ES529223A0 - Un procedimiento de preparacion de imino-2-pirrolidinas. - Google Patents
Un procedimiento de preparacion de imino-2-pirrolidinas.Info
- Publication number
- ES529223A0 ES529223A0 ES529223A ES529223A ES529223A0 ES 529223 A0 ES529223 A0 ES 529223A0 ES 529223 A ES529223 A ES 529223A ES 529223 A ES529223 A ES 529223A ES 529223 A0 ES529223 A0 ES 529223A0
- Authority
- ES
- Spain
- Prior art keywords
- pyrrolidines
- imino
- procedure
- preparation
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8301360A FR2540109B1 (fr) | 1983-01-28 | 1983-01-28 | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES529223A0 true ES529223A0 (es) | 1984-10-01 |
| ES8500226A1 ES8500226A1 (es) | 1984-10-01 |
Family
ID=9285402
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES529223A Expired ES8500226A1 (es) | 1983-01-28 | 1984-01-27 | Un procedimiento de preparacion de imino-2-pirrolidinas. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US4556674A (es) |
| EP (1) | EP0117771B1 (es) |
| JP (1) | JPS59141558A (es) |
| AT (1) | ATE30719T1 (es) |
| AU (1) | AU562183B2 (es) |
| CA (1) | CA1223597A (es) |
| DE (1) | DE3467346D1 (es) |
| DK (1) | DK39084A (es) |
| ES (1) | ES8500226A1 (es) |
| FI (1) | FI77021C (es) |
| FR (1) | FR2540109B1 (es) |
| HU (1) | HU189402B (es) |
| IE (1) | IE56547B1 (es) |
| OA (1) | OA07642A (es) |
| ZA (1) | ZA84562B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
| KR100342275B1 (ko) * | 1993-10-21 | 2002-12-05 | 지.디. 썰 엘엘씨 | 산화질소신타제저해제로서유용한아미디노유도체 |
| CA2216882A1 (en) * | 1995-04-20 | 1996-10-24 | G.D. Searle & Co. | Cyclic amidino agents useful as nitric oxide synthase inhibitors |
| US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
| CA2333691A1 (en) | 1998-06-10 | 1999-12-16 | G.D. Searle & Co. | Heterobicyclic and tricyclic nitric oxide synthase inhibitors |
| US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
| DE10214832A1 (de) * | 2002-04-04 | 2003-10-16 | Merck Patent Gmbh | Phenylderivate 4 |
| EP2535330A3 (en) * | 2006-10-23 | 2012-12-26 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| CN102066327B (zh) * | 2008-04-23 | 2013-05-29 | 武田药品工业株式会社 | 亚氨基吡啶衍生物及其用途 |
| US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
| US8481569B2 (en) * | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
| WO2020121334A1 (en) * | 2018-12-15 | 2020-06-18 | Natco Pharma Limited | An improved process for the preparation of tipiracil hydrochloride and intermediates thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1516776A (fr) * | 1966-07-21 | 1968-03-15 | Rhone Poulenc Sa | Nouveaux dérivés du pyrrole et leur préparation |
| DE1770752A1 (de) * | 1968-06-29 | 1971-11-25 | Mcneilab Inc | 2-Imino-methylenimine |
| GB1210848A (en) * | 1968-07-01 | 1970-11-04 | Mcneilab Inc | 2-imino-methyleneimines |
| US3632604A (en) * | 1970-04-09 | 1972-01-04 | Sandoz Ag | 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines |
| US3887569A (en) * | 1970-10-30 | 1975-06-03 | Mcneilab Inc | 2-Imino-piperidines |
| US3725435A (en) * | 1970-11-05 | 1973-04-03 | Mc Neil Labor Inc | 2-imino-pyrrolidines |
| FR2186236B1 (es) * | 1972-05-03 | 1975-08-01 | Logeais Labor Jacques | |
| US4055561A (en) * | 1973-04-25 | 1977-10-25 | Richardson-Merrell Inc. | α-Alkylbenzyl lactamimides |
| NZ179580A (en) * | 1974-12-30 | 1978-04-03 | Mcneilab Inc | 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs |
| FR2431494A1 (fr) * | 1978-07-17 | 1980-02-15 | Logeais Labor Jacques | Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique |
| FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
-
1983
- 1983-01-28 FR FR8301360A patent/FR2540109B1/fr not_active Expired
-
1984
- 1984-01-13 DE DE8484400081T patent/DE3467346D1/de not_active Expired
- 1984-01-13 AT AT84400081T patent/ATE30719T1/de not_active IP Right Cessation
- 1984-01-13 EP EP84400081A patent/EP0117771B1/fr not_active Expired
- 1984-01-16 IE IE85/84A patent/IE56547B1/xx unknown
- 1984-01-17 US US06/571,524 patent/US4556674A/en not_active Expired - Fee Related
- 1984-01-18 CA CA000445497A patent/CA1223597A/en not_active Expired
- 1984-01-24 AU AU23711/84A patent/AU562183B2/en not_active Ceased
- 1984-01-25 ZA ZA84562A patent/ZA84562B/xx unknown
- 1984-01-26 FI FI840322A patent/FI77021C/fi not_active IP Right Cessation
- 1984-01-26 OA OA58214A patent/OA07642A/xx unknown
- 1984-01-27 DK DK39084A patent/DK39084A/da not_active Application Discontinuation
- 1984-01-27 HU HU84381A patent/HU189402B/hu not_active IP Right Cessation
- 1984-01-27 ES ES529223A patent/ES8500226A1/es not_active Expired
- 1984-01-27 JP JP59013207A patent/JPS59141558A/ja active Pending
-
1985
- 1985-09-17 US US06/777,038 patent/US4699918A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IE840085L (en) | 1984-07-28 |
| AU562183B2 (en) | 1987-06-04 |
| AU2371184A (en) | 1984-08-02 |
| US4699918A (en) | 1987-10-13 |
| DK39084D0 (da) | 1984-01-27 |
| JPS59141558A (ja) | 1984-08-14 |
| FR2540109B1 (fr) | 1985-08-30 |
| OA07642A (fr) | 1985-05-23 |
| FI840322A0 (fi) | 1984-01-26 |
| FI840322A (fi) | 1984-07-29 |
| EP0117771B1 (fr) | 1987-11-11 |
| HU189402B (en) | 1986-07-28 |
| US4556674A (en) | 1985-12-03 |
| EP0117771A1 (fr) | 1984-09-05 |
| ATE30719T1 (de) | 1987-11-15 |
| DK39084A (da) | 1984-07-29 |
| CA1223597A (en) | 1987-06-30 |
| DE3467346D1 (en) | 1987-12-17 |
| IE56547B1 (en) | 1991-08-28 |
| ES8500226A1 (es) | 1984-10-01 |
| ZA84562B (en) | 1984-09-26 |
| FI77021C (fi) | 1989-01-10 |
| FR2540109A1 (fr) | 1984-08-03 |
| FI77021B (fi) | 1988-09-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19960603 |