GB801856A - The production of lyophilised preparations - Google Patents
The production of lyophilised preparationsInfo
- Publication number
- GB801856A GB801856A GB6062/56A GB606256A GB801856A GB 801856 A GB801856 A GB 801856A GB 6062/56 A GB6062/56 A GB 6062/56A GB 606256 A GB606256 A GB 606256A GB 801856 A GB801856 A GB 801856A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- freeze
- flask
- drying
- layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F26—DRYING
- F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
- F26B5/00—Drying solid materials or objects by processes not involving the application of heat
- F26B5/04—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum
- F26B5/06—Drying solid materials or objects by processes not involving the application of heat by evaporation or sublimation of moisture under reduced pressure, e.g. in a vacuum the process involving freezing
Abstract
A process for producing stable chemical preparations including at least two components which are incompatible in common solution consists in successively freezing separate solutions comprising said components within a common vessel to form a stratified frozen mass and thereafter freeze-drying said frozen mass. In one example of the process, a flask of 5 c.c. capacity was filled with 3 c.c. of an aqueous solution of 20 mg. of glycine and 2 mg. of gelatin per c.c. and placed upon a metal plate cooled to about -85 DEG C. by a mixture of carbon dioxide and acetone so as to freeze the solution. Thereupon, 1 c.c. of a similar solution, together with 10 mg. of a sodium salt of 7-acetamido-4-(sulphamyl-phenylazo) - 1 - naphthol - 3,6 - disulphonic acid, a strong red dyestuff is added to the flask. Upon freezing of the added solution, the whole is freeze-dried at an initial temperature of -40 DEG C. and an absolute pressure of 0.01 mm. of Hg, the temperature being gradually raised to 40 DEG C. The resulting product has a lower white layer and an upper cherry red layer. In another example, the above process was repeated with 2 c.c. of an aqueous solution of 45 mg. of sodium bicarbonate and 40 mg. of cane sugar per c.c. as a lower layer, and 2 c.c. of a solution of 25 mg. of citric acid and 40 mg. of cane sugar. Following freeze-drying there was obtained a finely-structured mass consisting of two distinct layers.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE801856X | 1955-02-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB801856A true GB801856A (en) | 1958-09-24 |
Family
ID=6717089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB6062/56A Expired GB801856A (en) | 1955-02-25 | 1956-02-27 | The production of lyophilised preparations |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB801856A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754597A (en) * | 1981-12-11 | 1988-07-05 | John Wyeth & Brother Ltd. | Solid shaped articles |
-
1956
- 1956-02-27 GB GB6062/56A patent/GB801856A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4754597A (en) * | 1981-12-11 | 1988-07-05 | John Wyeth & Brother Ltd. | Solid shaped articles |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB801856A (en) | The production of lyophilised preparations | |
| ES410994A1 (en) | Process for the preparation of a hydrolyzate of proteins for use as a foodstuff | |
| SU959786A1 (en) | Whole blood preservation method | |
| DK542089A (en) | STORAGE STABLE LYOFIXED MDM PREPARATION AND PROCEDURE FOR PREPARING THEREOF | |
| GB586157A (en) | Process for manufacturing soft impervious bodies, sheets and films such as edible bodies useful for imitation soft fruit and the like | |
| ES392844A1 (en) | Ice for human consumption | |
| JPS5588679A (en) | Preparation of ground fish meat | |
| GB772345A (en) | Improvements in or relating to preparation of polyvinylamine | |
| GB1227744A (en) | ||
| JPS5515722A (en) | Production of whipped cream | |
| EP0048194A3 (en) | Lyophilization process | |
| JPS5245759A (en) | Refrigerating containr | |
| ES420106A1 (en) | Stimulative composition and process for its production | |
| GB284636A (en) | Process for obtaining an alimentary extract from fish | |
| JPS59164701A (en) | Manufacture of dry flower | |
| ES472923A1 (en) | Improvements introduced in a process to produce an ice preparation (Machine-translation by Google Translate, not legally binding) | |
| US2950201A (en) | Method of preserving royal jelly | |
| JPS52130978A (en) | Preparation of materials for citric acid fermentation | |
| SU477150A1 (en) | The method of obtaining peat bacterial drug | |
| GB634919A (en) | Process for the treatment of baker's yeast | |
| GB727475A (en) | Improvements in or relating to the manufacture of artificial fruits gelled pharmaceutical products and the like | |
| GB1400411A (en) | Process for the production of protein containing food products | |
| GB1346319A (en) | Artificial insemination of sows | |
| JPS5515728A (en) | Food antiseptic | |
| SU593694A1 (en) | Method of making marmalade jelly |