GEP20125413B - Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1h-1, 2, 4-triazol-1-yl)-1-[(phosphonooxy) methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine - Google Patents
Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1h-1, 2, 4-triazol-1-yl)-1-[(phosphonooxy) methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazineInfo
- Publication number
- GEP20125413B GEP20125413B GEAP200610811A GEAP2006010811A GEP20125413B GE P20125413 B GEP20125413 B GE P20125413B GE AP200610811 A GEAP200610811 A GE AP200610811A GE AP2006010811 A GEAP2006010811 A GE AP2006010811A GE P20125413 B GEP20125413 B GE P20125413B
- Authority
- GE
- Georgia
- Prior art keywords
- methyl
- dioxoethyl
- phosphonooxy
- pyrrolo
- triazol
- Prior art date
Links
- SWMDAPWAQQTBOG-UHFFFAOYSA-N fostemsavir Chemical compound C1=2N(COP(O)(O)=O)C=C(C(=O)C(=O)N3CCN(CC3)C(=O)C=3C=CC=CC=3)C=2C(OC)=CN=C1N1C=NC(C)=N1 SWMDAPWAQQTBOG-UHFFFAOYSA-N 0.000 title abstract 2
- ZLDOPRCGRXGVGY-UHFFFAOYSA-N CCO.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O Chemical compound CCO.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O ZLDOPRCGRXGVGY-UHFFFAOYSA-N 0.000 abstract 1
- 239000007983 Tris buffer Substances 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000000634 powder X-ray diffraction Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75024705P | 2005-12-14 | 2005-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP20125413B true GEP20125413B (en) | 2012-03-12 |
Family
ID=38163502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP200610811A GEP20125413B (en) | 2005-12-14 | 2006-12-13 | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1h-1, 2, 4-triazol-1-yl)-1-[(phosphonooxy) methyl]-1h-pyrrolo[2,3-c]pyridin-3-yl]-1,2-dioxoethyl]-piperazine |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US7851476B2 (https=) |
| EP (1) | EP1963342A2 (https=) |
| JP (1) | JP5400387B2 (https=) |
| KR (1) | KR20080077010A (https=) |
| CN (1) | CN101365708B (https=) |
| AU (1) | AU2006326432B2 (https=) |
| BR (1) | BRPI0619851A2 (https=) |
| CA (1) | CA2635717A1 (https=) |
| EA (1) | EA014706B1 (https=) |
| GE (1) | GEP20125413B (https=) |
| IL (1) | IL191769A (https=) |
| MY (1) | MY144293A (https=) |
| NO (1) | NO20082477L (https=) |
| NZ (2) | NZ568776A (https=) |
| UA (1) | UA94928C2 (https=) |
| WO (1) | WO2007070589A2 (https=) |
| ZA (1) | ZA200805063B (https=) |
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| US20040110785A1 (en) * | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| JP5433690B2 (ja) | 2008-06-25 | 2014-03-05 | ブリストル−マイヤーズ スクイブ カンパニー | 抗−ｈｉｖ薬としてのジケト縮合アゾロピペリジンおよびアゾロピペラジン |
| JP5433691B2 (ja) * | 2008-06-25 | 2014-03-05 | ブリストル−マイヤーズ スクイブ カンパニー | Ｈｉｖ結合阻害剤としてのジケトピペリジン誘導体 |
| WO2010028108A2 (en) * | 2008-09-04 | 2010-03-11 | Bristol-Myers Squibb Company | Stable pharmaceutical composition for optimized delivery of an hiv attachment inhibitor |
| WO2012075235A1 (en) | 2010-12-02 | 2012-06-07 | Bristol-Myers Squibb Company | Alkyl amides as hiv attachment inhibitors |
| WO2012106189A1 (en) * | 2011-01-31 | 2012-08-09 | Bristol-Myers Squibb Company | Methods of making hiv attachment inhibitor prodrug compound and intermediates |
| ES2636312T3 (es) | 2011-04-12 | 2017-10-05 | VIIV Healthcare UK (No.5) Limited | Derivados de tioamida, amidoxima y amidrazona como inhibidores de la fijación del VIH |
| ES2609579T3 (es) | 2011-08-29 | 2017-04-21 | VIIV Healthcare UK (No.5) Limited | Derivados espiro de diamina bicíclica como inhibidores de la unión del VIH |
| EP2751119B1 (en) | 2011-08-29 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Fused bicyclic diamine derivatives as hiv attachment inhibitors |
| WO2013138436A1 (en) | 2012-03-14 | 2013-09-19 | Bristol-Myers Squibb Company | Cyclolic hydrazine derivatives as hiv attachment inhibitors |
| EP2895472B1 (en) | 2012-08-09 | 2016-11-23 | VIIV Healthcare UK (No.5) Limited | Tricyclic alkene derivatives as HIV attachment inhibitors |
| ES2616492T3 (es) | 2012-08-09 | 2017-06-13 | VIIV Healthcare UK (No.5) Limited | Derivados de piperidina amida como inhibidores de la fijación del VIH |
| AR099354A1 (es) | 2013-11-15 | 2016-07-20 | Akebia Therapeutics Inc | Formas sólidas de ácido {[5-(3-clorofenil)-3-hidroxipiridin-2-carbonil]amino}acético, composiciones, y sus usos |
| RU2663466C1 (ru) * | 2017-03-20 | 2018-08-06 | Общество с ограниченной ответственностью "МБА-групп" | Композиция для профилактики и/или лечения вич-инфекции |
| FI3645001T3 (fi) | 2017-06-29 | 2024-09-25 | G1 Therapeutics Inc | Git38:n morfisia muotoja ja niiden valmistusmenetelmiä |
| KR102195348B1 (ko) | 2018-11-15 | 2020-12-24 | 에이치케이이노엔 주식회사 | 단백질 키나제 억제제로서의 신규 화합물 및 이를 포함하는 약제학적 조성물 |
| US11548895B2 (en) | 2019-04-24 | 2023-01-10 | Elanco Us Inc. | Process for making crystalline 2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(cyclopropylsulfonyl)azetidin-3-yl)acetonitrile |
| KR102847760B1 (ko) | 2019-04-30 | 2025-08-18 | 베이징 타이드 파마슈티컬 코퍼레이션 리미티드 | 디아미노피리미딘 화합물 또는 이의 수화물의 고체 형태, 이의 제조 방법 및 이의 용도 |
| US12516036B2 (en) | 2019-05-31 | 2026-01-06 | Hyundai Pharm Co., Ltd. | Crystal form of 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative |
| CA3142444C (en) | 2019-06-06 | 2025-02-11 | Genfleet Therapeutics (Shanghai) Inc. | CDK9 INHIBITOR POLYMORPH, POLYMORPH PREPARATION METHOD AND ASSOCIATED USES |
| WO2021007189A1 (en) | 2019-07-08 | 2021-01-14 | Rezolute, Inc. | Crystalline forms of plasma kallikrein inhibitors |
| CN114728957B (zh) | 2019-08-06 | 2023-09-22 | 无锡智康弘义生物科技有限公司 | 一种atr抑制剂的晶型及其应用 |
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| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
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-
2006
- 2006-12-11 US US11/636,755 patent/US7851476B2/en active Active
- 2006-12-13 AU AU2006326432A patent/AU2006326432B2/en active Active
- 2006-12-13 CA CA002635717A patent/CA2635717A1/en not_active Abandoned
- 2006-12-13 NZ NZ568776A patent/NZ568776A/en unknown
- 2006-12-13 UA UAA200809079A patent/UA94928C2/ru unknown
- 2006-12-13 JP JP2008545772A patent/JP5400387B2/ja active Active
- 2006-12-13 WO PCT/US2006/047571 patent/WO2007070589A2/en not_active Ceased
- 2006-12-13 CN CN2006800472167A patent/CN101365708B/zh active Active
- 2006-12-13 KR KR1020087016884A patent/KR20080077010A/ko not_active Ceased
- 2006-12-13 BR BRPI0619851-1A patent/BRPI0619851A2/pt not_active Application Discontinuation
- 2006-12-13 EP EP06848592A patent/EP1963342A2/en not_active Withdrawn
- 2006-12-13 MY MYPI20082090A patent/MY144293A/en unknown
- 2006-12-13 NZ NZ592684A patent/NZ592684A/en unknown
- 2006-12-13 EA EA200801529A patent/EA014706B1/ru not_active IP Right Cessation
- 2006-12-13 GE GEAP200610811A patent/GEP20125413B/en unknown
-
2008
- 2008-05-27 IL IL191769A patent/IL191769A/en active IP Right Grant
- 2008-05-29 NO NO20082477A patent/NO20082477L/no not_active Application Discontinuation
- 2008-06-10 ZA ZA200805063A patent/ZA200805063B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1963342A2 (en) | 2008-09-03 |
| ZA200805063B (en) | 2009-10-28 |
| JP2009521414A (ja) | 2009-06-04 |
| AU2006326432A1 (en) | 2007-06-21 |
| IL191769A0 (en) | 2008-12-29 |
| US20070155702A1 (en) | 2007-07-05 |
| KR20080077010A (ko) | 2008-08-20 |
| AU2006326432B2 (en) | 2012-07-12 |
| WO2007070589A2 (en) | 2007-06-21 |
| NO20082477L (no) | 2008-09-05 |
| EA200801529A1 (ru) | 2009-02-27 |
| BRPI0619851A2 (pt) | 2011-10-25 |
| CN101365708B (zh) | 2012-12-12 |
| US7851476B2 (en) | 2010-12-14 |
| WO2007070589A3 (en) | 2007-09-27 |
| EA014706B1 (ru) | 2011-02-28 |
| MY144293A (en) | 2011-08-29 |
| UA94928C2 (en) | 2011-06-25 |
| JP5400387B2 (ja) | 2014-01-29 |
| IL191769A (en) | 2011-08-31 |
| NZ568776A (en) | 2011-06-30 |
| CN101365708A (zh) | 2009-02-11 |
| NZ592684A (en) | 2012-07-27 |
| CA2635717A1 (en) | 2007-06-21 |
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