GB998294A - 11ª‡-halo-tetracycline-6,12 hemiketals - Google Patents

11ª‡-halo-tetracycline-6,12 hemiketals

Info

Publication number
GB998294A
GB998294A GB36490/63A GB3649063A GB998294A GB 998294 A GB998294 A GB 998294A GB 36490/63 A GB36490/63 A GB 36490/63A GB 3649063 A GB3649063 A GB 3649063A GB 998294 A GB998294 A GB 998294A
Authority
GB
United Kingdom
Prior art keywords
acid
compounds
reaction
specified
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB36490/63A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp
Pfizer Inc
Original Assignee
Pfizer Corp
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27567787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB998294(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US76441A external-priority patent/US2984686A/en
Application filed by Pfizer Corp, Pfizer Inc filed Critical Pfizer Corp
Publication of GB998294A publication Critical patent/GB998294A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D23/00—Producing tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D33/00—Details of, or accessories for, sacks or bags
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L11/00—Hoses, i.e. flexible pipes
    • F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB36490/63A 1960-05-23 1961-05-04 11ª‡-halo-tetracycline-6,12 hemiketals Expired GB998294A (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3123660A 1960-05-23 1960-05-23
US3841460A 1960-06-29 1960-06-29
US7285760A 1960-12-01 1960-12-01
US7287560A 1960-12-01 1960-12-01
US76441A US2984686A (en) 1960-12-19 1960-12-19 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines
US8705961A 1961-02-06 1961-02-06
US106146A US3200149A (en) 1960-05-23 1961-05-05 alpha-6-deoxytetracycline derivatives and process

Publications (1)

Publication Number Publication Date
GB998294A true GB998294A (en) 1965-07-14

Family

ID=27567787

Family Applications (4)

Application Number Title Priority Date Filing Date
GB36489/63A Expired GB995033A (en) 1960-05-23 1961-05-04 11a-halo-6-methylenetetracyclines and method of preparing same
GB36490/63A Expired GB998294A (en) 1960-05-23 1961-05-04 11ª‡-halo-tetracycline-6,12 hemiketals
GB1615861A Expired - Lifetime GB995031A (en) 1960-05-23 1961-05-04 6-methylene-tetracyclines and method of preparing same
GB18544/61A Expired GB995032A (en) 1960-05-23 1961-05-23 Tetracycline derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB36489/63A Expired GB995033A (en) 1960-05-23 1961-05-04 11a-halo-6-methylenetetracyclines and method of preparing same

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB1615861A Expired - Lifetime GB995031A (en) 1960-05-23 1961-05-04 6-methylene-tetracyclines and method of preparing same
GB18544/61A Expired GB995032A (en) 1960-05-23 1961-05-23 Tetracycline derivatives

Country Status (10)

Country Link
US (1) US3200149A (US20100268047A1-20101021-C00003.png)
CH (3) CH444853A (US20100268047A1-20101021-C00003.png)
CY (4) CY366A (US20100268047A1-20101021-C00003.png)
DE (3) DE1300934B (US20100268047A1-20101021-C00003.png)
FI (1) FI40534B (US20100268047A1-20101021-C00003.png)
FR (1) FR1430859A (US20100268047A1-20101021-C00003.png)
GB (4) GB995033A (US20100268047A1-20101021-C00003.png)
MY (4) MY6700047A (US20100268047A1-20101021-C00003.png)
OA (1) OA00136A (US20100268047A1-20101021-C00003.png)
SE (1) SE302119B (US20100268047A1-20101021-C00003.png)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US4089900A (en) * 1967-09-13 1978-05-16 Pfizer Inc. Antimicrobial agents
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
BR6915425D0 (pt) * 1969-06-27 1973-01-16 Farmaceutici Italia Preparacao de cloro-metileno-tetraciclina
BE754596A (fr) * 1969-08-08 1971-02-08 Farmaceutici Italia Esters de la methylenetetracycline et procede de leur fabrication
BE755678R (fr) * 1969-09-04 1971-03-03 Farmaceutici Italia Esters de la methylenetetracycline et procede de leur fabrication
DK153393C (da) * 1970-07-03 1988-11-28 Ivan Villax Fremgangsmaade til fremstilling af metacyklin ved dehalogenering af et syreadditionssalt af 11a-klor-6-desoxy-6-demetyl-6-metylen-5-hydroxytetracyklin
US3795707A (en) * 1970-12-28 1974-03-05 Rachelle Labor Italia Spa Manufacture of alpha-6-deoxytetracyclines
CH579531A5 (US20100268047A1-20101021-C00003.png) * 1972-02-24 1976-09-15 Ankerfarm Spa
US3954862A (en) * 1973-04-20 1976-05-04 Pfizer Inc. Process for producing α-6-deoxytetracyclines
GB1459861A (en) * 1973-06-21 1976-12-31 Pfizer Process for 11a-dehalogenation of 11a-halotetracyclines
US3907890A (en) * 1974-05-28 1975-09-23 Pfizer Preparation of alpha-6-deoxy-5-hydroxytetracycline
US4001321A (en) * 1975-06-26 1977-01-04 Pfizer Inc. Preparation of α-6-deoxytetracyclines
YU41480B (en) * 1979-03-12 1987-08-31 Pliva Pharm & Chem Works Process for obtaining alpha-6-deoxy-5-hydroxytetracycline
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
HU188367B (en) * 1983-09-02 1986-04-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for preparing 6-demethy-6-deoxy-6-methylene-5-exytetracycline and 11a-chloro-derivative thereof
EP0391005B1 (en) * 1989-04-03 1991-10-16 Ranbaxy Laboratories, Ltd. Process for the production of alpha-6-deoxytetracyclines
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
US5494903A (en) * 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
IL137445A0 (en) * 1998-01-23 2001-07-24 Tufts College Pharmaceutically active compounds and methods of use thereof
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
CN102336680A (zh) * 1999-09-14 2012-02-01 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP1474380A4 (en) * 2002-01-08 2007-04-18 Paratek Pharm Innc 4-DESDIMETHYL AMINO TETRA CYCLINE COMPOUNDS
EP1503981A4 (en) * 2002-03-21 2007-08-15 Paratek Pharm Innc SUBSTITUTED TETRACYCLINE COMPOUNDS
KR20040094833A (ko) * 2002-03-29 2004-11-10 더 리서치 파운데이션 오브 스테이트 유니버시티 오브 뉴욕 비-항균성 테트라사이클린 동족체의 용도 및 박테리아외독소의 치료를 위한 이의 제형
JP4733028B2 (ja) 2003-07-09 2011-07-27 パラテック ファーマシューティカルズ インコーポレイテッド 置換テトラサイクリン化合物
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
AU2006214543A1 (en) 2005-02-15 2006-08-24 Wyeth 9-substituted tetracyclines
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
WO2007027599A1 (en) * 2005-08-31 2007-03-08 Wyeth 9-aminocarbonylsubstituted derivatives of glycylcyclines
CN102688492A (zh) * 2007-03-23 2012-09-26 分子研究中心公司 包含四环素类的抗炎组合物及其用途
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
TW202021946A (zh) * 2008-05-23 2020-06-16 美商派洛泰克藥物股份有限公司 四環素化合物之甲苯磺酸鹽及同素異形體
RU2647972C2 (ru) 2010-05-12 2018-03-21 Ремпекс Фармацеутикалс, Инк. Тетрациклиновая композиция
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物
CN102086165B (zh) * 2010-12-29 2013-06-19 开封制药(集团)有限公司 Pd催化剂在生产强力霉素氢化工艺中的应用
PT108978B (pt) 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
CN111732522B (zh) * 2020-07-21 2022-10-18 山东国邦药业有限公司 一种脱氧土霉素的制备方法
WO2023205787A1 (en) * 2022-04-22 2023-10-26 Mork Benjamin V Compositions and methods for remediation using dithionite and activated carbons

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE566456A (US20100268047A1-20101021-C00003.png) *
BE565025A (US20100268047A1-20101021-C00003.png) *
DE1073482B (de) * 1960-01-21 American Cyanamid Company New York N Y (V St A) \ertr Dr F Zumstem Dipl Chem Dr rer nat E Assmann und Dipl Chem Dr R Koe nigsberger Pat Anwalte München 2 Verfahren zur Herstellung von Tetracyclmen und ihren 5a Epimeren
BE572236A (US20100268047A1-20101021-C00003.png) *
BE572584A (US20100268047A1-20101021-C00003.png) *
DE932670C (de) * 1952-10-23 1955-09-05 Pfizer & Co C Verfahren zur Herstellung von Tetracyclin und seinen Salzen
DE1011417B (de) * 1954-01-15 1957-07-04 Pfizer & Co C Verfahren zur Herstellung von Anhydrodesdimethylaminochlortetracyclin bzw. Anhydrodesdimethylaminotetracyclin
US2731497A (en) * 1954-05-14 1956-01-17 American Cyanamid Co Production of tetracycline
DE1007775B (de) * 1955-02-12 1957-05-09 Pfizer & Co C Verfahren zur Herstellung von Tetracyclin und seinen Salzen
CH365484A (fr) * 1956-05-28 1962-11-15 American Cyanamid Co Procédé de préparation d'une substance antibiotique
GB855170A (en) * 1957-03-01 1960-11-30 American Cyanamid Co 6-demethyl-6-deoxytetracycline and the 4-epimers thereof
US3005023A (en) * 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US3036129A (en) * 1959-10-09 1962-05-22 American Cyanamid Co Preparation of 7-halo-6-deoxy-tetracyclines
US3019260A (en) * 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
US2976318A (en) * 1959-05-18 1961-03-21 Pfizer & Co C Tetracycline derivatives and process of producing the same

Also Published As

Publication number Publication date
MY6900209A (en) 1969-12-31
FI40534B (US20100268047A1-20101021-C00003.png) 1968-11-30
GB995033A (en) 1965-06-10
SE302119B (US20100268047A1-20101021-C00003.png) 1968-07-08
OA00136A (fr) 1966-03-15
US3200149A (en) 1965-08-10
CH459189A (de) 1968-07-15
CY366A (en) 1967-02-02
CY381A (en) 1967-03-08
CY480A (en) 1969-04-10
MY6700048A (en) 1967-12-31
GB995032A (en) 1965-06-10
DE1283834B (de) 1968-11-28
CY365A (en) 1967-02-02
FR1430859A (US20100268047A1-20101021-C00003.png) 1966-05-25
CH434238A (de) 1967-04-30
MY6700047A (en) 1967-12-31
MY7400226A (en) 1974-12-31
GB995031A (en)
DE1298522B (de) 1969-07-03
DE1300934B (de) 1969-08-14
CH444853A (de) 1967-10-15

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