GR3017497T3 - Recombinant DNA-derived bordetella toxin subunit analogs. - Google Patents
Recombinant DNA-derived bordetella toxin subunit analogs.Info
- Publication number
- GR3017497T3 GR3017497T3 GR950402614T GR950402614T GR3017497T3 GR 3017497 T3 GR3017497 T3 GR 3017497T3 GR 950402614 T GR950402614 T GR 950402614T GR 950402614 T GR950402614 T GR 950402614T GR 3017497 T3 GR3017497 T3 GR 3017497T3
- Authority
- GR
- Greece
- Prior art keywords
- recombinant dna
- derived
- subunit analogs
- toxin subunit
- bordetella
- Prior art date
Links
- 241000588807 Bordetella Species 0.000 title abstract 2
- 108020004511 Recombinant DNA Proteins 0.000 title abstract 2
- 239000003053 toxin Substances 0.000 title abstract 2
- 231100000765 toxin Toxicity 0.000 title abstract 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical compound C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002255 enzymatic effect Effects 0.000 abstract 1
- 231100000776 exotoxin Toxicity 0.000 abstract 1
- 239000002095 exotoxin Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000005847 immunogenicity Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K2039/10—Brucella; Bordetella, e.g. Bordetella pertussis; Not used, see subgroups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9430787A | 1987-09-04 | 1987-09-04 | |
| US23248288A | 1988-08-17 | 1988-08-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR3017497T3 true GR3017497T3 (en) | 1995-12-31 |
Family
ID=26788722
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR950402614T GR3017497T3 (en) | 1987-09-04 | 1995-09-21 | Recombinant DNA-derived bordetella toxin subunit analogs. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US5773600A (el) |
| EP (2) | EP0629696A1 (el) |
| JP (1) | JP2918895B2 (el) |
| KR (1) | KR0168039B1 (el) |
| CN (1) | CN1033866C (el) |
| AT (1) | ATE125568T1 (el) |
| CA (1) | CA1341560C (el) |
| DE (1) | DE3854213T3 (el) |
| DK (1) | DK175821B1 (el) |
| ES (1) | ES2076160T5 (el) |
| FI (1) | FI101632B1 (el) |
| GR (1) | GR3017497T3 (el) |
| IE (1) | IE69753B1 (el) |
| IL (3) | IL103121A (el) |
| NO (2) | NO301844B1 (el) |
| WO (1) | WO1989001976A1 (el) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713072B1 (en) * | 1987-11-02 | 2004-03-30 | Chiron S.R.L. | Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine |
| US5925546A (en) * | 1987-11-02 | 1999-07-20 | Chiron S.P.A. | Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine |
| IT1223334B (it) * | 1987-11-02 | 1990-09-19 | Sclavo Spa | Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse |
| US5332583A (en) * | 1987-11-24 | 1994-07-26 | Connaught Laboratories Limited | Vaccine containing genetically-detoxified pertussis holotoxin |
| GB8727489D0 (en) * | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| US5358868A (en) * | 1987-11-24 | 1994-10-25 | Connaught Laboratories Limited | Genetic detoxification of pertussis toxin |
| CA2009991A1 (en) * | 1989-02-15 | 1990-08-15 | Witold Cieplak | Pertussis toxin gene: cloning and expression of protective antigen |
| US7232671B2 (en) * | 1989-02-15 | 2007-06-19 | The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Pertussis toxin gene: cloning and expression of protective antigen |
| DK0396964T3 (da) * | 1989-04-28 | 1995-10-30 | Sclavo Spa | Pertussistoxin-mutanter, Bordetella-stammer, der er i stand til at producere sådanne mutanter, samt deres anvendelse til udvikling af antipertussis-vacciner |
| US5786189A (en) * | 1989-11-29 | 1998-07-28 | Smithkline Beecham Biologicals (S.A.) | Vaccine |
| GB9326174D0 (en) * | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| US20030072774A1 (en) * | 1994-06-10 | 2003-04-17 | Diane M. Gajewczyk | Proteinaceous adjuvants |
| EP1234579A1 (en) * | 1995-05-04 | 2002-08-28 | Aventis Pasteur Limited | Acellular Pertussis Vaccines and Methods of Preparation Thereof |
| CA2253937A1 (en) * | 1996-05-10 | 1997-11-20 | Phylomed Corporation | Methods for oxidizing disulfide bonds using ozone |
| FR2754543B1 (fr) * | 1996-10-11 | 1998-12-31 | Pasteur Institut | Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US9453251B2 (en) | 2002-10-08 | 2016-09-27 | Pfenex Inc. | Expression of mammalian proteins in Pseudomonas fluorescens |
| GB0313916D0 (en) | 2003-06-16 | 2003-07-23 | Glaxosmithkline Biolog Sa | Vaccine composition |
| JP2008507294A (ja) | 2004-07-26 | 2008-03-13 | ダウ グローバル テクノロジーズ インコーポレイティド | 菌株遺伝子操作による改善されたタンパク質発現のための方法 |
| DK1828378T3 (da) * | 2004-12-17 | 2014-09-01 | Staat Der Nederlanden Vert Door De Minister Van Vws Ministerie Van Volksgezondheit Welzijn En Sport | Deacylering af LPS i gram-negative bakterier |
| US9580719B2 (en) | 2007-04-27 | 2017-02-28 | Pfenex, Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| EP2142651B1 (en) | 2007-04-27 | 2013-05-22 | Pfenex Inc. | Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins |
| ITMI20090946A1 (it) | 2009-05-28 | 2010-11-29 | Novartis Ag | Espressione di proteine ricombinanti |
| WO2011126811A2 (en) | 2010-03-30 | 2011-10-13 | Pfenex Inc. | High level expression of recombinant toxin proteins |
| US9169304B2 (en) | 2012-05-01 | 2015-10-27 | Pfenex Inc. | Process for purifying recombinant Plasmodium falciparum circumsporozoite protein |
| JP2015525794A (ja) | 2012-08-06 | 2015-09-07 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法 |
| US20140037680A1 (en) | 2012-08-06 | 2014-02-06 | Glaxosmithkline Biologicals, S.A. | Novel method |
| US8916173B2 (en) | 2013-03-08 | 2014-12-23 | Crucell Holland B.V. | Acellular pertussis vaccine |
| CN105555304A (zh) | 2013-08-05 | 2016-05-04 | 葛兰素史密丝克莱恩生物有限公司 | 联合免疫原性组合物 |
| CN109172818B (zh) * | 2018-08-02 | 2021-10-22 | 浙江康佰裕生物科技有限公司 | 一种蛋白牛痘疫苗及其效力检测方法 |
| CN113226361A (zh) * | 2018-10-15 | 2021-08-06 | 代表亚利桑那大学的亚利桑那校董会 | 疫苗多肽组合物及方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704362A (en) * | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| FR2590483B1 (fr) * | 1985-11-22 | 1988-12-09 | Pasteur Institut | Antigenes purifies ayant des proprietes vaccinantes contre b. pertussis, moyens notamment adns recombinants pour les produire et compositions de vaccins les contenant |
| CA1340373C (en) * | 1986-01-28 | 1999-02-02 | Rino Rappuoli | Cloning and sequencing of the dna fragment which codes for the five subunits of the pertussis toxin, a hybrid plasmid containing the dna fragment and micro-organisms transformed by the hybrid plasmid and capable of expressing all or some of the subunits of the pertussis toxin |
| ATE80179T1 (de) * | 1986-12-23 | 1992-09-15 | Univ Leland Stanford Junior | Modifiziertes pertussistoxin. |
| IT1223334B (it) * | 1987-11-02 | 1990-09-19 | Sclavo Spa | Polipeptidi immunologicamente attivi con una tossicita' alterata utili per la preparazione di un vaccino antipertosse |
| GB8727489D0 (en) * | 1987-11-24 | 1987-12-23 | Connaught Lab | Detoxification of pertussis toxin |
| IT1223529B (it) * | 1987-12-18 | 1990-09-19 | Sclavo Spa | Epitopo immunodominante protettivo contenuto nella subunita' s1 della tossina della pertosse |
-
1988
- 1988-08-26 KR KR1019890700803A patent/KR0168039B1/ko not_active IP Right Cessation
- 1988-08-26 JP JP63507460A patent/JP2918895B2/ja not_active Expired - Lifetime
- 1988-08-26 WO PCT/US1988/002983 patent/WO1989001976A1/en active IP Right Grant
- 1988-08-30 IL IL10312188A patent/IL103121A/en not_active IP Right Cessation
- 1988-08-30 IL IL87608A patent/IL87608A0/xx not_active IP Right Cessation
- 1988-09-01 EP EP94109317A patent/EP0629696A1/en not_active Withdrawn
- 1988-09-01 ES ES88308124T patent/ES2076160T5/es not_active Expired - Lifetime
- 1988-09-01 EP EP88308124A patent/EP0306318B2/en not_active Expired - Lifetime
- 1988-09-01 DE DE3854213T patent/DE3854213T3/de not_active Expired - Lifetime
- 1988-09-01 AT AT88308124T patent/ATE125568T1/de not_active IP Right Cessation
- 1988-09-02 IE IE266888A patent/IE69753B1/en not_active IP Right Cessation
- 1988-09-02 CA CA 576469 patent/CA1341560C/en not_active Expired - Fee Related
- 1988-09-05 CN CN88107056A patent/CN1033866C/zh not_active Expired - Lifetime
-
1989
- 1989-05-03 NO NO891842A patent/NO301844B1/no not_active IP Right Cessation
- 1989-05-03 DK DK198902162A patent/DK175821B1/da active
- 1989-05-03 FI FI892131A patent/FI101632B1/fi not_active IP Right Cessation
-
1992
- 1992-09-09 IL IL103121A patent/IL103121A0/xx unknown
-
1995
- 1995-06-06 US US08/468,679 patent/US5773600A/en not_active Expired - Lifetime
- 1995-09-21 GR GR950402614T patent/GR3017497T3/el unknown
-
1997
- 1997-06-09 NO NO19972642A patent/NO325016B1/no not_active IP Right Cessation
Also Published As
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