GB2058791B - Cephalosporin antibiotics - Google Patents

Cephalosporin antibiotics

Info

Publication number
GB2058791B
GB2058791B GB7918488A GB8033718A GB2058791B GB 2058791 B GB2058791 B GB 2058791B GB 7918488 A GB7918488 A GB 7918488A GB 8033718 A GB8033718 A GB 8033718A GB 2058791 B GB2058791 B GB 2058791B
Authority
GB
United Kingdom
Prior art keywords
cephalosporin antibiotics
cephalosporin
antibiotics
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7918488A
Other languages
English (en)
Other versions
GB2058791A (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB2058791A publication Critical patent/GB2058791A/en
Application granted granted Critical
Publication of GB2058791B publication Critical patent/GB2058791B/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/587—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with aliphatic hydrocarbon radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms, said aliphatic radicals being substituted in the alpha-position to the ring by a hetero atom, e.g. with m >= 0, Z being a singly or a doubly bound hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7918488A 1978-05-26 1979-05-25 Cephalosporin antibiotics Expired GB2058791B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2291178 1978-05-26

Publications (2)

Publication Number Publication Date
GB2058791A GB2058791A (en) 1981-04-15
GB2058791B true GB2058791B (en) 1982-11-24

Family

ID=10187065

Family Applications (2)

Application Number Title Priority Date Filing Date
GB7918488A Expired GB2025398B (en) 1978-05-26 1979-05-25 Gephalosporin antibiotics
GB7918488A Expired GB2058791B (en) 1978-05-26 1979-05-25 Cephalosporin antibiotics

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB7918488A Expired GB2025398B (en) 1978-05-26 1979-05-25 Gephalosporin antibiotics

Country Status (10)

Country Link
JP (6) JPS54154786A (ja)
KR (2) KR830000606B1 (ja)
AT (2) AT369380B (ja)
BE (1) BE876538A (ja)
CA (1) CA1132538A (ja)
CY (1) CY1168A (ja)
GB (2) GB2025398B (ja)
HU (1) HU184631B (ja)
IT (1) IT1210588B (ja)
ZA (2) ZA807323B (ja)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1145686B (it) * 1979-05-25 1986-11-05 Glaxo Group Ltd Intermedi per la preparazione di antibiotici cefalosporinici e procedimento per prepararli
ZA806977B (en) * 1979-11-19 1981-10-28 Fujisawa Pharmaceutical Co 7-acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
DE3006888A1 (de) * 1980-02-23 1981-09-10 Hoechst Ag, 6000 Frankfurt Cephalosporinderivate und verfahren zu ihrer herstellung
JPS5756486A (en) * 1980-08-11 1982-04-05 Fujisawa Pharmaceut Co Ltd Novel cephem compound or its salt, their preparation and prophylactic or remedy for microbism containing the same as active ingredient
US4336253A (en) * 1981-03-11 1982-06-22 Eli Lilly And Company Cephalosporin antibiotics
DE3207840A1 (de) * 1982-03-04 1983-09-15 Hoechst Ag, 6230 Frankfurt "cephalosporinderivate und verfahren zu ihrer herstellung"
JPS5910593A (ja) 1982-06-28 1984-01-20 Bristol Mayers Kenkyusho Kk セフアロスポリン誘導体
DE3239365A1 (de) * 1982-10-23 1984-04-26 Bayer Ag, 5090 Leverkusen Neue cephalosporine und verfahren zu ihrer herstellung
DE3381408D1 (de) * 1982-12-27 1990-05-10 Lilly Co Eli Zwischenverbindungen fuer die herstellung von ceftazidin und verfahren zu ihrer herstellung.
DE3313818A1 (de) * 1983-04-16 1984-10-18 Hoechst Ag, 6230 Frankfurt Neue kristallmodifikation von ceftazidim
GB8413152D0 (en) * 1983-06-03 1984-06-27 Ici Pharma Cephalosporin derivatives
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
GB8406218D0 (en) * 1984-03-09 1984-04-11 Glaxo Group Ltd Process
GB8410991D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410993D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
GB8410992D0 (en) * 1984-04-30 1984-06-06 Glaxo Group Ltd Process
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
CA1296012C (en) 1986-03-19 1992-02-18 Susumu Nakagawa 6,7-dihydroxy-isoquinoline derivatives
KR0164458B1 (ko) * 1995-04-04 1999-01-15 김은영 암모니오세팔로스포린 계열 항생제 및 그의 제조방법
US5872249A (en) * 1995-09-01 1999-02-16 Korea Institute Of Science And Technology 3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same
JPH09110877A (ja) 1995-10-17 1997-04-28 Katayama Seiyakushiyo:Kk セフェム化合物、その製造法及びそれを含有する抗菌剤

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS597717B2 (ja) * 1976-09-08 1984-02-20 武田薬品工業株式会社 セフアロスポリン誘導体およびその製造法

Also Published As

Publication number Publication date
JPH0257073B2 (ja) 1990-12-03
JPS6127990A (ja) 1986-02-07
JPS6322093A (ja) 1988-01-29
IT8149648A0 (it) 1981-11-06
JPS625916B2 (ja) 1987-02-07
KR830000835B1 (ko) 1983-04-20
GB2025398A (en) 1980-01-23
JPH0257069B2 (ja) 1990-12-03
KR830000606B1 (ko) 1983-03-17
ZA792581B (en) 1981-01-28
IT1210588B (it) 1989-09-14
AT369381B (de) 1982-12-27
ZA807323B (en) 1981-02-25
JPS6354689B2 (ja) 1988-10-28
AT369380B (de) 1982-12-27
CY1168A (en) 1983-06-10
JPS6127989A (ja) 1986-02-07
JPS55149289A (en) 1980-11-20
JPH0257554B2 (ja) 1990-12-05
ATA173881A (de) 1982-05-15
HU184631B (en) 1984-09-28
JPS54154786A (en) 1979-12-06
BE876538A (fr) 1979-11-26
GB2058791A (en) 1981-04-15
GB2025398B (en) 1982-08-11
ATA173981A (de) 1982-05-15
CA1132538A (en) 1982-09-28
JPS6127921A (ja) 1986-02-07

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19930525