GB201421083D0 - Enzyme inhibitors - Google Patents

Enzyme inhibitors

Info

Publication number
GB201421083D0
GB201421083D0 GBGB1421083.5A GB201421083A GB201421083D0 GB 201421083 D0 GB201421083 D0 GB 201421083D0 GB 201421083 A GB201421083 A GB 201421083A GB 201421083 D0 GB201421083 D0 GB 201421083D0
Authority
GB
United Kingdom
Prior art keywords
enzyme inhibitors
inhibitors
enzyme
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
GBGB1421083.5A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kalvista Pharmaceuticals Ltd
Original Assignee
Kalvista Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52349552&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB201421083(D0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kalvista Pharmaceuticals Ltd filed Critical Kalvista Pharmaceuticals Ltd
Priority to GBGB1421083.5A priority Critical patent/GB201421083D0/en
Publication of GB201421083D0 publication Critical patent/GB201421083D0/en
Priority to MDE20191295T priority patent/MD3567037T2/ro
Priority to DK15804210.1T priority patent/DK3224256T3/da
Priority to PL19176610T priority patent/PL3556752T3/pl
Priority to MA41014A priority patent/MA41014B1/fr
Priority to US15/527,923 priority patent/US10364238B2/en
Priority to PT191766104T priority patent/PT3556752T/pt
Priority to PH1/2017/500901A priority patent/PH12017500901B1/en
Priority to LTEP19182383.0T priority patent/LT3567037T/lt
Priority to RS20220301A priority patent/RS63155B1/sr
Priority to NZ731945A priority patent/NZ731945A/en
Priority to MYPI2017701845A priority patent/MY176853A/en
Priority to BR112017010882A priority patent/BR112017010882B8/pt
Priority to IL278182A priority patent/IL278182B/en
Priority to CN201580071671.XA priority patent/CN107108576B/zh
Priority to PL19182383T priority patent/PL3567037T3/pl
Priority to RSP20191116 priority patent/RS59395B1/sr
Priority to DK19176610.4T priority patent/DK3556752T3/da
Priority to MX2020013038A priority patent/MX2020013038A/es
Priority to PT15804210T priority patent/PT3224256T/pt
Priority to PCT/GB2015/053615 priority patent/WO2016083820A1/en
Priority to JP2017527570A priority patent/JP6653702B2/ja
Priority to CN201910782520.5A priority patent/CN110577519A/zh
Priority to KR1020217018472A priority patent/KR102496404B1/ko
Priority to HRP20220314TT priority patent/HRP20220314T1/hr
Priority to SG11201703988PA priority patent/SG11201703988PA/en
Priority to RS20210205A priority patent/RS61497B1/sr
Priority to MX2017006823A priority patent/MX378283B/es
Priority to KR1020177017538A priority patent/KR102267623B1/ko
Priority to MA52063A priority patent/MA52063B1/fr
Priority to SM20210112T priority patent/SMT202100112T1/it
Priority to SG10201907819WA priority patent/SG10201907819WA/en
Priority to MA47217A priority patent/MA47217B1/fr
Priority to DK19182383.0T priority patent/DK3567037T3/da
Priority to EP15804210.1A priority patent/EP3224256B1/en
Priority to HUE15804210A priority patent/HUE047425T2/hu
Priority to MEP-2019-234A priority patent/ME03514B/me
Priority to AU2015352193A priority patent/AU2015352193B2/en
Priority to SM20220107T priority patent/SMT202200107T1/it
Priority to NZ770256A priority patent/NZ770256B2/en
Priority to HK18103626.6A priority patent/HK1244268B/en
Priority to LTEP15804210.1T priority patent/LT3224256T/lt
Priority to ARP150103900A priority patent/AR102850A1/es
Priority to ES15804210T priority patent/ES2745815T3/es
Priority to ES19182383T priority patent/ES2858082T3/es
Priority to EP21215491.8A priority patent/EP4039681A1/en
Priority to RU2019131174A priority patent/RU2821520C2/ru
Priority to SI201530836T priority patent/SI3224256T1/sl
Priority to MDE20191218T priority patent/MD3556752T2/ro
Priority to MDE20170127T priority patent/MD3224256T2/ro
Priority to LTEP19176610.4T priority patent/LT3556752T/lt
Priority to CA2967894A priority patent/CA2967894C/en
Priority to HUE19182383A priority patent/HUE053317T2/hu
Priority to HUE19176610A priority patent/HUE057647T2/hu
Priority to RU2017122364A priority patent/RU2707870C2/ru
Priority to HRP20191524 priority patent/HRP20191524T1/hr
Priority to PT191823830T priority patent/PT3567037T/pt
Priority to EP19182383.0A priority patent/EP3567037B1/en
Priority to SI201531527T priority patent/SI3567037T1/sl
Priority to SM20190497T priority patent/SMT201900497T1/it
Priority to PL15804210T priority patent/PL3224256T3/pl
Priority to SI201531813T priority patent/SI3556752T1/sl
Priority to UAA201706473A priority patent/UA123087C2/uk
Priority to EP19176610.4A priority patent/EP3556752B1/en
Priority to ES19176610T priority patent/ES2908303T3/es
Priority to TW104139776A priority patent/TWI686383B/zh
Priority to TW108135558A priority patent/TWI741377B/zh
Priority to IL252287A priority patent/IL252287B/en
Priority to CL2017001362A priority patent/CL2017001362A1/es
Priority to ECIEPI201739127A priority patent/ECSP17039127A/es
Priority to CONC2017/0006230A priority patent/CO2017006230A2/es
Priority to US16/438,061 priority patent/US11001578B2/en
Priority to US16/460,630 priority patent/US10611758B2/en
Priority to CY20191101020T priority patent/CY1122255T1/el
Priority to AU2019240616A priority patent/AU2019240616B2/en
Priority to JP2019184938A priority patent/JP6995101B2/ja
Priority to ZA2019/07052A priority patent/ZA201907052B/en
Priority to US16/804,872 priority patent/US11198691B2/en
Priority to US16/944,658 priority patent/US11084809B2/en
Priority to ARP210100300A priority patent/AR121273A2/es
Priority to HRP20210350TT priority patent/HRP20210350T1/hr
Priority to CY20211100194T priority patent/CY1124046T1/el
Priority to JP2021123024A priority patent/JP7148683B2/ja
Priority to US17/506,261 priority patent/US20220289729A1/en
Priority to CY20221100202T priority patent/CY1125214T1/el
Priority to JP2022149897A priority patent/JP2022180520A/ja
Priority to US18/604,389 priority patent/US20250074903A1/en
Priority to JP2024173032A priority patent/JP2025000918A/ja
Priority to FIC20265004C priority patent/FIC20265004I1/fi
Priority to LTPA2026502C priority patent/LTPA2026502I1/lt
Priority to FR26C1004C priority patent/FR26C1004I1/fr
Priority to NO2026004C priority patent/NO2026004I1/no
Priority to NL301364C priority patent/NL301364I2/nl
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GBGB1421083.5A 2014-11-27 2014-11-27 Enzyme inhibitors Ceased GB201421083D0 (en)

Priority Applications (93)

Application Number Priority Date Filing Date Title
GBGB1421083.5A GB201421083D0 (en) 2014-11-27 2014-11-27 Enzyme inhibitors
MDE20191295T MD3567037T2 (ro) 2014-11-27 2015-11-26 Compuși N-((het)arilmetil)-heteroaril-carboxamide în calitate de inhibitori ai kallikreinei plasmatice
DK15804210.1T DK3224256T3 (da) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamid-forbindelser som plasma kallikrein-inhibitorer
PL19176610T PL3556752T3 (pl) 2014-11-27 2015-11-26 Związki n-((het)arylometylo-heteroarylo-karboksyamidowe jako inhibitory kalikreiny osoczowej
MA41014A MA41014B1 (fr) 2014-11-27 2015-11-26 Composés n-((het)arylméthyl)-hétéroaryl-carboxamides comme inhibiteurs de la kallikréine plasmatique
US15/527,923 US10364238B2 (en) 2014-11-27 2015-11-26 N-((het) arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
PT191766104T PT3556752T (pt) 2014-11-27 2015-11-26 Compostos de n-((het)arilmetil)-heteroarilcarboxamidas como inibidores da calicreína plasmática
PH1/2017/500901A PH12017500901B1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
LTEP19182383.0T LT3567037T (lt) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroarilkarboksamidų junginiai, kaip plazmos kalikreino inhibitoriai
RS20220301A RS63155B1 (sr) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroaril-karboksiamidna jedinjenja kao inhibitori kalikrein plazme
NZ731945A NZ731945A (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
MYPI2017701845A MY176853A (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
BR112017010882A BR112017010882B8 (pt) 2014-11-27 2015-11-26 Compostos de n-((het)-arilmetil)-heteroaril-carboxamidas como inibidores de calicreína plasmática e seus usos
IL278182A IL278182B (en) 2014-11-27 2015-11-26 Compounds n-((het)arylmethyl)-heteroaryl-carboxamides as plasma kallikrein inhibitors
CN201580071671.XA CN107108576B (zh) 2014-11-27 2015-11-26 作为血浆激肽释放酶抑制剂的n-((杂)芳基甲基)-杂芳基-甲酰胺化合物
PL19182383T PL3567037T3 (pl) 2014-11-27 2015-11-26 Związki n-((het)arylometylo-heteroarylo-karboksyamidowe jako inhibitory kalikreiny osoczowej
RSP20191116 RS59395B1 (sr) 2014-11-27 2015-11-26 Jedinjenja n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori kalikreina plazme
DK19176610.4T DK3556752T3 (da) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamidforbindelser som plasmakallikreininhibitorer
MX2020013038A MX2020013038A (es) 2014-11-27 2015-11-26 Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreina plasmatica.
PT15804210T PT3224256T (pt) 2014-11-27 2015-11-26 Compostos de n-((het)arilmetil)-heteroarilcarboxamidas como inibidores da calicreína plasmática
PCT/GB2015/053615 WO2016083820A1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
JP2017527570A JP6653702B2 (ja) 2014-11-27 2015-11-26 血漿カリクレイン阻害剤としてのｎ−（（ヘタ）アリールメチル）−ヘテロアリール−カルボキサミド化合物
CN201910782520.5A CN110577519A (zh) 2014-11-27 2015-11-26 作为血浆激肽释放酶抑制剂的n-((杂)芳基甲基)-杂芳基-甲酰胺化合物
KR1020217018472A KR102496404B1 (ko) 2014-11-27 2015-11-26 혈장 칼리크레인의 저해제로서의 n-((het)아릴메틸)-헤테로아릴-카르복사미드 화합물
HRP20220314TT HRP20220314T1 (hr) 2014-11-27 2015-11-26 Spojevi n-((het)arilmetil)-heteroaril-karboksamida kao plazma kallikrein inhibitori
SG11201703988PA SG11201703988PA (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
RS20210205A RS61497B1 (sr) 2014-11-27 2015-11-26 Jedinjenja n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori kalikreina plazme
MX2017006823A MX378283B (es) 2014-11-27 2015-11-26 Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreina plasmatica.
KR1020177017538A KR102267623B1 (ko) 2014-11-27 2015-11-26 혈장 칼리크레인의 저해제로서의 n-((het)아릴메틸)-헤테로아릴-카르복사미드 화합물
MA52063A MA52063B1 (fr) 2014-11-27 2015-11-26 Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique
SM20210112T SMT202100112T1 (it) 2014-11-27 2015-11-26 Composti di n-((et)arilmetil)-eteroaril-carbossammidi come inibitori della callicreina plasmatica
SG10201907819WA SG10201907819WA (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
MA47217A MA47217B1 (fr) 2014-11-27 2015-11-26 Composés de n-((hét)arylméthyl)hétéroaryle-carboxamides en tant qu'inhibiteurs de la kallicréine plasmatique
DK19182383.0T DK3567037T3 (da) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamidforbindelser som plasmakallikreininhibitorer
EP15804210.1A EP3224256B1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
HUE15804210A HUE047425T2 (hu) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroaril-karboxamid vegyületek, mint plazma kallikrein inhibitorok
MEP-2019-234A ME03514B (me) 2014-11-27 2015-11-26 Jedinjenja n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori kalikreina plazme
AU2015352193A AU2015352193B2 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors,
SM20220107T SMT202200107T1 (it) 2014-11-27 2015-11-26 Composti di n-((et)arilmetil)-eteroaril-carbossammidi come inibitori della callicreina plasmatica
NZ770256A NZ770256B2 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
HK18103626.6A HK1244268B (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
LTEP15804210.1T LT3224256T (lt) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroarilkarboksamidų junginiai, kaip plazmos kalikreino inhibitoriai
ARP150103900A AR102850A1 (es) 2014-11-27 2015-11-26 Inhibidores de enzimas
ES15804210T ES2745815T3 (es) 2014-11-27 2015-11-26 Compuestos N-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de la calicreína plasmática
ES19182383T ES2858082T3 (es) 2014-11-27 2015-11-26 Compuestos N-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de la calicreína plasmática
EP21215491.8A EP4039681A1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
RU2019131174A RU2821520C2 (ru) 2014-11-27 2015-11-26 N-((гет)арилметил)-гетероарил-карбоксамидные соединения в качестве ингибиторов плазменного калликреина
SI201530836T SI3224256T1 (sl) 2014-11-27 2015-11-26 Spojine N-((HET)arilmetil)-heteroaril-karboksamidov kot inhibitorji plazemskega kalikreina
MDE20191218T MD3556752T2 (ro) 2014-11-27 2015-11-26 Compuși de N-((het)arilmetil)-heteroaril-carboxamide în calitate de inhibitori ai kallikreinei plasmatice
MDE20170127T MD3224256T2 (ro) 2014-11-27 2015-11-26 Compuși N-((het)arilmetil)-heteroaril-carboxamidici în calitate de inhibitori ai kalikreinei plasmatice
LTEP19176610.4T LT3556752T (lt) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroaril-karboksamidų junginiai kaip plazmos kalikreino inhibitoriai
CA2967894A CA2967894C (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
HUE19182383A HUE053317T2 (hu) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroaril-karboxamid vegyületek mint plazma kallikrein inhibitorok
HUE19176610A HUE057647T2 (hu) 2014-11-27 2015-11-26 N-((het)arilmetil)-heteroaril-karboxamid-vegyületek mint plazma kallikrein inhibitorok
RU2017122364A RU2707870C2 (ru) 2014-11-27 2015-11-26 N-((гет)арилметил)-гетероарил-карбоксамидные соединения в качестве ингибиторов плазменного калликреина
HRP20191524 HRP20191524T1 (hr) 2014-11-27 2015-11-26 Spojevi n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori kalikreina plazme
PT191823830T PT3567037T (pt) 2014-11-27 2015-11-26 Compostos de n-((het)arilmetil)-heteroarilcarboxamidas como inibidores da calicreína plasmática
EP19182383.0A EP3567037B1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
SI201531527T SI3567037T1 (sl) 2014-11-27 2015-11-26 Spojine N-((Het)arilmetil)-heteroaril-karboksamidov, kot zaviralci plazemskega kalikreina
SM20190497T SMT201900497T1 (it) 2014-11-27 2015-11-26 Composti di n-((et)arilmetil)-eteroaril-carbossammidi come inibitori della callicreina plasmatica
PL15804210T PL3224256T3 (pl) 2014-11-27 2015-11-26 Związki n-((het)arylometylo-heteroarylo-karboksyamidowe jako inhibitory kalikreiny osoczowej
SI201531813T SI3556752T1 (sl) 2014-11-27 2015-11-26 Spojine N-((HET)ARILMETIL)-HETEROARIL-KARBOKSAMIDOV kot zaviralci plazemskega kalikreina
UAA201706473A UA123087C2 (uk) 2014-11-27 2015-11-26 N-((гет)арилметил)-гетероарилкарбоксамідні сполуки як інгібітори плазмового калікреїну
EP19176610.4A EP3556752B1 (en) 2014-11-27 2015-11-26 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
ES19176610T ES2908303T3 (es) 2014-11-27 2015-11-26 Compuestos de N-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de la calicreína plasmática
TW104139776A TWI686383B (zh) 2014-11-27 2015-11-27 酶抑制劑
TW108135558A TWI741377B (zh) 2014-11-27 2015-11-27 酶抑制劑
IL252287A IL252287B (en) 2014-11-27 2017-05-15 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
CL2017001362A CL2017001362A1 (es) 2014-11-27 2017-05-26 Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreína plasmática
ECIEPI201739127A ECSP17039127A (es) 2014-11-27 2017-06-22 Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreína plasmática
CONC2017/0006230A CO2017006230A2 (es) 2014-11-27 2017-06-23 Compuestos de n-((het)arilmetil)-heteroaril-carboxamidas como inhibidores de calicreína plasmática
US16/438,061 US11001578B2 (en) 2014-11-27 2019-06-11 N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
US16/460,630 US10611758B2 (en) 2014-11-27 2019-07-02 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
CY20191101020T CY1122255T1 (el) 2014-11-27 2019-09-30 Ενωσεις ν-((ετ)αρυλμεθυλ)-ετεροαρυλ-καρβοξαμιδιων ως αναστολεις καλλικρεϊνης πλασματος
AU2019240616A AU2019240616B2 (en) 2014-11-27 2019-10-02 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
JP2019184938A JP6995101B2 (ja) 2014-11-27 2019-10-08 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物
ZA2019/07052A ZA201907052B (en) 2014-11-27 2019-10-25 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as plasma kallikrein inhibitors
US16/804,872 US11198691B2 (en) 2014-11-27 2020-02-28 N-((het)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
US16/944,658 US11084809B2 (en) 2014-11-27 2020-07-31 N-((HET)arylmethyl)-heteroaryl-carboxamides compounds as kallikrein inhibitors
ARP210100300A AR121273A2 (es) 2014-11-27 2021-02-04 Inhibidores enzimáticos para uso en medicina y composición farmacéutica que los comprende
HRP20210350TT HRP20210350T1 (hr) 2014-11-27 2021-03-01 Spojevi n-((het)arilmetil)-heteroaril-karboksamida kao inhibitori plazmatskog kalikreina
CY20211100194T CY1124046T1 (el) 2014-11-27 2021-03-08 Ενωσεις ν-((ετ)αρυλμεθυλ)-ετεροαρυλ-καρβοξαμιδιων ως αναστολεις καλλικρεϊνης πλασματος
JP2021123024A JP7148683B2 (ja) 2014-11-27 2021-07-28 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物
US17/506,261 US20220289729A1 (en) 2014-11-27 2021-10-20 N-((HET)Arylmethyl)-Heteroaryl-Carboxamides Compounds As Kallikrein Inhibitors
CY20221100202T CY1125214T1 (el) 2014-11-27 2022-03-11 Ενωσεις ν-((ετ)αρυλμεθυλ)-ετεροαρυλ-καρβοξαμιδιων ως αναστολεις καλλικρεϊνης πλασματος
JP2022149897A JP2022180520A (ja) 2014-11-27 2022-09-21 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物
US18/604,389 US20250074903A1 (en) 2014-11-27 2024-03-13 N-((HET)Arylmethyl)-Heteroaryl-Carboxamides Compounds As Kallikrein Inhibitors
JP2024173032A JP2025000918A (ja) 2014-11-27 2024-10-02 血漿カリクレイン阻害剤としてのｎ－（（ヘタ）アリールメチル）－ヘテロアリール－カルボキサミド化合物
FIC20265004C FIC20265004I1 (fi) 2014-11-27 2026-01-13 Sebetralstaatti tai sen farmaseuttisesti hyväksyttävä suola tai solvaatti
LTPA2026502C LTPA2026502I1 (https=) 2014-11-27 2026-01-14
FR26C1004C FR26C1004I1 (fr) 2014-11-27 2026-01-14 Composés n-((het)arylméthyl)-hétéroaryl-carboxamides comme inhibiteurs de la kallikréine plasmatique
NO2026004C NO2026004I1 (no) 2014-11-27 2026-01-16 Sebetralstat or a pharmaceutically acceptable salt or solvate thereof
NL301364C NL301364I2 (nl) 2014-11-27 2026-01-30 sebetralstat of een farmaceutisch aanvaardbaar zout of solvaat daarvan

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB1421083.5A GB201421083D0 (en) 2014-11-27 2014-11-27 Enzyme inhibitors

Publications (1)

Publication Number Publication Date
GB201421083D0 true GB201421083D0 (en) 2015-01-14

Family

ID=52349552

Family Applications (1)

Application Number Title Priority Date Filing Date
GBGB1421083.5A Ceased GB201421083D0 (en) 2014-11-27 2014-11-27 Enzyme inhibitors

Country Status (42)

Country Link
US (7) US10364238B2 (https=)
EP (4) EP3556752B1 (https=)
JP (5) JP6653702B2 (https=)
KR (2) KR102267623B1 (https=)
CN (2) CN107108576B (https=)
AR (2) AR102850A1 (https=)
AU (2) AU2015352193B2 (https=)
BR (1) BR112017010882B8 (https=)
CA (1) CA2967894C (https=)
CL (1) CL2017001362A1 (https=)
CO (1) CO2017006230A2 (https=)
CY (3) CY1122255T1 (https=)
DK (3) DK3224256T3 (https=)
EC (1) ECSP17039127A (https=)
ES (3) ES2908303T3 (https=)
FI (1) FIC20265004I1 (https=)
FR (1) FR26C1004I1 (https=)
GB (1) GB201421083D0 (https=)
HR (3) HRP20191524T1 (https=)
HU (3) HUE047425T2 (https=)
IL (2) IL278182B (https=)
LT (4) LT3556752T (https=)
MA (3) MA47217B1 (https=)
MD (3) MD3567037T2 (https=)
ME (1) ME03514B (https=)
MX (2) MX378283B (https=)
MY (1) MY176853A (https=)
NL (1) NL301364I2 (https=)
NO (1) NO2026004I1 (https=)
NZ (1) NZ731945A (https=)
PH (1) PH12017500901B1 (https=)
PL (3) PL3556752T3 (https=)
PT (3) PT3224256T (https=)
RS (3) RS61497B1 (https=)
RU (1) RU2707870C2 (https=)
SG (2) SG11201703988PA (https=)
SI (3) SI3567037T1 (https=)
SM (3) SMT202100112T1 (https=)
TW (2) TWI741377B (https=)
UA (1) UA123087C2 (https=)
WO (1) WO2016083820A1 (https=)
ZA (1) ZA201907052B (https=)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
DK4019022T3 (en) 2015-10-01 2024-02-19 Biocryst Pharm Inc Human plasma kallikrein inhibitors
GB201609519D0 (en) * 2016-05-31 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyr idin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
DK3464271T3 (da) * 2016-05-31 2020-06-15 Kalvista Pharmaceuticals Ltd Pyrazolderivater som plasma-kallikreininhibitorer
GB201609607D0 (en) * 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) * 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
US11168080B2 (en) 2017-04-26 2021-11-09 Mitobridge, Inc. Dynamin-1-like protein inhibitors
PT3716952T (pt) * 2017-11-29 2022-04-14 Kalvista Pharmaceuticals Ltd Formas de administração que incluem um inibidor de calicreína plasmática
WO2019106359A1 (en) * 2017-11-29 2019-06-06 Kalvista Pharmaceuticals Limited Enzyme inhibitors
GB201719882D0 (en) * 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of a plasma kallikrein inhibitor and salts thereof
GB201719881D0 (en) * 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
GB201721515D0 (en) * 2017-12-21 2018-02-07 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibtor
EP3765459A1 (en) 2018-03-13 2021-01-20 Shire Human Genetic Therapies, Inc. Substituted imidazopyridines as inhibitors of plasma kallikrein and uses thereof
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
GB201910116D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
GB201910125D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of angioedema
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
DK4031547T3 (da) 2019-09-18 2024-09-09 Takeda Pharmaceuticals Co Plasmakallikreininhibitorer og anvendelser deraf
EP4031245A1 (en) 2019-09-18 2022-07-27 Takeda Pharmaceutical Company Limited Heteroaryl plasma kallikrein inhibitors
CN113004286B (zh) * 2019-12-20 2022-08-12 成都康弘药业集团股份有限公司 作为血浆激肽释放酶抑制剂的三环类化合物及其用途
TW202144331A (zh) * 2020-02-13 2021-12-01 德商百靈佳殷格翰國際股份有限公司 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物
CN115210230A (zh) * 2020-03-04 2022-10-18 南京明德新药研发有限公司 杂环类化合物
CN115989224B (zh) 2020-06-16 2025-02-25 默沙东有限责任公司 血浆激肽释放酶抑制剂
KR20230038526A (ko) 2020-07-10 2023-03-20 머크 샤프 앤드 돔 엘엘씨 혈장 칼리크레인 억제제
WO2022079446A1 (en) 2020-10-15 2022-04-21 Kalvista Pharmaceuticals Limited Treatments of angioedema
EP4232031A1 (en) 2020-10-23 2023-08-30 Kalvista Pharmaceuticals Limited Treatments of angioedema
JP2024505596A (ja) 2021-02-09 2024-02-06 カルビスタ・ファーマシューティカルズ・リミテッド 遺伝性血管性浮腫の治療
WO2023002219A1 (en) 2021-07-23 2023-01-26 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023185634A1 (zh) * 2022-03-30 2023-10-05 南京明德新药研发有限公司 作为血浆激肽释放酶抑制剂的杂环类化合物
EP4480545A3 (en) 2022-04-27 2025-02-26 Kalvista Pharmaceuticals Limited Formulations of a plasma kallikrein inhibitor
KR20250083452A (ko) * 2022-07-29 2025-06-10 레졸루트 인크 혈장 칼리크레인 억제제
WO2024180100A1 (en) 2023-02-27 2024-09-06 Kalvista Pharmaceuticals Limited New solid form of a plasma kallikrein inhibitor
WO2025001956A1 (zh) 2023-06-30 2025-01-02 远森制药（杭州）有限公司 杂芳族甲酰胺类化合物及其在医药上的应用
WO2025153806A1 (en) 2024-01-15 2025-07-24 Kalvista Pharmaceuticals Limited Methods for determining amidolytic activity
WO2025172693A1 (en) 2024-02-13 2025-08-21 Kalvista Pharmaceuticals Limited Oral sebetralstat for the treatment of an attack of hereditary angioedema
WO2025172692A1 (en) 2024-02-13 2025-08-21 Kalvista Pharmaceuticals Limited Oral sebetralstat for the treatment of an attack of hereditary angioedema

Family Cites Families (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
GB9019558D0 (en) 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
SE9301911D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptide derivatives
US5589467A (en) 1993-09-17 1996-12-31 Novo Nordisk A/S 2,5',N6-trisubstituted adenosine derivatives
US5786328A (en) 1995-06-05 1998-07-28 Genentech, Inc. Use of kunitz type plasma kallikrein inhibitors
US7101878B1 (en) 1998-08-20 2006-09-05 Agouron Pharmaceuticals, Inc. Non-peptide GNRH agents, methods and intermediates for their preparation
EP1169038B9 (en) * 1999-04-15 2013-07-10 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
ATE355064T1 (de) 2001-10-26 2006-03-15 Angeletti P Ist Richerche Bio Dihydroxypyrimidin-carbonsäueramid-hemmer der hiv-integrase
WO2003037274A2 (en) 2001-11-01 2003-05-08 Icagen, Inc. Pyrazole-amides and-sulfonamides
GB0205527D0 (en) 2002-03-08 2002-04-24 Ferring Bv Inhibitors
AU2003230829B8 (en) 2002-04-26 2008-12-11 Eli Lilly And Company Triazole derivatives as tachykinin receptor antagonists
EP1426364A1 (en) 2002-12-04 2004-06-09 Aventis Pharma Deutschland GmbH Imidazole-derivatives as factor Xa inhibitors
DE10301300B4 (de) 2003-01-15 2009-07-16 Curacyte Chemistry Gmbh Verwendung von acylierten 4-Amidino- und 4-Guanidinobenzylaminen zur Inhibierung von Plasmakallikrein
US20040192728A1 (en) 2003-02-03 2004-09-30 Ellen Codd Quinoline-derived amide modulators of vanilloid VR1 receptor
NZ592039A (en) 2003-08-27 2013-03-28 Ophthotech Corp Combination therapy for the treatment of ocular neovascular disorders
TW200526588A (en) * 2003-11-17 2005-08-16 Smithkline Beecham Corp Chemical compounds
GB0403155D0 (en) 2004-02-12 2004-03-17 Vernalis Res Ltd Chemical compounds
EP1568698A1 (en) 2004-02-27 2005-08-31 Aventis Pharma Deutschland GmbH Pyrrole-derivatives as factor Xa inhibitors
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
ATE518858T1 (de) 2004-09-03 2011-08-15 Yuhan Corp Pyrroloä3,2-cüpyridinderivate und herstellungsverfahren dafür
EP1858542A4 (en) 2005-02-24 2009-08-19 Joslin Diabetes Center Inc COMPOSITIONS AND METHOD FOR THE TREATMENT OF VASPEREPERMABILITY
GB0508472D0 (en) 2005-04-26 2005-06-01 Glaxo Group Ltd Compounds
KR101142363B1 (ko) 2005-06-27 2012-05-21 주식회사유한양행 피롤로피리딘 유도체를 포함하는 항암제 조성물
EA200800321A1 (ru) 2005-07-14 2008-06-30 Такеда Сан Диего, Инк. Ингибиторы гистондеацетилазы
WO2007011328A1 (en) * 2005-07-14 2007-01-25 Jackson Kenneth A A method for disabling a hypodermic needle after use
US20070254894A1 (en) 2006-01-10 2007-11-01 Kane John L Jr Novel small molecules with selective cytotoxicity against human microvascular endothelial cell proliferation
GB0606876D0 (en) * 2006-04-05 2006-05-17 Glaxo Group Ltd Compounds
US20070258976A1 (en) 2006-05-04 2007-11-08 Ward Keith W Combination Therapy for Diseases Involving Angiogenesis
MX2009000117A (es) 2006-07-06 2009-01-23 Glaxo Group Ltd N-fenilmetil-5-oxo-prolin-2-amidas sustituidas como antagonistas de receptores p2x7 y sus metodos de uso.
WO2008016883A2 (en) 2006-07-31 2008-02-07 Activesite Pharmaceuticals, Inc. Inhibitors of plasma kallikrein
DE102006050672A1 (de) 2006-10-24 2008-04-30 Curacyte Discovery Gmbh Hemmstoffe des Plasmins und des Plasmakallikreins
AR064693A1 (es) 2006-12-29 2009-04-22 Abbott Gmbh & Co Kg Compuestos carboxamidas y su utilizacion en la elaboracion de un medicamento para el tratamiento de enfermedades asociadas a alta actividad de calpaina.
US20100119512A1 (en) 2007-01-25 2010-05-13 Joslin Diabetes Center Methods of diagnosing, treating, and preventing increased vascular permeability
JP2010520293A (ja) 2007-03-07 2010-06-10 アラントス・フアーマシユーテイカルズ・ホールデイング・インコーポレイテツド 複素環式部分を含有するメタロプロテアーゼ阻害剤
NZ579892A (en) 2007-03-30 2012-03-30 Sanofi Aventis Pyrimidine hydrazide compounds as prostaglandin D synthase inhibitors
MX2009010759A (es) 2007-04-03 2009-10-28 Glaxo Group Ltd Derivados de carboxamida imidazolidina como modulares de p2x7.
CN101778827B (zh) 2007-07-26 2012-10-10 先正达参股股份有限公司 杀微生物剂
EP2185506A1 (en) 2007-08-22 2010-05-19 Allergan, Inc. Pyrrole compounds having sphingosine-1-phosphate receptor agonist or antagonist biological activity
WO2009086303A2 (en) 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
WO2009083553A1 (en) 2007-12-31 2009-07-09 Rheoscience A/S Azine compounds as glucokinase activators
EP2259679A4 (en) 2008-01-31 2011-09-14 Joslin Diabetes Ct METHODS OF TREATING KALLIKREIN RELATED DISORDERS
WO2009106980A2 (en) 2008-02-29 2009-09-03 Pfizer Inc. Indazole derivatives
US8324199B2 (en) 2008-03-13 2012-12-04 Bristol-Myers Squibb Company Pyridazine derivatives as factor xia inhibitors
TWI435875B (zh) 2008-07-08 2014-05-01 Daiichi Sankyo Co Ltd 含氮芳香族雜環化合物
US8324385B2 (en) 2008-10-30 2012-12-04 Madrigal Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
AU2010330743A1 (en) 2009-12-18 2012-07-05 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
JP2011157349A (ja) 2010-01-07 2011-08-18 Daiichi Sankyo Co Ltd 含窒素芳香族ヘテロシクリル化合物を含有する医薬組成物
MX345259B (es) 2010-01-28 2017-01-23 The Medicines Company (Leipzig) Gmbh Inhibidores de serina proteasas similares a tripsina, y su preparación y uso.
JP2013121919A (ja) 2010-03-25 2013-06-20 Astellas Pharma Inc 血漿カリクレイン阻害剤
WO2012004678A2 (en) 2010-07-07 2012-01-12 The Medicines Company (Leipzig) Gmbh Serine protease inhibitors
EP2595986A2 (en) 2010-07-14 2013-05-29 Addex Pharma SA Novel 2-amino-4-pyrazolyl-thiazole derivatives and their use as allosteric modulators of metabotropic glutamate receptors
US9290485B2 (en) * 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
EP2458315B1 (de) 2010-11-25 2017-01-04 Balcke-Dürr GmbH Regenerativer Wärmetauscher mit zwangsgeführter Rotordichtung
WO2012142308A1 (en) 2011-04-13 2012-10-18 Activesite Pharmaceuticals, Inc. Prodrugs of inhibitors of plasma kallikrein
WO2012174362A1 (en) 2011-06-17 2012-12-20 Research Triangle Institute Pyrazole derivatives as cannabinoid receptor 1 antagonists
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
EP2760829B1 (en) 2011-09-27 2016-05-18 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2760828B1 (en) 2011-09-27 2015-10-21 Bristol-Myers Squibb Company Pyrrolinone carboxamide compounds useful as endothelial lipase inhibitors
EP2807156A1 (en) 2012-01-27 2014-12-03 Novartis AG Aminopyridine derivatives as plasma kallikrein inhibitors
US20140378474A1 (en) * 2012-01-27 2014-12-25 Novartis Ag 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
JP5989805B2 (ja) 2012-02-10 2016-09-07 コンステレーション・ファーマシューティカルズ・インコーポレイテッドＣｏｎｓｔｅｌｌａｔｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． メチル基変更酵素の調節物質、組成物及びその使用
WO2013130603A1 (en) 2012-02-27 2013-09-06 Board Of Regents, The University Of Texas System Ganglioside gd2 as a marker and target on cancer stem cells
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
GB201300304D0 (en) * 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
CA2894642A1 (en) 2013-01-08 2014-07-17 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
EP4234583A3 (en) 2013-01-20 2024-01-24 Takeda Pharmaceutical Company Limited Evaluation and treatment of bradykinin-mediated disorders
LT2968297T (lt) 2013-03-15 2019-01-10 Verseon Corporation Multipakeistieji aromatiniai junginiai kaip serino proteazės inhibitoriai
EP2999697B1 (en) 2013-05-23 2017-04-19 Kalvista Pharmaceuticals Limited Heterocyclic derivates
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
HUE14755117T2 (hu) 2013-08-14 2018-12-28 Kalvista Pharmaceuticals Ltd Plazma-kallikrein inhibitorok
CA2935683A1 (en) 2013-12-30 2015-07-09 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
US9611252B2 (en) 2013-12-30 2017-04-04 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
KR102736869B1 (ko) 2014-03-07 2024-12-02 바이오크리스트파마슈티컬즈,인코포레이티드 인간 혈장 칼리크레인 저해제
WO2015171526A2 (en) 2014-05-05 2015-11-12 Global Blood Therapeutics, Inc. Tricyclic pyrazolopyridine compounds
WO2015171527A1 (en) 2014-05-05 2015-11-12 Global Blood Therapeutics, Inc. Pyrazolopyridine pyrazolopyrimidine and related compounds
AU2015289643B2 (en) 2014-07-16 2020-10-22 Attune Pharmaceuticals, Inc. Therapeutic inhibitory compounds
JP6824876B2 (ja) 2014-08-22 2021-02-03 バイオクライスト ファーマシューティカルズ， インコーポレイテッド アミジン誘導体組成物及びそれらの使用
CN106687445A (zh) 2014-09-17 2017-05-17 维颂公司 作为丝氨酸蛋白酶抑制剂的吡唑基取代的吡啶酮化合物
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
RU2017131562A (ru) 2015-02-27 2019-03-27 Версеон Корпорейшн Замещенные пиразольные соединения как ингибиторы сериновых протеаз
CA2991174A1 (en) 2015-07-01 2017-01-05 Lifesci Pharmaceuticals, Inc. Therapeutic inhibitory compounds
US10981893B2 (en) 2015-07-01 2021-04-20 Attune Pharmaceuticals, Inc. Therapeutic inhibitory compounds
WO2017072020A1 (en) 2015-10-27 2017-05-04 Boehringer Ingelheim International Gmbh Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
EP3368524B1 (en) 2015-10-27 2021-08-18 Boehringer Ingelheim International GmbH Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
GB201609519D0 (en) 2016-05-31 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of n-[(2,6-difluoro-3-methoxyphenyl)methyl]-3-(methoxymethyl)-1-({4-[(2-oxopyr idin-1-yl)methyl]phenyl}methyl)pyrazole-4-carboxamide
DK3464271T3 (da) 2016-05-31 2020-06-15 Kalvista Pharmaceuticals Ltd Pyrazolderivater som plasma-kallikreininhibitorer
GB201609601D0 (en) 2016-06-01 2016-07-13 Nucana Biomed Ltd Phosphoramidate compounds
GB201609602D0 (en) 2016-06-01 2016-07-13 Nucuna Biomed Ltd Chemical compounds
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
CN110022875A (zh) 2016-07-11 2019-07-16 莱福斯希医药公司 治疗性抑制化合物
WO2019106359A1 (en) 2017-11-29 2019-06-06 Kalvista Pharmaceuticals Limited Enzyme inhibitors
GB201719882D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of a plasma kallikrein inhibitor and salts thereof
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof

Also Published As

Publication number Publication date
CO2017006230A2 (es) 2017-09-11
AU2019240616A1 (en) 2019-10-17
RU2017122364A (ru) 2018-12-27
MD3556752T2 (ro) 2022-07-31
WO2016083820A1 (en) 2016-06-02
MA41014B1 (fr) 2019-09-30
MA41014A (fr) 2017-10-04
SI3567037T1 (sl) 2021-04-30
SMT202200107T1 (it) 2022-05-12
BR112017010882A2 (pt) 2017-12-26
PL3556752T3 (pl) 2022-05-02
US10364238B2 (en) 2019-07-30
JP2020033357A (ja) 2020-03-05
ES2745815T3 (es) 2020-03-03
CN107108576B (zh) 2020-03-10
NZ770256A (en) 2021-11-26
ES2908303T3 (es) 2022-04-28
FIC20265004I1 (fi) 2026-01-13
IL278182B (en) 2022-09-01
US20200361923A1 (en) 2020-11-19
RU2017122364A3 (https=) 2019-06-19
SG11201703988PA (en) 2017-06-29
JP2017535568A (ja) 2017-11-30
US11198691B2 (en) 2021-12-14
US20200199116A1 (en) 2020-06-25
RS61497B1 (sr) 2021-03-31
TW201625548A (zh) 2016-07-16
MX378283B (es) 2025-03-10
SMT201900497T1 (it) 2019-11-13
DK3224256T3 (da) 2019-09-23
BR112017010882B1 (pt) 2023-10-31
US20190330200A1 (en) 2019-10-31
LT3556752T (lt) 2022-03-10
IL252287B (en) 2020-11-30
HUE057647T2 (hu) 2022-05-28
NO2026004I1 (no) 2026-01-16
LT3567037T (lt) 2021-02-25
DK3567037T3 (da) 2021-02-08
JP2025000918A (ja) 2025-01-07
EP3567037B1 (en) 2020-12-23
JP7148683B2 (ja) 2022-10-05
JP2021185138A (ja) 2021-12-09
CY1122255T1 (el) 2020-11-25
US20180319782A1 (en) 2018-11-08
US20190300517A1 (en) 2019-10-03
HRP20191524T1 (hr) 2019-11-29
TWI686383B (zh) 2020-03-01
ES2858082T3 (es) 2021-09-29
JP2022180520A (ja) 2022-12-06
RU2019131174A (ru) 2019-10-10
ME03514B (me) 2020-04-20
KR20210075227A (ko) 2021-06-22
SG10201907819WA (en) 2019-09-27
MD3567037T2 (ro) 2021-05-31
RU2707870C2 (ru) 2019-12-02
SI3556752T1 (sl) 2022-05-31
KR102496404B1 (ko) 2023-02-06
TW202026285A (zh) 2020-07-16
US20250074903A1 (en) 2025-03-06
KR102267623B1 (ko) 2021-06-18
PH12017500901B1 (en) 2022-04-27
EP3224256A1 (en) 2017-10-04
EP3224256B1 (en) 2019-07-03
AR121273A2 (es) 2022-05-04
NZ731945A (en) 2021-07-30
MA47217A (fr) 2019-11-13
HRP20220314T1 (hr) 2022-05-13
CN110577519A (zh) 2019-12-17
MA52063B1 (fr) 2022-01-31
PL3224256T3 (pl) 2020-01-31
LTPA2026502I1 (https=) 2026-02-10
CA2967894A1 (en) 2016-06-02
AU2015352193A1 (en) 2017-06-08
HRP20210350T1 (hr) 2021-04-16
HUE053317T2 (hu) 2021-06-28
ZA201907052B (en) 2025-01-29
EP3556752A1 (en) 2019-10-23
PT3556752T (pt) 2022-04-14
PL3567037T3 (pl) 2021-06-14
PH12017500901A1 (en) 2017-12-18
HUE047425T2 (hu) 2020-04-28
EP3567037A1 (en) 2019-11-13
MA52063A (fr) 2021-05-26
US20220289729A1 (en) 2022-09-15
MY176853A (en) 2020-08-24
CN107108576A (zh) 2017-08-29
EP3556752B1 (en) 2022-01-05
NL301364I2 (nl) 2026-03-30
IL252287A0 (en) 2017-07-31
MA47217B1 (fr) 2021-04-30
HK1244268A1 (en) 2018-08-03
UA123087C2 (uk) 2021-02-17
DK3556752T3 (da) 2022-03-07
JP6653702B2 (ja) 2020-02-26
IL278182A (en) 2020-11-30
US11084809B2 (en) 2021-08-10
AR102850A1 (es) 2017-03-29
PT3567037T (pt) 2021-02-23
RS59395B1 (sr) 2019-11-29
RS63155B1 (sr) 2022-05-31
AU2015352193B2 (en) 2019-10-10
US10611758B2 (en) 2020-04-07
LT3224256T (lt) 2019-09-25
SI3224256T1 (sl) 2019-12-31
CA2967894C (en) 2024-01-30
US11001578B2 (en) 2021-05-11
CY1125214T1 (el) 2023-06-09
CL2017001362A1 (es) 2018-02-09
PT3224256T (pt) 2019-09-23
KR20170090451A (ko) 2017-08-07
JP6995101B2 (ja) 2022-01-14
MX2020013038A (es) 2022-12-09
FR26C1004I1 (fr) 2026-03-06
SMT202100112T1 (it) 2021-05-07
TWI741377B (zh) 2021-10-01
CY1124046T1 (el) 2022-05-27
MX2017006823A (es) 2017-09-27
AU2019240616B2 (en) 2021-07-29
MD3224256T2 (ro) 2019-12-31
ECSP17039127A (es) 2017-12-01
BR112017010882B8 (pt) 2023-11-14
EP4039681A1 (en) 2022-08-10

Similar Documents

Publication Publication Date Title
IL287113A (en) smyd inhibitors
GB201421083D0 (en) Enzyme inhibitors
GB201421088D0 (en) New enzyme inhibitors
IL251584B (en) Dihydropyrrolopyridines ror–gamma inhibitors
ZA201608847B (en) Beta-lactamase inhibitors
IL246785A0 (en) Benzimidazole-2-amines as midh1 inhibitors
IL246902A0 (en) Dihydropyrrolopyridine ror–gamma inhibitors
EP3116503A4 (en) Hptp-beta inhibitors
IL248895A0 (en) Phosphatidylinositol 3-kinase inhibitors
GB201421085D0 (en) New enzyme inhibitors
GB201416446D0 (en) New enzyme inhibitor compounds
IL246400A0 (en) Neprilysin inhibitors
GB201501004D0 (en) Inhibitors
GB201400299D0 (en) Corrosion inhibitors
IL247025A0 (en) enzyme inhibitors
GB201520949D0 (en) Inhibitors
GB201401005D0 (en) Inhibitor
EP3180003A4 (en) Pkc-epsilon inhibitors
GB201609517D0 (en) Enzyme inhibitors
GB201415554D0 (en) Enzyme inhibition
GB201415549D0 (en) Enzyme inhibition
GB201418154D0 (en) Inhibitors
HK1239455A1 (zh) Smyd抑制剂
GB201404718D0 (en) Modified enzymes
AU2014900536A0 (en) Inhibitors

Legal Events

Date Code Title Description
AT Applications terminated before publication under section 16(1)