GB2488838A - A stable antimicrobial aqueous hypochlorous acid solution - Google Patents
A stable antimicrobial aqueous hypochlorous acid solution Download PDFInfo
- Publication number
- GB2488838A GB2488838A GB1104180.3A GB201104180A GB2488838A GB 2488838 A GB2488838 A GB 2488838A GB 201104180 A GB201104180 A GB 201104180A GB 2488838 A GB2488838 A GB 2488838A
- Authority
- GB
- United Kingdom
- Prior art keywords
- solution
- composition
- calcium
- chloride
- hypochlorous acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 title claims abstract description 99
- 230000000845 anti-microbial effect Effects 0.000 title claims abstract description 10
- 239000000203 mixture Substances 0.000 claims abstract description 110
- 239000000243 solution Substances 0.000 claims abstract description 98
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims abstract description 50
- 239000000460 chlorine Substances 0.000 claims abstract description 50
- 229910052801 chlorine Inorganic materials 0.000 claims abstract description 49
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims abstract description 45
- WQYVRQLZKVEZGA-UHFFFAOYSA-N hypochlorite Inorganic materials Cl[O-] WQYVRQLZKVEZGA-UHFFFAOYSA-N 0.000 claims abstract description 41
- 238000000034 method Methods 0.000 claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 33
- 229910001868 water Inorganic materials 0.000 claims abstract description 30
- 239000002253 acid Substances 0.000 claims abstract description 27
- 230000008569 process Effects 0.000 claims abstract description 24
- ZKQDCIXGCQPQNV-UHFFFAOYSA-N Calcium hypochlorite Chemical compound [Ca+2].Cl[O-].Cl[O-] ZKQDCIXGCQPQNV-UHFFFAOYSA-N 0.000 claims abstract description 20
- 239000007864 aqueous solution Substances 0.000 claims abstract description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims abstract description 17
- 239000011575 calcium Substances 0.000 claims abstract description 17
- 229910052791 calcium Inorganic materials 0.000 claims abstract description 17
- -1 hypochlorite ions Chemical class 0.000 claims abstract description 16
- 239000003381 stabilizer Substances 0.000 claims abstract description 12
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims abstract description 11
- 239000001110 calcium chloride Substances 0.000 claims abstract description 11
- 229910001628 calcium chloride Inorganic materials 0.000 claims abstract description 11
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 9
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 9
- 239000007787 solid Substances 0.000 claims abstract description 9
- 239000012670 alkaline solution Substances 0.000 claims abstract description 4
- 230000001376 precipitating effect Effects 0.000 claims abstract description 3
- 150000002367 halogens Chemical class 0.000 claims description 19
- 229910052736 halogen Inorganic materials 0.000 claims description 18
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 14
- 230000001954 sterilising effect Effects 0.000 claims description 10
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 8
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 7
- 239000004599 antimicrobial Substances 0.000 claims description 5
- 239000003139 biocide Substances 0.000 claims description 5
- 239000008367 deionised water Substances 0.000 claims description 5
- 239000000872 buffer Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 230000003115 biocidal effect Effects 0.000 claims description 3
- 229910001919 chlorite Inorganic materials 0.000 claims description 3
- 229910052619 chlorite group Inorganic materials 0.000 claims description 3
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000011065 in-situ storage Methods 0.000 claims description 3
- 239000002671 adjuvant Substances 0.000 claims description 2
- 239000002738 chelating agent Substances 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
- 239000003205 fragrance Substances 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims description 2
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- YAZGETHGAUUENC-UHFFFAOYSA-M [Na+].[Cl-].OCl Chemical compound [Na+].[Cl-].OCl YAZGETHGAUUENC-UHFFFAOYSA-M 0.000 claims 1
- 125000000129 anionic group Chemical group 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 238000002360 preparation method Methods 0.000 abstract description 7
- 150000002500 ions Chemical class 0.000 abstract description 4
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 15
- 239000004094 surface-active agent Substances 0.000 description 15
- 241000894007 species Species 0.000 description 12
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- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 description 8
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- 239000005708 Sodium hypochlorite Substances 0.000 description 7
- 239000012267 brine Substances 0.000 description 7
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 7
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 7
- 238000001356 surgical procedure Methods 0.000 description 7
- 235000013311 vegetables Nutrition 0.000 description 7
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 206010052428 Wound Diseases 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 244000005700 microbiome Species 0.000 description 6
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
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- 231100000397 ulcer Toxicity 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000003513 alkali Substances 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
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- YIROYDNZEPTFOL-UHFFFAOYSA-N 5,5-Dimethylhydantoin Chemical compound CC1(C)NC(=O)NC1=O YIROYDNZEPTFOL-UHFFFAOYSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- XTEGARKTQYYJKE-UHFFFAOYSA-M Chlorate Chemical compound [O-]Cl(=O)=O XTEGARKTQYYJKE-UHFFFAOYSA-M 0.000 description 2
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- 240000008415 Lactuca sativa Species 0.000 description 2
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
- 229910019142 PO4 Inorganic materials 0.000 description 2
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- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000004061 bleaching Methods 0.000 description 2
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- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
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- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 1
- 239000002019 doping agent Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 210000000883 ear external Anatomy 0.000 description 1
- 210000003027 ear inner Anatomy 0.000 description 1
- 238000002848 electrochemical method Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229940096118 ella Drugs 0.000 description 1
- 231100000013 eye irritation Toxicity 0.000 description 1
- 238000009313 farming Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 150000004820 halides Chemical class 0.000 description 1
- 125000001475 halogen functional group Chemical group 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 description 1
- 229940091173 hydantoin Drugs 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 1
- 230000005847 immunogenicity Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 238000012994 industrial processing Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910001502 inorganic halide Inorganic materials 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 229940048866 lauramine oxide Drugs 0.000 description 1
- 229910052744 lithium Inorganic materials 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 1
- 235000019341 magnesium sulphate Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 235000009973 maize Nutrition 0.000 description 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
- 239000011976 maleic acid Substances 0.000 description 1
- 238000007726 management method Methods 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 229910052751 metal Chemical group 0.000 description 1
- 239000002184 metal Chemical group 0.000 description 1
- 150000001455 metallic ions Chemical class 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 230000002906 microbiologic effect Effects 0.000 description 1
- 230000003158 microbiostatic effect Effects 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
- 230000004719 natural immunity Effects 0.000 description 1
- 230000007524 negative regulation of DNA replication Effects 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000002352 nonmutagenic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 231100000418 oral toxicity Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- ZVBCXGNEXBNMRA-UHFFFAOYSA-N oxalic acid phosphorous acid Chemical compound OP(O)O.OC(=O)C(O)=O ZVBCXGNEXBNMRA-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229940086539 peg-7 glyceryl cocoate Drugs 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000003239 periodontal effect Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 235000014102 seafood Nutrition 0.000 description 1
- 238000009958 sewing Methods 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 201000010153 skin papilloma Diseases 0.000 description 1
- 231100000370 skin sensitisation Toxicity 0.000 description 1
- 231100000019 skin ulcer Toxicity 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- 229940045885 sodium lauroyl sarcosinate Drugs 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 239000012265 solid product Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000009182 swimming Effects 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
- OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
- 230000035899 viability Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N59/00—Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
- A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/04—Hypochlorous acid
- C01B11/06—Hypochlorites
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/04—Hypochlorous acid
- C01B11/06—Hypochlorites
- C01B11/064—Hypochlorites of alkaline-earth metals
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B11/00—Oxides or oxyacids of halogens; Salts thereof
- C01B11/04—Hypochlorous acid
- C01B11/06—Hypochlorites
- C01B11/068—Stabilisation by additives other than oxides, hydroxides, carbonates of alkali or alkaline-earth metals; Coating of particles; Shaping; Granulation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Environmental Sciences (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1104180.3A GB2488838A (en) | 2011-03-11 | 2011-03-11 | A stable antimicrobial aqueous hypochlorous acid solution |
| PCT/GB2012/000228 WO2012123695A2 (en) | 2011-03-11 | 2012-03-08 | A stable composition of hoci, processes for its production and uses thereof |
| EP12712138.2A EP2683240A2 (en) | 2011-03-11 | 2012-03-08 | A stable composition of hoci, processes for its production and uses thereof |
| JP2013558492A JP2014515737A (ja) | 2011-03-11 | 2012-03-08 | ＨＯＣｌの安定な組成物、その製造方法、およびその使用 |
| EA201391317A EA201391317A1 (ru) | 2011-03-11 | 2012-03-08 | Стабильная композиция хлорноватистой кислоты, способы ее получения и применение |
| US14/004,094 US20140134224A1 (en) | 2011-03-11 | 2012-03-08 | Stable composition of hoci, a process for its production and uses thereof |
| CN201280012861.0A CN103501605B (zh) | 2011-03-11 | 2012-03-08 | HOCl的稳定的组合物、其生产和使用方法 |
| MX2013010362A MX2013010362A (es) | 2011-03-11 | 2012-03-08 | Una composicion estable de hoc1, procedimientos para su produccion y usos de los mismos. |
| CA2829449A CA2829449A1 (en) | 2011-03-11 | 2012-03-08 | A stable composition of hoci, processes for its production and uses thereof |
| BR112013023170A BR112013023170A2 (pt) | 2011-03-11 | 2012-03-08 | processo para preparar uma solução aquosa, solução aquosa, composição, uso de uma solução aquosa, material não tecido, e, método para esterilizar um objeto animado ou inanimado |
| CL2013002599A CL2013002599A1 (es) | 2011-03-11 | 2013-09-10 | Composición que comprende una solución de ácido hipocloroso (hocl); proceso para preparar solución acuosa de hocl; uso como agente antimicrobiano, como agente de limpieza o esterilizador; material impregnado con la composición y uso para esterilizar objetos. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1104180.3A GB2488838A (en) | 2011-03-11 | 2011-03-11 | A stable antimicrobial aqueous hypochlorous acid solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| GB201104180D0 GB201104180D0 (en) | 2011-04-27 |
| GB2488838A true GB2488838A (en) | 2012-09-12 |
Family
ID=43980865
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1104180.3A Withdrawn GB2488838A (en) | 2011-03-11 | 2011-03-11 | A stable antimicrobial aqueous hypochlorous acid solution |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20140134224A1 (enExample) |
| EP (1) | EP2683240A2 (enExample) |
| JP (1) | JP2014515737A (enExample) |
| CN (1) | CN103501605B (enExample) |
| BR (1) | BR112013023170A2 (enExample) |
| CA (1) | CA2829449A1 (enExample) |
| CL (1) | CL2013002599A1 (enExample) |
| EA (1) | EA201391317A1 (enExample) |
| GB (1) | GB2488838A (enExample) |
| MX (1) | MX2013010362A (enExample) |
| WO (1) | WO2012123695A2 (enExample) |
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| WO2017189792A1 (en) * | 2016-04-27 | 2017-11-02 | Biiosmart Technologies Llc | Use of hypochlorous acid as a topical antimicrobial |
| RU2710600C1 (ru) * | 2018-10-12 | 2019-12-30 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" (ФГБНУ ФНЦ ВИЭВ РАН) | Способ дезинфекции объектов ветеринарного надзора |
| RU2711189C1 (ru) * | 2018-10-12 | 2020-01-15 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" (ФГБНУ ФНЦ ВИЭВ РАН) | Способ дезинфекции объектов ветеринарного надзора |
| GB2584528A (en) * | 2019-02-28 | 2020-12-09 | Clinical Health Tech Ltd | Stabilised hypochlorous solutions and their medical and cosmetic uses |
| US11672825B2 (en) * | 2012-02-17 | 2023-06-13 | Wiab Water Innovation Ab | Acetic acid and hypochlorous acid compositions for treatment of biofilms and wound care |
| EP4332272A1 (en) | 2022-08-31 | 2024-03-06 | Ioannis Kontonis | Solution |
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| US20220323626A1 (en) * | 2019-06-14 | 2022-10-13 | Collidion, Inc. | Compositions, Kits, Methods and Uses for Preventing Microbial Growth |
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| BR112022016156A2 (pt) * | 2020-02-14 | 2022-11-22 | Collidion Inc | Composiçoes, kits, métodos e usos para limpeza, desinfecção, esterilização e/ou tratamento |
| JP7573845B2 (ja) * | 2020-02-19 | 2024-10-28 | 株式会社ピーズガード | 清拭シート及び清拭シート製品 |
| US20230149444A1 (en) * | 2020-04-03 | 2023-05-18 | Phase One Health, Llc | Hypochlorous acid solutions and methods of use |
| JP2021172649A (ja) * | 2020-04-17 | 2021-11-01 | ニプロ株式会社 | 次亜塩素酸を主成分とする水溶液 |
| JPWO2021235554A1 (enExample) * | 2020-05-22 | 2021-11-25 | ||
| US11845916B2 (en) | 2020-06-24 | 2023-12-19 | The Clorox Company | Burstable sporicidal cleaning wipe system containing stabilized hypochlorite |
| IL299751A (en) * | 2020-07-07 | 2023-03-01 | Wiab Water Innovation Ab | Preparations and methods for disinfection, treatment and prevention of bacterial infections |
| CN112501638A (zh) * | 2020-08-10 | 2021-03-16 | 中山市原域企业投资有限公司 | 一种两液法结合电解法制备次氯酸的工艺及设备 |
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| CN112586506A (zh) * | 2020-12-26 | 2021-04-02 | 深圳市疆河生物科技有限公司 | 一种高稳定的分子态次氯酸水溶液及其制备方法 |
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| KR20220154289A (ko) | 2021-05-12 | 2022-11-22 | 이희두 | 드라이포그 방식의 공기(Air) 살균소독세척 방역 시스템 |
| WO2022243919A1 (en) * | 2021-05-20 | 2022-11-24 | Swiss Newater Holding Sàrl | A sanitizer composition comprising electrolyzed water |
| CN115868482A (zh) * | 2022-11-30 | 2023-03-31 | 上海卓景生物科技有限公司 | 一种次氯酸钠消毒液的生产工艺 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2028930A1 (en) * | 1990-10-30 | 1992-05-01 | Norman A. Miner | Stable hypochlorous acid sterilizing solution and kit |
| EP1236398A1 (en) * | 1999-12-10 | 2002-09-04 | Kao Corporation | Microbicide compositions |
| JP2003040715A (ja) * | 2001-07-26 | 2003-02-13 | Tadashi Inoue | 次亜塩素酸水溶液散布による農作物病害の防除方法 |
| WO2010148004A1 (en) * | 2009-06-15 | 2010-12-23 | Oculus Innovative Sciences, Inc. | Solution containing hypochlorous acid and methods of using same |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2111194A (en) * | 1934-01-12 | 1938-03-15 | Sanchez Pedro | Method of producing hypochlorous acid solution |
| US2438781A (en) | 1944-09-07 | 1948-03-30 | Boyle Midway Inc | Stabilized hypochlorite solutions and process therefor |
| GB1021287A (en) | 1964-09-21 | 1966-03-02 | Samuel Raymond | Improvements in vertical gel electrophoresis apparatus |
| US3791840A (en) * | 1970-10-21 | 1974-02-12 | Union Carbide Corp | Treatment of carbon fibers to improve shear strength in composites |
| US3749672A (en) | 1971-04-19 | 1973-07-31 | Du Pont | Stabilized solutions of n-halo compounds |
| AU536179B2 (en) * | 1979-05-29 | 1984-04-19 | Toyo Soda Manufacturing Co. Ltd. | Calcium hypochlorite |
| GB2078522B (en) * | 1980-06-26 | 1984-01-11 | Antec Ah International Ltd | Improvements in and relating to sanitizing compositions |
| US4337236A (en) | 1980-08-07 | 1982-06-29 | Olin Corporation | Process for manufacture of calcium hypochlorite |
| US4468377A (en) * | 1983-03-07 | 1984-08-28 | Olin Corporation | Continuous process for the manufacture of calcium hypochlorite |
| GB8920973D0 (en) | 1989-09-15 | 1989-11-01 | Auchincloss Thomas R | Effervescent tablets |
| US5532389A (en) * | 1993-11-23 | 1996-07-02 | The Dow Chemical Company | Process for preparing alkylene oxides |
| US6162371A (en) | 1997-12-22 | 2000-12-19 | S. C. Johnson & Son, Inc. | Stabilized acidic chlorine bleach composition and method of use |
| US6019905A (en) * | 1998-01-20 | 2000-02-01 | Waggoner; Mark B. | Process for sanitizing chlorinated water |
| JP3004958B2 (ja) * | 1998-02-19 | 2000-01-31 | クリーンケミカル株式会社 | 殺菌消毒用製剤 |
| DE60027550T2 (de) * | 1999-02-24 | 2007-04-26 | Kay Chemical Co. | Farbstabiler hypochloriger entkeimer und entkeimungsverfahren |
| US6471974B1 (en) | 1999-06-29 | 2002-10-29 | S.C. Johnson & Son, Inc. | N-chlorosulfamate compositions having enhanced antimicrobial efficacy |
| JP3607578B2 (ja) * | 2000-03-31 | 2005-01-05 | 花王株式会社 | 硬質表面用殺菌洗浄剤組成物 |
| JP3554749B2 (ja) * | 2001-02-22 | 2004-08-18 | 株式会社アクシス | 殺菌消毒剤 |
| WO2004098657A1 (ja) * | 2003-05-12 | 2004-11-18 | Veeta Inc. | 次亜塩素酸又は亜塩素酸を含む殺菌水の生成方法、殺菌原料パッケージ及び殺菌水生成キット並びに空間殺菌方法及び装置 |
| US20040256330A1 (en) * | 2003-05-12 | 2004-12-23 | Tatsuo Okazaki | Method of preparing sterile water containing hypochlorous or chlorous acid, package of sterile source materials, sterile water preparation kit, method and apparatus for spatial sterilization |
| US20040226894A1 (en) * | 2003-05-12 | 2004-11-18 | Tatsuo Okazaki | Method of preparing a sterile water containing hypochlorous or chlorous acid, package of sterile source materials, and sterile water preparation kit |
| JP2005000238A (ja) * | 2003-06-09 | 2005-01-06 | Hiromaito Co Ltd | 殺菌剤水溶液充填容器の製造方法 |
| KR101190766B1 (ko) * | 2003-06-27 | 2012-10-12 | 더 유니버시티 오브 헐 | 스포로폴레닌 또는 유도체화된 스포로폴레닌의 외피막을포함하는 투약 제형 |
| JP2004337582A (ja) * | 2003-10-27 | 2004-12-02 | Tatsuo Okazaki | 殺菌液保存方法及び殺菌用容器並びにこれに用いられる開閉弁付きノズル |
| US8945630B2 (en) | 2008-04-11 | 2015-02-03 | Aquilabs S.A. | Method of producing and applications of composition of hypochlorous acid |
| GB2477717A (en) * | 2010-02-03 | 2011-08-17 | Mauve Technology Ltd | Disinfectant materials and methods |
-
2011
- 2011-03-11 GB GB1104180.3A patent/GB2488838A/en not_active Withdrawn
-
2012
- 2012-03-08 MX MX2013010362A patent/MX2013010362A/es not_active Application Discontinuation
- 2012-03-08 CN CN201280012861.0A patent/CN103501605B/zh not_active Expired - Fee Related
- 2012-03-08 JP JP2013558492A patent/JP2014515737A/ja active Pending
- 2012-03-08 WO PCT/GB2012/000228 patent/WO2012123695A2/en not_active Ceased
- 2012-03-08 EP EP12712138.2A patent/EP2683240A2/en not_active Withdrawn
- 2012-03-08 US US14/004,094 patent/US20140134224A1/en not_active Abandoned
- 2012-03-08 CA CA2829449A patent/CA2829449A1/en not_active Abandoned
- 2012-03-08 BR BR112013023170A patent/BR112013023170A2/pt not_active IP Right Cessation
- 2012-03-08 EA EA201391317A patent/EA201391317A1/ru unknown
-
2013
- 2013-09-10 CL CL2013002599A patent/CL2013002599A1/es unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2028930A1 (en) * | 1990-10-30 | 1992-05-01 | Norman A. Miner | Stable hypochlorous acid sterilizing solution and kit |
| EP1236398A1 (en) * | 1999-12-10 | 2002-09-04 | Kao Corporation | Microbicide compositions |
| JP2003040715A (ja) * | 2001-07-26 | 2003-02-13 | Tadashi Inoue | 次亜塩素酸水溶液散布による農作物病害の防除方法 |
| WO2010148004A1 (en) * | 2009-06-15 | 2010-12-23 | Oculus Innovative Sciences, Inc. | Solution containing hypochlorous acid and methods of using same |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11672825B2 (en) * | 2012-02-17 | 2023-06-13 | Wiab Water Innovation Ab | Acetic acid and hypochlorous acid compositions for treatment of biofilms and wound care |
| US12220429B2 (en) | 2012-02-17 | 2025-02-11 | Wiab Water Innovation Ab | Hand disinfectant |
| WO2017189792A1 (en) * | 2016-04-27 | 2017-11-02 | Biiosmart Technologies Llc | Use of hypochlorous acid as a topical antimicrobial |
| US20190125790A1 (en) * | 2016-04-27 | 2019-05-02 | Biiosmart Technologies Llc | Use of hypochlorous acid as a topical antimicrobial |
| RU2710600C1 (ru) * | 2018-10-12 | 2019-12-30 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" (ФГБНУ ФНЦ ВИЭВ РАН) | Способ дезинфекции объектов ветеринарного надзора |
| RU2711189C1 (ru) * | 2018-10-12 | 2020-01-15 | Федеральное государственное бюджетное научное учреждение "Федеральный научный центр - Всероссийский научно-исследовательский институт экспериментальной ветеринарии имени К.И. Скрябина и Я.Р. Коваленко Российской академии наук" (ФГБНУ ФНЦ ВИЭВ РАН) | Способ дезинфекции объектов ветеринарного надзора |
| GB2584528A (en) * | 2019-02-28 | 2020-12-09 | Clinical Health Tech Ltd | Stabilised hypochlorous solutions and their medical and cosmetic uses |
| US11517526B2 (en) | 2019-02-28 | 2022-12-06 | Clinical Health Technologies Ltd. | Stabilised hypochlorous solutions and their medical cosmetic uses |
| GB2584528B (en) * | 2019-02-28 | 2023-03-22 | Clinical Health Tech Ltd | Stabilised hypochlorous solutions and their medical and cosmetic uses |
| EP4332272A1 (en) | 2022-08-31 | 2024-03-06 | Ioannis Kontonis | Solution |
| WO2024047136A1 (en) | 2022-08-31 | 2024-03-07 | Ioannis Kontonis | Solution |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103501605A (zh) | 2014-01-08 |
| WO2012123695A3 (en) | 2013-08-01 |
| EP2683240A2 (en) | 2014-01-15 |
| MX2013010362A (es) | 2014-04-14 |
| BR112013023170A2 (pt) | 2016-07-26 |
| CL2013002599A1 (es) | 2014-10-03 |
| JP2014515737A (ja) | 2014-07-03 |
| EA201391317A1 (ru) | 2014-02-28 |
| GB201104180D0 (en) | 2011-04-27 |
| CA2829449A1 (en) | 2012-09-20 |
| US20140134224A1 (en) | 2014-05-15 |
| CN103501605B (zh) | 2015-07-22 |
| WO2012123695A2 (en) | 2012-09-20 |
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