GB754845A - Improvements in or relating to pteridines - Google Patents

Improvements in or relating to pteridines

Info

Publication number
GB754845A
GB754845A GB651454A GB651454A GB754845A GB 754845 A GB754845 A GB 754845A GB 651454 A GB651454 A GB 651454A GB 651454 A GB651454 A GB 651454A GB 754845 A GB754845 A GB 754845A
Authority
GB
United Kingdom
Prior art keywords
amyl
acid
prepared
indoxyl
refluxing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB651454A
Inventor
James Henry Dunsmuir
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Allen and Hanburys Ltd
Original Assignee
Allen and Hanburys Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allen and Hanburys Ltd filed Critical Allen and Hanburys Ltd
Priority to GB651454A priority Critical patent/GB754845A/en
Publication of GB754845A publication Critical patent/GB754845A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises 2,4-diamino-11-n-amyl-indols-(21,31-6,7) -pteridine and the preparation thereof by condensing 5-nitroso-2,4,6-triaminopyrimidine with an N-n-amyl-O-acyl-indoxyl in solution or suspension in a solvent in the presence of an acid binding condensing agent. In an example 2,4-diamino-11-n - amyl - indolo - (21,31 - 6,7) - pteridine is prepared using N - n - amyl - O - acetyl - indoxyl for reaction with the substituted pyrimidine in the presence of piperidine as the condensing agent. N - n - amyl - anthranilic acid is prepared by refluxing anthranilic acid, n-amyl iodide, potassium carbonate and water. N - n - amyl - N - phenyl - glycine - 2 - carboxylic acid is prepared by refluxing N-n-amylanthranilic acid, monochloroacetic acid, sodium carbonate and water. N - n - amyl - O - acetyl - indoxyl is prepared by refluxing N - n - amyl - N - phenyl - glycine-2-carboxylic acid, sodium acetate and acetic anhydride in the presence of a few drops of concentrated sulphuric acid. Other N-n-amyl-O-acyl-indoxyls may be prepared by a similar method.
GB651454A 1954-03-05 1954-03-05 Improvements in or relating to pteridines Expired GB754845A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB651454A GB754845A (en) 1954-03-05 1954-03-05 Improvements in or relating to pteridines

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB651454A GB754845A (en) 1954-03-05 1954-03-05 Improvements in or relating to pteridines

Publications (1)

Publication Number Publication Date
GB754845A true GB754845A (en) 1956-08-15

Family

ID=9815899

Family Applications (1)

Application Number Title Priority Date Filing Date
GB651454A Expired GB754845A (en) 1954-03-05 1954-03-05 Improvements in or relating to pteridines

Country Status (1)

Country Link
GB (1) GB754845A (en)

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