GB2128615B - Platinum 1,3-propane diamine complexes - Google Patents

Platinum 1,3-propane diamine complexes

Info

Publication number
GB2128615B
GB2128615B GB08328084A GB8328084A GB2128615B GB 2128615 B GB2128615 B GB 2128615B GB 08328084 A GB08328084 A GB 08328084A GB 8328084 A GB8328084 A GB 8328084A GB 2128615 B GB2128615 B GB 2128615B
Authority
GB
United Kingdom
Prior art keywords
platinum
propane diamine
diamine complexes
complexes
propane
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08328084A
Other languages
English (en)
Other versions
GB8328084D0 (en
GB2128615A (en
Inventor
Francois Verbeek
Jan Berg
Eric Jan Bulten
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Original Assignee
Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO filed Critical Nederlandse Organisatie voor Toegepast Natuurwetenschappelijk Onderzoek TNO
Publication of GB8328084D0 publication Critical patent/GB8328084D0/en
Publication of GB2128615A publication Critical patent/GB2128615A/en
Application granted granted Critical
Publication of GB2128615B publication Critical patent/GB2128615B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB08328084A 1982-10-21 1983-10-20 Platinum 1,3-propane diamine complexes Expired GB2128615B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8204067A NL8204067A (nl) 1982-10-21 1982-10-21 Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een geneesmiddel met toepassing van een dergelijk platinadiaminecomplex voor de behandeling van kanker, alsmede aldus verkregen gevormd geneesmiddel.

Publications (3)

Publication Number Publication Date
GB8328084D0 GB8328084D0 (en) 1983-11-23
GB2128615A GB2128615A (en) 1984-05-02
GB2128615B true GB2128615B (en) 1986-07-16

Family

ID=19840444

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08328084A Expired GB2128615B (en) 1982-10-21 1983-10-20 Platinum 1,3-propane diamine complexes

Country Status (28)

Country Link
JP (1) JPS5993091A (fi)
KR (1) KR910002536B1 (fi)
AT (1) AT390610B (fi)
AU (1) AU562964B2 (fi)
BE (1) BE898058A (fi)
CA (1) CA1229618A (fi)
CH (1) CH658244A5 (fi)
CS (1) CS242888B2 (fi)
DD (1) DD217522A5 (fi)
DE (1) DE3337333A1 (fi)
DK (2) DK483083A (fi)
ES (1) ES526670A0 (fi)
FI (1) FI76351C (fi)
FR (1) FR2534907B1 (fi)
GB (1) GB2128615B (fi)
GR (1) GR79652B (fi)
HU (1) HU188035B (fi)
IE (1) IE56124B1 (fi)
IT (1) IT1169858B (fi)
LU (1) LU85054A1 (fi)
NL (1) NL8204067A (fi)
NO (1) NO171276C (fi)
NZ (1) NZ206018A (fi)
PH (1) PH24077A (fi)
PT (1) PT77542B (fi)
SE (1) SE8305783L (fi)
YU (1) YU43554B (fi)
ZA (1) ZA837857B (fi)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150299237A1 (en) * 2012-10-29 2015-10-22 Southeast University Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4786725A (en) * 1982-06-28 1988-11-22 Engelhard Corporation Solubilized platinum (II) complexes
US4758588A (en) * 1983-06-20 1988-07-19 Research Corporation Technologies Diaminocyclohexane platinum complexes
US4661516A (en) * 1983-06-20 1987-04-28 Research Corporation Diaminocyclohexane platinum complexes
EP0169645A1 (en) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platinum co-ordination compounds
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
HU193809B (en) * 1984-09-12 1987-12-28 Chugai Pharmaceutical Co Ltd Process for producing new platinum complexes
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
US4880790A (en) * 1986-01-31 1989-11-14 American Cyanamid Company (Gem-heterocyclodimethanamine-N,N')platinum complexes
US4760157A (en) * 1986-01-31 1988-07-26 American Cyanamid Company (2,2,-bis(aminomethyl)-1,3-propanediol-N,N')platinum complexes
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
ES2016313B3 (es) * 1986-10-03 1990-11-01 Asta Pharma Ag Compuestos de complejos diamina-platino (ii) con un anillo fenil-indol hidroxilado.
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
AT390065B (de) * 1987-10-08 1990-03-12 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
NL8802149A (nl) * 1988-08-31 1990-03-16 Tno Platina-(iv)diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat ten minste een platinaverbinding bevat, alsmede gevormde preparaten met anti-tumor werking.
NL8802150A (nl) * 1988-08-31 1990-03-16 Tno Platina-(ii)-diaminecomplex, werkwijze voor het bereiden van deze verbinding, preparaat met anti-tumor werking, dat deze verbinding bevat, alsmede gevormde preparaten met anti-tumor werking.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4115418A (en) * 1976-09-02 1978-09-19 Government Of The United States Of America 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity
US4206226A (en) * 1977-08-29 1980-06-03 The United States Of America As Represented By The Department Of Health, Education And Welfare Use of 4-carboxy-phthalato-(1,2-diaminocyclohexane)-platinum(II) and alkali metal salts thereof in alleviating L1210 murine leukemia
NL7807334A (nl) * 1978-07-06 1980-01-08 Tno Platina-diaminecomplexen, werkwijze voor het bereiden daarvan, werkwijze voor het bereiden van een genees- middel met toepassing van een dergelijk platina-dia- minecomplex voor de behandeling van kanker, alsmede al- dus verkregen gevormd geneesmiddel.
NL189358C (nl) * 1978-07-06 1993-03-16 Tno Werkwijze voor het bereiden van een geneesmiddel voor de behandeling van kanker, alsmede een van een 1,3-alkaandiamine afgeleid platina-diamminecomplex.
AU538863B2 (en) * 1980-05-27 1984-08-30 Bristol-Myers Company Platinum complex salts have anti-tumor property
US4322362A (en) * 1980-07-28 1982-03-30 Bristol-Myers Company Salts of 2-hydroxymalonate platinum complexes

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150299237A1 (en) * 2012-10-29 2015-10-22 Southeast University Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex
US9227991B2 (en) * 2012-10-29 2016-01-05 Southeast University Anti-tumor bivalent platinum complex and preparation method for complex and ligand of complex

Also Published As

Publication number Publication date
ES8406498A1 (es) 1984-07-01
PT77542B (en) 1986-02-12
SE8305783D0 (sv) 1983-10-20
IT8323359A0 (it) 1983-10-19
NO171276B (no) 1992-11-09
FI76351B (fi) 1988-06-30
KR840006492A (ko) 1984-11-30
FI76351C (fi) 1988-10-10
AT390610B (de) 1990-06-11
BE898058A (nl) 1984-04-24
IE56124B1 (en) 1991-04-24
GR79652B (fi) 1984-10-31
CH658244A5 (de) 1986-10-31
NO171276C (no) 1993-02-17
AU2027583A (en) 1984-05-03
DK75592A (da) 1992-06-09
DK483083D0 (da) 1983-10-20
ES526670A0 (es) 1984-07-01
NL8204067A (nl) 1984-05-16
DD217522A5 (de) 1985-01-16
GB8328084D0 (en) 1983-11-23
CS775283A2 (en) 1985-08-15
HU188035B (en) 1986-03-28
AU562964B2 (en) 1987-06-25
NZ206018A (en) 1986-02-21
FI833842A0 (fi) 1983-10-20
FR2534907A1 (fr) 1984-04-27
IE832459L (en) 1984-04-21
PT77542A (en) 1983-11-01
YU43554B (en) 1989-08-31
PH24077A (en) 1990-03-05
SE8305783L (sv) 1984-04-22
ZA837857B (en) 1984-06-27
JPS5993091A (ja) 1984-05-29
CA1229618A (en) 1987-11-24
DE3337333A1 (de) 1984-04-26
LU85054A1 (fi) 1984-03-22
JPH0244479B2 (fi) 1990-10-04
IT1169858B (it) 1987-06-03
KR910002536B1 (ko) 1991-04-23
DK75592D0 (da) 1992-06-09
DK483083A (da) 1984-04-22
FI833842A (fi) 1984-04-22
FR2534907B1 (fr) 1988-08-19
CS242888B2 (en) 1986-05-15
YU210783A (en) 1986-08-31
ATA373083A (de) 1989-11-15
NO833825L (no) 1984-04-24
GB2128615A (en) 1984-05-02

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19931020