GB1583602A - N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives - Google Patents

N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives Download PDF

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Publication number
GB1583602A
GB1583602A GB22218/77A GB2221877A GB1583602A GB 1583602 A GB1583602 A GB 1583602A GB 22218/77 A GB22218/77 A GB 22218/77A GB 2221877 A GB2221877 A GB 2221877A GB 1583602 A GB1583602 A GB 1583602A
Authority
GB
United Kingdom
Prior art keywords
acetyl
general formula
para
amino
aminophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22218/77A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sterwin AG
Original Assignee
Sterwin AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterwin AG filed Critical Sterwin AG
Priority to GB22218/77A priority Critical patent/GB1583602A/en
Priority to FI781610A priority patent/FI70208C/fi
Priority to DE2822789A priority patent/DE2822789C2/de
Priority to AT0380178A priority patent/AT368489B/de
Priority to NLAANVRAGE7805675,A priority patent/NL176070C/xx
Priority to LU79703A priority patent/LU79703A1/fr
Priority to SE7806038A priority patent/SE448991B/sv
Priority to DK231578A priority patent/DK155832C/da
Priority to IE1047/78A priority patent/IE47072B1/en
Priority to NO781824A priority patent/NO146392C/no
Priority to IT49547/78A priority patent/IT1202822B/it
Priority to FR7815759A priority patent/FR2391998A1/fr
Priority to BE188076A priority patent/BE867531A/fr
Priority to CH578078A priority patent/CH644590A5/de
Priority to US05/909,846 priority patent/US4181719A/en
Priority to US06/026,329 priority patent/US4482495A/en
Publication of GB1583602A publication Critical patent/GB1583602A/en
Priority to US06/246,234 priority patent/US4361703A/en
Priority to US06/360,312 priority patent/US4405800A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GB22218/77A 1977-05-26 1977-05-26 N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives Expired GB1583602A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
GB22218/77A GB1583602A (en) 1977-05-26 1977-05-26 N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives
FI781610A FI70208C (fi) 1977-05-26 1978-05-22 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara n-acetyl-para-aminofenyl-n'-acetyl aminotioalkansyraesterderivat
DE2822789A DE2822789C2 (de) 1977-05-26 1978-05-24 N-Acetyl-DL-methionin-(p-acetylaminophenyl)-ester, Verfahren zu seiner Herstellung und seine Verwendung
AT0380178A AT368489B (de) 1977-05-26 1978-05-24 Verfahren zur herstellung von neuen n-acetyl-paminophenyl-n'acetylaminothioalkansaeureestern
NO781824A NO146392C (no) 1977-05-26 1978-05-25 Analogifremgangsmaate ved fremstilling av nye analgesisk aktive n-acetyl-para-aminofenyl-n`-acetyl-aminoalkansyreester-derivater
LU79703A LU79703A1 (fr) 1977-05-26 1978-05-25 Composes a effet analgesique,procedes pour leur preparation,composes intermediaires utiles pour leurs preparations et compositions pharmaceutiques contenant ces composes
SE7806038A SE448991B (sv) 1977-05-26 1978-05-25 Analogiforfarande for framstellning av n-acetyl-para-aminofenyl-n'acetyl-d,l-metionat som har analgetisk aktivitet
DK231578A DK155832C (da) 1977-05-26 1978-05-25 Analogifremgangsmaade til fremstilling af n-acetyl--p-aminophenyl-n'-acetyl-alfa-amino-omega-methyl-thioalkansyreester
IE1047/78A IE47072B1 (en) 1977-05-26 1978-05-25 N-acetyl-para-aminohenyl-n'-acetyl-aminothioalkanoic acid ester derivatives
NLAANVRAGE7805675,A NL176070C (nl) 1977-05-26 1978-05-25 Farmaceutisch preparaat met analgetische werking, alsmede ester van 4-(acetylamino)fenol met een aminozuur.
IT49547/78A IT1202822B (it) 1977-05-26 1978-05-25 Derivati esterei dell'acido n-acetil-para-aminofenolico e loro preparazione
FR7815759A FR2391998A1 (fr) 1977-05-26 1978-05-26 Compose presentant notamment une activite analgesique du type ester d'acide n-acetyl-p-aminophenyl-n'-acetylaminothioalcanoique
BE188076A BE867531A (fr) 1977-05-26 1978-05-26 N-acetyl-para-aminophenyl-n'-acetyl-aminothioalcanates, leur preparation et compositions en contenant
CH578078A CH644590A5 (de) 1977-05-26 1978-05-26 N-acetyl-para-aminophenyl-n'-acetylaminothiofettsaeureester-derivate.
US05/909,846 US4181719A (en) 1977-05-26 1978-05-26 Analgesic N-acetyl-para-aminophenyl N'-acetylaminothioalkanoates
US06/026,329 US4482495A (en) 1977-05-26 1979-04-02 Mixed anhydrides of N'-acetylaminothioalkanoates
US06/246,234 US4361703A (en) 1977-05-26 1981-03-23 Para-amino(or nitro)phenyl N-acetylaminothioalkanoates
US06/360,312 US4405800A (en) 1977-05-26 1982-03-22 N-Acetyl-para-aminophenyl N'-acetylamino-S-(tetrahydro-2-pyranyl)thioalkanoates

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB22218/77A GB1583602A (en) 1977-05-26 1977-05-26 N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives

Publications (1)

Publication Number Publication Date
GB1583602A true GB1583602A (en) 1981-01-28

Family

ID=10175844

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22218/77A Expired GB1583602A (en) 1977-05-26 1977-05-26 N-acetyl-para-aminophenyl-n'-acetyl-amino-thioalkanoic acid ester derivatives

Country Status (15)

Country Link
US (4) US4181719A (fr)
AT (1) AT368489B (fr)
BE (1) BE867531A (fr)
CH (1) CH644590A5 (fr)
DE (1) DE2822789C2 (fr)
DK (1) DK155832C (fr)
FI (1) FI70208C (fr)
FR (1) FR2391998A1 (fr)
GB (1) GB1583602A (fr)
IE (1) IE47072B1 (fr)
IT (1) IT1202822B (fr)
LU (1) LU79703A1 (fr)
NL (1) NL176070C (fr)
NO (1) NO146392C (fr)
SE (1) SE448991B (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567192A (en) * 1983-05-04 1986-01-28 Sandoz Ltd. Acylaminophenol derivatives
AU674934B2 (en) * 1993-03-12 1997-01-16 Penn Pharmaceutical Services Limited Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
US6441011B1 (en) * 1997-03-03 2002-08-27 Rudy Susilo Combined preparation consisting of 2-methylthiazolidine-2,4-dicarboxylic acid and paracetamol
US9951001B2 (en) 2008-05-20 2018-04-24 Acorda Therapeutics, Inc. Hepatoprotectant acetaminophen mutual prodrugs

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1111384B (it) * 1978-12-21 1986-01-13 Sigma Tau Ind Farmaceuti Guaiacil esteri di derivati dello acido mercaptopropionico procedimento per la loro preparazione e loro uso terapeutico
US4307073A (en) * 1980-08-08 1981-12-22 The Research Foundation Of State University Of New York Method and composition for reducing the toxicity of acetaminophen
US4504413A (en) * 1982-04-02 1985-03-12 Syva Company Acetaminophen analogs, antigens, and antibodies
US5103021A (en) * 1982-04-02 1992-04-07 Syntex (U.S.A.) Inc. Acetaminophen analogs, antigens, and antibodies
US4605754A (en) * 1982-04-02 1986-08-12 Syntex (U.S.A.) Inc. Acetaminophen analogs
FR2814366A1 (fr) * 2000-09-22 2002-03-29 Rhodia Chimie Sa Procede de granulation de matieres actives par extrusion basse pression pour l'obtention de granules directement compressibles
WO2002036077A2 (fr) * 2000-11-06 2002-05-10 Andrx Pharmaceuticals, Inc. Preparation decongestionnante et antihistaminique a prise quotidienne unique
GB0114069D0 (en) * 2001-06-08 2001-08-01 Smithkline Beecham Plc Composition
US8092831B2 (en) * 2002-11-08 2012-01-10 Andrx Pharmaceuticals, Llc Antihistamine and decongestant system
AU2003291103A1 (en) * 2002-11-15 2004-06-15 Branded Products For The Future Pharmaceutical composition
US20050220862A1 (en) * 2004-03-31 2005-10-06 Bernstein Joel E Compositions with reduced hepatotoxicity
US20090298923A1 (en) * 2008-05-13 2009-12-03 Genmedica Therapeutics Sl Salicylate Conjugates Useful for Treating Metabolic Disorders
WO2010106083A1 (fr) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Thérapies combinatoires pour le traitement de troubles métaboliques
WO2010106082A1 (fr) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Conjugués anti-inflammatoires et anti-oxydants utiles pour traiter des troubles métaboliques
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR462M (fr) * 1958-10-13 1961-05-02
US3591686A (en) * 1967-08-01 1971-07-06 Mead Johnson & Co Anti-inflammatory compositions and methods utilizing n-acylcysteines and the beta-alkyl and carboxyl derivatives thereof
US4038306A (en) * 1967-08-07 1977-07-26 Merck & Co., Inc. N-t-butoxycarbonyl-s-lower alkanoylamidomethyl-cysteine and p-nitrophenyl esters
GB1428803A (en) * 1973-05-29 1976-03-17 Gallardo Antonio Sa 4-acetamidophenyl esters of aryl-alkane carboxylic acids and a process for their preparation
US3983138A (en) * 1973-09-25 1976-09-28 Merck & Co., Inc. Amino acid esters
GB1463505A (en) * 1973-11-21 1977-02-02 Nat Res Dev Pharmaceutical compositions
US3996268A (en) * 1974-09-03 1976-12-07 The Regents Of The University Of California Cross-linking reagent for insulin synthesis

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4567192A (en) * 1983-05-04 1986-01-28 Sandoz Ltd. Acylaminophenol derivatives
AU674934B2 (en) * 1993-03-12 1997-01-16 Penn Pharmaceutical Services Limited Pharmaceutical compositions comprising paracetamol and L-cysteine or a precursor thereof
US6441011B1 (en) * 1997-03-03 2002-08-27 Rudy Susilo Combined preparation consisting of 2-methylthiazolidine-2,4-dicarboxylic acid and paracetamol
US9951001B2 (en) 2008-05-20 2018-04-24 Acorda Therapeutics, Inc. Hepatoprotectant acetaminophen mutual prodrugs

Also Published As

Publication number Publication date
IT7849547A0 (it) 1978-05-25
FR2391998A1 (fr) 1978-12-22
NO146392C (no) 1982-09-22
LU79703A1 (fr) 1978-11-06
DK155832B (da) 1989-05-22
SE448991B (sv) 1987-03-30
US4482495A (en) 1984-11-13
SE7806038L (sv) 1978-11-27
NO781824L (no) 1978-11-28
DE2822789C2 (de) 1984-01-12
US4405800A (en) 1983-09-20
US4361703A (en) 1982-11-30
FR2391998B1 (fr) 1981-11-13
ATA380178A (de) 1982-02-15
DE2822789A1 (de) 1978-12-07
NL176070C (nl) 1985-02-18
IE47072B1 (en) 1983-12-14
IE781047L (en) 1978-11-26
US4181719A (en) 1980-01-01
IT1202822B (it) 1989-02-09
NL176070B (nl) 1984-09-17
NL7805675A (nl) 1978-11-28
FI70208B (fi) 1986-02-28
CH644590A5 (de) 1984-08-15
FI781610A (fi) 1978-11-27
DK231578A (da) 1978-11-27
FI70208C (fi) 1986-09-15
BE867531A (fr) 1978-09-18
NO146392B (no) 1982-06-14
AT368489B (de) 1982-10-11
DK155832C (da) 1989-10-02

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PCNP Patent ceased through non-payment of renewal fee