GR3035867T3 - Process of preparation of hexahydroazepinones and hexahydroazepinoles. - Google Patents

Process of preparation of hexahydroazepinones and hexahydroazepinoles.

Info

Publication number
GR3035867T3
GR3035867T3 GR20010400720T GR20010400720T GR3035867T3 GR 3035867 T3 GR3035867 T3 GR 3035867T3 GR 20010400720 T GR20010400720 T GR 20010400720T GR 20010400720 T GR20010400720 T GR 20010400720T GR 3035867 T3 GR3035867 T3 GR 3035867T3
Authority
GR
Greece
Prior art keywords
reaction
column
yields
inn
theory
Prior art date
Application number
GR20010400720T
Other languages
English (en)
Inventor
Dr Alfred Olbrich
Prof Juergen Engel
Dr Bernd Kutscher
Roland Moeller
Original Assignee
Asta Medica Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19934343409 external-priority patent/DE4343409C2/de
Application filed by Asta Medica Ag filed Critical Asta Medica Ag
Publication of GR3035867T3 publication Critical patent/GR3035867T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside
    • B01J19/1868—Stationary reactors having moving elements inside resulting in a loop-type movement
    • B01J19/1881—Stationary reactors having moving elements inside resulting in a loop-type movement externally, i.e. the mixture leaving the vessel and subsequently re-entering it
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2208/00—Processes carried out in the presence of solid particles; Reactors therefor
    • B01J2208/00008—Controlling the process
    • B01J2208/00017—Controlling the temperature
    • B01J2208/00106—Controlling the temperature by indirect heat exchange
    • B01J2208/00168—Controlling the temperature by indirect heat exchange with heat exchange elements outside the bed of solid particles
    • B01J2208/00247—Reflux columns

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
GR20010400720T 1993-12-18 2001-05-15 Process of preparation of hexahydroazepinones and hexahydroazepinoles. GR3035867T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19934343409 DE4343409C2 (de) 1993-12-18 1993-12-18 Verbessertes Verfahren zur Herstellung von Hexahydroazepinonen und Hexahydroazepinolen

Publications (1)

Publication Number Publication Date
GR3035867T3 true GR3035867T3 (en) 2001-08-31

Family

ID=6505486

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20010400720T GR3035867T3 (en) 1993-12-18 2001-05-15 Process of preparation of hexahydroazepinones and hexahydroazepinoles.

Country Status (11)

Country Link
US (1) US5760221A (el)
EP (1) EP0659744B1 (el)
JP (1) JP2994220B2 (el)
AT (1) ATE199374T1 (el)
CA (1) CA2138308C (el)
DE (2) DE4345224C2 (el)
DK (1) DK0659744T3 (el)
ES (1) ES2155843T3 (el)
GR (1) GR3035867T3 (el)
PT (1) PT659744E (el)
SG (1) SG46986A1 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100421282B1 (ko) * 2001-08-22 2004-03-09 부광약품 주식회사 1-메틸헥사히드로-4-아제피논 염산염의 제조방법
KR100426534B1 (ko) * 2001-09-03 2004-04-28 한올제약주식회사 아젤라스틴의 개선된 합성방법
DE10201689A1 (de) * 2002-01-17 2003-07-31 Merck Patent Gmbh Kontinuierliches Verfahren zur Hydrolyse einer lösungsmittelhaltigen organischen Verbindung
CN114507184B (zh) * 2020-11-17 2024-02-13 好医生药业集团有限公司 1-甲基六氢氮杂卓-4-酮盐酸盐的合成方法及其应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH572914A5 (el) * 1971-01-22 1976-02-27 Asta Werke Ag Chem Fab
US3813384A (en) * 1972-01-17 1974-05-28 Asta Werke Ag Chem Fab Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof
BE795257A (fr) * 1972-02-10 1973-08-09 Thomae Gmbh Dr K Nouveaux oxazols
DE3530793A1 (de) * 1984-09-14 1986-03-27 Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld Substituierte benzylphthalazinon-derivate
DE3634942A1 (de) * 1985-11-11 1987-05-14 Asta Werke Ag Chem Fab Neue 4-benzyl-1-(2h)-phthalazinon-derivate

Also Published As

Publication number Publication date
CA2138308A1 (en) 1995-06-19
ATE199374T1 (de) 2001-03-15
PT659744E (pt) 2001-08-30
JP2994220B2 (ja) 1999-12-27
US5760221A (en) 1998-06-02
DE4345224C2 (de) 1999-07-01
EP0659744A1 (de) 1995-06-28
DE4345224A1 (de) 1995-06-22
ES2155843T3 (es) 2001-06-01
EP0659744B1 (de) 2001-02-28
DK0659744T3 (da) 2001-05-14
JPH0812656A (ja) 1996-01-16
DE59409665D1 (de) 2001-04-05
SG46986A1 (en) 1998-03-20
CA2138308C (en) 2002-11-19

Similar Documents

Publication Publication Date Title
EP1254126B1 (en) Process for the epoxidation of olefins
JPH11228555A (ja) エピクロロヒドリン主体生成物及びその生成物の製造方法
KR910007860A (ko) 비닐 아세테이트 분리법
KR100772760B1 (ko) 무수 포름산의 생성 방법에서의 폐수 처리
MY132188A (en) Process for the purification of acrylic acid obtained by catalytic oxidation of propylene
KR20020070351A (ko) 무수 포름산을 생성시키는 방법
SG46986A1 (en) Improved method for the preparation of hexahydroazepinones and hexahydroazepinoles
KR101269493B1 (ko) 메틸 메타크릴레이트 정제시 생성되는 스트림으로부터 유용한 화합물을 회수하는 방법
ATE148692T1 (de) Verfahren zur herstellung von n-phenylmaleinimid
CS213394B2 (en) Method of gaining the acrylic acid,acrolein,water and impurities
JP4471976B2 (ja) アンモニアとエチレンオキサイドとの反応により得られる混合物からのトリエタノールアミンの分離方法
KR100830758B1 (ko) 폐가스 흐름의 세정 방법
Lee et al. Novel synthetic method for allylic amination of cyclic allylic ethers using chlorosulfonyl isocyanate
HK1025087A1 (en) Process for preparing and purifying complex esters
Iqbal et al. Cobalt catalysed regioselective cleavage of oxiranes with acylchlorides
Palomo et al. Exo, exo-2, 3-Diaminoborneol-derived imidazolidinone as chiral auxiliary for asymmetric alkylations
Fuji et al. Enantioselective construction of highly functionalized bicyclo [4.3. 0] system through Diels-Alder cycloaddition
AU614256B2 (en) Recovery of hydrogen peroxide
EP0612714B1 (en) Process and plant for the purification of raw maleic anhydride recovered from gaseous reaction mixtures
Beugelmans et al. A NOVEL ACCESS TO 3-BENLAZEPINES AND TO 3-BENZOXEPINES SRN1 REACTIONS
MY139965A (en) Continuous process for preparing caprolactam
ATE146777T1 (de) Herstellung von beta-jonon
JPH0813783B2 (ja) マレイン酸ジアルキルの製造方法
JPS56103127A (en) Preparation of ethylene glycol monotert-alkyl ether
JP2739658B2 (ja) イソブチル酸からメタクリル酸メチルを製造する方法の改良