GB2027703A - 1-Phenylpiperazine derivatives - Google Patents

1-Phenylpiperazine derivatives Download PDF

Info

Publication number
GB2027703A
GB2027703A GB7926224A GB7926224A GB2027703A GB 2027703 A GB2027703 A GB 2027703A GB 7926224 A GB7926224 A GB 7926224A GB 7926224 A GB7926224 A GB 7926224A GB 2027703 A GB2027703 A GB 2027703A
Authority
GB
United Kingdom
Prior art keywords
radical
formula
atom
pharmaceutically acceptable
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
GB7926224A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Synthelabo SA
Original Assignee
Synthelabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR7822672A external-priority patent/FR2432515A1/fr
Priority claimed from FR7833105A external-priority patent/FR2442234A2/fr
Application filed by Synthelabo SA filed Critical Synthelabo SA
Publication of GB2027703A publication Critical patent/GB2027703A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/096—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7926224A 1978-08-01 1979-07-27 1-Phenylpiperazine derivatives Withdrawn GB2027703A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR7822672A FR2432515A1 (fr) 1978-08-01 1978-08-01 Derives de phenyl-1 piperazine et leur application en therapeutique
FR7833105A FR2442234A2 (fr) 1978-08-01 1978-11-23 Derives de phenyl-1 piperazine et leur application en therapeutique
FR7916029A FR2459797A2 (fr) 1978-08-01 1979-06-22 Derives de phenyl-1 piperazine et leur application en therapeutique

Publications (1)

Publication Number Publication Date
GB2027703A true GB2027703A (en) 1980-02-27

Family

ID=27250847

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7926224A Withdrawn GB2027703A (en) 1978-08-01 1979-07-27 1-Phenylpiperazine derivatives

Country Status (18)

Country Link
JP (1) JPS5522690A (el)
AU (1) AU4930979A (el)
BE (1) BE877994A (el)
DE (1) DE2930440A1 (el)
DK (1) DK321479A (el)
ES (1) ES483003A1 (el)
FI (1) FI792401A (el)
FR (1) FR2459797A2 (el)
GB (1) GB2027703A (el)
GR (1) GR69703B (el)
IL (1) IL57920A0 (el)
IT (1) IT1123497B (el)
LU (1) LU81562A1 (el)
NL (1) NL7905810A (el)
NO (1) NO792502L (el)
NZ (1) NZ191140A (el)
PT (1) PT70007A (el)
SE (1) SE7906507L (el)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001046145A1 (en) * 1999-12-22 2001-06-28 A. Carlsson Research Ab New modulators of dopamine neurotransmission
US6924374B2 (en) 1999-12-22 2005-08-02 A. Carlsson Research Ab Modulators of dopamine neurotransmission
WO2005121087A1 (en) 2004-06-08 2005-12-22 A. Carlsson Research Ab New disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
US7763639B2 (en) 2004-06-08 2010-07-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
US7923459B2 (en) 2004-10-13 2011-04-12 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
US8501777B2 (en) 2005-10-13 2013-08-06 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
US9012476B2 (en) 2011-12-08 2015-04-21 IVAX International GmbH Hydrobromide salt of pridopidine
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2582288B1 (fr) * 1985-05-21 1987-08-07 Massonnet Henry Poubelle compacteuse perfectionnee

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH353743A (fr) * 1955-06-29 1961-04-30 Parke Davis & Co Procédé de préparation de pipérazines
US2976290A (en) * 1959-04-24 1961-03-21 Parke Davis & Co Piperazine derivatives and methods for their production
FR2224464A1 (en) * 1973-04-05 1974-10-31 Synthelabo N-Phenyl-N'-beta-hydroxy-ethyl piperazines - as analgesic and anti-inflammatory agents

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE41315E1 (en) 1999-12-22 2010-05-04 Nsab, Filial Af Neurosearch Sweden Ab Modulators of dopamine neurotransmission
WO2001046144A1 (en) * 1999-12-22 2001-06-28 A. Carlsson Research Ab New modulators of dopamine neurotransmission
EP1428822A2 (en) 1999-12-22 2004-06-16 A. Carlsson Research AB 1-phenylpiperazine derivative as modulators of dopamine neurotransmission
US6903120B2 (en) 1999-12-22 2005-06-07 A. Carlsson Research Ab Modulators of dopamine neurotransmission
US6924374B2 (en) 1999-12-22 2005-08-02 A. Carlsson Research Ab Modulators of dopamine neurotransmission
WO2001046145A1 (en) * 1999-12-22 2001-06-28 A. Carlsson Research Ab New modulators of dopamine neurotransmission
USRE46117E1 (en) 1999-12-22 2016-08-23 Teva Pharmaceuticals International Gmbh Modulators of dopamine neurotransmission
US7417043B2 (en) 1999-12-22 2008-08-26 Neurosearch Sweden Ab Modulators of dopamine neurotransmission
EP1428822A3 (en) * 1999-12-22 2009-07-01 NSAB, Filial af NeuroSearch Sweden AB, Sverige 1-phenylpiperazine derivative as modulators of dopamine neurotransmission
BG65698B1 (bg) * 1999-12-22 2009-07-31 A. Carlsson Research Ab Заместени 4-(фенил-n-алкил)-пиперидинови съединения, фармацевтичен състав и използването им в медицината
BG65854B1 (bg) * 1999-12-22 2010-03-31 A. Carlsson Research Ab Модулатори на допамин невротрансмисия
WO2005121087A1 (en) 2004-06-08 2005-12-22 A. Carlsson Research Ab New disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
US7763639B2 (en) 2004-06-08 2010-07-27 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines/piperazines as modulators of dopamine neurotransmission
US7851629B2 (en) 2004-06-08 2010-12-14 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
US8314126B2 (en) 2004-06-08 2012-11-20 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Disubstituted phenylpiperdines/piperazines as modulators of dopamine neurotransmission
WO2005121088A1 (en) 2004-06-08 2005-12-22 A. Carlsson Research Ab New disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
US7923459B2 (en) 2004-10-13 2011-04-12 Nsab, Filial Af Neurosearch Sweden Ab, Sverige Process for the synthesis of 4-(3-methanesulfonylphenyl)-1-N-propyl-piperidine
US8501777B2 (en) 2005-10-13 2013-08-06 Nsab, Filial Af Neurosearch Sweden Ab, Sverige 3,5-disubstituted phenyl-piperidines as modulators of dopamine neurotransmission
US9012476B2 (en) 2011-12-08 2015-04-21 IVAX International GmbH Hydrobromide salt of pridopidine
US9814706B2 (en) 2011-12-08 2017-11-14 Teva Pharmaceuticals International Gmbh Hydrobromide salt of pridopidine

Also Published As

Publication number Publication date
FI792401A (fi) 1980-02-02
PT70007A (fr) 1979-08-01
LU81562A1 (fr) 1981-03-24
ES483003A1 (es) 1980-04-16
NL7905810A (nl) 1980-02-05
SE7906507L (sv) 1980-02-02
IT1123497B (it) 1986-04-30
FR2459797B2 (el) 1982-05-14
BE877994A (fr) 1980-01-31
NO792502L (no) 1980-02-04
DE2930440A1 (de) 1980-02-28
IT7924749A0 (it) 1979-07-27
NZ191140A (en) 1981-01-23
GR69703B (el) 1982-07-09
DK321479A (da) 1980-02-02
JPS5522690A (en) 1980-02-18
IL57920A0 (en) 1979-11-30
FR2459797A2 (fr) 1981-01-16
AU4930979A (en) 1980-02-07

Similar Documents

Publication Publication Date Title
US4675319A (en) Antianaphylactic and antibronchospastic piperazinyl-(N-substituted phenyl)carboxamides, compositions and use
US4267328A (en) 1-Phenylpiperazines
PL69767B1 (en) 11-substituted 5 11-dihydro-6h-pyrido(2 3-b)(1 4)benzodiazepin-6-ones [us3660380a]
NO792020L (no) Fremgangsmaate for fremstilling av farmakologisk aktive fenylpiperaziner
GB2027703A (en) 1-Phenylpiperazine derivatives
EP0025111A1 (en) 3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DK148688B (da) Analogifremgangsmaade til fremstilling af basisk substituerede 7-alkylteofyllinderivater eller salte deraf med farmaceutisk acceptable syrer
EP0541617B1 (en) 1,4-disubstituted piperazines
SU772484A3 (ru) Способ получени производных бензодиазепинона или их солей
US5153207A (en) Piperidine derivative, method for preparation thereof, and a pharmaceutical composition comprising the same
SU1223843A3 (ru) Способ получени 1-фенил-2-аминокарбонилиндольных соединений или их кислотно-аддитивных солей
US3337554A (en) Piperazino and homopiperazino-10-11-dihydrobenzo[b, f]-thiepin
US3573291A (en) Cinnamylpiperazine preparations
DK151965B (da) Analogifremgangsmaade til fremstilling af piperazinsubstituerede 3-alkyltheobrominforbindelser
SU428602A3 (ru) Способ получения основпозамещенных производных 1
EP0383318A2 (en) Aralkylamine compounds
IE53653B1 (en) Derivatives of 4-phenyl quinazoline active on the central nervous system
EP0150235A1 (en) Derivatives of 3-pyrrolidinopropiophenone and a process for preparation thereof
EP0001759B1 (en) (omega-aminoalkoxy) bibenzyls, processes for their preparation and pharmaceutical compositions containing these substances
US3370066A (en) Substituted methylenedioxybenzamides
US4242343A (en) Phenylpiperazine derivatives
EP0451772A1 (en) Piperidine compounds, method for preparation thereof, and a pharamceutical composition comprising the same
US4127666A (en) Disubstituted 2,5-benzamides and pharmaceutical compositions containing the same
CA1125756A (en) Indane-acetic acid aminoesters, their preparation and their use in therapy
US5276035A (en) 1,4-disubstituted piperazines

Legal Events

Date Code Title Description
WAP Application withdrawn, taken to be withdrawn or refused ** after publication under section 16(1)