GB1592975A - Propanolamine derivatives - Google Patents

Propanolamine derivatives Download PDF

Info

Publication number
GB1592975A
GB1592975A GB41251/77A GB4125177A GB1592975A GB 1592975 A GB1592975 A GB 1592975A GB 41251/77 A GB41251/77 A GB 41251/77A GB 4125177 A GB4125177 A GB 4125177A GB 1592975 A GB1592975 A GB 1592975A
Authority
GB
United Kingdom
Prior art keywords
group
formula
acid addition
compounds
addition salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB41251/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
C.H. Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Original Assignee
C.H. Boehringer Sohn AG and Co KG
Boehringer Ingelheim GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H. Boehringer Sohn AG and Co KG, Boehringer Ingelheim GmbH filed Critical C.H. Boehringer Sohn AG and Co KG
Publication of GB1592975A publication Critical patent/GB1592975A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Quinoline Compounds (AREA)
GB41251/77A 1976-10-05 1977-10-04 Propanolamine derivatives Expired GB1592975A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19762644833 DE2644833A1 (de) 1976-10-05 1976-10-05 Neue 1-aryloxy-2-hydroxy-3-alkylenaminopropane und verfahren zu ihrer herstellung

Publications (1)

Publication Number Publication Date
GB1592975A true GB1592975A (en) 1981-07-15

Family

ID=5989679

Family Applications (3)

Application Number Title Priority Date Filing Date
GB41251/77A Expired GB1592975A (en) 1976-10-05 1977-10-04 Propanolamine derivatives
GB41738/79A Expired GB1592977A (en) 1976-10-05 1977-10-04 Substituted azetidinols
GB41737/79A Expired GB1592976A (en) 1976-10-05 1977-10-04 N-aminoalkyl nitrogencontaining heterocyclic compounds

Family Applications After (2)

Application Number Title Priority Date Filing Date
GB41738/79A Expired GB1592977A (en) 1976-10-05 1977-10-04 Substituted azetidinols
GB41737/79A Expired GB1592976A (en) 1976-10-05 1977-10-04 N-aminoalkyl nitrogencontaining heterocyclic compounds

Country Status (33)

Country Link
US (7) US4256756A (cg-RX-API-DMAC7.html)
JP (1) JPS5368775A (cg-RX-API-DMAC7.html)
AT (15) AT361908B (cg-RX-API-DMAC7.html)
AU (1) AU514600B2 (cg-RX-API-DMAC7.html)
BE (1) BE859415A (cg-RX-API-DMAC7.html)
BG (1) BG33153A3 (cg-RX-API-DMAC7.html)
CA (4) CA1101859A (cg-RX-API-DMAC7.html)
CS (1) CS197304B2 (cg-RX-API-DMAC7.html)
DD (5) DD148052A5 (cg-RX-API-DMAC7.html)
DE (1) DE2644833A1 (cg-RX-API-DMAC7.html)
DK (1) DK439077A (cg-RX-API-DMAC7.html)
ES (16) ES462868A1 (cg-RX-API-DMAC7.html)
FI (1) FI69066C (cg-RX-API-DMAC7.html)
FR (1) FR2394534A1 (cg-RX-API-DMAC7.html)
GB (3) GB1592975A (cg-RX-API-DMAC7.html)
GR (1) GR64229B (cg-RX-API-DMAC7.html)
HK (1) HK19385A (cg-RX-API-DMAC7.html)
HU (1) HU177173B (cg-RX-API-DMAC7.html)
IE (3) IE46159B1 (cg-RX-API-DMAC7.html)
IL (1) IL53043A (cg-RX-API-DMAC7.html)
LU (1) LU78240A1 (cg-RX-API-DMAC7.html)
MY (1) MY8500909A (cg-RX-API-DMAC7.html)
NL (1) NL7710840A (cg-RX-API-DMAC7.html)
NO (1) NO151411C (cg-RX-API-DMAC7.html)
NZ (1) NZ185356A (cg-RX-API-DMAC7.html)
PH (4) PH15763A (cg-RX-API-DMAC7.html)
PL (1) PL113879B1 (cg-RX-API-DMAC7.html)
PT (1) PT67107B (cg-RX-API-DMAC7.html)
SE (1) SE442400B (cg-RX-API-DMAC7.html)
SG (1) SG70884G (cg-RX-API-DMAC7.html)
SU (1) SU665801A3 (cg-RX-API-DMAC7.html)
YU (1) YU40484B (cg-RX-API-DMAC7.html)
ZA (1) ZA775905B (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434174A (en) 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
EP0171702A1 (en) * 1984-08-03 1986-02-19 Beecham Group Plc Benzoxazinone derivatives, preparation and use

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4404380A (en) * 1977-02-14 1983-09-13 Mead Johnson & Company Triazolopyrimidines
DE2833140A1 (de) * 1978-07-28 1980-02-07 Boehringer Sohn Ingelheim Neue n-substituierte heterocyclen
FR2455587A1 (fr) * 1979-05-04 1980-11-28 Continental Pharma Derives de benzimidazole, leur preparation et utilisation dans le traitement des affections cardiovasculaires et compositions les contenant
IE810250L (en) 1980-02-11 1981-08-11 Berlex Lab N-(3-phenoxy-2-hydroxypropyl) benzimidazole -1-¹alkanamines.
US4349673A (en) * 1980-12-23 1982-09-14 Merck & Co., Inc. Benzoxazines
US4656168A (en) * 1980-12-23 1987-04-07 Merck & Co., Inc. (3-aralkylamino-2-or-propoxy)heterocyclic compounds in method of effecting bronchodilation
US4473501A (en) * 1981-05-04 1984-09-25 G. D. Searle & Co. Dihydro azino isoquinolines
US4379508A (en) * 1981-10-14 1983-04-12 Nestier Corporation Nesting tray with stacking keyed interlock
IT1193608B (it) * 1983-01-21 1988-07-21 Pierrel Spa Derivati di arilossipropanolamina,procedimento per la loro preparazione composizioni farmaceutiche che li contengono e loro impiego terapeutico
DE3324903A1 (de) * 1983-07-09 1985-01-17 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung substituierter ethylenharnstoffe sowie neue n-vinylethylenharnstoffe
DE3807922A1 (de) * 1988-03-10 1989-09-21 Boehringer Mannheim Gmbh Substituierte heterocyclen, verfahren zu ihrer herstellung sowie arzneimittel, die diese verbindungen enthalten
TW203049B (cg-RX-API-DMAC7.html) * 1990-04-13 1993-04-01 Yamanouchi Pharma Co Ltd
US6860524B1 (en) 1993-05-14 2005-03-01 William W. Rowley Polyolefin connectors
US6557907B2 (en) 1993-05-14 2003-05-06 William W. Rowley Polyethylene connectors
US6372712B1 (en) 1998-05-22 2002-04-16 The Board Of Trustees Of The Leland Stanford Jr. University Synthetic bifunctional molecules containing a drug moiety and presenter protein ligand
CA2450073C (en) 2001-07-25 2017-08-29 Biomarin Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
US6848719B2 (en) 2001-09-06 2005-02-01 William W. Rowley Bendable polymer-lined water heater connector
MY143244A (en) * 2002-11-26 2011-04-15 Smithkline Beecham Corp Calcilytic compounds
AU2003300297A1 (en) * 2002-12-23 2004-07-22 Artesian Therapeutics, Inc. CARDIOTONIC COMPOUNDS WITH INHIBITORY ACTIVITY AGAINST Beta-ADRENERGIC RECEPTORS AND PHOSPHODIESTERASE
DE102004045648A1 (de) * 2004-09-21 2006-03-23 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Betamimetika zur Behandlung von Atemwegserkrankungen
JP2008521805A (ja) * 2004-11-30 2008-06-26 アーテシアン セラピューティクス， インコーポレイテッド β−アドレナリン作用性受容体およびホスホジエステラーゼに対する阻害活性を有する強心性化合物
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2010503710A (ja) 2006-09-18 2010-02-04 ラプトール ファーマシューティカル インコーポレイテッド 受容体関連タンパク質（ｒａｐ）結合体の投与による肝障害の処置
ES2582555T3 (es) * 2007-11-29 2016-09-13 Inolex Investment Corporation Conservantes para composiciones cosméticas, de tocador y farmacéuticas
ES2919563T3 (es) 2009-02-20 2022-07-27 Enhanx Biopharm Inc Sistema de administración de medicamentos a base de glutatión
KR20180114970A (ko) 2009-05-06 2018-10-19 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
US20120077778A1 (en) 2010-09-29 2012-03-29 Andrea Bourdelais Ladder-Frame Polyether Conjugates

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL284529A (cg-RX-API-DMAC7.html) * 1961-10-24
GB1066613A (en) * 1965-03-03 1967-04-26 Ici Ltd Naphthalene derivatives
FR2073434B1 (cg-RX-API-DMAC7.html) * 1969-11-28 1975-08-01 Teikoku Hormone Mfg Co Ltd
ZA71932B (en) * 1970-02-27 1971-10-27 Ici Ltd Organic compounds
BE787103A (fr) * 1971-08-04 1973-02-02 Pfizer Nouveaux derives de propanolamine et composition pharmaceutiqueles contenant
US3894030A (en) * 1973-01-04 1975-07-08 Janssen Pharmaceutica Nv 1-{8 1-(2-Hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
US3818017A (en) * 1973-01-04 1974-06-18 Janssen Pharmaceutica Nv 1-{8 1-(2-hydroxy-3-aryloxypropyl)-4-piperidyl{9 -2-benzimidazolinones and related compounds
GB1456525A (en) * 1973-07-18 1976-11-24 Ici Ltd Process for the manufacture of alkanolamine derivatives
DE2503222A1 (de) * 1975-01-27 1976-07-29 Boehringer Sohn Ingelheim Verfahren zur herstellung von 1-aryl- oxy-3-n-substituierten aminopropanderivaten
US4081447A (en) * 1975-04-09 1978-03-28 Abbott Laboratories 5-[2-Hydroxy-3-(3,4-dimethoxy phenethylamino)]-propoxy-3,4-dihydro carbostyril and pharmaceutically acceptable salts thereof
CH624395A5 (cg-RX-API-DMAC7.html) * 1976-01-08 1981-07-31 Ciba Geigy Ag
DE2609645A1 (de) * 1976-03-09 1977-09-15 Boehringer Sohn Ingelheim Aminoalkylheterocyclen

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4434174A (en) 1980-02-11 1984-02-28 Berlex Laboratories, Inc. Treating cardiovascular diseases with N-(3-phenoxy-2-hydroxypropyl)benzimidazole-1-alkanamines
EP0171702A1 (en) * 1984-08-03 1986-02-19 Beecham Group Plc Benzoxazinone derivatives, preparation and use

Also Published As

Publication number Publication date
CA1127643A (en) 1982-07-13
US4343800A (en) 1982-08-10
ES471795A1 (es) 1979-02-01
ATA57680A (de) 1980-12-15
AT362363B (de) 1981-05-11
AT361912B (de) 1981-04-10
JPS5368775A (en) 1978-06-19
AT362364B (de) 1981-05-11
ATA57280A (de) 1980-10-15
IE46159B1 (en) 1983-03-09
DK439077A (da) 1978-04-06
MY8500909A (en) 1985-12-31
HK19385A (en) 1985-03-22
US4296117A (en) 1981-10-20
US4256756A (en) 1981-03-17
ES471807A1 (es) 1979-02-01
US4255430A (en) 1981-03-10
FR2394534B1 (cg-RX-API-DMAC7.html) 1982-04-30
AU2933377A (en) 1979-04-12
PH19028A (en) 1985-12-06
FI69066B (fi) 1985-08-30
ES471804A1 (es) 1979-02-01
ATA57580A (de) 1980-12-15
FI69066C (fi) 1985-12-10
ATA57480A (de) 1980-10-15
PH15763A (en) 1983-03-22
US4604468A (en) 1986-08-05
ES471805A1 (es) 1979-02-01
ES471802A1 (es) 1979-02-01
SE7711168L (sv) 1978-05-18
ATA57080A (de) 1980-09-15
NZ185356A (en) 1981-05-01
AT363082B (de) 1981-07-10
BG33153A3 (bg) 1982-12-15
ES462868A1 (es) 1978-12-16
PL113879B1 (en) 1981-01-31
DE2644833A1 (de) 1978-04-20
ES471800A1 (es) 1979-02-01
ES471796A1 (es) 1979-02-01
DD148051A5 (de) 1981-05-06
PT67107B (de) 1980-04-07
GB1592977A (en) 1981-07-15
AT363079B (de) 1981-07-10
CA1126271A (en) 1982-06-22
AT364828B (de) 1981-11-25
SE442400B (sv) 1985-12-23
AT361914B (de) 1981-04-10
ATA57780A (de) 1980-12-15
AT363080B (de) 1981-07-10
IE822409L (en) 1978-04-05
AT362362B (de) 1981-05-11
GR64229B (en) 1980-02-14
LU78240A1 (cg-RX-API-DMAC7.html) 1979-02-02
SG70884G (en) 1985-04-04
ATA56980A (de) 1980-09-15
US4381309A (en) 1983-04-26
IE46160B1 (en) 1983-03-09
NL7710840A (nl) 1978-04-07
DD143074A5 (de) 1980-07-30
NO151411B (no) 1984-12-27
CS197304B2 (en) 1980-04-30
NO151411C (no) 1985-04-10
GB1592976A (en) 1981-07-15
AT361911B (de) 1981-04-10
US4212877A (en) 1980-07-15
ES471801A1 (es) 1979-02-01
FR2394534A1 (fr) 1979-01-12
AT361913B (de) 1981-04-10
ATA57380A (de) 1980-10-15
ES471803A1 (es) 1979-02-01
ATA57980A (de) 1980-12-15
DD148050A5 (de) 1981-05-06
ATA56780A (de) 1980-09-15
IL53043A0 (en) 1977-12-30
ZA775905B (en) 1979-06-27
ATA679377A (de) 1980-09-15
ES471798A1 (es) 1979-02-01
AT362365B (de) 1981-05-11
ES471797A1 (es) 1979-02-01
CA1101859A (en) 1981-05-26
ES471806A1 (es) 1979-02-01
YU236977A (en) 1983-01-21
FI772823A7 (fi) 1978-04-06
JPS6210988B2 (cg-RX-API-DMAC7.html) 1987-03-10
BE859415A (fr) 1978-04-05
AT361915B (de) 1981-04-10
IL53043A (en) 1982-01-31
DD134642A5 (de) 1979-03-14
ATA57880A (de) 1980-10-15
ES471799A1 (es) 1979-02-01
ES471808A1 (es) 1979-02-01
PT67107A (de) 1977-11-01
DD148052A5 (de) 1981-05-06
YU40484B (en) 1986-02-28
NO773384L (no) 1978-04-06
ATA58080A (de) 1981-04-15
PH16053A (en) 1983-06-09
IE46158B1 (en) 1983-03-09
PL201286A1 (pl) 1978-12-04
IE822410L (en) 1978-04-05
PH18363A (en) 1985-06-13
CA1125751A (en) 1982-06-15
AT363081B (de) 1981-07-10
ATA56880A (de) 1980-09-15
SU665801A3 (ru) 1979-05-30
AU514600B2 (en) 1981-02-19
HU177173B (en) 1981-08-28
ATA57180A (de) 1980-09-15
IE46158L (en) 1978-04-05
ES471794A1 (es) 1979-02-01
AT361908B (de) 1981-04-10

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