GB1532682A - Process for the preparation of cephadroxil - Google Patents

Process for the preparation of cephadroxil

Info

Publication number
GB1532682A
GB1532682A GB17028/76A GB1702876A GB1532682A GB 1532682 A GB1532682 A GB 1532682A GB 17028/76 A GB17028/76 A GB 17028/76A GB 1702876 A GB1702876 A GB 1702876A GB 1532682 A GB1532682 A GB 1532682A
Authority
GB
United Kingdom
Prior art keywords
cephadroxil
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB17028/76A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10087928&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GB1532682(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Priority to GB17028/76A priority Critical patent/GB1532682A/en
Priority to CY1066A priority patent/CY1066A/xx
Priority to SE7704739A priority patent/SE437521B/xx
Priority to ZA00772485A priority patent/ZA772485B/xx
Priority to DK183277A priority patent/DK157026C/da
Priority to GR53296A priority patent/GR72788B/el
Priority to CA276,959A priority patent/CA1115268A/en
Priority to IE835/77A priority patent/IE44872B1/en
Priority to YU1086/77A priority patent/YU39801B/xx
Priority to LU77202A priority patent/LU77202A1/xx
Priority to FR7712622A priority patent/FR2349589A1/fr
Priority to BE177035A priority patent/BE853974A/xx
Priority to PH19706A priority patent/PH16581A/en
Priority to JP52048003A priority patent/JPS6022717B2/ja
Priority to CH523277A priority patent/CH632270A5/de
Priority to AT296277A priority patent/AT350183B/de
Priority to ES77458241A priority patent/ES458241A1/es
Priority to AU24607/77A priority patent/AU510338B2/en
Priority to FI771339A priority patent/FI67704C/fi
Priority to DE2718741A priority patent/DE2718741C2/de
Priority to NL7704618A priority patent/NL7704618A/xx
Priority to FR7738820A priority patent/FR2365570A1/fr
Publication of GB1532682A publication Critical patent/GB1532682A/en
Priority to US06/071,951 priority patent/US4234721A/en
Priority to PH22820A priority patent/PH17254A/en
Priority to KE3064A priority patent/KE3064A/xx
Priority to HK397/80A priority patent/HK39780A/xx
Priority to IT8049917A priority patent/IT8049917A0/it
Priority to MY1981135A priority patent/MY8100135A/xx
Priority to US06/358,567 priority patent/US4504657A/en
Priority to YU1379/82A priority patent/YU43081B/xx
Priority to US06/455,398 priority patent/USRE31730E/en
Priority to JP60013652A priority patent/JPS60185718A/ja
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB17028/76A 1976-04-27 1976-04-27 Process for the preparation of cephadroxil Expired GB1532682A (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
GB17028/76A GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil
CY1066A CY1066A (en) 1976-04-27 1977-03-07 Process for the preparation of cephadroxil
SE7704739A SE437521B (sv) 1976-04-27 1977-04-25 Ett forbettrat forfarande for framstellning av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)-acetamido)-3-metyl-3-cefem-4-karboxylsyra
ZA00772485A ZA772485B (en) 1976-04-27 1977-04-25 Antibacterial agents
PH19706A PH16581A (en) 1976-04-27 1977-04-26 Process for preparing 7-(d-2-amino-alpha-(p-hydroxyphenyl)acetamido-)-3-methyl-3-cephem-4-carboxylic acid
DK183277A DK157026C (da) 1976-04-27 1977-04-26 Fremgangsmaade til fremstilling af 7-oed-alfa-amino-alfa-(p-hydroxy-phenyl)acetamidoaa-3-methyl-cephem-4-carboxylsyre
GR53296A GR72788B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-04-27 1977-04-26
CA276,959A CA1115268A (en) 1976-04-27 1977-04-26 PROCESS FOR THE PREPARATION OF CRYSTALLINE MONOHYDRATE OF 7-¬D-.alpha.-AMINO-.alpha.-(P- HYDROXYPHENYL)ACETAMIDO|-3-METHYL-3-CEPHEM-4- CARBOXYLIC ACID
IE835/77A IE44872B1 (en) 1976-04-27 1977-04-26 Process for the preparation of cephadroxil
YU1086/77A YU39801B (en) 1976-04-27 1977-04-26 Process for producing 7-(d-alpha-amino-alpha(p-hydroxyphenyl)-acetamido)-3-methyl-3-cephem-4-carboxylic acid
LU77202A LU77202A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1976-04-27 1977-04-26
FR7712622A FR2349589A1 (fr) 1976-04-27 1977-04-26 Procede de preparation d'une cephalosporine et produit obtenu
BE177035A BE853974A (fr) 1976-04-27 1977-04-26 Agents antibacteriens
NL7704618A NL7704618A (nl) 1976-04-27 1977-04-27 Cefalosporinen.
AT296277A AT350183B (de) 1976-04-27 1977-04-27 Verfahren zur herstellung eines cephalosporin- derivates, dessen monohydrates, sowie dessen salzen
DE2718741A DE2718741C2 (de) 1976-04-27 1977-04-27 Kristallines Cefadroxil-monohydrat, Verfahren zu dessen Herstellung und pharmazeutisches Mittel
CH523277A CH632270A5 (de) 1976-04-27 1977-04-27 Verfahren zur herstellung von cephalosporinverbindungen.
JP52048003A JPS6022717B2 (ja) 1976-04-27 1977-04-27 セファドロキシル一水和物結晶とその製造方法
ES77458241A ES458241A1 (es) 1976-04-27 1977-04-27 Un procedimiento para la preparacion del acido (d-alfa-ami- no-alfa-(p-hidroxifenil) acetamido) - 3 - metil-3-cefem-4- carboxilico.
AU24607/77A AU510338B2 (en) 1976-04-27 1977-04-27 Cephalosporins
FI771339A FI67704C (fi) 1976-04-27 1977-04-27 Foerfarande foer framstaellning av ett nytt terapeutiskt anvaendbart kristallint monohydrat av 7-(d-alfa-amino-alfa-(p-hydroxifenyl)acetamido)-3-metyl-3-cefem-4-karboxylsyra
FR7738820A FR2365570A1 (fr) 1976-04-27 1977-12-22 Monohydrate cristallin de cefadroxile et son procede de preparation
US06/071,951 US4234721A (en) 1976-04-27 1979-05-21 Process for the preparation of the crystalline monohydrate of 7-[D-amino-(p-hydroxyphenyl]acetamido)-3-methyl-3-cephen-4-carboxylic acid
PH22820A PH17254A (en) 1976-04-27 1979-07-27 Crystalline 7-/d-amino-(p-hydroxyphenyl)acetamido/-3-methyl-3-cephem-4-carboxylic acid
KE3064A KE3064A (en) 1976-04-27 1980-07-09 Process for the preparation of cephadroxil
HK397/80A HK39780A (en) 1976-04-27 1980-07-31 Process for the preparation of cephadroxil
IT8049917A IT8049917A0 (it) 1976-04-27 1980-10-16 Procedimento per la preparazione di acido 7-(d-alfa-ammino-alfa-(pidrossifenil)acetammido)-3-metil-3cefem-4-carbossilico e suoi sali eprodotto ottenuto
MY1981135A MY8100135A (en) 1976-04-27 1981-12-31 Process for the preparation of cephadroxil
US06/358,567 US4504657A (en) 1976-04-27 1982-03-16 Cephadroxil monohydrate
YU1379/82A YU43081B (en) 1976-04-27 1982-06-24 Process for obtaining monohydrate of 7-/d-alpha-amino-alpha-/(p-hydroxyphenyl)acetamido-3-methyl-3-cephem-4-carboxylic acid
US06/455,398 USRE31730E (en) 1976-04-27 1982-11-30 Process for the preparation of the crystalline monohydrate of 7-(D-α-aα-(p-hydroxyphenyl)acetamido)-3-methyl-3-cephem-4-carboxylic acid
JP60013652A JPS60185718A (ja) 1976-04-27 1985-01-29 抗菌剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB17028/76A GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil

Publications (1)

Publication Number Publication Date
GB1532682A true GB1532682A (en) 1978-11-22

Family

ID=10087928

Family Applications (1)

Application Number Title Priority Date Filing Date
GB17028/76A Expired GB1532682A (en) 1976-04-27 1976-04-27 Process for the preparation of cephadroxil

Country Status (26)

Country Link
US (3) US4234721A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (2) JPS6022717B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) AT350183B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU510338B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
BE (1) BE853974A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1115268A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (1) CH632270A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (1) CY1066A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE2718741C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK157026C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES458241A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI67704C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (2) FR2349589A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB1532682A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR72788B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK39780A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IE (1) IE44872B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IT (1) IT8049917A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KE (1) KE3064A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
LU (1) LU77202A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (1) MY8100135A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NL (1) NL7704618A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (2) PH16581A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE437521B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
YU (2) YU39801B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA772485B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2150931A (en) * 1983-12-06 1985-07-10 Bristol Myers Co Chlorocefadroxil monohydrate
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid

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IT1126544B (it) 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico
KR820001564B1 (ko) * 1981-05-09 1982-09-02 동신제약 주식회사 새로운 실릴화제를 이용한 세팔로스포린 유도체의 제조방법
JPS60169486A (ja) * 1984-02-10 1985-09-02 Yamanouchi Pharmaceut Co Ltd ７−アミノ−３−置換メチル−３−セフエム−４−カルボン酸およびその低級アルキルシリル誘導体の製造法
GB8714180D0 (en) * 1987-06-17 1987-07-22 Rifar Srl Anhydrous crystalline cefadroxil
US4904776A (en) * 1987-04-24 1990-02-27 Rifar S.R.L. Method for producing crystalline cefadroxil hemihydrate
US4962195A (en) * 1987-04-24 1990-10-09 Rifar S.R.L. Solvate of cefadroxyl
US5023331A (en) * 1987-04-24 1991-06-11 Rifar S.R.L. Cefadroxil solvates
US4898938A (en) * 1987-08-03 1990-02-06 Rifar S.R.L. Method for preparing crystalline cefadroxil monohydrate
IT1233863B (it) * 1988-02-24 1992-04-21 Opos Biochimica Srl Procedimento per la preparazione dell'acido 7-(d(-)-alfa-amino-alfa- (p-idrossifenil)acetamido)-3-metil-3-cefem-4-carbossilico monoidrato
US5034522A (en) * 1988-08-02 1991-07-23 Biocraft Laboratories, Inc. Method for the production of 3-methyl cephem derivatives
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US5142043A (en) * 1990-05-10 1992-08-25 Biocraft Laboratories, Inc. Process for preparing cephalexin monohydrate
AT396106B (de) * 1991-03-08 1993-06-25 Biochemie Gmbh Neues verfahren zur herstellung von 3-vinylcephalosporinverbindungen
US6248881B1 (en) 1991-03-08 2001-06-19 Biochemie Gmbh Intermediates and process for the production of 3-vinyl cephalosporins
ES2157199T3 (es) 1991-03-08 2001-08-16 Biochemie Gmbh Nuevo procedimiento para la produccion de cefalosporinas y nuevos compuestos intermedios para este procedimiento.
JP3852946B2 (ja) * 1993-03-12 2006-12-06 ファルマシア・アンド・アップジョン・カンパニー 結晶性セフチオフル遊離酸
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IT1289955B1 (it) * 1997-02-21 1998-10-19 Solchem Italiana Spa Acyclovir sale sodico biidrato e sua preparazione
US6080427A (en) * 1997-04-17 2000-06-27 Bristol-Myers Squibb Company Cefadroxil monohydrate tablet formulation
IN190389B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1999-07-14 2003-07-26 Ranbaxy Lab Ltd
WO2001004126A1 (en) * 1999-07-14 2001-01-18 Ranbaxy Laboratories Limited Process for preparing crystalline cefadroxil hemihydrate from cefadroxil dimethylformamide solvate
US20060173064A1 (en) * 2001-08-24 2006-08-03 Lippa Arnold S (-)-1-(3,4-Dichlorophenyl)-3-azabi cyclo[3.1.0]hexane, compositions thereof, and uses for treating alcohol-related disorders
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US4160863A (en) * 1977-04-07 1979-07-10 Bristol-Myers Company Process for the preparation of the crystalline monohydrate of 7-[D-α-aα-(p-hydroxyphenyl)acetamido]-3-methyl-3-cephem-4-carboxylic acid
NL162387C (nl) * 1977-09-06 1980-05-16 Gist Brocades Nv Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
IT1126544B (it) * 1979-12-07 1986-05-21 Dobfar Spa Procedimento per la preparazione di derivati dell'acido 7-amino-desacetossi cefalosporanico

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2150931A (en) * 1983-12-06 1985-07-10 Bristol Myers Co Chlorocefadroxil monohydrate
US7230097B2 (en) 2003-03-10 2007-06-12 Lupin Ltd. Process for preparation of 7-[α-Amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid
US7427692B2 (en) 2003-03-10 2008-09-23 Lupin Ltd. Process for preparation of 7-[α-amino (4-hydroxyphenyl) acetamido]-3-substituted-3-cephem-4-carboxylic acid

Also Published As

Publication number Publication date
SE437521B (sv) 1985-03-04
DK157026B (da) 1989-10-30
FI67704C (fi) 1985-05-10
YU43081B (en) 1989-02-28
YU39801B (en) 1985-04-30
IE44872L (en) 1977-10-27
ATA296277A (de) 1978-10-15
FI67704B (fi) 1985-01-31
SE7704739L (sv) 1977-12-01
AU2460777A (en) 1978-11-02
DE2718741A1 (de) 1977-11-17
DK157026C (da) 1990-04-02
HK39780A (en) 1980-08-08
FR2349589B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1981-11-20
LU77202A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-11-22
USRE31730E (en) 1984-11-13
YU137982A (en) 1983-04-30
JPS60185718A (ja) 1985-09-21
FI771339A7 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1977-10-28
PH17254A (en) 1984-07-03
NL7704618A (nl) 1977-10-31
MY8100135A (en) 1981-12-31
IT8049917A0 (it) 1980-10-16
FR2365570A1 (fr) 1978-04-21
KE3064A (en) 1980-07-25
PH16581A (en) 1983-11-22
DK183277A (da) 1977-10-28
DE2718741C2 (de) 1985-03-21
JPS6022717B2 (ja) 1985-06-03
JPS52142091A (en) 1977-11-26
AU510338B2 (en) 1980-06-19
ZA772485B (en) 1978-03-29
IE44872B1 (en) 1982-04-21
YU108677A (en) 1982-10-31
GR72788B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1983-12-05
FR2349589A1 (fr) 1977-11-25
BE853974A (fr) 1977-10-26
FR2365570B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1980-06-06
JPH0246009B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1990-10-12
CY1066A (en) 1980-10-24
ES458241A1 (es) 1978-11-01
US4504657A (en) 1985-03-12
CA1115268A (en) 1981-12-29
CH632270A5 (de) 1982-09-30
AT350183B (de) 1979-05-10
US4234721A (en) 1980-11-18

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19970306