GEP20125711B - Piperazine salt and method for their preparation - Google Patents

Piperazine salt and method for their preparation

Info

Publication number
GEP20125711B
GEP20125711B GEAP200912300A GEAP2009012300A GEP20125711B GE P20125711 B GEP20125711 B GE P20125711B GE AP200912300 A GEAP200912300 A GE AP200912300A GE AP2009012300 A GEAP2009012300 A GE AP2009012300A GE P20125711 B GEP20125711 B GE P20125711B
Authority
GE
Georgia
Prior art keywords
preparation
piperazine salt
piperazine
salt
dra
Prior art date
Application number
GEAP200912300A
Other languages
English (en)
Inventor
István Vágó
János Galambos
Ferenc Sebők
Bálint Juhász
Katalin Nógrádi
Csongor Éva Ágainé
László Czibula
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of GEP20125711B publication Critical patent/GEP20125711B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
GEAP200912300A 2008-12-17 2009-12-17 Piperazine salt and method for their preparation GEP20125711B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU0800763A HU230067B1 (hu) 2008-12-17 2008-12-17 Új piperazin só és eljárás előállítására

Publications (1)

Publication Number Publication Date
GEP20125711B true GEP20125711B (en) 2012-12-10

Family

ID=89988672

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP200912300A GEP20125711B (en) 2008-12-17 2009-12-17 Piperazine salt and method for their preparation

Country Status (22)

Country Link
US (1) US8569496B2 (enExample)
EP (1) EP2358690B1 (enExample)
JP (1) JP5735923B2 (enExample)
CN (1) CN102256953B (enExample)
AU (1) AU2009329294B2 (enExample)
BR (1) BRPI0923007B8 (enExample)
CA (1) CA2743924C (enExample)
DK (1) DK2358690T3 (enExample)
EA (1) EA019024B1 (enExample)
ES (1) ES2573957T3 (enExample)
GE (1) GEP20125711B (enExample)
HR (1) HRP20160726T1 (enExample)
HU (2) HU230067B1 (enExample)
IL (1) IL212639A0 (enExample)
MX (1) MX2011006591A (enExample)
NZ (1) NZ592907A (enExample)
PL (1) PL2358690T3 (enExample)
PT (1) PT2358690E (enExample)
SI (1) SI2358690T1 (enExample)
TW (1) TWI448455B (enExample)
UA (1) UA104163C2 (enExample)
WO (1) WO2010070369A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) * 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
AU2009270823B2 (en) 2008-07-16 2014-07-17 Richter Gedeon Nyrt. Pharmaceutical formulations containing dopamine receptor ligands
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
ITMI20131693A1 (it) * 2013-10-14 2015-04-15 Chemo Res S L Derivati della 1,4-cicloesilammina e loro preparazione
CN104496854B (zh) * 2015-01-06 2017-09-22 上海医药工业研究院 3‑环己基‑1,1‑二甲基脲类化合物及其制备方法和应用
HU231173B1 (hu) 2016-07-08 2021-06-28 Richter Gedeon Nyrt. Ipari eljárás cariprazine előállítására
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
CN111269199B (zh) * 2018-12-05 2022-04-08 浙江京新药业股份有限公司 一种卡利拉嗪的制备方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
CN111892556A (zh) * 2019-05-06 2020-11-06 北京万全德众医药生物技术有限公司 新的卡利拉嗪制备方法
CN110372557B (zh) * 2019-08-06 2021-05-18 上海勋和医药科技有限公司 环己烷胺类d3/d2受体部分激动剂
CN114539185B (zh) * 2020-11-24 2024-12-24 上海新礼泰药业有限公司 一种卡利拉嗪及其中间体的制备方法
HUP2100108A1 (hu) 2021-03-12 2022-09-28 Richter Gedeon Nyrt Eljárás és berendezés gyógyászatilag alkalmazható piperazin származékok folyamatos áramú, áramlásos konszekutív redukálással történõ elõállítására
CN119874636B (zh) * 2025-01-16 2026-07-28 鲁南制药集团股份有限公司 一种卡利拉嗪的制备方法

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4957921A (en) 1989-12-06 1990-09-18 Warner-Lambert Company Substituted cyclohexanols as central nervous system agents
US5047406A (en) 1989-12-06 1991-09-10 Warner-Lambert Co. Substituted cyclohexanols as central nervous system agents
US6334997B1 (en) 1994-03-25 2002-01-01 Isotechnika, Inc. Method of using deuterated calcium channel blockers
KR100477070B1 (ko) 1994-03-25 2006-04-21 이소테크니카 인코포레이티드 중수소화작용에의한의약품의효능강화법
US5977110A (en) 1995-09-22 1999-11-02 Warner-Lambert Company Substituted cyclohexylamines as central nervous systems agents
KR100672186B1 (ko) 1998-03-31 2007-01-19 아카디아 파마슈티칼스 인코포레이티드 무스카린 수용체에 대해 활성을 갖는 화합물
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
SE9802208D0 (sv) 1998-06-22 1998-06-22 Astra Pharma Inc Novel compounds
JP2000191570A (ja) * 1998-12-24 2000-07-11 Sumitomo Chem Co Ltd ヒドロキシフェニルプロパノール類の製造法
US6489341B1 (en) 1999-06-02 2002-12-03 Sepracor Inc. Methods for the treatment of neuroleptic and related disorders using sertindole derivatives
DE60223506T2 (de) 2001-02-27 2008-09-18 Ortho-Mcneil Pharmaceutical, Inc. Carbamatverbindungen zur vorbeugung oder behandlung bipolarer erkrankungen
US6566550B2 (en) 2001-06-21 2003-05-20 Pfizer Inc Substituted aromatic ethers as inhibitors of glycine transport
HU227543B1 (en) * 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
SE0200301D0 (sv) 2002-02-01 2002-02-01 Axon Biochemicals Bv Thio-carbostyril derivative
US6833459B2 (en) * 2002-04-26 2004-12-21 Orchid Chemicals & Pharmaceuticals Limited Process for the preparation of thiazole intermediate
US6919342B2 (en) 2003-06-05 2005-07-19 Abbott Gmbh & Co. Kg Triazole compounds suitable for treating disorders that respond to modulation of the dopamine D3 receptor
HU227534B1 (en) 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
DE102004047517A1 (de) 2004-09-28 2006-03-30 Merck Patent Gmbh Neuartige Kristallform von (3-Cyan-1H-indol-7-yl)-[4-(4-fluorphenethyl)-piperazin-1-yl]-methanon, Hydrochlorid
HUP0500170A3 (en) 2005-02-03 2007-11-28 Richter Gedeon Nyrt Piperazine derivatives, process for producing them and pharmaceutical compositions containing them
GT200600414A (es) 2005-09-12 2007-09-20 Sal de glucuranato de compuesto de piperazine
JP2008001633A (ja) * 2006-06-22 2008-01-10 Showa Denko Kk テトラヒドロピランを溶媒とする塩化アルミニウム存在下での水素化ホウ素化合物による還元反応
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
MY148643A (en) 2007-05-11 2013-05-15 Richter Gedeon Nyrt Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
HU230748B1 (hu) 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
HUP0700353A2 (en) * 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
CN101790374A (zh) 2007-08-01 2010-07-28 H.隆德贝克有限公司 Kcnq钾通道开放剂用于减轻多巴胺能系统受到干扰的障碍或病症的症状或治疗这种障碍或病症的用途
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CA2715760C (en) 2008-02-21 2017-06-13 Mitsubishi Tanabe Pharma Corporation Solid preparation for oral administration of cariprazine hydrochloride
AU2009270823B2 (en) 2008-07-16 2014-07-17 Richter Gedeon Nyrt. Pharmaceutical formulations containing dopamine receptor ligands
HUP0800765A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
HUP0800766A2 (en) 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives

Also Published As

Publication number Publication date
EP2358690A1 (en) 2011-08-24
PT2358690E (pt) 2016-06-03
US20110275816A1 (en) 2011-11-10
IL212639A0 (en) 2011-07-31
CN102256953A (zh) 2011-11-23
CA2743924C (en) 2015-03-31
TW201035056A (en) 2010-10-01
ES2573957T3 (es) 2016-06-13
BRPI0923007B1 (pt) 2021-08-17
BRPI0923007B8 (pt) 2021-10-26
CN102256953B (zh) 2016-06-01
HUP0800763A2 (en) 2010-11-29
PL2358690T3 (pl) 2016-10-31
JP5735923B2 (ja) 2015-06-17
JP2012512239A (ja) 2012-05-31
HUE029667T2 (en) 2017-04-28
HRP20160726T1 (hr) 2016-07-15
NZ592907A (en) 2013-05-31
BRPI0923007A2 (pt) 2015-08-11
WO2010070369A8 (en) 2011-04-28
UA104163C2 (ru) 2014-01-10
US8569496B2 (en) 2013-10-29
EA019024B1 (ru) 2013-12-30
CA2743924A1 (en) 2010-06-24
AU2009329294B2 (en) 2014-04-10
MX2011006591A (es) 2011-07-12
DK2358690T3 (en) 2016-07-18
WO2010070369A1 (en) 2010-06-24
HU0800763D0 (en) 2009-03-02
HU230067B1 (hu) 2015-06-29
SI2358690T1 (sl) 2016-07-29
AU2009329294A1 (en) 2010-06-24
TWI448455B (zh) 2014-08-11
EP2358690B1 (en) 2016-03-30
EA201170810A1 (ru) 2011-12-30

Similar Documents

Publication Publication Date Title
MY158648A (en) Compositions for modulating a kinase cascade and methods of use thereof
GEP20156243B (en) Fused heteroaromatic pyrrolidinones as syk inhibitors
ES2573957T3 (es) Sal de piperazina y procedimiento de preparación de la misma
MX352731B (es) Derivados de heteroarilpiperidina y -piperazina como fungicidas.
UA109775C2 (xx) N-вмісні гетероарильні похідні як інгібітори jak3-кінази
MX2011001679A (es) Derivados de flavina.
MY148643A (en) Solvate and crystalline forms of carbamoyl-cyclohexane derivatives
ZA200802488B (en) 1-heterocyclylsulfonyl, 2-aminomethyl, 5- (hetero-) aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors
GEP201706735B (en) Kinase inhibitors
IL184504A0 (en) 4-(2,6-dichlorobenzoylamino)-1h-pyrazole-3-carboxylic acid piperidin-4-ylamid acid addition salts as kinase inhibitors
IL192242A0 (en) Improved process for the preparation of the salts of 4-(benzimidazolylmethylamino)-benzamides
MX2011013325A (es) 2-(lh-pirazol-4-ilamino)-pirimidina como inhibidores de cinasa.
MX388849B (es) Derivados de heteroarilpiperidina y de heteroarilpiperazina como fungicidas.
ZA201201360B (en) New compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine
EA201100696A1 (ru) 1-(арилсульфонил)-4-(пиперазин-1-ил)-1h-бензимидазолы в качестве лигандов 5-гидрокситриптамина-6
MY152042A (en) 3,4- substituted piperidine derivatives as renin inhibitors
TW200619206A (en) Chemokine-binding heterocyclic compound salts, and methods of use thereof
MX2008015250A (es) Sales de acido clorhidrico de la 6-metoxi-8-[4-(1-(5-fluoro)-quino lin-8-il-piperidin-4-il)-piperazin-1-il]-quinolina.
WO2013175499A3 (en) Process for the preparation of 5-(4-[4-(5-cyano-1 h-indol-3-yl)butyl]piperazin-1 -yl)benzofuran-2-carboxamide and intermediates thereof, polymorphic forms thereof
TW200702330A (en) 3,4,5-Substituted piperidines
WO2007146202A3 (en) Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof
EA201001252A1 (ru) Способ получения производных 3,6-дигидро-1,3,5-триазина
WO2010056585A3 (en) Heteroaryl diamide compounds useful as mmp-13 inhibitors
AU2013314244A8 (en) Novel inhibitor compounds of phosphodiesterase type 10A
MX2012007837A (es) Derivados de oxazolopirimidina 2, 5 - sustituidos.