FR2457295A1 - Composes intermediaires pour la preparation de cephalosporines - Google Patents
Composes intermediaires pour la preparation de cephalosporinesInfo
- Publication number
- FR2457295A1 FR2457295A1 FR8011530A FR8011530A FR2457295A1 FR 2457295 A1 FR2457295 A1 FR 2457295A1 FR 8011530 A FR8011530 A FR 8011530A FR 8011530 A FR8011530 A FR 8011530A FR 2457295 A1 FR2457295 A1 FR 2457295A1
- Authority
- FR
- France
- Prior art keywords
- cephalosporins
- preparation
- dichlorhydrate
- intermediate compounds
- ceph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/18—7-Aminocephalosporanic or substituted 7-aminocephalosporanic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Cephalosporin Compounds (AREA)
Abstract
L'INVENTION CONCERNE DES CEPHEMES. L'INVENTION A PLUS PARTICULIEREMENT POUR OBJET LE DICHLORHYDRATE DE (6R, 7R)-7-AMINO-3- (1-PYRIDINIUM-METHYL) CEPH-3-EME-4-CARBOXYLATE. L'INVENTION CONCERNE AUSSI LES SOLVATES DU DICHLORHYDRATE DE (6R, 7R)-7-AMINO-3- (1-PYRIDINIUMMETHYL) CEPH-3-ENE-4-CARBOXYLATE, AINSI QUE LE DIHYDRATE DU DICHLORHYDRATE PRECITE. ON OBTIENT LE COMPOSE EN QUESTION PAR UNE REACTION DE DESACYLATION. LE COMPOSE OBTENU EST UN INTERMEDIAIRE POUR LA PREPARATION DE CEPHALOSPORINES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB7918428 | 1979-05-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
FR2457295A1 true FR2457295A1 (fr) | 1980-12-19 |
FR2457295B1 FR2457295B1 (fr) | 1983-11-10 |
Family
ID=10505477
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FR8011530A Granted FR2457295A1 (fr) | 1979-05-25 | 1980-05-23 | Composes intermediaires pour la preparation de cephalosporines |
Country Status (10)
Country | Link |
---|---|
US (3) | US4374983A (fr) |
JP (2) | JPS5612397A (fr) |
BE (1) | BE883453A (fr) |
CH (1) | CH654010A5 (fr) |
DE (1) | DE3019838A1 (fr) |
FR (1) | FR2457295A1 (fr) |
GB (1) | GB2052490B (fr) |
IT (1) | IT1145686B (fr) |
NL (1) | NL8003003A (fr) |
ZA (1) | ZA803093B (fr) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0070706A2 (fr) * | 1981-07-17 | 1983-01-26 | Glaxo Group Limited | Dérivés de céphalosporine |
EP0135258A2 (fr) * | 1983-06-20 | 1985-03-27 | Eli Lilly And Company | 7-(R)-Amino-3-(1-pyridiniumméthyle)-céph-3-em-4-carboxylique cristallin |
EP0175544A2 (fr) * | 1984-09-17 | 1986-03-26 | Eli Lilly And Company | Procédé pour la préparation d'intermédiaires de céphalosporine |
EP0222577A2 (fr) * | 1985-11-06 | 1987-05-20 | Eli Lilly And Company | Céphalosporine cristalline monohydratée |
EP0233271A1 (fr) * | 1985-08-20 | 1987-08-26 | Bristol Myers Co | Procede de preparation d'intermediaires de cephalosporine. |
EP0587121A1 (fr) * | 1992-09-08 | 1994-03-16 | Bristol-Myers Squibb Company | Dihydrate cristallisé d'un dihydrochlorure de céphalosporine et ses compositions injectables |
EP0612750A2 (fr) * | 1984-11-23 | 1994-08-31 | BIOCHEMIE Gesellschaft m.b.H. | Dérivés de céphalosporine |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2457295A1 (fr) * | 1979-05-25 | 1980-12-19 | Glaxo Group Ltd | Composes intermediaires pour la preparation de cephalosporines |
AU540382B2 (en) * | 1979-10-02 | 1984-11-15 | Glaxo Group Limited | 7(2-(2-aminothiazol-4-yl)-2-(2-carboxy prop-2-oxyimino) acetamido)-3-(1-pyridiniummethyl) ceph-3-em-4-carboxylate |
JPS5859991A (ja) * | 1981-09-14 | 1983-04-09 | Fujisawa Pharmaceut Co Ltd | 新規セフェム化合物 |
DE3381408D1 (de) * | 1982-12-27 | 1990-05-10 | Lilly Co Eli | Zwischenverbindungen fuer die herstellung von ceftazidin und verfahren zu ihrer herstellung. |
DE3248281A1 (de) * | 1982-12-28 | 1984-06-28 | Hoechst Ag, 6230 Frankfurt | Kristalisierte cephem-saeureadditionssalze und verfahren zu ihrer herstellung |
DE3419014A1 (de) * | 1984-05-22 | 1985-11-28 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von 7-amino-3-(3-formamidopyridinium)methyl-3-cephem-4-carboxylat und verwendung zur synthese von ss-lactamantibiotika |
JPS6160296A (ja) * | 1984-08-30 | 1986-03-27 | Yoshitsuka Seiki:Kk | 全自動粉末成形プレス |
JPH0649707B2 (ja) * | 1985-03-01 | 1994-06-29 | 第一製薬株式会社 | 3−ピリジニウムメチルセフエム誘導体 |
US4703118A (en) * | 1985-04-08 | 1987-10-27 | Eli Lilly And Company | Synthesis of 3-iodomethyl cephalosporins |
US4910301A (en) * | 1985-08-05 | 1990-03-20 | Bristol-Myers Company | Cefepime cephalosporin salts |
US4665168A (en) * | 1986-04-14 | 1987-05-12 | Eli Lilly And Company | Cephalosporin intermediate |
KR100342600B1 (ko) | 2000-03-06 | 2002-07-04 | 한미정밀화학주식회사 | 신규한 티아졸 화합물 및 그의 제조 방법 |
KR100392409B1 (ko) | 2000-03-20 | 2003-07-22 | 한미정밀화학주식회사 | 신규한 티아졸 화합물을 이용한 세팔로스포린계항생물질의 제조 방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB953695A (en) * | 1959-08-04 | 1964-03-25 | Nat Res Dev | Derivatives of cephalosporin c |
BE638034A (fr) * | 1962-10-03 | |||
GB1028563A (en) | 1962-12-14 | 1966-05-04 | Glaxo Lab Ltd | Antibacterial derivative of 7-aminocephalosporanic acid |
FR116F (fr) * | 1963-11-04 | |||
US3422099A (en) * | 1966-02-18 | 1969-01-14 | Bristol Myers Co | 7-(alpha-hydroxy-(2' or 3'-thienyl)-acetamido) cephalosporanic acids and related salts and derivatives |
GB1522140A (en) | 1974-12-20 | 1978-08-23 | Glaxo Lab Ltd | Syn-7-(2-hydroxyiminoacetamido)-3-pyridiniummethyl cephalosporins methods for their preparation and compositions containing them |
NL162387C (nl) * | 1977-09-06 | 1980-05-16 | Gist Brocades Nv | Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur. |
AR228726A1 (es) * | 1978-05-26 | 1983-04-15 | Glaxo Group Ltd | Procedimiento para la preparacion del antibiotico(6r,7r)-7-((z)-2-(2-aminotiazol-4-il)-2-(2-carboxiprop-2-oxiimino)acetamido)-3-(1-piridiniometil)cef-3-em-4-carboxilato |
ZA792581B (en) * | 1978-05-26 | 1981-01-28 | Glaxo Group Ltd | Cephalosporin antibiotics |
FR2457295A1 (fr) * | 1979-05-25 | 1980-12-19 | Glaxo Group Ltd | Composes intermediaires pour la preparation de cephalosporines |
AU540382B2 (en) * | 1979-10-02 | 1984-11-15 | Glaxo Group Limited | 7(2-(2-aminothiazol-4-yl)-2-(2-carboxy prop-2-oxyimino) acetamido)-3-(1-pyridiniummethyl) ceph-3-em-4-carboxylate |
-
1980
- 1980-05-23 FR FR8011530A patent/FR2457295A1/fr active Granted
- 1980-05-23 NL NL8003003A patent/NL8003003A/nl not_active Application Discontinuation
- 1980-05-23 IT IT48772/80A patent/IT1145686B/it active
- 1980-05-23 GB GB8017093A patent/GB2052490B/en not_active Expired
- 1980-05-23 JP JP6797480A patent/JPS5612397A/ja active Granted
- 1980-05-23 CH CH4078/80A patent/CH654010A5/de not_active IP Right Cessation
- 1980-05-23 DE DE19803019838 patent/DE3019838A1/de not_active Withdrawn
- 1980-05-23 BE BE0/200740A patent/BE883453A/fr not_active IP Right Cessation
- 1980-05-23 ZA ZA00803093A patent/ZA803093B/xx unknown
-
1981
- 1981-03-03 US US06/240,104 patent/US4374983A/en not_active Expired - Fee Related
- 1981-03-03 US US06/239,203 patent/US4369313A/en not_active Expired - Lifetime
-
1982
- 1982-09-30 US US06/429,134 patent/US4433141A/en not_active Expired - Lifetime
-
1989
- 1989-06-28 JP JP1164113A patent/JPH0242085A/ja active Pending
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0070706A2 (fr) * | 1981-07-17 | 1983-01-26 | Glaxo Group Limited | Dérivés de céphalosporine |
EP0070706A3 (en) * | 1981-07-17 | 1984-04-25 | Glaxo Group Limited | Cephalosporin compounds |
EP0135258A2 (fr) * | 1983-06-20 | 1985-03-27 | Eli Lilly And Company | 7-(R)-Amino-3-(1-pyridiniumméthyle)-céph-3-em-4-carboxylique cristallin |
EP0135258A3 (en) * | 1983-06-20 | 1985-12-18 | Eli Lilly And Company | Improvements in or relating to a crystalline 7-(r)-amino-3-(1-pyridiniummethyl)-ceph-3-em-4-carboxylate |
EP0175544A3 (fr) * | 1984-09-17 | 1987-06-03 | Eli Lilly And Company | Procédé pour la préparation d'intermédiaires de céphalosporine |
EP0175544A2 (fr) * | 1984-09-17 | 1986-03-26 | Eli Lilly And Company | Procédé pour la préparation d'intermédiaires de céphalosporine |
EP0612750A2 (fr) * | 1984-11-23 | 1994-08-31 | BIOCHEMIE Gesellschaft m.b.H. | Dérivés de céphalosporine |
EP0612750A3 (en) * | 1984-11-23 | 1994-09-28 | Biochemie Gmbh | Cephalosporinderivatives. |
EP0233271A1 (fr) * | 1985-08-20 | 1987-08-26 | Bristol Myers Co | Procede de preparation d'intermediaires de cephalosporine. |
EP0233271A4 (fr) * | 1985-08-20 | 1988-10-20 | Bristol Myers Co | Procede de preparation d'intermediaires de cephalosporine. |
EP0222577A2 (fr) * | 1985-11-06 | 1987-05-20 | Eli Lilly And Company | Céphalosporine cristalline monohydratée |
EP0222577A3 (fr) * | 1985-11-06 | 1988-10-05 | Eli Lilly And Company | Céphalosporine cristalline monohydratée |
EP0587121A1 (fr) * | 1992-09-08 | 1994-03-16 | Bristol-Myers Squibb Company | Dihydrate cristallisé d'un dihydrochlorure de céphalosporine et ses compositions injectables |
Also Published As
Publication number | Publication date |
---|---|
US4369313A (en) | 1983-01-18 |
IT8048772A0 (it) | 1980-05-23 |
IT1145686B (it) | 1986-11-05 |
JPS5612397A (en) | 1981-02-06 |
US4433141A (en) | 1984-02-21 |
JPH0250914B2 (fr) | 1990-11-05 |
GB2052490A (en) | 1981-01-28 |
NL8003003A (nl) | 1980-11-27 |
BE883453A (fr) | 1980-11-24 |
JPH0242085A (ja) | 1990-02-13 |
ZA803093B (en) | 1981-07-29 |
US4374983A (en) | 1983-02-22 |
CH654010A5 (de) | 1986-01-31 |
DE3019838A1 (de) | 1980-12-04 |
FR2457295B1 (fr) | 1983-11-10 |
GB2052490B (en) | 1983-09-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
ST | Notification of lapse |