GR1000019B - Μεθοδος παρασκευης μητρας επιβραδυνομενης απελευθερωσεως ιμπουπροφενης - Google Patents
Μεθοδος παρασκευης μητρας επιβραδυνομενης απελευθερωσεως ιμπουπροφενηςInfo
- Publication number
- GR1000019B GR1000019B GR880100258A GR880100258A GR1000019B GR 1000019 B GR1000019 B GR 1000019B GR 880100258 A GR880100258 A GR 880100258A GR 880100258 A GR880100258 A GR 880100258A GR 1000019 B GR1000019 B GR 1000019B
- Authority
- GR
- Greece
- Prior art keywords
- ibuprofen
- granule
- preparation
- tablet
- magnesium
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 2
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 abstract 3
- 239000008187 granular material Substances 0.000 abstract 3
- 229960001680 ibuprofen Drugs 0.000 abstract 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 2
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 229910052749 magnesium Inorganic materials 0.000 abstract 2
- 239000011777 magnesium Substances 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 abstract 1
- 229920000881 Modified starch Polymers 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 238000005469 granulation Methods 0.000 abstract 1
- 230000003179 granulation Effects 0.000 abstract 1
- 238000000227 grinding Methods 0.000 abstract 1
- 239000000314 lubricant Substances 0.000 abstract 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 abstract 1
- 239000008108 microcrystalline cellulose Substances 0.000 abstract 1
- 229940016286 microcrystalline cellulose Drugs 0.000 abstract 1
- 229940069328 povidone Drugs 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 239000000377 silicon dioxide Substances 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
- A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
'Ενα δισκίον ιμπουπροφέν βραδείας απελευθερώσεως ή μια στρώσις δισκίου σχηματίζοντος δια παρασκευής ενός υγρού γκρανουλέ τη χρησιμοποιήσει Povidone (PVP) εντός αλκοόλης ως υγρού κοκκοποιήσεως το οποίον αναμιγνύεται με ιμπουπροφέν, αιθυλοκυτταρίνη, έναν παράγοντα φυτιλιού (τριχοειδών δυνάμεων) π.χ. μικροκρυσταλλική κυτταρίνη, ένα συντελεστή αποσαθρώσεως π.χ. προζελατινοποιημένον άμυλον και εν συνεχεία ξηράνσεως και αλέσεως του γκρανουλέ και αναμίξεως με ξηρόν κονιοποιημένον συντελεστή αποσαθρώσεως, παράγοντα φυτιλιού (τριχοειδών δυνάμεων) λιπαντικών, π.χ. στεατικόν μαγνήσιον και ολισθητικόν, π.χ. διοξείδιον πυριτίου και δισκιοποιήσεως του προκύπτοντος γκρανουλέ, το οποίον μετά την χορήγησιν προκαλεί παρατεταμένη βραδεία και σχετικώς κανονική αυξανόμενη απελευθέρωσιν του ιμπουπροφέν.ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/041,164 US4806359A (en) | 1987-04-22 | 1987-04-22 | Iburprofen sustained release matrix and process |
Publications (2)
Publication Number | Publication Date |
---|---|
GR880100258A GR880100258A (en) | 1989-01-31 |
GR1000019B true GR1000019B (el) | 1990-01-31 |
Family
ID=21915089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR880100258A GR1000019B (el) | 1987-04-22 | 1988-04-20 | Μεθοδος παρασκευης μητρας επιβραδυνομενης απελευθερωσεως ιμπουπροφενης |
Country Status (21)
Country | Link |
---|---|
US (1) | US4806359A (el) |
EP (2) | EP0290168B1 (el) |
JP (2) | JP2519296B2 (el) |
KR (1) | KR960007750B1 (el) |
AT (1) | ATE86479T1 (el) |
AU (2) | AU604110B2 (el) |
CA (1) | CA1310272C (el) |
DE (2) | DE3865077D1 (el) |
ES (1) | ES2039277T3 (el) |
GR (1) | GR1000019B (el) |
HK (1) | HK22892A (el) |
IE (1) | IE62786B1 (el) |
IN (1) | IN165929B (el) |
MY (1) | MY103076A (el) |
NO (1) | NO176203C (el) |
NZ (1) | NZ224278A (el) |
PH (1) | PH25176A (el) |
PT (1) | PT87285B (el) |
SG (1) | SG104091G (el) |
WO (1) | WO1988008299A1 (el) |
ZA (1) | ZA882827B (el) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5200193A (en) * | 1987-04-22 | 1993-04-06 | Mcneilab, Inc. | Pharmaceutical sustained release matrix and process |
US4999226A (en) * | 1988-06-01 | 1991-03-12 | Merrell Dow Pharmaceuticals Inc. | Pharmaceutical compositions for piperidinoalkanol-ibuprofen combination |
EP0373417A1 (en) * | 1988-11-30 | 1990-06-20 | Schering Corporation | Sustained release diltiazem formulation |
US5104648A (en) * | 1989-02-02 | 1992-04-14 | Mallinckrodt Specialty Chemicals Company | High ibuprofen content granulations |
US4911921A (en) * | 1989-02-02 | 1990-03-27 | Mallinckrodt, Inc. | High ibuprofen content granulations |
US5085865A (en) * | 1989-04-12 | 1992-02-04 | Warner-Lambert Company | Sustained release pharmaceutical preparations containing an analgesic and a decongestant |
KR920002148A (ko) * | 1990-07-03 | 1992-02-28 | 안드레아 엘. 콜비 | 비스테로이드계 소염제에 의해 유발된 위장 증상을 완화시키기 위한 약제 조성물 및 이를 완화시키는 방법 |
FR2677886B1 (fr) * | 1991-06-18 | 1995-03-31 | Adir | Comprime matriciel permettant la liberation prolongee d'indapamide apres administration par voie orale. |
DE4140183C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Retardform für ein Flurbiprofen enthaltendes Arzneimittel |
DE4140184C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Flurbiprofen enthaltendes Arzneimittel |
DE4140179C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Akutform für ein Ibuprofen enthaltendes Arzneimittel |
DE4140185C2 (de) * | 1991-12-05 | 1996-02-01 | Alfatec Pharma Gmbh | Ein 2-Arylpropionsäurederivat in Nanosolform enthaltendes Arzneimittel und seine Herstellung |
DE4140172C2 (de) * | 1991-12-05 | 1995-12-21 | Alfatec Pharma Gmbh | Retardform für ein Ibuprofen enthaltendes Arzneimittel |
DK138592D0 (da) * | 1992-11-17 | 1992-11-17 | Nycomed Dak As | Tabletter |
US20080075781A1 (en) * | 1992-11-25 | 2008-03-27 | Purdue Pharma Lp | Controlled release oxycodone compositions |
US20070275062A1 (en) * | 1993-06-18 | 2007-11-29 | Benjamin Oshlack | Controlled release oxycodone compositions |
IT1264696B1 (it) * | 1993-07-09 | 1996-10-04 | Applied Pharma Res | Forme farmaceutiche destinate alla somministrazione orale in grado di rilasciare sostanze attive a velocita' controllata e differenziata |
WO1995035099A1 (en) * | 1994-06-20 | 1995-12-28 | Kv Pharmaceutical Company | Vitamin/nutrient dosage regimentation |
AU3834295A (en) * | 1994-10-20 | 1996-05-15 | Merck & Co., Inc. | Wet granulation formulation for a piperazinylcamphorsulfonyl oxytocin receptor antagonist |
IT1276689B1 (it) * | 1995-06-09 | 1997-11-03 | Applied Pharma Res | Forma farmaceutica solida ad uso orale |
US6348216B1 (en) * | 1996-06-10 | 2002-02-19 | Knoll Pharmaceutical Company | Ibuprofen and narcotic analgesic compositions |
JP3628809B2 (ja) * | 1996-06-10 | 2005-03-16 | アルケア株式会社 | 薬剤徐放性医療用配合物及びその製造方法 |
US6361794B1 (en) | 1996-06-12 | 2002-03-26 | Basf Corporation | Method of making ibuprofen and narcotic analgesic composition |
AU721653B2 (en) * | 1996-10-25 | 2000-07-13 | Supernus Pharmaceuticals, Inc. | Soluble form osmotic dose delivery system |
US6361796B1 (en) | 1996-10-25 | 2002-03-26 | Shire Laboratories, Inc. | Soluble form osmotic dose delivery system |
HU230440B1 (hu) * | 1999-03-31 | 2016-06-28 | Janssen Pharmaceutica N.V | Előgélesített keményítőt tartalmazó szabályozott felszabadulású készítmények |
CO5200844A1 (es) * | 1999-09-17 | 2002-09-27 | Novartis Ag | Una combinacion que comprende nateglinida y cuando por menos otro compuesto antidiabetico usada para el tratamiento de desordenes metabolicos, especialmente diabetes, o de una enfermedad o condicion asociada con dibetes |
JP2004522752A (ja) * | 2001-02-05 | 2004-07-29 | アール.ピー. シェーラー テクノロジーズ インコーポレイテッド | 薬学的活性剤の味を軽減するための方法および組成物 |
US6602911B2 (en) * | 2001-11-05 | 2003-08-05 | Cypress Bioscience, Inc. | Methods of treating fibromyalgia |
PL223471B1 (pl) * | 2002-03-15 | 2016-10-31 | Cypress Bioscience Inc | Kompozycja farmaceutyczna zawierająca milnacypran do stosowania w leczeniu zespołu nadwrażliwości jelita grubego |
US20060003004A1 (en) * | 2002-10-25 | 2006-01-05 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
US20040121010A1 (en) * | 2002-10-25 | 2004-06-24 | Collegium Pharmaceutical, Inc. | Pulsatile release compositions of milnacipran |
US20040228830A1 (en) * | 2003-01-28 | 2004-11-18 | Collegium Pharmaceutical, Inc. | Multiparticulate compositions of milnacipran for oral administration |
JP2006528185A (ja) * | 2003-07-21 | 2006-12-14 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質製剤、その使用法及び作成方法 |
WO2005009365A2 (en) | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
WO2005009368A2 (en) * | 2003-07-21 | 2005-02-03 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
CA2535398C (en) | 2003-08-12 | 2013-11-12 | Advancis Pharmaceuticals Corporation | Antibiotic product, use and formulation thereof |
AU2004270170B2 (en) * | 2003-08-29 | 2011-01-27 | Shionogi, Inc. | Antibiotic product, use and formulation thereof |
CA2538064C (en) * | 2003-09-15 | 2013-12-17 | Advancis Pharmaceutical Corporation | Antibiotic product, use and formulation thereof |
KR20120106757A (ko) * | 2003-09-26 | 2012-09-26 | 알자 코포레이션 | 오피오이드 및 비오피오이드 진통제의 제어 방출 제제 |
EP1663145B1 (en) * | 2003-09-26 | 2011-04-06 | ALZA Corporation | Oros-push-stick for controlled delivery of active agents |
JP4919801B2 (ja) * | 2003-09-26 | 2012-04-18 | アルザ・コーポレーシヨン | 高い薬剤配合量を提供する薬剤コーティング及びそれを提供する方法 |
NZ546183A (en) * | 2003-09-26 | 2011-04-29 | Alza Corp | Controlled release formulations exhibiting an ascending rate of release |
JP2008505074A (ja) * | 2004-06-30 | 2008-02-21 | アルベマール・コーポレーシヨン | 高イブプロフェン含有量顆粒並びにそれらの製造および製薬学的薬用量形態中でのそれらの使用 |
US8541026B2 (en) | 2004-09-24 | 2013-09-24 | Abbvie Inc. | Sustained release formulations of opioid and nonopioid analgesics |
US20070077297A1 (en) | 2004-09-30 | 2007-04-05 | Scolr Pharma, Inc. | Modified release ibuprofen dosage form |
US20060099253A1 (en) * | 2004-10-20 | 2006-05-11 | Wyeth | Antibiotic product formulation |
ES2403069T3 (es) * | 2005-02-22 | 2013-05-13 | Sun Pharma Advanced Research Company Ltd | Composición oral de liberación controlada que contiene levetiracetam |
DE102005037630A1 (de) | 2005-08-09 | 2007-02-15 | Glatt Gmbh | Verfahren zur Herstellung von Teilchen aus pharmazeutischen Substanzen, Teilchen aus pharmazeutischen Substanzen sowie deren Verwendung |
US7994220B2 (en) * | 2005-09-28 | 2011-08-09 | Cypress Bioscience, Inc. | Milnacipran for the long-term treatment of fibromyalgia syndrome |
US8357394B2 (en) | 2005-12-08 | 2013-01-22 | Shionogi Inc. | Compositions and methods for improved efficacy of penicillin-type antibiotics |
US8778924B2 (en) | 2006-12-04 | 2014-07-15 | Shionogi Inc. | Modified release amoxicillin products |
GB0525461D0 (en) | 2005-12-15 | 2006-01-25 | Archimedes Dev Ltd | Pharmaceutical compositions |
CN101330904B (zh) * | 2005-12-16 | 2012-04-18 | 韩美控股株式会社 | 含有低熔点活性成分的固体分散体以及含有它的口服给药片剂 |
US7749537B2 (en) | 2006-12-04 | 2010-07-06 | Scolr Pharma, Inc. | Method of forming a tablet |
US8623397B2 (en) | 2007-04-13 | 2014-01-07 | The Regents Of The University Of Michigan | Delivery device and method for forming the same |
JP5553830B2 (ja) * | 2008-07-21 | 2014-07-16 | アルベマール・コーポレーシヨン | 高含量イブプロフェンナトリウム顆粒、その調製、および非発泡性固体剤形を調製する際のその使用 |
US9629809B2 (en) | 2008-07-21 | 2017-04-25 | Si Group, Inc. | High content sodium ibuprofen granules, their preparation and their use in preparing non-effervescent solid dosage forms |
US8343524B2 (en) * | 2008-07-31 | 2013-01-01 | Clarke Mosquito Control Products, Inc. | Extended release tablet and method for making and using same |
WO2014159798A1 (en) | 2013-03-13 | 2014-10-02 | Avery Dennison Corporation | Improving adhesive properties |
CN110037994B (zh) * | 2019-05-24 | 2022-04-12 | 中国药科大学 | 一种布洛芬速释缓释双层片及其制备方法 |
CN114177155B (zh) * | 2020-09-08 | 2023-10-03 | 越洋医药开发(广州)有限公司 | 一种布洛芬控释片及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773921A (en) * | 1971-11-15 | 1973-11-20 | Hoffmann La Roche | Therapeutic compositions |
US4264573A (en) * | 1979-05-21 | 1981-04-28 | Rowell Laboratories, Inc. | Pharmaceutical formulation for slow release via controlled surface erosion |
US4308251A (en) * | 1980-01-11 | 1981-12-29 | Boots Pharmaceuticals, Inc. | Controlled release formulations of orally-active medicaments |
US4465660A (en) * | 1981-04-01 | 1984-08-14 | Mead Johnson & Company | Sustained release tablet containing at least 95 percent theophylline |
FR2532177A1 (fr) * | 1982-08-30 | 1984-03-02 | Being Well Products Inc | Complement nutritionnel a zones de liberation determinees et son procede de fabrication |
US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
CA1261260A (en) * | 1984-04-16 | 1989-09-26 | Anil Salpekar | Directly compressible codeine salt compositions |
US4753801A (en) * | 1985-10-25 | 1988-06-28 | Eli Lilly And Company | Sustained release tablets |
-
1987
- 1987-04-22 US US07/041,164 patent/US4806359A/en not_active Expired - Lifetime
-
1988
- 1988-03-17 IN IN225/CAL/88A patent/IN165929B/en unknown
- 1988-04-15 NZ NZ224278A patent/NZ224278A/xx unknown
- 1988-04-19 AU AU14774/88A patent/AU604110B2/en not_active Ceased
- 1988-04-20 GR GR880100258A patent/GR1000019B/el unknown
- 1988-04-20 PH PH36823A patent/PH25176A/en unknown
- 1988-04-20 CA CA000564600A patent/CA1310272C/en not_active Expired - Lifetime
- 1988-04-21 JP JP63096955A patent/JP2519296B2/ja not_active Expired - Lifetime
- 1988-04-21 DE DE8888303614T patent/DE3865077D1/de not_active Expired - Fee Related
- 1988-04-21 IE IE119588A patent/IE62786B1/en not_active IP Right Cessation
- 1988-04-21 NO NO881732A patent/NO176203C/no unknown
- 1988-04-21 EP EP88303614A patent/EP0290168B1/en not_active Expired - Lifetime
- 1988-04-21 ES ES198888303614T patent/ES2039277T3/es not_active Expired - Lifetime
- 1988-04-21 PT PT87285A patent/PT87285B/pt not_active IP Right Cessation
- 1988-04-21 MY MYPI88000412A patent/MY103076A/en unknown
- 1988-04-21 ZA ZA882827A patent/ZA882827B/xx unknown
- 1988-04-22 KR KR1019880004564A patent/KR960007750B1/ko not_active IP Right Cessation
- 1988-04-22 AT AT88904333T patent/ATE86479T1/de not_active IP Right Cessation
- 1988-04-22 AU AU17197/88A patent/AU603675B2/en not_active Ceased
- 1988-04-22 JP JP63504150A patent/JP2776856B2/ja not_active Expired - Fee Related
- 1988-04-22 DE DE8888904333T patent/DE3879080T2/de not_active Expired - Lifetime
- 1988-04-22 WO PCT/US1988/001377 patent/WO1988008299A1/en active IP Right Grant
- 1988-04-22 EP EP88904333A patent/EP0312581B1/en not_active Expired - Lifetime
-
1991
- 1991-12-07 SG SG1040/91A patent/SG104091G/en unknown
-
1992
- 1992-03-26 HK HK228/92A patent/HK22892A/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GR1000019B (el) | Μεθοδος παρασκευης μητρας επιβραδυνομενης απελευθερωσεως ιμπουπροφενης | |
GR1000254B (el) | Μεθοδος παρασκευης διαμορφωσεως ακεταμινοφαινης βραδειας απελευθερωσεως απο το στομα. | |
ATE53176T1 (de) | Pharmazeutische zusammensetzung mit verzoegerter abgabe. | |
NO871774D0 (no) | Medikament-system med kontrollert frisettelse av det aktive middel. | |
ES516375A0 (es) | Procedimiento para la obtencion de una composicion a base de estireno para revestir alimentos y medicamentos. | |
KR880010757A (ko) | 제약정제, 제약과립 및 그의 제조방법 | |
KR930003906A (ko) | 약학적 구상 제형 | |
DE68909772T2 (de) | Diclofenac-Natrium-Arzneizubereitung mit verlängerter Wirkstoffabgabe. | |
SE409323B (sv) | Anvendning av en optisk isomer av bi-(4,5,6,7-tetrahydronaftyl)-fosforsyraderivat for kemisk upplosning av basiska optiska cis- och trans-isomerer | |
JPS51148013A (en) | Stable insulin preparation for nosal administration | |
ATE43497T1 (de) | Pharmazeutische formulierung mit gesteuerter absorption. | |
MX163553B (es) | Metodo para preparar una forma de liberacion sustentada solida de una composicion funcionalmente activa | |
ES2175073T3 (es) | Procedimiento de preparacion de formas para la administracion oral de antibioticos beta-lactamicos de rapida dispersabilidad en agua. | |
SE8701479L (sv) | Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav | |
ATE34300T1 (de) | Theophyllin mit verlaengerter abgabe. | |
CA2000932A1 (en) | Oral pharmaceutical controlled release multiple unit dosage form | |
KR880002510A (ko) | 다과립형 지속성 정제 | |
NO891114D0 (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater. | |
AU544975B2 (en) | Oxazole derivatives | |
DE59503283D1 (de) | Carbamazepin-arzneiform mit verzögerter wirkstofffreisetzung | |
NO891574D0 (no) | Fremgangsmaate for fremstilling av farmasoeytisk anvendbareforbindelser. | |
JPS54126722A (en) | Slow release antibiotic tablet | |
RU95115702A (ru) | Анальгезирующее жаропонижающее лекарственное средство и способ его получения | |
NO167511C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive substituerte tieno(3,4-d)imidazolderivater. | |
SE7707634L (sv) | Forfarande for stereoselektiv framstellning av optiskt aktiva trans-hexhydrodibensopyranoner |