DE3467346D1 - Imino-2 pyrrolidines, process for their preparation and their therapeutical use - Google Patents
Imino-2 pyrrolidines, process for their preparation and their therapeutical useInfo
- Publication number
- DE3467346D1 DE3467346D1 DE8484400081T DE3467346T DE3467346D1 DE 3467346 D1 DE3467346 D1 DE 3467346D1 DE 8484400081 T DE8484400081 T DE 8484400081T DE 3467346 T DE3467346 T DE 3467346T DE 3467346 D1 DE3467346 D1 DE 3467346D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrrolidines
- imino
- preparation
- therapeutical use
- therapeutical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003235 pyrrolidines Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8301360A FR2540109B1 (fr) | 1983-01-28 | 1983-01-28 | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3467346D1 true DE3467346D1 (en) | 1987-12-17 |
Family
ID=9285402
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484400081T Expired DE3467346D1 (en) | 1983-01-28 | 1984-01-13 | Imino-2 pyrrolidines, process for their preparation and their therapeutical use |
Country Status (15)
Country | Link |
---|---|
US (2) | US4556674A (de) |
EP (1) | EP0117771B1 (de) |
JP (1) | JPS59141558A (de) |
AT (1) | ATE30719T1 (de) |
AU (1) | AU562183B2 (de) |
CA (1) | CA1223597A (de) |
DE (1) | DE3467346D1 (de) |
DK (1) | DK39084A (de) |
ES (1) | ES8500226A1 (de) |
FI (1) | FI77021C (de) |
FR (1) | FR2540109B1 (de) |
HU (1) | HU189402B (de) |
IE (1) | IE56547B1 (de) |
OA (1) | OA07642A (de) |
ZA (1) | ZA84562B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
ATE177078T1 (de) * | 1993-10-21 | 1999-03-15 | Searle & Co | Amidino-derivate als no-synthetase inhibitoren |
ATE246678T1 (de) * | 1995-04-20 | 2003-08-15 | Searle & Co | Zyclische amidino mittel als stickstoffoxid- synthase inhibitoren |
US5981556A (en) * | 1997-07-22 | 1999-11-09 | G.D. Searle & Co. | 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors |
JP2002517502A (ja) | 1998-06-10 | 2002-06-18 | ジー・ディー・サール・アンド・カンパニー | 複素二環状及び三環状一酸化窒素シンターゼ阻害剤 |
US6344473B1 (en) | 2000-08-07 | 2002-02-05 | G.D. Searle & Co. | Imidazoles useful as nitric oxide synthase inhibitors |
DE10214832A1 (de) * | 2002-04-04 | 2003-10-16 | Merck Patent Gmbh | Phenylderivate 4 |
US8470859B2 (en) * | 2006-10-23 | 2013-06-25 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
US8481569B2 (en) * | 2008-04-23 | 2013-07-09 | Takeda Pharmaceutical Company Limited | Iminopyridine derivatives and use thereof |
ES2478823T3 (es) * | 2008-04-23 | 2014-07-23 | Takeda Pharmaceutical Company Limited | Derivados de iminopiridina y uso de los mismos |
US20110039892A1 (en) * | 2008-04-23 | 2011-02-17 | Takeda Pharmaceutical Company Limited | Iminopyridine derivative and use thereof |
WO2020121334A1 (en) * | 2018-12-15 | 2020-06-18 | Natco Pharma Limited | An improved process for the preparation of tipiracil hydrochloride and intermediates thereof |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1516776A (fr) * | 1966-07-21 | 1968-03-15 | Rhone Poulenc Sa | Nouveaux dérivés du pyrrole et leur préparation |
DE1770752A1 (de) * | 1968-06-29 | 1971-11-25 | Mcneilab Inc | 2-Imino-methylenimine |
GB1210848A (en) * | 1968-07-01 | 1970-11-04 | Mcneilab Inc | 2-imino-methyleneimines |
US3632604A (en) * | 1970-04-09 | 1972-01-04 | Sandoz Ag | 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines |
US3887569A (en) * | 1970-10-30 | 1975-06-03 | Mcneilab Inc | 2-Imino-piperidines |
US3725435A (en) * | 1970-11-05 | 1973-04-03 | Mc Neil Labor Inc | 2-imino-pyrrolidines |
FR2186236B1 (de) * | 1972-05-03 | 1975-08-01 | Logeais Labor Jacques | |
US4055561A (en) * | 1973-04-25 | 1977-10-25 | Richardson-Merrell Inc. | α-Alkylbenzyl lactamimides |
NZ179580A (en) * | 1974-12-30 | 1978-04-03 | Mcneilab Inc | 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs |
FR2431494A1 (fr) * | 1978-07-17 | 1980-02-15 | Logeais Labor Jacques | Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique |
FR2540109B1 (fr) * | 1983-01-28 | 1985-08-30 | Logeais Labor Jacques | Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique |
-
1983
- 1983-01-28 FR FR8301360A patent/FR2540109B1/fr not_active Expired
-
1984
- 1984-01-13 DE DE8484400081T patent/DE3467346D1/de not_active Expired
- 1984-01-13 EP EP84400081A patent/EP0117771B1/de not_active Expired
- 1984-01-13 AT AT84400081T patent/ATE30719T1/de not_active IP Right Cessation
- 1984-01-16 IE IE85/84A patent/IE56547B1/xx unknown
- 1984-01-17 US US06/571,524 patent/US4556674A/en not_active Expired - Fee Related
- 1984-01-18 CA CA000445497A patent/CA1223597A/en not_active Expired
- 1984-01-24 AU AU23711/84A patent/AU562183B2/en not_active Ceased
- 1984-01-25 ZA ZA84562A patent/ZA84562B/xx unknown
- 1984-01-26 FI FI840322A patent/FI77021C/fi not_active IP Right Cessation
- 1984-01-26 OA OA58214A patent/OA07642A/xx unknown
- 1984-01-27 ES ES529223A patent/ES8500226A1/es not_active Expired
- 1984-01-27 HU HU84381A patent/HU189402B/hu not_active IP Right Cessation
- 1984-01-27 DK DK39084A patent/DK39084A/da not_active Application Discontinuation
- 1984-01-27 JP JP59013207A patent/JPS59141558A/ja active Pending
-
1985
- 1985-09-17 US US06/777,038 patent/US4699918A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
OA07642A (fr) | 1985-05-23 |
DK39084D0 (da) | 1984-01-27 |
FI840322A (fi) | 1984-07-29 |
IE840085L (en) | 1984-07-28 |
JPS59141558A (ja) | 1984-08-14 |
EP0117771A1 (de) | 1984-09-05 |
FI77021C (fi) | 1989-01-10 |
IE56547B1 (en) | 1991-08-28 |
US4556674A (en) | 1985-12-03 |
EP0117771B1 (de) | 1987-11-11 |
CA1223597A (en) | 1987-06-30 |
ES529223A0 (es) | 1984-10-01 |
FR2540109B1 (fr) | 1985-08-30 |
HU189402B (en) | 1986-07-28 |
AU562183B2 (en) | 1987-06-04 |
US4699918A (en) | 1987-10-13 |
AU2371184A (en) | 1984-08-02 |
FI840322A0 (fi) | 1984-01-26 |
FR2540109A1 (fr) | 1984-08-03 |
FI77021B (fi) | 1988-09-30 |
ATE30719T1 (de) | 1987-11-15 |
DK39084A (da) | 1984-07-29 |
ES8500226A1 (es) | 1984-10-01 |
ZA84562B (en) | 1984-09-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |