KR102420323B1 - 아미노에스터 유도체 - Google Patents

아미노에스터 유도체 Download PDF

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Publication number
KR102420323B1
KR102420323B1 KR1020167032346A KR20167032346A KR102420323B1 KR 102420323 B1 KR102420323 B1 KR 102420323B1 KR 1020167032346 A KR1020167032346 A KR 1020167032346A KR 20167032346 A KR20167032346 A KR 20167032346A KR 102420323 B1 KR102420323 B1 KR 102420323B1
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KR
South Korea
Prior art keywords
ethyl
methyl
phenyl
ium
oxido
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Expired - Fee Related
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KR1020167032346A
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English (en)
Korean (ko)
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KR20170015294A (ko
Inventor
엘리사베타 아르마니
가브리엘 아마리
카르멜리다 카팔디
웨슬리 블랙커비
이안 린니
에르베 반 드 포엘
찰스 베이커-글렌
나이미샤 트리베디
Original Assignee
키에시 파르마슈티시 엣스. 피. 에이.
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Publication of KR20170015294A publication Critical patent/KR20170015294A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Hydrogenated Pyridines (AREA)
KR1020167032346A 2014-06-05 2015-06-03 아미노에스터 유도체 Expired - Fee Related KR102420323B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14171266 2014-06-05
EP14171266.1 2014-06-05
PCT/EP2015/062417 WO2015185649A1 (en) 2014-06-05 2015-06-03 Aminoester derivatives

Publications (2)

Publication Number Publication Date
KR20170015294A KR20170015294A (ko) 2017-02-08
KR102420323B1 true KR102420323B1 (ko) 2022-07-13

Family

ID=50884281

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167032346A Expired - Fee Related KR102420323B1 (ko) 2014-06-05 2015-06-03 아미노에스터 유도체

Country Status (32)

Country Link
US (2) US9763924B2 (enExample)
EP (1) EP3152201B1 (enExample)
JP (1) JP2017516824A (enExample)
KR (1) KR102420323B1 (enExample)
CN (1) CN106459020B (enExample)
AR (1) AR100732A1 (enExample)
AU (1) AU2015270539B2 (enExample)
BR (1) BR112016026725B1 (enExample)
CA (1) CA2953198C (enExample)
CL (1) CL2016003117A1 (enExample)
CY (1) CY1120698T1 (enExample)
DK (1) DK3152201T3 (enExample)
EA (1) EA032761B1 (enExample)
ES (1) ES2688826T3 (enExample)
GE (2) GEP20186922B (enExample)
HR (1) HRP20181967T1 (enExample)
HU (1) HUE042119T2 (enExample)
IL (1) IL249325B (enExample)
LT (1) LT3152201T (enExample)
MA (1) MA39947B1 (enExample)
MX (1) MX377669B (enExample)
PE (1) PE20161557A1 (enExample)
PH (1) PH12016502221A1 (enExample)
PL (1) PL3152201T3 (enExample)
PT (1) PT3152201T (enExample)
RS (1) RS57787B1 (enExample)
SG (1) SG11201610132RA (enExample)
SI (1) SI3152201T1 (enExample)
TN (1) TN2016000546A1 (enExample)
TW (1) TW201625600A (enExample)
WO (1) WO2015185649A1 (enExample)
ZA (1) ZA201608331B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA42048A (fr) 2015-05-07 2018-03-14 Chiesi Farm Spa Dérivés d'aminoesters
AR104822A1 (es) * 2015-06-01 2017-08-16 Chiesi Farm Spa Derivado de aminoésteres
TW201710254A (zh) * 2015-06-01 2017-03-16 吉斯藥品公司 胺基酯衍生物
CN106866474B (zh) * 2017-02-16 2018-12-28 陕西师范大学 一种手性α-芳基甘氨酸酯衍生物的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018909A2 (en) 2007-08-08 2009-02-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
US20090203657A1 (en) 2008-02-06 2009-08-13 Glaxo Group Limited Dual Pharmacophores - PDE4-Muscarinic Antagonistics
WO2010089107A1 (en) 2009-02-06 2010-08-12 Chiesi Farmaceutici S.P.A. Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104837828B (zh) 2012-12-05 2017-07-18 奇斯药制品公司 作为pde4‑抑制剂的苯基乙基吡啶衍生物
CA2893622A1 (en) 2012-12-05 2014-06-12 Chiesi Farmaceutici S.P.A. Novel compounds
TR201807181T4 (tr) 2012-12-05 2018-06-21 Chiesi Farm Spa Pde-4 i̇nhi̇bi̇törleri̇ ve muskari̇ni̇k reseptör antagoni̇stleri̇ olarak feni̇leti̇lpi̇ri̇di̇n türevleri̇
AR098621A1 (es) * 2013-12-05 2016-06-01 Chiesi Farm Spa Derivados de heteroarilo
WO2015082619A1 (en) 2013-12-05 2015-06-11 Chiesi Farmaceutici S.P.A. Benzhydryl derivatives for the treatment of respiratory diseases

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009018909A2 (en) 2007-08-08 2009-02-12 Chiesi Farmaceutici S.P.A. Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors
US20090203657A1 (en) 2008-02-06 2009-08-13 Glaxo Group Limited Dual Pharmacophores - PDE4-Muscarinic Antagonistics
WO2010089107A1 (en) 2009-02-06 2010-08-12 Chiesi Farmaceutici S.P.A. Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors

Also Published As

Publication number Publication date
WO2015185649A1 (en) 2015-12-10
JP2017516824A (ja) 2017-06-22
RS57787B1 (sr) 2018-12-31
PL3152201T3 (pl) 2019-02-28
ZA201608331B (en) 2018-05-30
BR112016026725A8 (pt) 2021-06-29
US9763924B2 (en) 2017-09-19
MA39947B1 (fr) 2018-10-31
CY1120698T1 (el) 2019-12-11
CA2953198C (en) 2023-06-13
CL2016003117A1 (es) 2017-06-23
TN2016000546A1 (en) 2018-04-04
PT3152201T (pt) 2018-10-26
LT3152201T (lt) 2018-10-10
PE20161557A1 (es) 2017-02-07
SI3152201T1 (sl) 2018-10-30
WO2015185649A9 (en) 2017-01-05
EP3152201B1 (en) 2018-08-29
CA2953198A1 (en) 2015-12-10
EA032761B1 (ru) 2019-07-31
TW201625600A (zh) 2016-07-16
MX377669B (es) 2025-03-11
EA201692227A1 (ru) 2017-05-31
AU2015270539B2 (en) 2018-11-08
ES2688826T3 (es) 2018-11-07
MX2016015958A (es) 2017-04-10
HRP20181967T1 (hr) 2019-02-08
SG11201610132RA (en) 2017-01-27
BR112016026725A2 (pt) 2017-08-15
AR100732A1 (es) 2016-10-26
PH12016502221A1 (en) 2017-02-06
KR20170015294A (ko) 2017-02-08
CN106459020B (zh) 2019-06-18
US20170340616A1 (en) 2017-11-30
MA39947A (fr) 2017-04-12
DK3152201T3 (en) 2018-11-19
IL249325A0 (en) 2017-02-28
CN106459020A (zh) 2017-02-22
US10117860B2 (en) 2018-11-06
BR112016026725B1 (pt) 2024-02-27
EP3152201A1 (en) 2017-04-12
US20150352091A1 (en) 2015-12-10
IL249325B (en) 2018-12-31
HUE042119T2 (hu) 2019-06-28
GEAP201814338A (en) 2018-07-25
GEP20186922B (en) 2018-11-12
AU2015270539A1 (en) 2016-12-22

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