GB992732A - 1-arylalkyl-4-(n-arylalkanamido)piperidines and related compounds and method for their preparation - Google Patents

1-arylalkyl-4-(n-arylalkanamido)piperidines and related compounds and method for their preparation

Info

Publication number
GB992732A
GB992732A GB38269/62A GB3826962A GB992732A GB 992732 A GB992732 A GB 992732A GB 38269/62 A GB38269/62 A GB 38269/62A GB 3826962 A GB3826962 A GB 3826962A GB 992732 A GB992732 A GB 992732A
Authority
GB
United Kingdom
Prior art keywords
compound
formula
reacting
give
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB38269/62A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Laboratorium C Janssen NV
Original Assignee
Research Laboratorium C Janssen NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Research Laboratorium C Janssen NV filed Critical Research Laboratorium C Janssen NV
Publication of GB992732A publication Critical patent/GB992732A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
GB38269/62A 1961-10-10 1962-10-09 1-arylalkyl-4-(n-arylalkanamido)piperidines and related compounds and method for their preparation Expired GB992732A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US144059A US3164600A (en) 1961-10-10 1961-10-10 1-aralkyl-4-(n-aryl-carbonyl amino)-piperidines and related compounds

Publications (1)

Publication Number Publication Date
GB992732A true GB992732A (en) 1965-05-19

Family

ID=22506870

Family Applications (1)

Application Number Title Priority Date Filing Date
GB38269/62A Expired GB992732A (en) 1961-10-10 1962-10-09 1-arylalkyl-4-(n-arylalkanamido)piperidines and related compounds and method for their preparation

Country Status (8)

Country Link
US (1) US3164600A (en, 2012)
BE (1) BE623427A (en, 2012)
CH (1) CH446329A (en, 2012)
DE (1) DE1470115C3 (en, 2012)
DK (1) DK103351C (en, 2012)
FR (1) FR1517671A (en, 2012)
GB (1) GB992732A (en, 2012)
NL (2) NL284196A (en, 2012)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396282A3 (en) * 1989-04-20 1992-01-08 Boc, Inc. N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds

Families Citing this family (50)

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US3452030A (en) * 1966-12-12 1969-06-24 Aldrich Chem Co Inc The 4-(n-isobutyrylanilino)-1-benzylpiperidine
DE2341965C3 (de) * 1973-08-20 1979-01-25 C.H. Boehringer Sohn, 6507 Ingelheim 4- [N- (o-PyridyD- N-acyl] -aminolphenäthylpiperidine, Verfahren zu deren Herstellung sowie deren Verwendung bei der Bekämpfung von Schmerzzuständen
US3998834A (en) * 1975-03-14 1976-12-21 Janssen Pharmaceutica N.V. N-(4-piperidinyl)-n-phenylamides and -carbamates
US4198411A (en) * 1976-08-12 1980-04-15 Janssen Pharmaceutica N.V. N-aryl-N-(1-L-4-piperidinyl)-arylaceytamides
US4584303A (en) * 1984-04-09 1986-04-22 The Boc Group, Inc. N-aryl-N-(4-piperidinyl)amides and pharmaceutical compositions and method employing such compounds
US4921864A (en) * 1987-11-02 1990-05-01 Boc, Inc. 4-Phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5013742A (en) * 1987-11-02 1991-05-07 Boc, Inc. 4-phenyl-4-N-(phenyl) amido piperidine derivatives and pharmaceutical compositions and method employing such compounds
USRE33495E (en) * 1987-11-02 1990-12-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-anilino-piperidine compounds and derivatives
US4849521A (en) * 1987-11-02 1989-07-18 Boc, Inc. Stereoselective preparation of 3-substituted-4-piperidine compounds and derivatives
US4791121A (en) * 1987-11-02 1988-12-13 The Boc Group, Inc. 4-phenyl-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4957929A (en) * 1987-11-02 1990-09-18 Boc, Inc. 4-phenyl-4-[N-(phenyl)amido]piperidine compounds and pharmaceutical compositions employing such compounds
US4801615A (en) * 1987-12-31 1989-01-31 The Boc Group, Inc. 4-heterohexacyclic-4-(N-(phenyl)amido) piperidine derivatives and pharmaceutical compositions and method employing such compounds
US4791120A (en) * 1987-12-31 1988-12-13 The Boc Group, Inc. 4-heteropentacyclic-4-[N-(phenyl)amino] piperidine derivatives and pharmaceutical compositions and method employing such compounds
US5019583A (en) * 1989-02-15 1991-05-28 Glaxo Inc. N-phenyl-N-(4-piperidinyl)amides useful as analgesics
KR900016129A (ko) * 1989-04-20 1990-11-12 테리 아아르 커세트 4-알콕시알킬-4-아미노페닐피페리딘 및 그들의 유도체의 제조 방법
US5145967A (en) * 1989-04-20 1992-09-08 Anaquest, Inc. Method for preparing 4-alkoxyalkyl-4-phenylaminopiperdines and derivatives thereof
US5100903A (en) * 1989-05-12 1992-03-31 Anaquest, Inc. N-aryl-n-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4994471A (en) * 1989-05-12 1991-02-19 Boc, Inc. N-aryl-N-(1-substituted-3-alkoxy-4-piperidinyl)amides and pharmaceutical compositions and methods employing such compounds
US4939161A (en) * 1989-05-12 1990-07-03 Boc, Inc. Analgesic N-aryl-N-[1-substituted-3,5-dimethyl-4-piperidinyl]amides
US5130321A (en) * 1990-12-18 1992-07-14 Glaxo Inc. Analgesic n-phenyl-n-(3-or 1-3-me-4-piperidinyl)amides
US5214148A (en) * 1990-12-18 1993-05-25 Glaxo Inc. Analgesic N-phenyl-N-(3-OR1 -3-ME-4-piperidinyl)amides
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
US6635661B2 (en) 2000-05-25 2003-10-21 Sepracor Inc. Heterocyclic analgesic compounds and methods of use thereof
US6677332B1 (en) 1999-05-25 2004-01-13 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
US7361666B2 (en) * 1999-05-25 2008-04-22 Sepracor, Inc. Heterocyclic analgesic compounds and methods of use thereof
CA2436263A1 (en) * 2000-12-15 2002-06-20 Astrazeneca Ab New process for the preparation diaryl-4-amino-piperidinyl compounds
US7645442B2 (en) 2001-05-24 2010-01-12 Alexza Pharmaceuticals, Inc. Rapid-heating drug delivery article and method of use
US20070122353A1 (en) * 2001-05-24 2007-05-31 Hale Ron L Drug condensation aerosols and kits
US7458374B2 (en) * 2002-05-13 2008-12-02 Alexza Pharmaceuticals, Inc. Method and apparatus for vaporizing a compound
US7585493B2 (en) 2001-05-24 2009-09-08 Alexza Pharmaceuticals, Inc. Thin-film drug delivery article and method of use
JP2005503425A (ja) 2001-05-24 2005-02-03 アレックザ モレキュラー デリヴァリー コーポレイション 所定の吸入ルートによる薬剤エステルの送出
US7090830B2 (en) * 2001-05-24 2006-08-15 Alexza Pharmaceuticals, Inc. Drug condensation aerosols and kits
US20030051728A1 (en) * 2001-06-05 2003-03-20 Lloyd Peter M. Method and device for delivering a physiologically active compound
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
US7913688B2 (en) * 2002-11-27 2011-03-29 Alexza Pharmaceuticals, Inc. Inhalation device for producing a drug aerosol
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
EP1625336B9 (en) 2003-05-21 2012-03-21 Alexza Pharmaceuticals, Inc. Use of a layer of solid fuel, method for producing such a layer and associated heating unit
JP2007509945A (ja) * 2003-10-29 2007-04-19 マリンクロッド・インコーポレイテッド 逆相分取クロマトグラフィーによるフェンタニルの分離および精製のための産業用の方法
US7540286B2 (en) * 2004-06-03 2009-06-02 Alexza Pharmaceuticals, Inc. Multiple dose condensation aerosol devices and methods of forming condensation aerosols
US7581540B2 (en) * 2004-08-12 2009-09-01 Alexza Pharmaceuticals, Inc. Aerosol drug delivery device incorporating percussively activated heat packages
US20100006092A1 (en) * 2004-08-12 2010-01-14 Alexza Pharmaceuticals, Inc. Aerosol Drug Delivery Device Incorporating Percussively Activated Heat Packages
ES2289888B1 (es) * 2005-09-08 2008-12-16 Consejo Superior Investig. Cientificas Derivados de pirazolcarboxamida, su procedimiento de obtencion y sus aplicaciones como antagonistas/agonistas inversos del receptor cannabinoide cb1 y opioide mu.
EP1966140A1 (en) * 2005-11-17 2008-09-10 Mallinckrodt, Inc. Process for synthesizing remifentanil
US20080216828A1 (en) 2007-03-09 2008-09-11 Alexza Pharmaceuticals, Inc. Heating unit for use in a drug delivery device
US8500706B2 (en) 2007-03-23 2013-08-06 Allegiance Corporation Fluid collection and disposal system having interchangeable collection and other features and methods relating thereto
US9889239B2 (en) 2007-03-23 2018-02-13 Allegiance Corporation Fluid collection and disposal system and related methods
WO2009077584A1 (en) * 2007-12-19 2009-06-25 Neurosearch A/S N-aryl-n-piperidin-4-yl-propionamide derivatives and their use as opioid receptor ligands
RU2495871C2 (ru) * 2008-03-19 2013-10-20 Дайректор Дженерал, Дифенс Рисерч Энд Дивелопмент Организейшн, Министри Оф Дифенс Способ получения фентанила
WO2010033540A1 (en) * 2008-09-19 2010-03-25 Mallinckrodt Inc. Crystalline forms of fentanyl alkaloid
EP3746138A4 (en) 2018-02-02 2021-11-03 Alexza Pharmaceuticals, Inc. ELECTRIC CONDENSING AEROSOL DEVICE

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US2824875A (en) * 1958-02-25 Certificate of correction
US2914532A (en) * 1955-09-12 1959-11-24 Sterling Drug Inc Lower alkyl 4-phenyl-1-(3-phenylpropyl) piperidine-4-carboxylates and their preparation
US2962501A (en) * 1956-09-19 1960-11-29 Merck & Co Inc 1-substituted propyl piperidines and processes of preparing same
US3004977A (en) * 1960-04-29 1961-10-17 Paul A J Janssen Lower alkyl esters of 1-(2-benzoylethyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid and 1-(3-hydroxy-3-phenylpropyl)-3-methyl-4-phenylpiperidine-4-carboxylic acid
US3012030A (en) * 1960-04-29 1961-12-05 Paul A J Janssen Lower alkyl esters of 1-cinnamyl-3-methyl-4-phenylpiperidine-4-carboxylic acid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0396282A3 (en) * 1989-04-20 1992-01-08 Boc, Inc. N-aryl-N-[4-(heterocyclicalkyl) piperidinyl]amides and pharmaceutical compositions and methods employing such compounds
USRE34201E (en) * 1989-04-20 1993-03-23 Anaquest, Inc. N-aryl-N-[4-(1-heterocyclicalkyl)piperidinyl]amides and pharmaceutical compositions and methods employing such compounds

Also Published As

Publication number Publication date
FR1517671A (fr) 1968-03-22
DE1470115A1 (de) 1969-05-29
NL284196A (en, 2012)
BE623427A (en, 2012)
DE1470115B2 (de) 1974-08-01
DE1470115C3 (de) 1975-03-27
NL135583C (en, 2012)
US3164600A (en) 1965-01-05
DK103351C (da) 1965-12-20
CH446329A (de) 1967-11-15

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