GB2477590A - A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier - Google Patents

A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier Download PDF

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Publication number
GB2477590A
GB2477590A GB1015878A GB201015878A GB2477590A GB 2477590 A GB2477590 A GB 2477590A GB 1015878 A GB1015878 A GB 1015878A GB 201015878 A GB201015878 A GB 201015878A GB 2477590 A GB2477590 A GB 2477590A
Authority
GB
United Kingdom
Prior art keywords
oil
composition according
acid
composition
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB1015878A
Other languages
English (en)
Other versions
GB201015878D0 (en
Inventor
John Brew
Robin Mark Bannister
Wilson Caparrys-Wanderley
Gregory Stoloff
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biocopea Ltd
Original Assignee
Biocopea Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1001912.3A external-priority patent/GB201001912D0/en
Application filed by Biocopea Ltd filed Critical Biocopea Ltd
Priority to GB1015878A priority Critical patent/GB2477590A/en
Publication of GB201015878D0 publication Critical patent/GB201015878D0/en
Priority to JP2012551685A priority patent/JP2013518869A/ja
Priority to US13/576,758 priority patent/US20130178448A1/en
Priority to AU2011212256A priority patent/AU2011212256A1/en
Priority to PCT/GB2011/050189 priority patent/WO2011095814A1/en
Priority to SG2012057865A priority patent/SG183176A1/en
Priority to NZ601594A priority patent/NZ601594A/en
Priority to CA2788766A priority patent/CA2788766A1/en
Priority to CN2011800180526A priority patent/CN102858333A/zh
Priority to SG10201500899VA priority patent/SG10201500899VA/en
Priority to RU2012137785/15A priority patent/RU2012137785A/ru
Priority to EP11702694A priority patent/EP2531188A1/en
Priority to MX2012009052A priority patent/MX2012009052A/es
Publication of GB2477590A publication Critical patent/GB2477590A/en
Priority to ZA2012/05829A priority patent/ZA201205829B/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Otolaryngology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB1015878A 2010-02-05 2010-09-22 A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier Withdrawn GB2477590A (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
GB1015878A GB2477590A (en) 2010-02-05 2010-09-22 A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier
EP11702694A EP2531188A1 (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
MX2012009052A MX2012009052A (es) 2010-02-05 2011-02-04 Tratamiento de trastornos respiratorios.
SG2012057865A SG183176A1 (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
CN2011800180526A CN102858333A (zh) 2010-02-05 2011-02-04 呼吸紊乱的治疗
AU2011212256A AU2011212256A1 (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
PCT/GB2011/050189 WO2011095814A1 (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
JP2012551685A JP2013518869A (ja) 2010-02-05 2011-02-04 呼吸器疾患の治療
NZ601594A NZ601594A (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
CA2788766A CA2788766A1 (en) 2010-02-05 2011-02-04 Treatment of respiratory disorders
US13/576,758 US20130178448A1 (en) 2010-02-05 2011-02-04 Treatment of Respiratory Disorders
SG10201500899VA SG10201500899VA (en) 2010-02-05 2011-02-04 Treatment Of Respiratory Disorders
RU2012137785/15A RU2012137785A (ru) 2010-02-05 2011-02-04 Лечение респираторных заболеваний
ZA2012/05829A ZA201205829B (en) 2010-02-05 2012-08-02 Treatment of respiratory disorders

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1001912.3A GB201001912D0 (en) 2010-02-05 2010-02-05 Treatment of respiratory disorders
GB1015878A GB2477590A (en) 2010-02-05 2010-09-22 A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier

Publications (2)

Publication Number Publication Date
GB201015878D0 GB201015878D0 (en) 2010-10-27
GB2477590A true GB2477590A (en) 2011-08-10

Family

ID=43927856

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1015878A Withdrawn GB2477590A (en) 2010-02-05 2010-09-22 A non-steroidal anti-inflammatory drug (NSAID) formulation comprising a lipid carrier

Country Status (13)

Country Link
US (1) US20130178448A1 (enExample)
EP (1) EP2531188A1 (enExample)
JP (1) JP2013518869A (enExample)
CN (1) CN102858333A (enExample)
AU (1) AU2011212256A1 (enExample)
CA (1) CA2788766A1 (enExample)
GB (1) GB2477590A (enExample)
MX (1) MX2012009052A (enExample)
NZ (1) NZ601594A (enExample)
RU (1) RU2012137785A (enExample)
SG (2) SG10201500899VA (enExample)
WO (1) WO2011095814A1 (enExample)
ZA (1) ZA201205829B (enExample)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2487808A (en) * 2010-10-29 2012-08-08 Biocopea Ltd Oral adjuvant or formulation comprising a lipid and an alcohol
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US9504664B2 (en) 2010-10-29 2016-11-29 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9737500B2 (en) 2010-10-29 2017-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain
US9744132B2 (en) 2010-10-29 2017-08-29 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
US10695431B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US10695432B2 (en) 2010-10-29 2020-06-30 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11202831B2 (en) 2010-10-29 2021-12-21 Infirst Healthcare Limited Solid solution compositions and use in cardiovascular disease
US11224659B2 (en) 2010-10-29 2022-01-18 Infirst Healthcare Limited Solid solution compositions and use in severe pain
US11730709B2 (en) 2010-10-29 2023-08-22 Infirst Healthcare Limited Compositions and methods for treating severe pain

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WO2012104655A2 (en) 2011-02-04 2012-08-09 Biocopea Limited Compostions and methods for treating chronic inflammation and inflammatory diseases
KR102162901B1 (ko) 2011-09-29 2020-10-08 피엘엑스 옵코 인코포레이티드 위장관을 따라 약물을 표적화 방출하기 위한 pH 감응성 담체, 그로부터의 조성물, 및 이들의 제조 및 사용 방법
EP2704696A1 (en) 2012-03-26 2014-03-12 Glatt AG Taste-masked ibuprofen granules
CN103893171B (zh) * 2014-04-19 2016-05-25 武汉胜达康生物科技有限公司 盐酸苄达明在制备治疗或预防流感病毒感染药物中的应用
US20150343139A1 (en) * 2014-05-30 2015-12-03 Boston Scientific Scimed, Inc. Implantable pumps and related methods of use
AR102172A1 (es) 2015-10-05 2017-02-08 Química Luar S R L Una composición farmacéutica bactericida y virucida
CN109464670B (zh) * 2017-09-08 2022-08-02 中国科学院微生物研究所 调控a型和b型流感病毒核蛋白出核的关键氨基酸位点及其作为抗流感病毒药物靶点的用途
MX2022011743A (es) 2020-03-26 2022-12-08 Plx Opco Inc Portadores farmaceuticos con capacidad de reconstitucion dependiente del ph y metodos para elaborar y usar los mismos.
US12324853B2 (en) 2020-08-10 2025-06-10 Quimica Luar S.R.L. Methods for treating respiratory viral infections
US20240083885A1 (en) * 2020-12-04 2024-03-14 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for inhibiting m pro protease activity and for preventing and treating sars-cov-2 infection

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JPH069381A (ja) * 1992-03-26 1994-01-18 Toyo Capsule Kk イブプロフェン含有軟カプセル剤
WO2002085414A2 (en) * 2000-12-19 2002-10-31 The Board Of Regents Of The University Of Texas System Nsaid formulations comprising lecithin oils for protecting the gastrointestinal tract and providing enhanced therapeutic activity
US20030232097A1 (en) * 2002-06-17 2003-12-18 Strides Inc. Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen
US20050152968A1 (en) * 2004-01-09 2005-07-14 Brophy Kristine M. Microemulsions for pharmaceutical compositions
US20060062810A1 (en) * 2002-11-08 2006-03-23 Jong-Soo Woo Microemulsion concentrate for oral administration of water-insoluble anti-cold drug and method for preparing same
JP2008143807A (ja) * 2006-12-07 2008-06-26 Sato Pharmaceutical Co Ltd 感冒薬カプセル剤及びその製造方法
WO2009069139A1 (en) * 2007-11-28 2009-06-04 Alkem Laboratories Ltd. Dosage form providing an ibuprofen-containing liquid fill
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WO2010059717A2 (en) * 2008-11-19 2010-05-27 Merial Limited Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol

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Publication number Priority date Publication date Assignee Title
JPH069381A (ja) * 1992-03-26 1994-01-18 Toyo Capsule Kk イブプロフェン含有軟カプセル剤
WO2002085414A2 (en) * 2000-12-19 2002-10-31 The Board Of Regents Of The University Of Texas System Nsaid formulations comprising lecithin oils for protecting the gastrointestinal tract and providing enhanced therapeutic activity
US20030232097A1 (en) * 2002-06-17 2003-12-18 Strides Inc. Oily wax matrix suspension formulation comprising ibuprofen free acid and potassium salt of ibuprofen
US20060062810A1 (en) * 2002-11-08 2006-03-23 Jong-Soo Woo Microemulsion concentrate for oral administration of water-insoluble anti-cold drug and method for preparing same
US20050152968A1 (en) * 2004-01-09 2005-07-14 Brophy Kristine M. Microemulsions for pharmaceutical compositions
JP2008143807A (ja) * 2006-12-07 2008-06-26 Sato Pharmaceutical Co Ltd 感冒薬カプセル剤及びその製造方法
WO2009069139A1 (en) * 2007-11-28 2009-06-04 Alkem Laboratories Ltd. Dosage form providing an ibuprofen-containing liquid fill
JP2009155282A (ja) * 2007-12-27 2009-07-16 Kowa Co 固体分散体含有医薬組成物
WO2010059717A2 (en) * 2008-11-19 2010-05-27 Merial Limited Formulations comprising ceftiofur and ketoprofen or ceftiofur and benzyl alcohol

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Cited By (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2487808A (en) * 2010-10-29 2012-08-08 Biocopea Ltd Oral adjuvant or formulation comprising a lipid and an alcohol
US8895537B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating cardiovascular diseases
US8895536B2 (en) 2010-10-29 2014-11-25 Infirst Healthcare Ltd. Compositions and methods for treating chronic inflammation and inflammatory diseases
US9265742B2 (en) 2010-10-29 2016-02-23 Infirst Healthcare Limited Compositions and methods for treating inflammatory pain
US9271950B2 (en) 2010-10-29 2016-03-01 Infirst Healthcare Limited Compositions for treating chronic inflammation and inflammatory diseases
US9308213B2 (en) 2010-10-29 2016-04-12 Infirst Healthcare Limited Solid solution compositions and use in chronic inflammation
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EP2531188A1 (en) 2012-12-12
AU2011212256A1 (en) 2012-08-23
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ZA201205829B (en) 2013-05-29
RU2012137785A (ru) 2014-03-10
CN102858333A (zh) 2013-01-02
MX2012009052A (es) 2012-11-29
US20130178448A1 (en) 2013-07-11
CA2788766A1 (en) 2011-08-11
JP2013518869A (ja) 2013-05-23

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