GR3002697T3 - 9-deazaguanines - Google Patents

9-deazaguanines

Info

Publication number
GR3002697T3
GR3002697T3 GR91401215T GR910401215T GR3002697T3 GR 3002697 T3 GR3002697 T3 GR 3002697T3 GR 91401215 T GR91401215 T GR 91401215T GR 910401215 T GR910401215 T GR 910401215T GR 3002697 T3 GR3002697 T3 GR 3002697T3
Authority
GR
Greece
Prior art keywords
cells
derivatives
deazaguanines
deoxyguanosine
gout
Prior art date
Application number
GR91401215T
Other languages
English (en)
Inventor
Catherine Rose Kostlan
Jagadish Chandra Sircar
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of GR3002697T3 publication Critical patent/GR3002697T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
GR91401215T 1986-08-26 1991-09-12 9-deazaguanines GR3002697T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US90048686A 1986-08-26 1986-08-26
US5941987A 1987-06-18 1987-06-18

Publications (1)

Publication Number Publication Date
GR3002697T3 true GR3002697T3 (en) 1993-01-25

Family

ID=26738724

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91401215T GR3002697T3 (en) 1986-08-26 1991-09-12 9-deazaguanines

Country Status (16)

Country Link
EP (1) EP0260491B1 (el)
JP (2) JP2595254B2 (el)
KR (2) KR940008421B1 (el)
AT (1) ATE67203T1 (el)
AU (1) AU619724B2 (el)
CA (2) CA1293727C (el)
DE (1) DE3772913D1 (el)
DK (1) DK169705B1 (el)
ES (1) ES2038635T3 (el)
FI (1) FI85856C (el)
GR (1) GR3002697T3 (el)
IE (1) IE60433B1 (el)
NO (1) NO166485C (el)
NZ (1) NZ221463A (el)
PH (1) PH24669A (el)
PT (1) PT85582B (el)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1294960C (en) * 1986-10-24 1992-01-28 Thomas C. Malone 7-deazaguanines as immunomodulators
EP0460116B1 (en) * 1989-02-27 1997-08-27 Biocryst Pharmaceuticals Inc. 9-substituted-8-unsubstituted-9-deazaguanines
HUT61765A (en) * 1989-10-31 1993-03-01 Biocryst Inc Process for producing purine nucleoside phosphorylase inhibitors and pharmaceutical compositions comprising same as active ingredient
US5726311A (en) * 1989-11-29 1998-03-10 Biocryst Pharmaceuticals, Inc. 7-disubstituted-methyl-4-oxo-3H,5H-pyrrolo 3,2-d!pyrimidine and pharmaceutical uses and compositions containing the same
WO1995001355A1 (en) * 1993-06-30 1995-01-12 Biocryst Pharmaceuticals, Inc. 9-deazahypoxanthines as pnp inhibitors
US5386031A (en) * 1993-12-15 1995-01-31 Warner-Lambert Company Process for the synthesis of 2-amino-3,5-dihydro-7-substituted-4H-pyrrolo[3,]pyrimidin-4-ones
AU695032B2 (en) * 1994-10-05 1998-08-06 Darwin Discovery Limited Purine and guanine compounds as inhibitors of PNP
FR2728181B1 (fr) * 1994-12-16 1997-01-31 Appryl Snc Composante catalytique pour la polymerisation des olefines, son procede de fabrication, et procede de polymerisation des olefines en presence de ladite composante catalytique
US6395733B1 (en) 1995-06-07 2002-05-28 Pfizer Inc Heterocyclic ring-fused pyrimidine derivatives
MX9709867A (es) * 1995-06-07 1998-03-31 Pfizer Derivados de pirimidina condensados con un anillo heterociclico, composiciones que contienen los mismos, y uso de los mismos.
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
CA2540598C (en) * 2003-10-03 2013-09-24 3M Innovative Properties Company Pyrazolopyridines and analogs thereof
NZ540160A (en) * 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
GB201417163D0 (en) 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Substituted pyrimidine derivatives useful in the treatment of autoimmune diseases
GB201417165D0 (en) * 2014-09-29 2014-11-12 Provost Fellows & Scholars College Of The Holy Undivided Trinity Of Queen Elizabeth Near Dublin Treatments for Autoimmune Disease

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN164556B (el) * 1986-03-06 1989-04-08 Takeda Chemical Industries Ltd
CA1294960C (en) * 1986-10-24 1992-01-28 Thomas C. Malone 7-deazaguanines as immunomodulators
DE3739366A1 (de) * 1987-04-10 1988-10-27 Boehringer Mannheim Gmbh Desaza-purin-nucleosid-derivate, verfahren zu deren herstellung sowie deren verwendung bei der nucleinsaeure-sequenzierung sowie als antivirale mittel

Also Published As

Publication number Publication date
AU7741687A (en) 1988-03-03
FI85856B (fi) 1992-02-28
NO166485C (no) 1991-07-31
JPH08311040A (ja) 1996-11-26
PT85582B (pt) 1990-05-31
NO873584D0 (no) 1987-08-25
CA1320203C (en) 1993-07-13
NO166485B (no) 1991-04-22
KR940008421B1 (ko) 1994-09-14
ES2038635T3 (es) 1993-08-01
JP2650644B2 (ja) 1997-09-03
DK169705B1 (da) 1995-01-16
PH24669A (en) 1990-09-07
CA1293727C (en) 1991-12-31
FI873648A (fi) 1988-02-27
IE872070L (en) 1988-02-26
JPS6388185A (ja) 1988-04-19
PT85582A (en) 1987-09-01
DK440287D0 (da) 1987-08-24
EP0260491A1 (en) 1988-03-23
NZ221463A (en) 1990-07-26
EP0260491B1 (en) 1991-09-11
FI873648A0 (fi) 1987-08-24
KR880002873A (ko) 1988-05-12
ATE67203T1 (de) 1991-09-15
DE3772913D1 (de) 1991-10-17
DK440287A (da) 1988-02-27
AU619724B2 (en) 1992-02-06
NO873584L (no) 1988-02-29
IE60433B1 (en) 1994-07-13
FI85856C (fi) 1992-06-10
KR940008848B1 (ko) 1994-09-28
JP2595254B2 (ja) 1997-04-02

Similar Documents

Publication Publication Date Title
AU619724B2 (en) Novel 9 - deazaguanines
HUT52769A (en) Process for producing pyrimidine derivatives and pharmaceutical compositions containing them
HUT70505A (en) Pyrrolo[2,3-d]pyrimidine derivatives, pharmaceutical compositions containing them and process for preparing them
DE69432087D1 (de) 6-Amino-purinderivate mit PDE-IV inhibierender Wirkung
AU3399889A (en) Immunostimulating guanine derivatives, compositions and methods
DK224286D0 (da) 2',3'-dideoxy-nucleosider
PT85551A (en) Process for the preparation of antiviral pyrimidine derivatives and of pharmaceutical compositions containing the same
DK322189A (da) Imidazo(1,2-a)-(pyridaziner eller pyraziner) til behandling af sygdomme med relation til knogletab
ZA872998B (en) Furo(3,4-d)pyrimidine-2,4-dione derivatives and intermediates thereof
EP0553294A4 (en) Methods and compositions for the treatment of cell proliferation disorders
PT84478A (en) Pyrazolo ]3,4-d" pyrimidine derivatives their production and use
GB9214053D0 (en) Heterocyclic amides
AU2527688A (en) Artificial dna base pair analogues
NZ224958A (en) Process for preparation of purine derivatives and intermediate pyrimidines
MY103593A (en) Bicyclic compounds, their use as pharmaceuticals, their preparation, and intermediates useful in their preparation
GR852525B (el)
NZ231478A (en) 5-prop-1-ynyl-1-(5-0-trimethylacetyl-beta-d-arabinofuranosyl)-uracil
NZ219598A (en) Composition of tissue plasminogen activator and oxypurinol (ie 1h-pyrazolo(3,4-d)pyrimidine-4,6(5h,7h)-dione)
DE3854158D1 (de) Nucleosid-analoge.
AU587562B2 (en) Adjustable supply of solid particles to one or more receiving stations
ES2062351T3 (es) Derivados de triazolo (4,5-c) piridina anticonvulsivos.