ZA84562B - 2-imino-pyrrolidines,process for their preparation,and therapeutic compositions containing same - Google Patents

2-imino-pyrrolidines,process for their preparation,and therapeutic compositions containing same

Info

Publication number
ZA84562B
ZA84562B ZA84562A ZA84562A ZA84562B ZA 84562 B ZA84562 B ZA 84562B ZA 84562 A ZA84562 A ZA 84562A ZA 84562 A ZA84562 A ZA 84562A ZA 84562 B ZA84562 B ZA 84562B
Authority
ZA
South Africa
Prior art keywords
pyrrolidines
imino
preparation
compositions containing
therapeutic compositions
Prior art date
Application number
ZA84562A
Other languages
English (en)
Inventor
Jacques Maillard
Vo Van Tri
Jacky Legeai
Marguerite Benharkate
Original Assignee
Logeais Labor Jacques
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Logeais Labor Jacques filed Critical Logeais Labor Jacques
Publication of ZA84562B publication Critical patent/ZA84562B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA84562A 1983-01-28 1984-01-25 2-imino-pyrrolidines,process for their preparation,and therapeutic compositions containing same ZA84562B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301360A FR2540109B1 (fr) 1983-01-28 1983-01-28 Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique

Publications (1)

Publication Number Publication Date
ZA84562B true ZA84562B (en) 1984-09-26

Family

ID=9285402

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA84562A ZA84562B (en) 1983-01-28 1984-01-25 2-imino-pyrrolidines,process for their preparation,and therapeutic compositions containing same

Country Status (15)

Country Link
US (2) US4556674A (xx)
EP (1) EP0117771B1 (xx)
JP (1) JPS59141558A (xx)
AT (1) ATE30719T1 (xx)
AU (1) AU562183B2 (xx)
CA (1) CA1223597A (xx)
DE (1) DE3467346D1 (xx)
DK (1) DK39084A (xx)
ES (1) ES529223A0 (xx)
FI (1) FI77021C (xx)
FR (1) FR2540109B1 (xx)
HU (1) HU189402B (xx)
IE (1) IE56547B1 (xx)
OA (1) OA07642A (xx)
ZA (1) ZA84562B (xx)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
CN1077886C (zh) * 1993-10-21 2002-01-16 G·D·瑟尔公司 用作一氧化一氮合酶抑制剂的脒基衍生物
US6011028A (en) * 1995-04-20 2000-01-04 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
EP1086108A1 (en) 1998-06-10 2001-03-28 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
DE10214832A1 (de) * 2002-04-04 2003-10-16 Merck Patent Gmbh Phenylderivate 4
US8470859B2 (en) * 2006-10-23 2013-06-25 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
BRPI0910737A2 (pt) * 2008-04-23 2019-09-24 Takeda Pharmaceuticals Co composto, pró-droga, agente farmacêutico, método para profilaxia ou tratamento de doenças do trato urinário inferior em um mamífero, e, uso de um composto ou uma pró-droga do mesmo.
WO2020121334A1 (en) * 2018-12-15 2020-06-18 Natco Pharma Limited An improved process for the preparation of tipiracil hydrochloride and intermediates thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516776A (fr) * 1966-07-21 1968-03-15 Rhone Poulenc Sa Nouveaux dérivés du pyrrole et leur préparation
DE1770752A1 (de) * 1968-06-29 1971-11-25 Mcneilab Inc 2-Imino-methylenimine
GB1210848A (en) * 1968-07-01 1970-11-04 Mcneilab Inc 2-imino-methyleneimines
US3632604A (en) * 1970-04-09 1972-01-04 Sandoz Ag 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines
US3887569A (en) * 1970-10-30 1975-06-03 Mcneilab Inc 2-Imino-piperidines
US3725435A (en) * 1970-11-05 1973-04-03 Mc Neil Labor Inc 2-imino-pyrrolidines
FR2186236B1 (xx) * 1972-05-03 1975-08-01 Logeais Labor Jacques
US4055561A (en) * 1973-04-25 1977-10-25 Richardson-Merrell Inc. α-Alkylbenzyl lactamimides
NZ179580A (en) * 1974-12-30 1978-04-03 Mcneilab Inc 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs
FR2431494A1 (fr) * 1978-07-17 1980-02-15 Logeais Labor Jacques Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
US4699918A (en) 1987-10-13
JPS59141558A (ja) 1984-08-14
ATE30719T1 (de) 1987-11-15
DK39084A (da) 1984-07-29
AU562183B2 (en) 1987-06-04
FI840322A (fi) 1984-07-29
EP0117771A1 (fr) 1984-09-05
FR2540109A1 (fr) 1984-08-03
ES8500226A1 (es) 1984-10-01
AU2371184A (en) 1984-08-02
CA1223597A (en) 1987-06-30
DK39084D0 (da) 1984-01-27
IE56547B1 (en) 1991-08-28
FI77021C (fi) 1989-01-10
US4556674A (en) 1985-12-03
DE3467346D1 (en) 1987-12-17
EP0117771B1 (fr) 1987-11-11
FI77021B (fi) 1988-09-30
FI840322A0 (fi) 1984-01-26
ES529223A0 (es) 1984-10-01
FR2540109B1 (fr) 1985-08-30
OA07642A (fr) 1985-05-23
IE840085L (en) 1984-07-28
HU189402B (en) 1986-07-28

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