GR3018506T3 - Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated - Google Patents

Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Info

Publication number
GR3018506T3
GR3018506T3 GR950403587T GR950403587T GR3018506T3 GR 3018506 T3 GR3018506 T3 GR 3018506T3 GR 950403587 T GR950403587 T GR 950403587T GR 950403587 T GR950403587 T GR 950403587T GR 3018506 T3 GR3018506 T3 GR 3018506T3
Authority
GR
Greece
Prior art keywords
pct
encapsulated
enhanced
foreign substances
making liposomes
Prior art date
Application number
GR950403587T
Other languages
Greek (el)
English (en)
Inventor
Michel Schneider
Herve Tournier
Roland Hyacinthe
Christian Guillot
Bernard Lamy
Original Assignee
Bracco Int Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bracco Int Bv filed Critical Bracco Int Bv
Publication of GR3018506T3 publication Critical patent/GR3018506T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR950403587T 1990-12-11 1995-12-21 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated GR3018506T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP90810969 1990-12-11
PCT/EP1991/002377 WO1992010166A1 (en) 1990-12-11 1991-12-09 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Publications (1)

Publication Number Publication Date
GR3018506T3 true GR3018506T3 (en) 1996-03-31

Family

ID=8205973

Family Applications (1)

Application Number Title Priority Date Filing Date
GR950403587T GR3018506T3 (en) 1990-12-11 1995-12-21 Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated

Country Status (20)

Country Link
US (1) US5393530A (https=)
EP (1) EP0514523B1 (https=)
JP (1) JP3241720B2 (https=)
KR (1) KR0137783B1 (https=)
AT (1) ATE131724T1 (https=)
AU (1) AU635456B2 (https=)
CA (1) CA2072559C (https=)
DE (1) DE69115682T2 (https=)
DK (1) DK0514523T3 (https=)
ES (1) ES2081605T3 (https=)
GR (1) GR3018506T3 (https=)
HU (1) HUT62458A (https=)
IE (1) IE72163B1 (https=)
IL (1) IL99835A (https=)
IN (1) IN172269B (https=)
IS (1) IS1685B (https=)
MX (1) MX9102516A (https=)
NZ (1) NZ240817A (https=)
WO (1) WO1992010166A1 (https=)
ZA (1) ZA918489B (https=)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352435A (en) * 1989-12-22 1994-10-04 Unger Evan C Ionophore containing liposomes for ultrasound imaging
US5542935A (en) * 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US20020150539A1 (en) 1989-12-22 2002-10-17 Unger Evan C. Ultrasound imaging and treatment
US5580575A (en) * 1989-12-22 1996-12-03 Imarx Pharmaceutical Corp. Therapeutic drug delivery systems
US5469854A (en) * 1989-12-22 1995-11-28 Imarx Pharmaceutical Corp. Methods of preparing gas-filled liposomes
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
JPH08505312A (ja) * 1992-10-16 1996-06-11 ザックセ，アンドレアス 液状分散系を製造する方法及び装置
US5869305A (en) * 1992-12-04 1999-02-09 The University Of Pittsburgh Recombinant viral vector system
US6217849B1 (en) 1993-09-29 2001-04-17 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US7083572B2 (en) 1993-11-30 2006-08-01 Bristol-Myers Squibb Medical Imaging, Inc. Therapeutic delivery systems
DE69527194T2 (de) * 1994-03-28 2003-02-06 Daiichi Pharmaceutical Co., Ltd. Liposomen enthaltend ein röntgen- oder ultraschallkontrastmittel
AU4546996A (en) * 1995-02-24 1996-09-11 Bracco Research S.A. Liposome suspensions as blood pool imaging contrast agents
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US5738868A (en) * 1995-07-18 1998-04-14 Lipogenics Ltd. Liposome compositions and kits therefor
US6447800B2 (en) 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
WO1997040679A1 (en) 1996-05-01 1997-11-06 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US20020052310A1 (en) * 1997-09-15 2002-05-02 Massachusetts Institute Of Technology The Penn State Research Foundation Particles for inhalation having sustained release properties
US20010051131A1 (en) * 1996-06-19 2001-12-13 Evan C. Unger Methods for delivering bioactive agents
US5846517A (en) 1996-09-11 1998-12-08 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a renal contrast agent and a vasodilator
DE19639811A1 (de) * 1996-09-27 1998-04-02 Artur Herzog Dr Mesmer Verwendung einer Liposomenlösung zur Verstärkung der Wirksamkeit und/oder Verminderung der Toxizität von Arzneimitteln
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
AU7104598A (en) 1997-04-09 1998-10-30 Philipp Lang New technique to monitor drug delivery noninvasively (in vivo)
US7452551B1 (en) 2000-10-30 2008-11-18 Imarx Therapeutics, Inc. Targeted compositions for diagnostic and therapeutic use
DE19731591C2 (de) * 1997-07-17 1999-09-16 Schering Ag Pharmazeutische Mittel enthaltend perfluoralkylgruppenhaltige Trijodaromaten und ihre Verwendung in der Tumortherapie und interventionellen Radiologie
US6106858A (en) * 1997-09-08 2000-08-22 Skyepharma, Inc. Modulation of drug loading in multivescular liposomes
US6306432B1 (en) * 1997-09-08 2001-10-23 Chiron Corporation High and low load formulations of IGF-I in multivesicular liposomes
CA2304096C (en) * 1997-09-18 2003-09-09 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
AU752802C (en) 1997-11-14 2006-04-13 Pacira Pharmaceuticals, Inc. Production of multivesicular liposomes
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
DE19813773A1 (de) * 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
IL140899A0 (en) 1998-07-17 2002-02-10 Skyepharma Inc Lipid/polymer containing pharmaceutical compositions and processes for the preparation thereof
US6511676B1 (en) 1999-11-05 2003-01-28 Teni Boulikas Therapy for human cancers using cisplatin and other drugs or genes encapsulated into liposomes
US7109167B2 (en) 2000-06-02 2006-09-19 Bracco International B.V. Compounds for targeting endothelial cells, compositions containing the same and methods for their use
DE10121903A1 (de) * 2001-04-27 2002-10-31 Nimbus Biotechnologie Gmbh System für die Membranpermeationsmessung
AU2002322024B2 (en) * 2001-05-31 2008-05-08 Pacira Pharmaceuticals, Inc. Encapsulation of nanosuspensions in liposomes and microspheres
JP3990880B2 (ja) * 2001-07-10 2007-10-17 キヤノン株式会社 ポリヒドロキシアルカノエート被覆リポソームの製造方法
KR100521526B1 (ko) * 2001-07-10 2005-10-13 캐논 가부시끼가이샤 폴리하이드록시알카노에이트로 이루어진 입상 구조체 및그 제조방법
ES2387886T3 (es) * 2001-11-13 2012-10-03 Celator Pharmaceuticals, Inc. Composiciones que transportan lípidos con una mejor estabilidad sanguínea
AU2002340670A1 (en) * 2001-11-13 2003-05-26 Celator Technologies, Inc. Lipid carrier compositions and methods for improved drug retention
US20030129224A1 (en) * 2001-11-13 2003-07-10 Paul Tardi Lipid carrier compositions and methods for improved drug retention
US20050129750A1 (en) * 2003-12-15 2005-06-16 Yu-Fang Hu Process for producing liposome suspension and product containing liposome suspension produced thereby
EP1547582A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Method of producing lipid complexed camptothecin-carboxylate
EP1547580A1 (en) * 2003-12-23 2005-06-29 MediGene Oncology GmbH Loading of a camptothecin drug into colloidal nanoparticles
DE602005010424D1 (de) 2004-06-03 2008-11-27 Bracco Research Sa Liposomale anordnung für die therapeutische und/oder diagnostische anwendung
CA2582242A1 (en) * 2004-10-08 2006-04-20 Alza Corporation Method of insertion of a lipid-linked moiety into a pre-formed lipid assembly using microwaves
CA2595731A1 (en) * 2005-01-26 2006-08-03 Celator Pharmaceuticals, Inc. Lipid carrier compositions with reduced polydispersity
US20070031342A1 (en) * 2005-06-22 2007-02-08 Nektar Therapeutics Sustained release microparticles for pulmonary delivery
ES2275443B1 (es) * 2005-11-30 2008-06-01 Italfarmaco, S.A. Procedimiento de preparacion de liposomas.
JP5080779B2 (ja) * 2006-10-25 2012-11-21 テルモ株式会社 リポソーム製剤の製造方法
WO2008141230A1 (en) * 2007-05-09 2008-11-20 Lawrence Livermore National Security, Llc Methods and systems for monitoring production of a target protein in a nanolipoprotein particle
WO2009067203A1 (en) * 2007-11-19 2009-05-28 Ceramoptec Industries, Inc. Pegylated compounds for age-related macular degeneration
US8907061B2 (en) * 2008-01-11 2014-12-09 Lawrence Livermore National Security, Llc. Nanolipoprotein particles and related methods and systems for protein capture, solubilization, and/or purification
US9303273B2 (en) 2008-05-09 2016-04-05 Lawrence Livermore National Security, Llc Nanolipoprotein particles comprising a natural rubber biosynthetic enzyme complex and related products, methods and systems
US8883729B2 (en) * 2008-05-22 2014-11-11 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions, methods and systems
US9445975B2 (en) * 2008-10-03 2016-09-20 Access Business Group International, Llc Composition and method for preparing stable unilamellar liposomal suspension
CN102202694B (zh) 2008-10-07 2014-03-12 博莱科瑞士股份有限公司 包含抗-聚合物抗体的靶向构建体和结合它们的脂质体或微泡
EP2184054A1 (en) * 2008-11-08 2010-05-12 Lipoxen Technologies Limited Small Interfering RNA Delivery
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
CA2781527C (en) 2009-09-23 2017-10-24 Indu Javeri Methods for the preparation of liposomes
US10736844B2 (en) 2011-01-13 2020-08-11 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
US9644038B2 (en) 2011-12-21 2017-05-09 The Regents Of The University Of California Apolipoprotein nanodiscs with telodendrimer
AU2013208693B2 (en) 2012-01-12 2017-12-07 Variation Biotechnologies Inc. Compositions and methods for treating viral infections
EP2806894A4 (en) * 2012-01-27 2015-11-04 Variation Biotechnologies Inc METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENTS
MX364310B (es) * 2013-11-05 2019-04-22 Gustavo A Garcia Sanchez Método para preparar una formulación inmunosupresora.
EP3138558B1 (en) * 2014-04-30 2023-06-07 FUJIFILM Corporation Liposome composition and production method therefor
WO2015166986A1 (ja) 2014-04-30 2015-11-05 富士フイルム株式会社 リポソーム組成物及びその製造方法
WO2016049061A1 (en) 2014-09-22 2016-03-31 Lawrence Livermore National Security, Llc Electrochemical flow-cell for hydrogen production and nicotinamide co-factor dependent target reduction, and related methods and systems
EP4154915A1 (en) 2014-12-31 2023-03-29 Lantheus Medical Imaging, Inc. Lipid-encapsulated gas microsphere compositions and related methods
AU2016256979B2 (en) 2015-05-04 2021-01-28 Genfit Method for preparing transmembrane pH-gradient vesicles
WO2017035326A1 (en) 2015-08-25 2017-03-02 Lawrence Livermore National Security, Llc Stable nanolipoprotein particles and related compositions methods and systems
WO2017044899A1 (en) 2015-09-11 2017-03-16 Lawrence Livermore National Security, Llc Synthetic apolipoproteins, and related compositions methods and systems for nanolipoprotein particles formation
EP3372223B1 (en) 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
KR20180133527A (ko) 2016-05-04 2018-12-14 랜티우스 메디컬 이메징, 인크. 초음파 조영제의 제조 방법 및 장치
US9789210B1 (en) 2016-07-06 2017-10-17 Lantheus Medical Imaging, Inc. Methods for making ultrasound contrast agents
JP7019201B2 (ja) 2016-08-02 2022-02-15 キュリアールエックス インコーポレーテッド リポソームの調製方法
US12083223B2 (en) 2017-05-02 2024-09-10 Lawrence Livermore National Security, Llc Nanolipoprotein particles and related compositions methods and systems for loading RNA
US11207422B2 (en) 2017-05-02 2021-12-28 Lawrence Livermore National Security, Llc MOMP telonanoparticles, and related compositions, methods and systems
ES2984147T3 (es) 2018-06-20 2024-10-29 Fujifilm Corp Medicamento combinado que comprende una composición liposómica de gemcitabina encapsulada y bloqueo de punto de control inmunitario
BR112021026480A2 (pt) * 2019-06-28 2022-02-08 Univ Texas Método para reconstituir anamicina, método para preparar uma dose eficaz de uma formulação lipossômica reconstituída de anamicina e método para tratar câncer
US11980636B2 (en) 2020-11-18 2024-05-14 Jazz Pharmaceuticals Ireland Limited Treatment of hematological disorders
US11357727B1 (en) 2021-01-22 2022-06-14 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12151024B2 (en) 2021-01-22 2024-11-26 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11033495B1 (en) 2021-01-22 2021-06-15 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US11278494B1 (en) 2021-01-22 2022-03-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
EP4415713A4 (en) 2021-10-14 2025-08-06 Pacira Pharmaceuticals Inc MULTIVESICULAR LIPOSOME FORMULATIONS OF BUPIVACAINE AND THEIR USES
US12280149B1 (en) 2024-05-20 2025-04-22 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12251472B1 (en) 2024-05-20 2025-03-18 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes
US12156940B1 (en) 2024-05-20 2024-12-03 Pacira Pharmaceuticals, Inc. Manufacturing of bupivacaine multivesicular liposomes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5186117A (en) * 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
CA1270198C (en) * 1984-08-08 1990-06-12 Marcel B Bally ENCAPSULATION OF ANTINEOPLASTIC AGENTS IN LIPOSONES
JPS6150912A (ja) * 1984-08-16 1986-03-13 Shionogi & Co Ltd リポソ−ム製剤の製造法
JPS63211222A (ja) * 1987-02-27 1988-09-02 Terumo Corp リポソ−ムの製法
US4963297A (en) * 1987-12-22 1990-10-16 The Liposome Company, Inc. Spontaneous vesticulation of multilamellar liposomes
CH672733A5 (https=) * 1987-05-22 1989-12-29 Bracco Ind Chimica Spa
US4870160A (en) * 1987-08-19 1989-09-26 Regents Of The University Of Minnesota Polypeptides with laminin activity
IE63518B1 (en) * 1987-11-18 1995-05-03 Vestar Inc Multiple step entrapment/loading procedure for preparing lipophilic drug-containing liposomes
JPH03501732A (ja) * 1987-12-22 1991-04-18 ザ　リポソーム　カンパニー，インコーポレイテッド 多重ラメラリポソームの自発的小胞化方法
ATE108651T1 (de) * 1988-05-20 1994-08-15 Liposome Co Inc Aktives mittel: lipid-komplex mit hohem verhältnis.
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release

Also Published As

Publication number Publication date
KR920703014A (ko) 1992-12-17
KR0137783B1 (ko) 1998-05-15
JP3241720B2 (ja) 2001-12-25
NZ240817A (en) 1993-01-27
IN172269B (https=) 1993-05-29
ES2081605T3 (es) 1996-03-16
CA2072559A1 (en) 1992-06-12
MX9102516A (es) 1992-06-01
DE69115682T2 (de) 1996-05-15
JPH05504150A (ja) 1993-07-01
DE69115682D1 (de) 1996-02-01
AU9062991A (en) 1992-07-08
IE914289A1 (en) 1992-06-17
WO1992010166A1 (en) 1992-06-25
IE72163B1 (en) 1997-03-26
AU635456B2 (en) 1993-03-18
IL99835A0 (en) 1992-08-18
US5393530A (en) 1995-02-28
CA2072559C (en) 1997-03-18
IS1685B (is) 1998-02-24
EP0514523A1 (en) 1992-11-25
DK0514523T3 (da) 1996-01-29
ATE131724T1 (de) 1996-01-15
HUT62458A (en) 1993-05-28
ZA918489B (en) 1992-07-29
IS3773A7 (is) 1992-06-12
EP0514523B1 (en) 1995-12-20
IL99835A (en) 1995-11-27

Similar Documents

Publication Publication Date Title
ZA918489B (en) Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
EP0140085A3 (en) Drug-containing lipid vesicle preparation and method for preparing them
NO901852L (no) Fremgangsmaate for fremstilling av liposomer.
GR3015813T3 (en) Multiple encapsulated flavor delivery system and method of preparation.
IE830690L (en) Stable plurilamellar vesicles
EP0474790A4 (en) Media for cell growth and method for making them
NZ503293A (en) Liposomal camptothecin formulations also comprising at least one phospholipid
DE3476338D1 (en) Preparation of unilamellar large diameter liposomes, their pharmaceutical application in view of the encapsulation of the active principle for sustained release, and device therefor
SK62395A3 (en) Advertising carrier and method of its manufacture
EP0800822A3 (en) Method for preparing closed vesicles by rehydration of dehydrated vesicles
SI0948319T1 (en) Encapsulated cells producing antibodies
Kallenbach Fine structure of the stratum intermedium, stellate reticulum, and outer enamel epithelium in the enamel organ of the kitten
HUT71909A (en) Method of encapsulating substances in biocapsules
Kasatkin State of Yb impurities in InP crystals.
DE69018258D1 (de) Aktive Bestandteile enthaltende phospholipidische Liposome und Verfahren zu ihrer Herstellung.
WO1990010436A3 (en) Membrane encapsulated essential oil
US4389209A (en) Method of providing systemic protection from bloodsucking insects and other parasites using encapsulated additives in resealed erythrocytes
Melkumyan The growth of Lacerta strigata in lowland and mountains.
GB9225588D0 (en) Improving effectiveness of drugs
VINSON a) Biosystematics and Genetics b) Host relations and Biology c) Physiology and behaviour d) Ecology and Population Dynamics e) Rearing (in vivo & in vitro), Production and Release
FR2579589B1 (fr) Produit du type suspension contenant notamment du petit lait concentre, pour regler la croissance et le developpement des plantes
HU885490D0 (en) Process for producing plasminogeous activator from cells bred in lactine containing fodder medium
Arizmendi et al. Growth of single crystals of LiNbO sub 3
Murai et al. Method of quantitative assay for vitamin B sub (12) and reagent for assaying vitamin B sub (12).
GR65422B (en) Method for the transmission of open-air commercial,social and civilizing messages in the communal place