DK0659744T3 - Forbedret fremgangsmåde til fremstilling af hexahydroazepioner og hexahydroazepinoler - Google Patents
Forbedret fremgangsmåde til fremstilling af hexahydroazepioner og hexahydroazepinolerInfo
- Publication number
- DK0659744T3 DK0659744T3 DK94120044T DK94120044T DK0659744T3 DK 0659744 T3 DK0659744 T3 DK 0659744T3 DK 94120044 T DK94120044 T DK 94120044T DK 94120044 T DK94120044 T DK 94120044T DK 0659744 T3 DK0659744 T3 DK 0659744T3
- Authority
- DK
- Denmark
- Prior art keywords
- reaction
- column
- yields
- inn
- theory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/18—Stationary reactors having moving elements inside
- B01J19/1868—Stationary reactors having moving elements inside resulting in a loop-type movement
- B01J19/1881—Stationary reactors having moving elements inside resulting in a loop-type movement externally, i.e. the mixture leaving the vessel and subsequently re-entering it
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/26—Nozzle-type reactors, i.e. the distribution of the initial reactants within the reactor is effected by their introduction or injection through nozzles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2208/00—Processes carried out in the presence of solid particles; Reactors therefor
- B01J2208/00008—Controlling the process
- B01J2208/00017—Controlling the temperature
- B01J2208/00106—Controlling the temperature by indirect heat exchange
- B01J2208/00168—Controlling the temperature by indirect heat exchange with heat exchange elements outside the bed of solid particles
- B01J2208/00247—Reflux columns
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19934343409 DE4343409C2 (de) | 1993-12-18 | 1993-12-18 | Verbessertes Verfahren zur Herstellung von Hexahydroazepinonen und Hexahydroazepinolen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0659744T3 true DK0659744T3 (da) | 2001-05-14 |
Family
ID=6505486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK94120044T DK0659744T3 (da) | 1993-12-18 | 1994-12-17 | Forbedret fremgangsmåde til fremstilling af hexahydroazepioner og hexahydroazepinoler |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5760221A (da) |
| EP (1) | EP0659744B1 (da) |
| JP (1) | JP2994220B2 (da) |
| AT (1) | ATE199374T1 (da) |
| CA (1) | CA2138308C (da) |
| DE (2) | DE4345224C2 (da) |
| DK (1) | DK0659744T3 (da) |
| ES (1) | ES2155843T3 (da) |
| GR (1) | GR3035867T3 (da) |
| PT (1) | PT659744E (da) |
| SG (1) | SG46986A1 (da) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100421282B1 (ko) * | 2001-08-22 | 2004-03-09 | 부광약품 주식회사 | 1-메틸헥사히드로-4-아제피논 염산염의 제조방법 |
| KR100426534B1 (ko) * | 2001-09-03 | 2004-04-28 | 한올제약주식회사 | 아젤라스틴의 개선된 합성방법 |
| DE10201689A1 (de) * | 2002-01-17 | 2003-07-31 | Merck Patent Gmbh | Kontinuierliches Verfahren zur Hydrolyse einer lösungsmittelhaltigen organischen Verbindung |
| CN114507184B (zh) * | 2020-11-17 | 2024-02-13 | 好医生药业集团有限公司 | 1-甲基六氢氮杂卓-4-酮盐酸盐的合成方法及其应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH572914A5 (da) * | 1971-01-22 | 1976-02-27 | Asta Werke Ag Chem Fab | |
| US3813384A (en) * | 1972-01-17 | 1974-05-28 | Asta Werke Ag Chem Fab | Basically substituted benzyl phthalazone derivatives,acid salts thereof and process for the production thereof |
| BE795257A (fr) * | 1972-02-10 | 1973-08-09 | Thomae Gmbh Dr K | Nouveaux oxazols |
| DE3530793A1 (de) * | 1984-09-14 | 1986-03-27 | Asta-Werke Ag Chemische Fabrik, 4800 Bielefeld | Substituierte benzylphthalazinon-derivate |
| DE3634942A1 (de) * | 1985-11-11 | 1987-05-14 | Asta Werke Ag Chem Fab | Neue 4-benzyl-1-(2h)-phthalazinon-derivate |
-
1993
- 1993-12-18 DE DE4345224A patent/DE4345224C2/de not_active Expired - Lifetime
-
1994
- 1994-12-15 JP JP6312189A patent/JP2994220B2/ja not_active Expired - Lifetime
- 1994-12-16 CA CA002138308A patent/CA2138308C/en not_active Expired - Lifetime
- 1994-12-17 EP EP94120044A patent/EP0659744B1/de not_active Expired - Lifetime
- 1994-12-17 PT PT94120044T patent/PT659744E/pt unknown
- 1994-12-17 SG SG1996001013A patent/SG46986A1/en unknown
- 1994-12-17 DE DE59409665T patent/DE59409665D1/de not_active Expired - Lifetime
- 1994-12-17 DK DK94120044T patent/DK0659744T3/da active
- 1994-12-17 AT AT94120044T patent/ATE199374T1/de active
- 1994-12-17 ES ES94120044T patent/ES2155843T3/es not_active Expired - Lifetime
- 1994-12-19 US US08/359,457 patent/US5760221A/en not_active Expired - Lifetime
-
2001
- 2001-05-15 GR GR20010400720T patent/GR3035867T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| GR3035867T3 (en) | 2001-08-31 |
| JPH0812656A (ja) | 1996-01-16 |
| JP2994220B2 (ja) | 1999-12-27 |
| EP0659744B1 (de) | 2001-02-28 |
| DE4345224A1 (de) | 1995-06-22 |
| SG46986A1 (en) | 1998-03-20 |
| ATE199374T1 (de) | 2001-03-15 |
| ES2155843T3 (es) | 2001-06-01 |
| DE59409665D1 (de) | 2001-04-05 |
| EP0659744A1 (de) | 1995-06-28 |
| PT659744E (pt) | 2001-08-30 |
| US5760221A (en) | 1998-06-02 |
| CA2138308A1 (en) | 1995-06-19 |
| CA2138308C (en) | 2002-11-19 |
| DE4345224C2 (de) | 1999-07-01 |
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