GB1489879A - N'-cyano-n'-3-pyridylguanidines - Google Patents

N'-cyano-n'-3-pyridylguanidines

Info

Publication number
GB1489879A
GB1489879A GB55209/74A GB5520974A GB1489879A GB 1489879 A GB1489879 A GB 1489879A GB 55209/74 A GB55209/74 A GB 55209/74A GB 5520974 A GB5520974 A GB 5520974A GB 1489879 A GB1489879 A GB 1489879A
Authority
GB
United Kingdom
Prior art keywords
formula
compound
radical
pyridyl
reacted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB55209/74A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leo Pharma AS
Original Assignee
Leo Pharmaceutical Products Ltd AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leo Pharmaceutical Products Ltd AS filed Critical Leo Pharmaceutical Products Ltd AS
Priority to GB55209/74A priority Critical patent/GB1489879A/en
Priority to IE2554/75A priority patent/IE42141B1/en
Priority to ZA7481A priority patent/ZA757481B/xx
Priority to AU87127/75A priority patent/AU493001B2/en
Priority to US05/636,747 priority patent/US4057636A/en
Priority to CA241,325A priority patent/CA1067083A/en
Priority to AT936075A priority patent/AT346357B/de
Priority to PH17861A priority patent/PH12506A/en
Priority to FI753520A priority patent/FI60560C/fi
Priority to FR7538285A priority patent/FR2294703A1/fr
Priority to YU3162/75A priority patent/YU39754B/xx
Priority to SE7514153A priority patent/SE424637B/xx
Priority to DK572975A priority patent/DK145341C/da
Priority to DD190290A priority patent/DD122529A5/xx
Priority to CH1644375A priority patent/CH618429A5/de
Priority to SU752198560A priority patent/SU683615A3/ru
Priority to JP50150732A priority patent/JPS6028819B2/ja
Priority to BE162952A priority patent/BE836885A/xx
Priority to DE2560633A priority patent/DE2560633C2/de
Priority to LU74071A priority patent/LU74071A1/xx
Priority to ES443725A priority patent/ES443725A1/es
Priority to DE19752557438 priority patent/DE2557438A1/de
Priority to NLAANVRAGE7514852,A priority patent/NL184109C/xx
Priority to IT70152/75A priority patent/IT1062213B/it
Publication of GB1489879A publication Critical patent/GB1489879A/en
Priority to US06/314,023 priority patent/USRE31244E/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
GB55209/74A 1974-12-20 1974-12-20 N'-cyano-n'-3-pyridylguanidines Expired GB1489879A (en)

Priority Applications (25)

Application Number Priority Date Filing Date Title
GB55209/74A GB1489879A (en) 1974-12-20 1974-12-20 N'-cyano-n'-3-pyridylguanidines
IE2554/75A IE42141B1 (en) 1974-12-20 1975-11-24 N'-cyano-n'-3-pyridylguanidines
ZA7481A ZA757481B (en) 1974-12-20 1975-11-27 New antihypertensive compounds and method of preparing same
AU87127/75A AU493001B2 (en) 1974-12-20 1975-12-01 new PYRIDYLYANOGUANIDINES
US05/636,747 US4057636A (en) 1974-12-20 1975-12-01 Antihypertensive pyridylguanidine compounds
CA241,325A CA1067083A (en) 1974-12-20 1975-12-09 Anti-hypertensive n"-cyano-pyridyl guanidines
AT936075A AT346357B (de) 1974-12-20 1975-12-10 Verfahren zur herstellung von neuen cyano- pyridylguanidinen sowie deren salzen mit nicht-toxischen, pharmazeutisch annehmbaren saeuren
PH17861A PH12506A (en) 1974-12-20 1975-12-12 New pyridylguanidines
FI753520A FI60560C (fi) 1974-12-20 1975-12-12 Foerfarande foer framstaellning av nya terapeutiskt anvaendbara substituerade pyridylguanidiner samt deras tautomera former
FR7538285A FR2294703A1 (fr) 1974-12-20 1975-12-15 Nouvelles cyanoguanidylpyridines, utiles notamment comme hypotenseurs, et leur procede de preparation
YU3162/75A YU39754B (en) 1974-12-20 1975-12-15 Process for obtining new pyridyl guanidine derivatives
SE7514153A SE424637B (sv) 1974-12-20 1975-12-15 Analogiforfarande for framstellning av pyridylguanidiner med terapeutisk verkan
DK572975A DK145341C (da) 1974-12-20 1975-12-17 Analogifremgangsmaade til fremstilling af pyridylguanidiner
DD190290A DD122529A5 (enrdf_load_stackoverflow) 1974-12-20 1975-12-18
CH1644375A CH618429A5 (enrdf_load_stackoverflow) 1974-12-20 1975-12-18
ES443725A ES443725A1 (es) 1974-12-20 1975-12-19 Metodo para producir un producto hipotensor.
JP50150732A JPS6028819B2 (ja) 1974-12-20 1975-12-19 新規なるグアニジン誘導体の製造方法
BE162952A BE836885A (fr) 1974-12-20 1975-12-19 Nouvelles cyanoguanidylpyridines, utiles notamment comme hypotenseurs,et leur procede de preparation
DE2560633A DE2560633C2 (enrdf_load_stackoverflow) 1974-12-20 1975-12-19
LU74071A LU74071A1 (enrdf_load_stackoverflow) 1974-12-20 1975-12-19
SU752198560A SU683615A3 (ru) 1974-12-20 1975-12-19 Способ получени -ил -производных -циано- -2-3 и 4-пиридилгуанидина или их солей
DE19752557438 DE2557438A1 (de) 1974-12-20 1975-12-19 N-substituierte n"cyano-n'pyridylguanidin-verbindungen
NLAANVRAGE7514852,A NL184109C (nl) 1974-12-20 1975-12-19 Werkwijze voor het bereiden of vervaardigen van een geneesmiddel met anti-hypertensieve activiteit; werkwijze voor het bereiden van een cyanoguanidineverbinding.
IT70152/75A IT1062213B (it) 1974-12-20 1975-12-19 Composti e composizioni di piridil guanidine particolarmente utili come ipotensivi e procedimento per la loro preparazione
US06/314,023 USRE31244E (en) 1974-12-20 1981-10-22 Antihypertensive pyridylguanidine compounds

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB55209/74A GB1489879A (en) 1974-12-20 1974-12-20 N'-cyano-n'-3-pyridylguanidines

Publications (1)

Publication Number Publication Date
GB1489879A true GB1489879A (en) 1977-10-26

Family

ID=10473276

Family Applications (1)

Application Number Title Priority Date Filing Date
GB55209/74A Expired GB1489879A (en) 1974-12-20 1974-12-20 N'-cyano-n'-3-pyridylguanidines

Country Status (22)

Country Link
US (2) US4057636A (enrdf_load_stackoverflow)
JP (1) JPS6028819B2 (enrdf_load_stackoverflow)
AT (1) AT346357B (enrdf_load_stackoverflow)
BE (1) BE836885A (enrdf_load_stackoverflow)
CA (1) CA1067083A (enrdf_load_stackoverflow)
CH (1) CH618429A5 (enrdf_load_stackoverflow)
DD (1) DD122529A5 (enrdf_load_stackoverflow)
DE (2) DE2557438A1 (enrdf_load_stackoverflow)
DK (1) DK145341C (enrdf_load_stackoverflow)
ES (1) ES443725A1 (enrdf_load_stackoverflow)
FI (1) FI60560C (enrdf_load_stackoverflow)
FR (1) FR2294703A1 (enrdf_load_stackoverflow)
GB (1) GB1489879A (enrdf_load_stackoverflow)
IE (1) IE42141B1 (enrdf_load_stackoverflow)
IT (1) IT1062213B (enrdf_load_stackoverflow)
LU (1) LU74071A1 (enrdf_load_stackoverflow)
NL (1) NL184109C (enrdf_load_stackoverflow)
PH (1) PH12506A (enrdf_load_stackoverflow)
SE (1) SE424637B (enrdf_load_stackoverflow)
SU (1) SU683615A3 (enrdf_load_stackoverflow)
YU (1) YU39754B (enrdf_load_stackoverflow)
ZA (1) ZA757481B (enrdf_load_stackoverflow)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010770A1 (de) * 1978-11-02 1980-05-14 Koichi Prof. Dr. Shudo In 2-Stellung substituierte 4-Pyridyl-harnstoffe bzw. -thioharnstoffe, Verfahren zu deren Herstellung sowie diese enthaltende Pflanzenwachstumsregulatoren
EP0055179A1 (en) * 1980-12-22 1982-06-30 Merck & Co. Inc. Aminoalkyl pyridine derivatives
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
US5032591A (en) * 1988-01-06 1991-07-16 Beecham Group P.L.C. Pharmaceutical preparations
WO1994006770A1 (en) * 1992-09-15 1994-03-31 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) N-cyano-n'-pyridylguanidines as serotonin antagonists
US6255323B1 (en) 1999-04-09 2001-07-03 Shionogi Bioresearch Corp. Cyanoguanidine compounds

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52935B1 (en) * 1981-04-15 1988-04-13 Leo Pharm Prod Ltd Pharmaceutical preparation
IE54196B1 (en) * 1981-09-10 1989-07-19 Leo Pharm Prod Ltd Chemical compounds
DK58983D0 (da) * 1983-02-11 1983-02-11 Leo Pharm Prod Ltd Farmaceutisk praeparat
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
US4617311A (en) * 1985-05-17 1986-10-14 Eli Lilly And Company Antiasthmatic method
GB8617623D0 (en) 1986-07-18 1986-08-28 Beecham Group Plc Treatment
EP0579260A1 (en) * 1987-07-07 1994-01-19 Beecham Group Plc Use of a vasodilator for the treatment of pulmonary hypertension and/or right heart failure-related conditions
GB8801318D0 (en) * 1988-01-21 1988-02-17 Leo Pharm Prod Ltd Pharmaceutical preparations
US5244664A (en) * 1988-01-21 1993-09-14 Leo Pharmaceutical Products Ltd. Topical preparation for treatment of alopecia
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
US5278169A (en) * 1988-08-09 1994-01-11 E. R. Squibb & Sons, Inc. Method of treating or prevention of fibrillation of the heart
JP2884412B2 (ja) * 1988-10-21 1999-04-19 日本バイエルアグロケム株式会社 殺虫性シアノ化合物
US5264445A (en) * 1989-02-03 1993-11-23 Eli Lilly And Company (-)-N"-cyano-N-3-pyridyl-N'-1,2,2-trimethylpropylguanidine
AU623217B2 (en) * 1989-02-03 1992-05-07 Eli Lilly And Company (-)-n"-cyano-n-3-pyridyl-n'-1,2,2-trimethyl- propylguanidine, a process for preparing the compound, and use of the compound as a medicament
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
US5217982A (en) * 1990-09-25 1993-06-08 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive properties
JPH05294935A (ja) * 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
US5371086A (en) * 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
FR2677019B1 (fr) * 1991-05-27 1994-11-25 Pf Medicament Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
DK0618798T3 (da) * 1991-12-23 1997-09-22 Upjohn Co Pyridylguanidinforbindelser til behandling af erektiv dysfunktion.
US5262419A (en) * 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
WO1994004499A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
JPH06228100A (ja) * 1992-12-07 1994-08-16 Green Cross Corp:The 光学活性アミノピリジン誘導体およびその用途
ES2127918T3 (es) * 1993-06-11 1999-05-01 Upjohn Co Pirimidinas-cianoguanidinas como bloqueantes del canal de potasio.
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
US5633374A (en) * 1993-11-26 1997-05-27 The Upjohn Company Pyrimidine, cyanoguanidines as K-channel blockers
JPH09508382A (ja) * 1994-01-28 1997-08-26 ジ・アップジョン・カンパニー Ｋ−チャネル遮断薬用シアノグアニジン類
US5525742A (en) * 1994-06-10 1996-06-11 The Upjohn Company Azidophenylcyanoguanidines as photoaffinity probes
US5856449A (en) * 1994-11-17 1999-01-05 Pharmacia & Upjohn Company Protein affecting KATP channels
US6335352B1 (en) * 1996-08-15 2002-01-01 Smithkline Beecham Corporation IL-8 receptor antagonists
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
US6458835B2 (en) 1997-08-13 2002-10-01 Bristol-Myers Squibb Company Method of inhibiting or treating chemotherapy-induced hair loss
US6013668A (en) * 1997-08-13 2000-01-11 Bristol-Myers Squibb Company Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile
AU9211098A (en) * 1997-09-03 1999-03-22 American Home Products Corporation Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents
GB9908410D0 (en) 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
KR20050071598A (ko) * 2002-10-24 2005-07-07 메르크 파텐트 게엠베하 라프-키나아제 억제제로서의 메틸렌 우레아 유도체
US9296697B2 (en) * 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
US20070250567A1 (en) * 2006-04-20 2007-10-25 Graham Philip R System and method for controlling a telepresence system
US20110009446A1 (en) * 2008-01-11 2011-01-13 Nektar Therapeutics Oligomer-guanidine class conjugates
PL2649048T3 (pl) * 2010-12-09 2016-10-31 Wielofunkcyjne pochodne nitroksydu i ich zastosowania
WO2021044413A1 (en) * 2019-09-03 2021-03-11 Salzman Group Ltd. Atp-regulated potassium channel openers comprising guanidine and uses thereof
JP2025066196A (ja) * 2022-03-14 2025-04-23 国立大学法人東北大学 認知機能改善剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036083A (en) * 1959-05-15 1962-05-22 Ciba Geigy Corp Certain 2-pyridyl lower alkyl guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010770A1 (de) * 1978-11-02 1980-05-14 Koichi Prof. Dr. Shudo In 2-Stellung substituierte 4-Pyridyl-harnstoffe bzw. -thioharnstoffe, Verfahren zu deren Herstellung sowie diese enthaltende Pflanzenwachstumsregulatoren
US4279639A (en) * 1978-11-02 1981-07-21 Toshihiko Okamoto N-(2-Substituted-4-pyridyl)ureas and thioureas as well as plant growth regulators containing same, and method for using compounds as plant growth regulators
EP0055179A1 (en) * 1980-12-22 1982-06-30 Merck & Co. Inc. Aminoalkyl pyridine derivatives
US5032591A (en) * 1988-01-06 1991-07-16 Beecham Group P.L.C. Pharmaceutical preparations
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
WO1994006770A1 (en) * 1992-09-15 1994-03-31 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) N-cyano-n'-pyridylguanidines as serotonin antagonists
AU670816B2 (en) * 1992-09-15 1996-08-01 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) N-cyano-N'-pyridylguanidines as serotonin antagonists
US5563160A (en) * 1992-09-15 1996-10-08 Leo Pharmaceutical Products Ltd. A/S (L.o slashed.vens Kemiske Fabrik Produktionsaktieselskab) N-cyano-N'-pyridylguanidines as serotonin antagonists
RU2141951C1 (ru) * 1992-09-15 1999-11-27 Лео Фармасьютикал Продактс Лтд. А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) N-циано-n'-пиридилгуанидины, или их n-оксиды, или их фармацевтически приемлемые нетоксичные соли, способы их получения, фармацевтическая композиция и способ ингибирования пролиферации опухолевых клеток
US6255323B1 (en) 1999-04-09 2001-07-03 Shionogi Bioresearch Corp. Cyanoguanidine compounds

Also Published As

Publication number Publication date
FI60560C (fi) 1982-02-10
ZA757481B (en) 1977-01-26
ATA936075A (de) 1978-03-15
FR2294703A1 (fr) 1976-07-16
ES443725A1 (es) 1977-04-16
USRE31244E (en) 1983-05-17
CH618429A5 (enrdf_load_stackoverflow) 1980-07-31
NL184109C (nl) 1989-04-17
IT1062213B (it) 1983-09-20
SE7514153L (sv) 1976-06-21
DK145341B (da) 1982-11-01
DK572975A (da) 1976-06-21
DD122529A5 (enrdf_load_stackoverflow) 1976-10-12
LU74071A1 (enrdf_load_stackoverflow) 1976-11-11
IE42141B1 (en) 1980-06-04
PH12506A (en) 1979-04-18
CA1067083A (en) 1979-11-27
FI753520A7 (enrdf_load_stackoverflow) 1976-06-21
NL7514852A (nl) 1976-06-22
DE2560633C2 (enrdf_load_stackoverflow) 1988-09-08
AT346357B (de) 1978-11-10
AU8712775A (en) 1977-06-09
SE424637B (sv) 1982-08-02
US4057636A (en) 1977-11-08
SU683615A3 (ru) 1979-08-30
DE2557438A1 (de) 1976-06-24
DE2557438C2 (enrdf_load_stackoverflow) 1989-01-05
YU316275A (en) 1982-02-28
NL184109B (nl) 1988-11-16
JPS6028819B2 (ja) 1985-07-06
JPS5186474A (enrdf_load_stackoverflow) 1976-07-29
FI60560B (fi) 1981-10-30
YU39754B (en) 1985-04-30
DK145341C (da) 1983-03-28
FR2294703B1 (enrdf_load_stackoverflow) 1980-06-27
BE836885A (fr) 1976-06-21
IE42141L (en) 1976-06-20

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Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
704A Declaration that licence is not available as of right for an excepted use (par. 4a/1977)
PE20 Patent expired after termination of 20 years

Effective date: 19951130