GB848515A - New water-soluble steroid compounds and a process for their manufacture - Google Patents

New water-soluble steroid compounds and a process for their manufacture

Info

Publication number
GB848515A
GB848515A GB28298/58A GB2829858A GB848515A GB 848515 A GB848515 A GB 848515A GB 28298/58 A GB28298/58 A GB 28298/58A GB 2829858 A GB2829858 A GB 2829858A GB 848515 A GB848515 A GB 848515A
Authority
GB
United Kingdom
Prior art keywords
semi
sulphate
hydrocortisone
salts
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB28298/58A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of GB848515A publication Critical patent/GB848515A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)

Abstract

The invention comprises hydrocortisone 21-semi-sulphate and salts thereof with physiologically acceptable bases, and the preparation thereof by reacting hydrocortisone with a reagent to form the 21-semi-sulphate residue and, if desired converting the 21-semi-sulphate into a salt with a physiologically acceptable base. The 21-semi-sulphate residue may be prepared by reacting hydrocortisone with the pyridine-sulphur trioxide adduct. Suitable salts are the sodium, potassium, trimethylammonium, tetramethylammonium, and choline salts. In the examples the 21-semi-sulphate is prepared using the pyridine-sulphur trioxide adduct, and aminosulphonic acid and chlorosulphonic acid in the presence of pyridine, and the specific salts referred to above are prepared thereform.ALSO:An injection or inhalant consists of an aqueous solution of a salt of the 21-semi-sulphate of hydrocortisone with a physiologically acceptable base such as the sodium, potassium, triethylammonium, tetramethylammonium and choline salt.
GB28298/58A 1957-10-26 1958-09-03 New water-soluble steroid compounds and a process for their manufacture Expired GB848515A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE848515X 1957-10-26

Publications (1)

Publication Number Publication Date
GB848515A true GB848515A (en) 1960-09-21

Family

ID=6775619

Family Applications (1)

Application Number Title Priority Date Filing Date
GB28298/58A Expired GB848515A (en) 1957-10-26 1958-09-03 New water-soluble steroid compounds and a process for their manufacture

Country Status (1)

Country Link
GB (1) GB848515A (en)

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