FR2453176A1 - Procede de preparation de cephalosporines substituees par un groupe carbamoyloxymethyle en position 3 - Google Patents

Procede de preparation de cephalosporines substituees par un groupe carbamoyloxymethyle en position 3

Info

Publication number
FR2453176A1
FR2453176A1 FR7923473A FR7923473A FR2453176A1 FR 2453176 A1 FR2453176 A1 FR 2453176A1 FR 7923473 A FR7923473 A FR 7923473A FR 7923473 A FR7923473 A FR 7923473A FR 2453176 A1 FR2453176 A1 FR 2453176A1
Authority
FR
France
Prior art keywords
preparation
cephalosporins
carbamoyloxymethyl group
carbamoyloxymethyl
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7923473A
Other languages
English (en)
Other versions
FR2453176B1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7912215A external-priority patent/GB2018764B/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of FR2453176A1 publication Critical patent/FR2453176A1/fr
Application granted granted Critical
Publication of FR2453176B1 publication Critical patent/FR2453176B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65613—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system (X = CH2, O, S, NH) optionally with an additional double bond and/or substituents, e.g. cephalosporins and analogs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • C07D501/34—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/26—Methylene radicals, substituted by oxygen atoms; Lactones thereof with the 2-carboxyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

L'invention concerne la préparation de céphalosporines. De manière plus particuliere, l'invention est relative à un procédé de préparation d'une 3-carbamoyloxyméthyl-céphalosporine, caractérisé en ce que l'on procède à l'hydrolyse d'une 3-phosphonocarbamoyloxyméthyl-céphalosporine. Les matières de départ que sont les phosphonocarbamoyloxyméthyl-céphalosporines peuvent se préparer d'une manière relativement simple et peu coûteuse, au besoin sans isolement.
FR7923473A 1979-04-06 1979-09-20 Procede de preparation de cephalosporines substituees par un groupe carbamoyloxymethyle en position 3 Granted FR2453176A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB7912215A GB2018764B (en) 1978-04-07 1979-04-06 Cephalosporin compounds

Publications (2)

Publication Number Publication Date
FR2453176A1 true FR2453176A1 (fr) 1980-10-31
FR2453176B1 FR2453176B1 (fr) 1983-12-30

Family

ID=10504408

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7923473A Granted FR2453176A1 (fr) 1979-04-06 1979-09-20 Procede de preparation de cephalosporines substituees par un groupe carbamoyloxymethyle en position 3

Country Status (17)

Country Link
US (1) US4258183A (fr)
JP (1) JPS55136289A (fr)
KR (1) KR830000686B1 (fr)
AT (1) AT367424B (fr)
BE (1) BE878900A (fr)
CH (1) CH646975A5 (fr)
DE (1) DE2938065A1 (fr)
DK (1) DK159155C (fr)
ES (1) ES484321A1 (fr)
FI (1) FI73437C (fr)
FR (1) FR2453176A1 (fr)
IL (1) IL58287A (fr)
IT (1) IT1164704B (fr)
NL (1) NL7907000A (fr)
PT (1) PT70205A (fr)
SE (1) SE445738B (fr)
YU (1) YU230379A (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU44680B (en) * 1982-07-30 1990-12-31 Glaxo Lab Ltd Process for obtaining very pure amorphous form of cephuroxim axetile
IN189046B (fr) 1998-03-30 2002-12-14 Ranbaxy Lab Ltd
WO2000053609A1 (fr) * 1999-03-09 2000-09-14 Ranbaxy Laboratories Limited Procede de preparation de cefuroxime
KR100669507B1 (ko) * 2000-08-01 2007-01-16 보령제약 주식회사 세푸록심의 제조방법
AT411996B (de) * 2000-09-11 2004-08-26 Sandoz Ag Verfahren zur herstellung von cefuroxim in der form seines n-butylammoniumsalzes

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664955A (fr) * 1964-06-05
US3905967A (en) * 1971-05-07 1975-09-16 Smithkline Corp Method for O-acylating 7-acylamino-cephalosporadesic acids
US3875152A (en) * 1971-11-09 1975-04-01 American Home Prod Intermediates for producing semi-synthetic cephalosporins and methods of production
NL7216136A (fr) * 1971-12-14 1973-06-18
GB1519997A (en) * 1974-09-20 1978-08-02 Sumitomo Chemical Co Preparation o peptides and cephalosporis
JPS53135996A (en) * 1977-04-27 1978-11-28 Takeda Chem Ind Ltd Preparation of cephalosporin compounds
AU534617B2 (en) * 1978-04-07 1984-02-09 Glaxo Group Limited Cephalosporin compounds

Also Published As

Publication number Publication date
JPS638955B2 (fr) 1988-02-25
FI792928A (fi) 1980-10-07
AT367424B (de) 1982-07-12
IL58287A (en) 1982-08-31
US4258183A (en) 1981-03-24
BE878900A (fr) 1980-03-20
CH646975A5 (de) 1984-12-28
DE2938065C2 (fr) 1991-03-14
FI73437C (fi) 1987-10-09
IL58287A0 (en) 1979-12-30
NL7907000A (nl) 1980-10-08
DK159155B (da) 1990-09-10
JPS55136289A (en) 1980-10-23
SE445738B (sv) 1986-07-14
FR2453176B1 (fr) 1983-12-30
PT70205A (en) 1979-10-01
ES484321A1 (es) 1980-10-01
IT1164704B (it) 1987-04-15
DK392879A (da) 1980-10-07
FI73437B (fi) 1987-06-30
IT7950306A0 (it) 1979-09-20
ATA619879A (de) 1981-11-15
DK159155C (da) 1991-02-11
DE2938065A1 (de) 1980-10-16
KR830000686B1 (ko) 1983-03-29
YU230379A (en) 1983-06-30
SE7907815L (sv) 1980-10-07

Similar Documents

Publication Publication Date Title
FR2564859B1 (fr) Procede de preparation d'acide hyaluronique par fermentation.
IT8048102A0 (it) Procedimento di preparazione di un idrolisato di proteine purificato
AU533035B2 (en) Eukaryotic protein synthesis by microorganism
EP0165033A3 (fr) Composés apparentés à la thymopentine à conformation restrictive
AU7449687A (en) Enhanced production of antibodies using insolubilized immune complexes
EP0069678A3 (fr) Dérivés de 3-fucosyl-N-acétyl lactosamine, leur préparation et leurs applications biologiques
IT7924131A0 (it) Gasolio. processo per la preparazione di
FR2457295A1 (fr) Composes intermediaires pour la preparation de cephalosporines
DE69230180T2 (de) Neuartige hefestämme zur herstellung von xylitol
GR930100259A (el) Μικροβιακή μέ?οδος παρασκευής μεβινολίνης.
IT7924132A0 (it) Processo per la preparazione di gasolio.
OA06973A (fr) Procédé pour préparer enzymatiquement l'acide amino-2 méthylphosphino-4 butiryque- (L).
AU584635B2 (en) Process for the preparation of 4-phenylpyrrole derivatives
FR2453176A1 (fr) Procede de preparation de cephalosporines substituees par un groupe carbamoyloxymethyle en position 3
AU579176B2 (en) A method of securing a cover to the end of a thin-walled tube
AU592952B2 (en) Monoclonal antibody stabilization
AU552874B2 (en) Process for the preparation of protein for hydrolysis
FR2666095B1 (fr) Production de la l-lysine par fermentation.
IT1221940B (it) Anticorpi monoclonali contro flagelli di pseudomonas aeruginosa
ES8607904A1 (es) Un procedimiento para preparar anhidrido trifluoroacetico
FR2416301A1 (fr) Procede de collage dans la masse du papier
AU574610B2 (en) Preparation of allyl-2-thioxopenam-3-carboxylates
AU7649187A (en) Preparation of monoclonal antibodies
AU568694B2 (en) N-benzyl-n-phenyl-b-pyrrolidinyl-f-isobutoxy-propylamine
AU561649B2 (en) Antibodies to proteins

Legal Events

Date Code Title Description
ST Notification of lapse