GB1503638A - Process for the manufacture of 3-methylenebutyric acid derivatives - Google Patents

Process for the manufacture of 3-methylenebutyric acid derivatives

Info

Publication number
GB1503638A
GB1503638A GB27582/77A GB2758277A GB1503638A GB 1503638 A GB1503638 A GB 1503638A GB 27582/77 A GB27582/77 A GB 27582/77A GB 2758277 A GB2758277 A GB 2758277A GB 1503638 A GB1503638 A GB 1503638A
Authority
GB
United Kingdom
Prior art keywords
acyl
feb
reaction
manufacture
protecting group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB27582/77A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Ciba Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH269374A external-priority patent/CH601310A5/en
Priority claimed from CH776674A external-priority patent/CH610584A5/en
Application filed by Ciba Geigy AG filed Critical Ciba Geigy AG
Priority claimed from GB7625/75A external-priority patent/GB1503581A/en
Publication of GB1503638A publication Critical patent/GB1503638A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C313/00—Sulfinic acids; Sulfenic acids; Halides, esters or anhydrides thereof; Amides of sulfinic or sulfenic acids, i.e. compounds having singly-bound oxygen atoms of sulfinic or sulfenic groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C313/02—Sulfinic acids; Derivatives thereof
    • C07C313/04—Sulfinic acids; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C07D205/095—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4 and with a nitrogen atom directly attached in position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1503638 2-Oxo-azetidine derivatives CIBA. GEIGY AG 24 Feb 1975 [26 Feb 1974 5 June 1974 12 Aug 1974] 27582/77 Divided out of 1503581 Heading C2C Novel compounds IV (R 1 <SP>A</SP> is an amino protecting group; R 1 <SP>b</SP> is H or acyl; or R 1 <SP>A</SP> and R 1 <SP>b</SP> together form a protecting group; -COR 2 <SP>A</SP> is a protected carboxyl group; and Y is -SO 2 R 5 or -S-SO 2 R 5 where R 5 is an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic hydrocarbon radical with up to 18C) and salts thereof are prepared (a) by reaction of a compound III with HSO 2 R 5 , NC-SO 2 R 5 or HSSO 2 R 5 , or (b) by reaction of a compound IVa (R 4 is aromatic heterocyclyl, acyl or thioacyl) with an appropriate heavy metal sulphinate or thiosulphonate.
GB27582/77A 1974-02-26 1975-02-24 Process for the manufacture of 3-methylenebutyric acid derivatives Expired GB1503638A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH269374A CH601310A5 (en) 1974-02-26 1974-02-26 7-Amino-3-hydroxy-2(or 3)-cephem-4-carboxylic acid derivs prepn
CH776674A CH610584A5 (en) 1974-02-26 1974-06-05 Process for the preparation of 2-(3-amino-2-oxo-4-sulphonylthio-1- azetidinyl)-3-methylenebutyric acid derivatives
CH1100074 1974-08-12
GB7625/75A GB1503581A (en) 1974-02-26 1975-02-24 Process for the manufacture of 7-beta-amino-cephem-3-ol-4-carboxylic acid compounds

Publications (1)

Publication Number Publication Date
GB1503638A true GB1503638A (en) 1978-03-15

Family

ID=27428477

Family Applications (3)

Application Number Title Priority Date Filing Date
GB27584/77A Expired GB1503640A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-substitutedhydrody-crotonic and isocrotonic acid derivatives
GB27583/77A Expired GB1503639A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-hydroxy-crotonic acid derivatives
GB27582/77A Expired GB1503638A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-methylenebutyric acid derivatives

Family Applications Before (2)

Application Number Title Priority Date Filing Date
GB27584/77A Expired GB1503640A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-substitutedhydrody-crotonic and isocrotonic acid derivatives
GB27583/77A Expired GB1503639A (en) 1974-02-26 1975-02-24 Process for the manufacture of 3-hydroxy-crotonic acid derivatives

Country Status (1)

Country Link
GB (3) GB1503640A (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213264A1 (en) * 1981-04-10 1982-10-21 Otsuka Kagaku Yakuhin K.K., Osaka NEW AZETIDINONE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3443225A1 (en) * 1983-11-28 1985-06-05 Otsuka Kagaku K.K., Osaka METHOD FOR PRODUCING AZETIDINONE DERIVATIVES
US4713452A (en) * 1983-12-12 1987-12-15 Otsuka Kagaku Kabushiki Kaisha Process for preparation of azetidinone derivatives
US4740596A (en) * 1983-11-28 1988-04-26 Otsuka Kagaku Kabushiki Kaisha Process for preparation of 4-sulfonylthio azetidinone derivatives
US4798890A (en) * 1984-05-08 1989-01-17 Otsuka Kagaku Kabushiki Kaisha Process for preparation of azetidinone derivatives

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS588060A (en) * 1981-06-29 1983-01-18 イ−・ア−ル・スクイブ・アンド・サンズ・インコ−ポレイテツド Arylthioazetidinone sulfonates

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3213264A1 (en) * 1981-04-10 1982-10-21 Otsuka Kagaku Yakuhin K.K., Osaka NEW AZETIDINONE COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF
DE3443225A1 (en) * 1983-11-28 1985-06-05 Otsuka Kagaku K.K., Osaka METHOD FOR PRODUCING AZETIDINONE DERIVATIVES
US4740596A (en) * 1983-11-28 1988-04-26 Otsuka Kagaku Kabushiki Kaisha Process for preparation of 4-sulfonylthio azetidinone derivatives
US4713452A (en) * 1983-12-12 1987-12-15 Otsuka Kagaku Kabushiki Kaisha Process for preparation of azetidinone derivatives
US4798890A (en) * 1984-05-08 1989-01-17 Otsuka Kagaku Kabushiki Kaisha Process for preparation of azetidinone derivatives

Also Published As

Publication number Publication date
GB1503639A (en) 1978-03-15
GB1503640A (en) 1978-03-15

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee