GEAP201814338A - Aminoester derivatives - Google Patents

Aminoester derivatives

Info

Publication number
GEAP201814338A
GEAP201814338A GEAP201814338A GEAP2018014338A GEAP201814338A GE AP201814338 A GEAP201814338 A GE AP201814338A GE AP201814338 A GEAP201814338 A GE AP201814338A GE AP2018014338 A GEAP2018014338 A GE AP2018014338A GE AP201814338 A GEAP201814338 A GE AP201814338A
Authority
GE
Georgia
Prior art keywords
aminoester derivatives
aminoester
derivatives
muscarine
pde4
Prior art date
Application number
GEAP201814338A
Other languages
English (en)
Inventor
Naimisha Trivedi
Charles Baker-Glenn
De Pöel Hervé Van
Ian Linney
Wesley Blackaby
Carmelida Capaldi
Gabriele Armani
Elisabetta Armani
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of GEAP201814338A publication Critical patent/GEAP201814338A/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/04Drugs for disorders of the respiratory system for throat disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D453/00Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
GEAP201814338A 2014-06-05 2015-06-03 Aminoester derivatives GEAP201814338A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP14171266 2014-06-05

Publications (1)

Publication Number Publication Date
GEAP201814338A true GEAP201814338A (en) 2018-07-25

Family

ID=50884281

Family Applications (2)

Application Number Title Priority Date Filing Date
GEAP201814338A GEAP201814338A (en) 2014-06-05 2015-06-03 Aminoester derivatives
GEAP201514338A GEP20186922B (en) 2014-06-05 2015-06-03 Aminoester derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
GEAP201514338A GEP20186922B (en) 2014-06-05 2015-06-03 Aminoester derivatives

Country Status (32)

Country Link
US (2) US9763924B2 (enExample)
EP (1) EP3152201B1 (enExample)
JP (1) JP2017516824A (enExample)
KR (1) KR102420323B1 (enExample)
CN (1) CN106459020B (enExample)
AR (1) AR100732A1 (enExample)
AU (1) AU2015270539B2 (enExample)
BR (1) BR112016026725B1 (enExample)
CA (1) CA2953198C (enExample)
CL (1) CL2016003117A1 (enExample)
CY (1) CY1120698T1 (enExample)
DK (1) DK3152201T3 (enExample)
EA (1) EA032761B1 (enExample)
ES (1) ES2688826T3 (enExample)
GE (2) GEAP201814338A (enExample)
HR (1) HRP20181967T1 (enExample)
HU (1) HUE042119T2 (enExample)
IL (1) IL249325B (enExample)
LT (1) LT3152201T (enExample)
MA (1) MA39947B1 (enExample)
MX (1) MX377669B (enExample)
PE (1) PE20161557A1 (enExample)
PH (1) PH12016502221A1 (enExample)
PL (1) PL3152201T3 (enExample)
PT (1) PT3152201T (enExample)
RS (1) RS57787B1 (enExample)
SG (1) SG11201610132RA (enExample)
SI (1) SI3152201T1 (enExample)
TN (1) TN2016000546A1 (enExample)
TW (1) TW201625600A (enExample)
WO (1) WO2015185649A1 (enExample)
ZA (1) ZA201608331B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA42048A (fr) 2015-05-07 2018-03-14 Chiesi Farm Spa Dérivés d'aminoesters
AR104822A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivado de aminoésteres
AR104829A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivados de aminoésteres
CN106866474B (zh) * 2017-02-16 2018-12-28 陕西师范大学 一种手性α-芳基甘氨酸酯衍生物的合成方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2022783A1 (en) * 2007-08-08 2009-02-11 CHIESI FARMACEUTICI S.p.A. "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors"
AR070562A1 (es) * 2008-02-06 2010-04-21 Glaxo Group Ltd Farmacoforos duales - antagonistas muscarinicos de pde4
EP2216327A1 (en) 2009-02-06 2010-08-11 CHIESI FARMACEUTICI S.p.A. Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors
KR20150092173A (ko) 2012-12-05 2015-08-12 키에시 파르마슈티시 엣스. 피. 에이. Pde4-억제제로서 페닐에틸피리딘 유도체
CA2893622A1 (en) 2012-12-05 2014-06-12 Chiesi Farmaceutici S.P.A. Novel compounds
CN104822669A (zh) * 2012-12-05 2015-08-05 奇斯药制品公司 作为pde-4抑制剂的苯基乙基吡啶衍生物
US9145409B2 (en) 2013-12-05 2015-09-29 Chiesi Farmaceutici S.P.A Benzhydryl derivatives
HK1225385A1 (zh) 2013-12-05 2017-09-08 奇斯药制品公司 用於治疗呼吸病的杂芳基衍生物

Also Published As

Publication number Publication date
PH12016502221A1 (en) 2017-02-06
US20170340616A1 (en) 2017-11-30
LT3152201T (lt) 2018-10-10
WO2015185649A1 (en) 2015-12-10
AR100732A1 (es) 2016-10-26
TN2016000546A1 (en) 2018-04-04
SG11201610132RA (en) 2017-01-27
TW201625600A (zh) 2016-07-16
KR20170015294A (ko) 2017-02-08
BR112016026725A8 (pt) 2021-06-29
IL249325B (en) 2018-12-31
ZA201608331B (en) 2018-05-30
SI3152201T1 (sl) 2018-10-30
EP3152201A1 (en) 2017-04-12
BR112016026725B1 (pt) 2024-02-27
CN106459020B (zh) 2019-06-18
PE20161557A1 (es) 2017-02-07
AU2015270539A1 (en) 2016-12-22
KR102420323B1 (ko) 2022-07-13
MA39947B1 (fr) 2018-10-31
PT3152201T (pt) 2018-10-26
GEP20186922B (en) 2018-11-12
EA032761B1 (ru) 2019-07-31
US10117860B2 (en) 2018-11-06
EP3152201B1 (en) 2018-08-29
PL3152201T3 (pl) 2019-02-28
CA2953198C (en) 2023-06-13
MA39947A (fr) 2017-04-12
HUE042119T2 (hu) 2019-06-28
CY1120698T1 (el) 2019-12-11
DK3152201T3 (en) 2018-11-19
RS57787B1 (sr) 2018-12-31
MX2016015958A (es) 2017-04-10
ES2688826T3 (es) 2018-11-07
CN106459020A (zh) 2017-02-22
JP2017516824A (ja) 2017-06-22
AU2015270539B2 (en) 2018-11-08
CA2953198A1 (en) 2015-12-10
HRP20181967T1 (hr) 2019-02-08
US9763924B2 (en) 2017-09-19
MX377669B (es) 2025-03-11
WO2015185649A9 (en) 2017-01-05
IL249325A0 (en) 2017-02-28
EA201692227A1 (ru) 2017-05-31
CL2016003117A1 (es) 2017-06-23
US20150352091A1 (en) 2015-12-10
BR112016026725A2 (pt) 2017-08-15

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