GR3027751T3 - Heterocyclic derivatives as platelet aggregation inhibitors - Google Patents

Heterocyclic derivatives as platelet aggregation inhibitors

Info

Publication number
GR3027751T3
GR3027751T3 GR980401930T GR980401930T GR3027751T3 GR 3027751 T3 GR3027751 T3 GR 3027751T3 GR 980401930 T GR980401930 T GR 980401930T GR 980401930 T GR980401930 T GR 980401930T GR 3027751 T3 GR3027751 T3 GR 3027751T3
Authority
GR
Greece
Prior art keywords
platelet aggregation
aggregation inhibitors
heterocyclic derivatives
ylüphenoxybutyric
piperazin
Prior art date
Application number
GR980401930T
Other languages
Greek (el)
English (en)
Inventor
Michael Garth Wayne
Michael James Smithers
John Wall Rayner
Alan Wellington Faull
Robert James Pearce
Andrew George Brewster
Richard Eden Shute
Stuart Dennett Mills
Peter William Rodney Caulkett
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB939306453A external-priority patent/GB9306453D0/en
Priority claimed from GB939325605A external-priority patent/GB9325605D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of GR3027751T3 publication Critical patent/GR3027751T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Electroluminescent Light Sources (AREA)
  • Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Pyrrole Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR980401930T 1993-03-29 1998-08-27 Heterocyclic derivatives as platelet aggregation inhibitors GR3027751T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB939306453A GB9306453D0 (en) 1993-03-29 1993-03-29 Heterocyclic derivatives
GB939325605A GB9325605D0 (en) 1993-12-15 1993-12-15 Heterocyclic derivatives
PCT/GB1994/000647 WO1994022834A1 (en) 1993-03-29 1994-03-28 Heterocyclic derivatives as platelet aggregation inhibitors

Publications (1)

Publication Number Publication Date
GR3027751T3 true GR3027751T3 (en) 1998-11-30

Family

ID=26302668

Family Applications (2)

Application Number Title Priority Date Filing Date
GR980401930T GR3027751T3 (en) 1993-03-29 1998-08-27 Heterocyclic derivatives as platelet aggregation inhibitors
GR20010401498T GR3036640T3 (en) 1993-03-29 2001-09-18 Heterocyclic derivatives as platelet aggregation inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
GR20010401498T GR3036640T3 (en) 1993-03-29 2001-09-18 Heterocyclic derivatives as platelet aggregation inhibitors

Country Status (26)

Country Link
US (1) US5556977A (cg-RX-API-DMAC7.html)
EP (2) EP0691959B1 (cg-RX-API-DMAC7.html)
JP (1) JPH08508291A (cg-RX-API-DMAC7.html)
KR (1) KR100231089B1 (cg-RX-API-DMAC7.html)
CN (1) CN1120334A (cg-RX-API-DMAC7.html)
AT (2) ATE168678T1 (cg-RX-API-DMAC7.html)
AU (1) AU692438B2 (cg-RX-API-DMAC7.html)
BR (1) BR9406613A (cg-RX-API-DMAC7.html)
CA (1) CA2156070A1 (cg-RX-API-DMAC7.html)
CZ (1) CZ250995A3 (cg-RX-API-DMAC7.html)
DE (2) DE69411900T2 (cg-RX-API-DMAC7.html)
DK (2) DK0825184T3 (cg-RX-API-DMAC7.html)
ES (2) ES2119184T3 (cg-RX-API-DMAC7.html)
FI (1) FI954616A7 (cg-RX-API-DMAC7.html)
GB (1) GB9406143D0 (cg-RX-API-DMAC7.html)
GR (2) GR3027751T3 (cg-RX-API-DMAC7.html)
HU (2) HUT72088A (cg-RX-API-DMAC7.html)
IL (1) IL109144A (cg-RX-API-DMAC7.html)
NO (1) NO305244B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ262941A (cg-RX-API-DMAC7.html)
PL (1) PL310889A1 (cg-RX-API-DMAC7.html)
PT (1) PT825184E (cg-RX-API-DMAC7.html)
SK (1) SK120895A3 (cg-RX-API-DMAC7.html)
TW (1) TW276254B (cg-RX-API-DMAC7.html)
WO (1) WO1994022834A1 (cg-RX-API-DMAC7.html)
ZW (1) ZW4294A1 (cg-RX-API-DMAC7.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5750754A (en) * 1993-03-29 1998-05-12 Zeneca Limited Heterocyclic compounds
IL115420A0 (en) 1994-09-26 1995-12-31 Zeneca Ltd Aminoheterocyclic derivatives
US5700801A (en) * 1994-12-23 1997-12-23 Karl Thomae, Gmbh Piperazine derivatives, pharmaceutical compositions containing these compounds, their use and processes for preparing them
JPH10511374A (ja) * 1994-12-23 1998-11-04 ドクトル カルル トーマエ ゲゼルシャフト ミット ベシュレンクテル ハフツング ピペラジン誘導体、これらの化合物を含む医薬品、それらの使用及びそれらの調製方法
FR2734818B1 (fr) * 1995-06-01 1998-07-10 Zeneca Ltd Acide (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazine-1-yl- phenoxy}-butyrique, procede pour sa preparation et composition pharmaceutique le contenant
BR9606409A (pt) * 1995-06-01 1997-09-30 Zeneca Ltd Composto opticamente ativo composição farmacêutica processos para inibir agregação de plaqueta em um animal de sangue quente ligação de fibrinogênio a gpiib/iia em um animal de sangue quente e eventos trombóticos que acompanham agnina instável em animal de sangue quente e uso do composto opticamante ativo
DE19524765A1 (de) * 1995-07-07 1997-01-09 Boehringer Mannheim Gmbh Neue Oxazolidinonderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
JP2000514779A (ja) * 1995-11-17 2000-11-07 ワーナー−ランバート・コンパニー マトリックスメタロプロティナーゼのスルホンアミド阻害剤
GB9525620D0 (en) * 1995-12-15 1996-02-14 Glaxo Group Ltd Chemical compounds
AU1608397A (en) * 1996-02-02 1997-08-22 Zeneca Limited Heterocyclic compounds useful as pharmaceutical agents
GB9602166D0 (en) * 1996-02-02 1996-04-03 Zeneca Ltd Aminoheterocyclic derivatives
GB9604242D0 (en) 1996-02-28 1996-05-01 Glaxo Wellcome Inc Chemical compounds
JP2000505471A (ja) * 1996-02-28 2000-05-09 メルク エンド カンパニー インコーポレーテッド フィブリノーゲン受容体拮抗物質
US5780480A (en) * 1996-02-28 1998-07-14 Merck & Co., Inc. Fibrinogen receptor antagonists
AU2044297A (en) * 1996-03-29 1997-10-22 Meiji Seika Kaisha Ltd. Novel heterocyclic compounds having platelet aggregation inhibitory effects
US5854245A (en) * 1996-06-28 1998-12-29 Merck & Co., Inc. Fibrinogen receptor antagonists
AU709631B2 (en) * 1996-06-28 1999-09-02 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5990107A (en) * 1996-06-28 1999-11-23 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
US5932582A (en) * 1996-06-28 1999-08-03 Merck & Co., Inc. Fibrinogen receptor antagonist prodrugs
EP0912175A4 (en) * 1996-06-28 1999-09-08 Merck & Co Inc FIBRINOGENIC RECEPTOR ANTAGONISTS
GB9821483D0 (en) 1998-10-03 1998-11-25 Glaxo Group Ltd Chemical compounds
UA56197C2 (uk) * 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні
US5945545A (en) * 1996-12-13 1999-08-31 Merck & Co., Inc. Fibrinogen receptor antagonists
US6440972B1 (en) 1997-02-13 2002-08-27 Zeneca Limited Heterocyclic compounds useful as oxido-squalene cyclase inhibitors
PT966462E (pt) 1997-02-13 2003-10-31 Astrazeneca Ab Compostos heterociclicos uteis como inibidores da ciclase do oxido-esqualeno
GB9715895D0 (en) 1997-07-29 1997-10-01 Zeneca Ltd Heterocyclic compounds
US6232322B1 (en) 1998-05-12 2001-05-15 American Home Products Corporation Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6451827B2 (en) 1998-05-12 2002-09-17 Wyeth 2,3,5-substituted biphenyls useful in the treatment of insulin resistance and hyperglycemia
US6166069A (en) * 1998-05-12 2000-12-26 American Home Products Corporation Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) * 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CN1308604A (zh) 1998-05-12 2001-08-15 美国家用产品公司 用于治疗胰岛素抗性和高血糖的2,3,5－取代的联苯化合物
US6699896B1 (en) 1998-05-12 2004-03-02 Wyeth Oxazole-aryl-carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
US6221902B1 (en) 1998-05-12 2001-04-24 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
JP2002521444A (ja) * 1998-07-31 2002-07-16 イーライ・リリー・アンド・カンパニー 複素環スルホンアミド誘導体
GB9902989D0 (en) 1999-02-11 1999-03-31 Zeneca Ltd Heterocyclic derivatives
ATE299861T1 (de) * 1999-04-19 2005-08-15 Coelacanth Corp Ppar-(gamma) agonisten zur behandlung von type ii diabetes
US6310081B1 (en) 1999-05-10 2001-10-30 American Home Products Corporation Biphenyl sulfonyl aryl carboxylic acids useful in the treatment of insulin resistance and hyperglycemia
ATE502928T1 (de) 2000-11-01 2011-04-15 Millennium Pharm Inc Stickstoffhaltige heterozyklische verbindungen und verfahren zu deren herstellung
DE202011000090U1 (de) 2011-01-14 2011-04-21 E-LEAD ELECTRONIC CO., LTD., Shengang Shiang Fahrzeug-Audiosystem mit auswechselbarem Plug-In-Computer
EP3684767B1 (en) 2017-09-22 2024-04-24 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
BR112020007607A2 (pt) 2017-10-18 2020-09-29 Jubilant Epipad LLC compostos das fórmulas (i), (ii) e (iii); processos de preparação de compostos das fórmulas (i), (ii) e (iii); composição farmacêutica; compostos; método para a inibição de uma ou mais famílias de pad em uma célula; método de tratamento de uma afecção mediada por uma ou mais pad; composto da fórmula (i), fórmula (ii) e fórmula (iii); uso do composto; método para o tratamento e/ou prevenção de uma afecção; método para o tratamento de artrite reumatoide; e método de tratamento de câncer
WO2019087214A1 (en) 2017-11-06 2019-05-09 Jubilant Biosys Limited Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
ES2979256T3 (es) 2017-11-24 2024-09-25 Jubilant Episcribe Llc Compuestos heterocíclicos como inhibidores de prmt5
SG11202008950PA (en) 2018-03-13 2020-10-29 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3875165A (en) * 1973-02-22 1975-04-01 Wyeth John & Brother Ltd (4-Quinolylamino)-(N-piperidyl)benzamides and N-{8 (quinolylamino)-benzoyl{9 piperidines
GB1474296A (en) * 1975-01-23 1977-05-18 Wyeth John & Brother Ltd 4-aminoquinoline derivatives
JPS57183738A (en) * 1981-05-06 1982-11-12 Yamanouchi Pharmaceut Co Ltd Aromatic carboxylic acid derivative
ZA825719B (en) * 1981-09-03 1983-06-29 Recordati Chem Pharm Alkanoylanilides
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
US4613598A (en) * 1984-03-13 1986-09-23 Mitsubishi Chemical Industries Limited Piperazine derivatives and their acid addition salts
AU5428686A (en) * 1985-03-12 1986-09-18 Smith Kline & French Laboratories Limited Imidazolinone and thiazolinone derivatives
GB8603120D0 (en) * 1986-02-07 1986-03-12 Pfizer Ltd Anti-dysrhythmia agents
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
EP0264883A3 (en) * 1986-10-21 1990-04-04 Banyu Pharmaceutical Co., Ltd. Substituted pyridine derivatives
MY104343A (en) * 1987-11-23 1994-03-31 Janssen Pharmaceutica Nv Novel pyridizinamine deravatives
GB8819307D0 (en) * 1988-08-13 1988-09-14 Pfizer Ltd Antiarrhythmic agents
US5039805A (en) * 1988-12-08 1991-08-13 Hoffmann-La Roche Inc. Novel benzoic and phenylacetic acid derivatives
US5084466A (en) * 1989-01-31 1992-01-28 Hoffmann-La Roche Inc. Novel carboxamide pyridine compounds which have useful pharmaceutical utility
CA2008116C (en) * 1989-02-23 2001-11-20 Thomas Weller Glycine derivatives
DE4134467A1 (de) * 1991-10-18 1993-04-22 Thomae Gmbh Dr K Heterobiarylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5318899A (en) * 1989-06-16 1994-06-07 Cor Therapeutics, Inc. Platelet aggregation inhibitors
DE69012570T2 (de) * 1989-07-25 1995-02-23 The Upjohn Co., Kalamazoo, Mich. Tertiäramin-alkenylphenylalkansulfonamide mit antiarrhythmischer wirkung.
US5051405A (en) * 1989-10-10 1991-09-24 Rhone-Poulenc Rorer Pharmaceuticals Inc. Anti-thrombotic peptides and pseudopeptides
CA2037153A1 (en) * 1990-03-09 1991-09-10 Leo Alig Acetic acid derivatives
GB9007751D0 (en) * 1990-04-05 1990-06-06 Ciba Geigy Ag Novel platelet-aggregation inhibitors
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
IL99537A (en) * 1990-09-27 1995-11-27 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
NZ239876A (en) * 1990-09-27 1993-12-23 Merck & Co Inc Glycyl-b-alanine derivatives and pharmaceutical compositions thereof.
NZ239846A (en) * 1990-09-27 1994-11-25 Merck & Co Inc Sulphonamide derivatives and pharmaceutical compositions thereof
IL99539A0 (en) * 1990-09-27 1992-08-18 Merck & Co Inc Fibrinogen receptor antagonists and pharmaceutical compositions containing them
US5264420A (en) * 1990-09-27 1993-11-23 Merck & Co., Inc. Fibrinogen receptor antagonists
DE4102024A1 (de) * 1991-01-24 1992-07-30 Thomae Gmbh Dr K Biphenylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
WO1992013552A1 (en) * 1991-02-05 1992-08-20 Smithkline Beecham Corporation Anti-aggregatory peptides containing an aromatic ester or amide
DE4107857A1 (de) * 1991-03-12 1992-09-17 Thomae Gmbh Dr K Cyclische harnstoffderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
UA39849C2 (uk) * 1991-03-26 2001-07-16 Ф.Хоффманн-Ля Рош Аг ПОХІДНІ N-АЦИЛ-<font face="Symbol">a</font>-АМІНОКИСЛОТИ АБО ЇХ ФІЗІОЛОГІЧНО ПРИЙНЯТНІ СОЛІ, ПРОСТІ АБО СКЛАДНІ ЕФІРИ, АМІДИ АБО ЇХ ГІДРАТИ ЯК ФАРМАЦЕВТИЧНО АКТИВНІ РЕЧОВИНИ
MX9201416A (es) * 1991-03-28 1992-10-01 Rhone Poulenc Rorer Int Peptidos y pseudopeptidos antitromboticos.
AU661659B2 (en) * 1991-04-11 1995-08-03 Rhone-Poulenc Rorer International (Holdings) Inc. Anti-thrombotic peptide and pseudopeptide derivatives
US5321034A (en) * 1991-05-07 1994-06-14 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT68769A (en) * 1991-05-07 1995-07-28 Merck & Co Inc FIBRINOGéN RECEPTOR ANTAGONIST COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AS EFFECTIVE SUBSTANCE
DE69213546T2 (de) * 1991-05-13 1997-02-27 Fujisawa Pharmaceutical Co Neue Peptid-Verbindungen und Verfahren zur Herstellung davon
JPH05213884A (ja) * 1991-06-14 1993-08-24 Upjohn Co:The 新規な４−アミノキノリン類およびこれを有効成分とする高血圧・鬱血性心不全の予防・治療剤
DE4124942A1 (de) * 1991-07-27 1993-01-28 Thomae Gmbh Dr K 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4127404A1 (de) * 1991-08-19 1993-02-25 Thomae Gmbh Dr K Cyclische iminoderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5294713A (en) * 1991-08-23 1994-03-15 Takeda Chemical Industries, Ltd. 2-piperazinone compounds and their use
US5254573A (en) * 1991-10-15 1993-10-19 Monsanto Company Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
US5239113A (en) * 1991-10-15 1993-08-24 Monsanto Company Substituted β-amino acid derivatives useful as platelet aggregation inhibitors and intermediates thereof
EP0630366B1 (en) * 1991-10-15 2003-01-02 G.D. Searle &amp; Co. Substituted heterocyclic derivatives useful as platelet aggregation inhibitors
GB9122016D0 (en) * 1991-10-16 1991-11-27 Glaxo Group Ltd Chemical compounds
US5250679A (en) * 1991-10-18 1993-10-05 Genentech, Inc. Nonpeptidyl platelet aggregation inhibitors having specificity for the GPIIb III.sub. receptor
US5272158A (en) * 1991-10-29 1993-12-21 Merck & Co., Inc. Fibrinogen receptor antagonists
WO1993010091A2 (en) * 1991-11-14 1993-05-27 Glaxo Group Limited Piperidine acetic acid derivatives as inhibitors of fibrinogen-dependent blood platelet aggregation
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
JPH07503459A (ja) * 1992-01-21 1995-04-13 グラクソ、グループ、リミテッド 酢酸誘導体
US5264457A (en) * 1992-02-14 1993-11-23 G. D. Searle & Co. Phenyl amidines sulfonamides useful as platelet aggregation inhibitors
US5227490A (en) * 1992-02-21 1993-07-13 Merck & Co., Inc. Fibrinogen receptor antagonists
HUT63609A (en) * 1992-03-10 1993-09-28 Sandoz Ag Process for producing new derivatives and isosters of beta-amino acids and pharmaceutical compositions comprising such compounds
DE4212304A1 (de) * 1992-04-13 1993-10-14 Cassella Ag Asparaginsäurederivate, ihre Herstellung und Verwendung
GB9208740D0 (en) * 1992-04-23 1992-06-10 Glaxo Group Ltd Chemical compounds
DE4213634A1 (de) * 1992-04-24 1993-10-28 Cassella Ag 2,4-Dioxo-imidazolidin-Derivate
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5726192A (en) * 1992-12-29 1998-03-10 Smithkline Beecham Corporation Platelet aggregation inhibiting compounds
TW301607B (cg-RX-API-DMAC7.html) * 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd

Also Published As

Publication number Publication date
PL310889A1 (en) 1996-01-08
NO953837L (no) 1995-09-28
TW276254B (cg-RX-API-DMAC7.html) 1996-05-21
BR9406613A (pt) 1996-02-06
FI954616A0 (fi) 1995-09-28
ATE202345T1 (de) 2001-07-15
EP0825184B1 (en) 2001-06-20
DE69411900D1 (de) 1998-08-27
DK0825184T3 (da) 2001-09-10
EP0691959B1 (en) 1998-07-22
HU9502290D0 (en) 1995-10-30
JPH08508291A (ja) 1996-09-03
DE69427548D1 (de) 2001-07-26
US5556977A (en) 1996-09-17
DK0691959T3 (da) 1999-04-26
ES2159798T3 (es) 2001-10-16
ATE168678T1 (de) 1998-08-15
CZ250995A3 (en) 1996-01-17
HUT72088A (en) 1996-03-28
KR100231089B1 (ko) 1999-11-15
ES2119184T3 (es) 1998-10-01
DE69427548T2 (de) 2002-04-18
FI954616L (fi) 1995-09-28
NO305244B1 (no) 1999-04-26
GB9406143D0 (en) 1994-05-18
CA2156070A1 (en) 1994-10-13
AU6288994A (en) 1994-10-24
AU692438B2 (en) 1998-06-11
GR3036640T3 (en) 2001-12-31
PT825184E (pt) 2001-11-30
DE69411900T2 (de) 1998-12-10
EP0691959A1 (en) 1996-01-17
FI954616A7 (fi) 1995-09-28
IL109144A (en) 2000-02-29
ZW4294A1 (en) 1994-12-21
IL109144A0 (en) 1994-06-24
NZ262941A (en) 1997-07-27
HU211336A9 (en) 1995-11-28
CN1120334A (zh) 1996-04-10
EP0825184A1 (en) 1998-02-25
WO1994022834A1 (en) 1994-10-13
NO953837D0 (no) 1995-09-28
SK120895A3 (en) 1996-06-05

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