16 |
2023-10-26 |
Walter & Eliza Hall Inst Medical Res |
Inhibición de la proteína SH2 inducida por citocinas en células NK
|
|
HK1259440A1
(zh)
|
2016-01-19 |
2019-11-29 |
Janssen Pharmaceutica Nv |
包含btk抑制剂的配制品/组合物
|
|
KR20180102150A
(ko)
|
2016-01-19 |
2018-09-14 |
얀센 파마슈티카 엔.브이. |
Btk 저해제를 포함하는 제형/조성물
|
|
TW201733600A
(zh)
|
2016-01-29 |
2017-10-01 |
帝聖工業公司 |
胎兒扶持組織物及使用方法
|
|
WO2017147146A1
(en)
|
2016-02-23 |
2017-08-31 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic trpv1 agonists
|
|
WO2017176652A2
(en)
|
2016-04-04 |
2017-10-12 |
Sinopia Biosciences, Inc. |
Treating extrapyramidal syndrome using trapidil
|
|
US10821105B2
(en)
|
2016-05-25 |
2020-11-03 |
Concentric Analgesics, Inc. |
Prodrugs of phenolic TRPV1 agonists in combination with local anesthetics and vasoconstrictors for improved local anesthesia
|
|
WO2017205762A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205769A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
WO2017205766A1
(en)
|
2016-05-27 |
2017-11-30 |
Pharmacyclics Llc |
Inhibitors of interleukin-1 receptor-associated kinase
|
|
USD802756S1
(en)
|
2016-06-23 |
2017-11-14 |
Warsaw Orthopedic, Inc. |
Drug pellet cartridge
|
|
US11090702B2
(en)
*
|
2016-06-28 |
2021-08-17 |
Trustees Of Tufts College |
Compositions and methods for delivery of active agents
|
|
JP2019524747A
(ja)
|
2016-07-18 |
2019-09-05 |
アースローシ セラピューティクス，インク． |
痛風または高尿酸血症に関連する症状を処置または予防するための化合物、組成物、および方法
|
|
EA201990508A1
(ru)
|
2016-08-26 |
2019-09-30 |
Куртана Фармасьютикалс, Инк. |
ИНГИБИРОВАНИЕ АКТИВНОСТИ Olig2
|
|
US10434261B2
(en)
|
2016-11-08 |
2019-10-08 |
Warsaw Orthopedic, Inc. |
Drug pellet delivery system and method
|
|
BR112019010003A2
(pt)
|
2016-11-16 |
2019-08-20 |
Abide Therapeutics Inc |
formas cristalinas de um inibidor de magl
|
|
EP3541385A4
(en)
|
2016-11-16 |
2020-06-24 |
Lundbeck La Jolla Research Center, Inc. |
PHARMACEUTICAL FORMULATIONS
|
|
KR20200086257A
(ko)
|
2017-09-01 |
2020-07-16 |
유니버시티 오브 워싱톤 |
감각 모 세포 사멸 예방 또는 치료용 화합물의 결정질 형태
|
|
WO2019169112A1
(en)
|
2018-02-28 |
2019-09-06 |
Curtana Pharmaceuticals, Inc. |
Inhibition of olig2 activity
|
|
US10717712B2
(en)
|
2018-07-27 |
2020-07-21 |
Concentric Analgesics, Inc. |
Pegylated prodrugs of phenolic TRPV1 agonists
|
|
WO2020118113A1
(en)
|
2018-12-06 |
2020-06-11 |
Arthrosi Therapeutics, Inc. |
Crystalline forms of a compound for treating or preventing gout or hyperuricemia
|
|
CN113164439A
(zh)
|
2018-12-06 |
2021-07-23 |
安索治疗公司 |
用于治疗或预防痛风或高尿酸血症的方法
|
|
CA3125350A1
(en)
|
2018-12-31 |
2020-07-09 |
Biomea Fusion, Llc |
Irreversible inhibitors of menin-mll interaction
|
|
AU2020240015B2
(en)
|
2019-03-15 |
2025-10-09 |
Unicycive Therapeutics Inc. |
Nicorandil derivatives
|
|
AU2021259496A1
(en)
|
2020-04-21 |
2022-11-10 |
H. Lundbeck A/S |
Synthesis of a monoacylglycerol lipase inhibitor
|
|
CN116234804A
(zh)
|
2020-05-11 |
2023-06-06 |
克立弗治疗学股份有限公司 |
VCP/p97抑制剂的结晶形式和制剂
|
|
WO2022133064A1
(en)
|
2020-12-16 |
2022-06-23 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin-mll interaction
|
|
CA3204457A1
(en)
|
2021-01-06 |
2022-07-14 |
Ben SESSA |
Mdma in the treatment of alcohol use disorder
|
|
EP4337316A1
(en)
|
2021-05-11 |
2024-03-20 |
Awakn Ls Europe Holdings Limited |
Therapeutic aminoindane compounds and compositions
|
|
WO2022256720A2
(en)
|
2021-06-03 |
2022-12-08 |
Arcadia Medicine, Inc. |
Enantiomeric entactogen compositions and methods of their use
|
|
AU2022325861A1
(en)
|
2021-08-11 |
2024-02-29 |
Biomea Fusion, Inc. |
Covalent inhibitors of menin-mll interaction for diabetes mellitus
|
|
MX2024002189A
(es)
|
2021-08-20 |
2024-06-11 |
Biomea Fusion Inc |
Forma cristalina de n-[4-[4-(4-morfolinil)-7h-pirrolo[2,3-d]pirimi din-6-il]fenil]-4-[[3(r)-[(1-oxo)-2-propen-1-il)amino]-1-piperidi nil]metil]-2-piridinacarboxamida, un inhibidor irreversible de menina-mll para el tratamiento del cancer.
|
|
CA3229907A1
(en)
|
2021-08-23 |
2023-03-02 |
Nicholas COZZI |
Deuterated empathogens
|
|
IL311051A
(en)
|
2021-08-23 |
2024-05-01 |
Alexander Shulgin Res Institute Inc |
Fluorinated empathogens
|
|
WO2023027966A1
(en)
|
2021-08-24 |
2023-03-02 |
Biomea Fusion, Inc. |
Pyrazine compounds as irreversible inhibitors of flt3
|
|
CA3230151A1
(en)
|
2021-08-31 |
2023-03-09 |
Cerespir Incorporated |
Co-crystals
|
|
WO2023034645A2
(en)
|
2021-09-03 |
2023-03-09 |
Alexander Shulgin Research Institute |
Asymmetric allyl tryptamines
|
|
WO2023039240A1
(en)
|
2021-09-13 |
2023-03-16 |
Biomea Fusion, Inc. |
IRREVERSIBLE INHIBITORS OF KRas
|
|
IL311647A
(en)
|
2021-09-25 |
2024-05-01 |
Alexander Shulgin Res Institute Inc |
Converted phenylalkylamines
|
|
WO2023086341A1
(en)
|
2021-11-09 |
2023-05-19 |
Biomea Fusion, Inc. |
Inhibitors of kras
|
|
CA3242316A1
(en)
|
2021-12-30 |
2023-07-06 |
Biomea Fusion, Inc. |
Pyrazine compounds as inhibitors of flt3
|
|
WO2023139163A1
(en)
|
2022-01-19 |
2023-07-27 |
Awakn Ls Europe Holdings Limited |
1,3-benzodioxole esters and their therapeutic use
|
|
CA3244485A1
(en)
|
2022-02-16 |
2023-08-24 |
Awakn Ls Europe Holdings Limited |
BRIDGED CYCLIC COMPOUNDS AND THEIR THERAPEUTIC USE AS CNS AGENTS
|
|
US20250353854A1
(en)
|
2022-06-03 |
2025-11-20 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
CN119836422A
(zh)
|
2022-07-06 |
2025-04-15 |
奥比兰制药有限公司 |
S1p受体调节剂的结晶形式
|
|
WO2024155719A1
(en)
|
2023-01-18 |
2024-07-25 |
Biomea Fusion, Inc. |
Crystalline forms of n-[4-[4-(4-morpholinyl)-7h-pyrrolo[2,3-d]pyrimidin-6-yl]phenyl]-4-[[3(r)-[(l-oxo-2-propen-l-yl)amino]-l-piperidinyl]methyl]-2- pyridinecarboxamide as a covalentinhibitor of menin-mll interaction
|
|
US20250002458A1
(en)
|
2023-05-24 |
2025-01-02 |
Unicycive Therapeutics Inc. |
Salt forms of nicorandil derivative
|
|
WO2024249950A1
(en)
|
2023-06-02 |
2024-12-05 |
Biomea Fusion, Inc. |
Fused pyrimidine compounds as inhibitors of menin
|
|
US20250145571A1
(en)
|
2023-09-26 |
2025-05-08 |
Unicycive Therapeutics, Inc. |
Amino acid prodrugs of nicorandil
|
|
WO2025194102A1
(en)
|
2024-03-15 |
2025-09-18 |
Unicycive Therapeutics, Inc. |
Pyridine modified nicorandil derivatives
|