GB1503581A - Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds - Google Patents

Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Info

Publication number
GB1503581A
GB1503581A GB7625/75A GB762575A GB1503581A GB 1503581 A GB1503581 A GB 1503581A GB 7625/75 A GB7625/75 A GB 7625/75A GB 762575 A GB762575 A GB 762575A GB 1503581 A GB1503581 A GB 1503581A
Authority
GB
United Kingdom
Prior art keywords
cephem
beta
amino
manufacture
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7625/75A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/de
Priority claimed from CH776674A external-priority patent/CH610584A5/de
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority to GB27583/77A priority Critical patent/GB1503639A/en
Priority to GB27582/77A priority patent/GB1503638A/en
Priority to GB27584/77A priority patent/GB1503640A/en
Publication of GB1503581A publication Critical patent/GB1503581A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7625/75A 1974-02-26 1975-02-24 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds Expired GB1503581A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
GB27583/77A GB1503639A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-hydroxy-crotonic acid derivatives
GB27582/77A GB1503638A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-methylenebutyric acid derivatives
GB27584/77A GB1503640A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-substitutedhydrody-crotonic and isocrotonic acid derivatives

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12

Publications (1)

Publication Number Publication Date
GB1503581A true GB1503581A (en) 1978-03-15

Family

ID=27173851

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7625/75A Expired GB1503581A (en) 1974-02-26 1975-02-24 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Country Status (21)

Country Link
JP (1) JPS625919B2 (hu)
AR (1) AR208538A1 (hu)
AT (2) AT337362B (hu)
AU (1) AU498131B2 (hu)
BE (1) BE825919A (hu)
BG (1) BG26201A3 (hu)
CA (2) CA1059988A (hu)
DD (1) DD117074A5 (hu)
DE (1) DE2506330A1 (hu)
DK (2) DK73475A (hu)
ES (2) ES435110A1 (hu)
FI (1) FI66389C (hu)
FR (1) FR2261761B1 (hu)
GB (1) GB1503581A (hu)
HU (1) HU175212B (hu)
IE (1) IE40695B1 (hu)
IL (1) IL46699A (hu)
NL (1) NL7502292A (hu)
NO (1) NO750625L (hu)
NZ (1) NZ176623A (hu)
SE (3) SE431652B (hu)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1044247B (it) * 1974-08-02 1980-03-20 Farmaceutici Italia Intermedi per la sintesi di derivati b lattamici e procedimento per la loro preparazone
JPS5198265A (hu) * 1975-02-17 1976-08-30
CA1136132A (en) * 1975-02-17 1982-11-23 Teruji Tsuji Cyclization to form cephem ring and intermediates therefor
AT342197B (de) * 1975-02-20 1978-03-28 Ciba Geigy Ag Neues verfahren zur herstellung von 3-cephemverbindungen
US4029645A (en) * 1975-11-17 1977-06-14 E. R. Squibb & Sons, Inc. Mercury intermediates useful in the preparation of 2-alkoxy cephalosporins
JPH0639474B2 (ja) * 1983-03-04 1994-05-25 大塚化学株式会社 セファロスポリン化合物の製造法
JPS59228854A (ja) * 1983-06-08 1984-12-22 真井　康博 薬液収納兼即効注出器
JPS60237061A (ja) * 1984-05-08 1985-11-25 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS60126263A (ja) * 1983-12-12 1985-07-05 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
GB2152497B (en) * 1983-11-28 1987-08-05 Otsuka Kagaku Kk Process for the preparation of azetidinone derivatives
JPS60115562A (ja) * 1983-11-28 1985-06-22 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
JPS61178961A (ja) * 1985-02-01 1986-08-11 Otsuka Chem Co Ltd アゼチジノン誘導体の製造法
DE3725375A1 (de) * 1987-07-31 1989-02-09 Bayer Ag Stabile oxapenem-3-carbonsaeuren
JP3195959B2 (ja) * 1991-03-13 2001-08-06 大塚化学株式会社 ３−ヒドロキシセフェム誘導体の製造法
AU2003269416A1 (en) * 2002-11-01 2004-05-25 Orchid Chemicals And Pharmaceuticals Ltd An improved process for the preparation of chloro methyl cephem derivatives
AU2012357986B2 (en) 2011-12-20 2017-02-02 Riboscience Llc 4'-Azido, 3'-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
AU2012357940B2 (en) 2011-12-20 2017-02-16 Riboscience Llc 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
MA46490A1 (fr) 2013-05-16 2021-04-30 Riboscience Llc Dérivés de nucléosides 4'- fluoro-2' - méthyle substitués
EA201592185A1 (ru) 2013-05-16 2016-05-31 Рибосайенс Ллк 4'-азидо, 3'-дезокси-3'-фторзамещенные нуклеозидные производные
US20180200280A1 (en) 2013-05-16 2018-07-19 Riboscience Llc 4'-Fluoro-2'-Methyl Substituted Nucleoside Derivatives as Inhibitors of HCV RNA Replication

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2230372A1 (de) * 1972-06-21 1973-01-11 Fujisawa Pharmaceutical Co Verfahren zur herstellung von oxidierten penam-derivaten
SE428022B (sv) * 1972-06-29 1983-05-30 Ciba Geigy Ag 7beta-amino-cefam-3-on-4-karboxylsyraforeningar till anvendning for framstellning av cefalosporinderivat
AR206201A1 (es) * 1972-06-29 1976-07-07 Ciba Geigy Ag Procedimiento para la obtencion de compuestos de acido 7beta-amino-3-cefem-3-01-4-carboxilico0-substituidos

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10682369B2 (en) 2017-09-21 2020-06-16 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
US11351186B2 (en) 2017-09-21 2022-06-07 Riboscience Llc 4′-fluoro-2′-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication

Also Published As

Publication number Publication date
CA1080713A (en) 1980-07-01
AT337362B (de) 1977-06-27
FR2261761B1 (hu) 1978-08-18
DE2506330A1 (de) 1975-09-04
FI66389C (fi) 1984-10-10
BE825919A (fr) 1975-08-25
IL46699A (en) 1977-11-30
IL46699A0 (en) 1975-04-25
SE7807810L (sv) 1978-07-13
IE40695B1 (en) 1979-08-01
FI750503A (hu) 1975-08-27
AU7849875A (en) 1976-08-26
CA1059988A (en) 1979-08-07
ATA28178A (de) 1978-10-15
DK348678A (da) 1978-08-07
DD117074A5 (hu) 1975-12-20
FR2261761A1 (hu) 1975-09-19
FI66389B (fi) 1984-06-29
AR208538A1 (es) 1977-02-15
AU498131B2 (en) 1979-02-15
HU175212B (hu) 1980-06-28
IE40695L (en) 1975-08-26
JPS625919B2 (hu) 1987-02-07
SE7501317L (hu) 1975-08-27
ES452915A1 (es) 1977-11-01
SE438854B (sv) 1985-05-13
NO750625L (hu) 1975-08-27
AT350068B (de) 1979-05-10
DK73475A (hu) 1975-10-20
ES435110A1 (es) 1977-03-16
SE438855B (sv) 1985-05-13
BG26201A3 (bg) 1979-02-15
ATA108275A (de) 1976-10-15
JPS50129590A (hu) 1975-10-13
SE431652B (sv) 1984-02-20
NZ176623A (en) 1978-04-03
SE7807811L (sv) 1978-07-13
NL7502292A (nl) 1975-08-28

Similar Documents

Publication Publication Date Title
GB1503581A (en) Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds
GB1432576A (en) Substituted phenylacetic acids
GB1418822A (en) Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof
GB1480772A (en) Antibiotic derivatives
GB1355147A (en) Oxoprostanoic acid derivatives
ES454063A1 (es) Un procedimiento para la preparacion de nuevos derivados delalcohol bencilico.
ES8401926A1 (es) Un procedimiento para la preparacion de un compuesto de hidroxibencilaminobenceno, dotado de propiedades antiinflamatorias.
GB1503640A (en) Process for the manufacture of 3-substitutedhydrody-crotonic and isocrotonic acid derivatives
GB1409648A (en) Substituted pyrrolidinemethanol compounds and pharmaceutical compositions thereof
ES8502118A1 (es) Procedimiento de preparar derivados de penicilina.
GB1530872A (en) Derivatives of 7-(2-amino-4-thiazolylacetamido)-cephalosporanic acid processes for preparing them and pharmaceutical compositions containing them
GB1529403A (en) Isoxazole derivative
JPS5225740A (en) Preparation of o-acyl-amidinophenols or acid addition salts thereof
GB1369580A (en) Tricyclic diphenylamine derivatives
ES482194A1 (es) Procedimiento para la obtencion de compuestos de acido 7- aminotiazolilacetamido-3-cefem-4-carboxilico.
GB1438422A (en) Cephalosporin derivatives
GB1321361A (en) Preparation of pyrimidylmethyl-pyridinium derivatives
GB1420728A (en) Cephalosporins
ES445343A1 (es) Procedimiento para la preparacion de derivados cuaternarios de xantinil-alcohil-nortropina.
IE34081B1 (en) Butanolamine derivatives
JPS527919A (en) Process for preparation of beta-sulfenylacrylic acid and its salt
JPS5278826A (en) Preparation of ester-group-containing fluorocarbosylic acid alkali sal ts
GB1527941A (en) 1-(3-phenylpropyl)-4-(beta-alkoxyacryloyl)piperazine derivatives
GB1500010A (en) 3,7-disubstituted cephalosporins and their preparation
GB1250589A (hu)

Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee