FR2294703B1 - - Google Patents

Info

Publication number
FR2294703B1
FR2294703B1 FR7538285A FR7538285A FR2294703B1 FR 2294703 B1 FR2294703 B1 FR 2294703B1 FR 7538285 A FR7538285 A FR 7538285A FR 7538285 A FR7538285 A FR 7538285A FR 2294703 B1 FR2294703 B1 FR 2294703B1
Authority
FR
France
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR7538285A
Other languages
French (fr)
Other versions
FR2294703A1 (fr
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECH APPLICATIONS THERAP
Original Assignee
RECH APPLICATIONS THERAP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECH APPLICATIONS THERAP filed Critical RECH APPLICATIONS THERAP
Publication of FR2294703A1 publication Critical patent/FR2294703A1/fr
Application granted granted Critical
Publication of FR2294703B1 publication Critical patent/FR2294703B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
FR7538285A 1974-12-20 1975-12-15 Nouvelles cyanoguanidylpyridines, utiles notamment comme hypotenseurs, et leur procede de preparation Granted FR2294703A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB55209/74A GB1489879A (en) 1974-12-20 1974-12-20 N'-cyano-n'-3-pyridylguanidines

Publications (2)

Publication Number Publication Date
FR2294703A1 FR2294703A1 (fr) 1976-07-16
FR2294703B1 true FR2294703B1 (enrdf_load_stackoverflow) 1980-06-27

Family

ID=10473276

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7538285A Granted FR2294703A1 (fr) 1974-12-20 1975-12-15 Nouvelles cyanoguanidylpyridines, utiles notamment comme hypotenseurs, et leur procede de preparation

Country Status (22)

Country Link
US (2) US4057636A (enrdf_load_stackoverflow)
JP (1) JPS6028819B2 (enrdf_load_stackoverflow)
AT (1) AT346357B (enrdf_load_stackoverflow)
BE (1) BE836885A (enrdf_load_stackoverflow)
CA (1) CA1067083A (enrdf_load_stackoverflow)
CH (1) CH618429A5 (enrdf_load_stackoverflow)
DD (1) DD122529A5 (enrdf_load_stackoverflow)
DE (2) DE2557438A1 (enrdf_load_stackoverflow)
DK (1) DK145341C (enrdf_load_stackoverflow)
ES (1) ES443725A1 (enrdf_load_stackoverflow)
FI (1) FI60560C (enrdf_load_stackoverflow)
FR (1) FR2294703A1 (enrdf_load_stackoverflow)
GB (1) GB1489879A (enrdf_load_stackoverflow)
IE (1) IE42141B1 (enrdf_load_stackoverflow)
IT (1) IT1062213B (enrdf_load_stackoverflow)
LU (1) LU74071A1 (enrdf_load_stackoverflow)
NL (1) NL184109C (enrdf_load_stackoverflow)
PH (1) PH12506A (enrdf_load_stackoverflow)
SE (1) SE424637B (enrdf_load_stackoverflow)
SU (1) SU683615A3 (enrdf_load_stackoverflow)
YU (1) YU39754B (enrdf_load_stackoverflow)
ZA (1) ZA757481B (enrdf_load_stackoverflow)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5562066A (en) * 1978-11-03 1980-05-10 Toshihiko Okamoto N-(2-substituted-4-pyridyl)-urea and thio urea, their preparation and plant growth regulator
US4490533A (en) * 1980-12-22 1984-12-25 Merck & Co., Inc. Aminoalkyl pyridine derivatives
IE52935B1 (en) * 1981-04-15 1988-04-13 Leo Pharm Prod Ltd Pharmaceutical preparation
IE54196B1 (en) * 1981-09-10 1989-07-19 Leo Pharm Prod Ltd Chemical compounds
DK58983D0 (da) * 1983-02-11 1983-02-11 Leo Pharm Prod Ltd Farmaceutisk praeparat
JPS604120A (ja) * 1983-06-22 1985-01-10 Shionogi & Co Ltd 作用持続型ピナシジル製剤
US4617311A (en) * 1985-05-17 1986-10-14 Eli Lilly And Company Antiasthmatic method
GB8617623D0 (en) 1986-07-18 1986-08-28 Beecham Group Plc Treatment
EP0579260A1 (en) * 1987-07-07 1994-01-19 Beecham Group Plc Use of a vasodilator for the treatment of pulmonary hypertension and/or right heart failure-related conditions
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
GB8801318D0 (en) * 1988-01-21 1988-02-17 Leo Pharm Prod Ltd Pharmaceutical preparations
US5244664A (en) * 1988-01-21 1993-09-14 Leo Pharmaceutical Products Ltd. Topical preparation for treatment of alopecia
WO1989010757A1 (en) * 1988-05-10 1989-11-16 Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis New ophthalmic preparation for treating glaucoma
US5011837A (en) * 1988-08-09 1991-04-30 E. R. Squibb & Sons, Inc. Aryl cyanoguanidines: potassium channel activators and method of making same
NZ229828A (en) * 1988-08-09 1992-03-26 Squibb & Sons Inc Aryl cyanoguanidine derivatives and pharmaceutical compositions
US5278169A (en) * 1988-08-09 1994-01-11 E. R. Squibb & Sons, Inc. Method of treating or prevention of fibrillation of the heart
JP2884412B2 (ja) * 1988-10-21 1999-04-19 日本バイエルアグロケム株式会社 殺虫性シアノ化合物
US5264445A (en) * 1989-02-03 1993-11-23 Eli Lilly And Company (-)-N"-cyano-N-3-pyridyl-N'-1,2,2-trimethylpropylguanidine
AU623217B2 (en) * 1989-02-03 1992-05-07 Eli Lilly And Company (-)-n"-cyano-n-3-pyridyl-n'-1,2,2-trimethyl- propylguanidine, a process for preparing the compound, and use of the compound as a medicament
EP0407346A3 (en) * 1989-07-07 1991-10-02 Ciba-Geigy Ag Aminopyridines
US5006523A (en) * 1989-10-26 1991-04-09 E. R. Squibb & Sons, Inc. Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers
US5217982A (en) * 1990-09-25 1993-06-08 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having antihypertensive properties
JPH05294935A (ja) * 1991-03-15 1993-11-09 Green Cross Corp:The アミノピリジン系化合物
US5371086A (en) * 1991-03-15 1994-12-06 The Green Cross Corporation Aminopyridine compounds
FR2677019B1 (fr) * 1991-05-27 1994-11-25 Pf Medicament Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique.
US5593993A (en) * 1991-08-02 1997-01-14 Medivir Ab Method for inhibition of HIV related viruses
IL102548A (en) * 1991-08-02 1998-08-16 Medivir Ab Thiourea derivatives for use in the preparation of medicaments for the inhibition of hiv and the treatment of aids and some such novel compounds
DK0618798T3 (da) * 1991-12-23 1997-09-22 Upjohn Co Pyridylguanidinforbindelser til behandling af erektiv dysfunktion.
US5262419A (en) * 1992-06-11 1993-11-16 E. R. Squibb & Sons, Inc. Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator
WO1994004499A1 (en) * 1992-08-13 1994-03-03 The Upjohn Company Cyanoguanidines as potassium channel blockers
GB9219472D0 (en) * 1992-09-15 1992-10-28 Leo Pharm Prod Ltd Chemical compounds
JPH06228100A (ja) * 1992-12-07 1994-08-16 Green Cross Corp:The 光学活性アミノピリジン誘導体およびその用途
ES2127918T3 (es) * 1993-06-11 1999-05-01 Upjohn Co Pirimidinas-cianoguanidinas como bloqueantes del canal de potasio.
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
US5633374A (en) * 1993-11-26 1997-05-27 The Upjohn Company Pyrimidine, cyanoguanidines as K-channel blockers
JPH09508382A (ja) * 1994-01-28 1997-08-26 ジ・アップジョン・カンパニー Ｋ−チャネル遮断薬用シアノグアニジン類
US5525742A (en) * 1994-06-10 1996-06-11 The Upjohn Company Azidophenylcyanoguanidines as photoaffinity probes
US5856449A (en) * 1994-11-17 1999-01-05 Pharmacia & Upjohn Company Protein affecting KATP channels
US6335352B1 (en) * 1996-08-15 2002-01-01 Smithkline Beecham Corporation IL-8 receptor antagonists
US5972894A (en) * 1997-08-07 1999-10-26 Cytran, Inc. Peptides having potassium channel opener activity
US6458835B2 (en) 1997-08-13 2002-10-01 Bristol-Myers Squibb Company Method of inhibiting or treating chemotherapy-induced hair loss
US6013668A (en) * 1997-08-13 2000-01-11 Bristol-Myers Squibb Company Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile
AU9211098A (en) * 1997-09-03 1999-03-22 American Home Products Corporation Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents
WO2000061561A1 (en) 1999-04-09 2000-10-19 Shionogi Bioresearch Corp. Cyanoguanidine compounds
GB9908410D0 (en) 1999-04-13 1999-06-09 Pfizer Ltd Pyridines
WO2000067754A1 (en) 1999-05-12 2000-11-16 Nitromed, Inc. Nitrosated and nitrosylated potassium channel activators, compositions and methods of use
US6645968B2 (en) 1999-08-03 2003-11-11 Abbott Laboratories Potassium channel openers
KR20050071598A (ko) * 2002-10-24 2005-07-07 메르크 파텐트 게엠베하 라프-키나아제 억제제로서의 메틸렌 우레아 유도체
US9296697B2 (en) * 2005-08-24 2016-03-29 Abbott Laboratories Hetaryl-substituted guanidine compounds and use thereof as binding partners for 5-HT5-receptors
US20070250567A1 (en) * 2006-04-20 2007-10-25 Graham Philip R System and method for controlling a telepresence system
US20110009446A1 (en) * 2008-01-11 2011-01-13 Nektar Therapeutics Oligomer-guanidine class conjugates
PL2649048T3 (pl) * 2010-12-09 2016-10-31 Wielofunkcyjne pochodne nitroksydu i ich zastosowania
WO2021044413A1 (en) * 2019-09-03 2021-03-11 Salzman Group Ltd. Atp-regulated potassium channel openers comprising guanidine and uses thereof
JP2025066196A (ja) * 2022-03-14 2025-04-23 国立大学法人東北大学 認知機能改善剤

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3036083A (en) * 1959-05-15 1962-05-22 Ciba Geigy Corp Certain 2-pyridyl lower alkyl guanidines
GB1397436A (en) * 1972-09-05 1975-06-11 Smith Kline French Lab Heterocyclic n-cyanoguinidines

Also Published As

Publication number Publication date
GB1489879A (en) 1977-10-26
FI60560C (fi) 1982-02-10
ZA757481B (en) 1977-01-26
ATA936075A (de) 1978-03-15
FR2294703A1 (fr) 1976-07-16
ES443725A1 (es) 1977-04-16
USRE31244E (en) 1983-05-17
CH618429A5 (enrdf_load_stackoverflow) 1980-07-31
NL184109C (nl) 1989-04-17
IT1062213B (it) 1983-09-20
SE7514153L (sv) 1976-06-21
DK145341B (da) 1982-11-01
DK572975A (da) 1976-06-21
DD122529A5 (enrdf_load_stackoverflow) 1976-10-12
LU74071A1 (enrdf_load_stackoverflow) 1976-11-11
IE42141B1 (en) 1980-06-04
PH12506A (en) 1979-04-18
CA1067083A (en) 1979-11-27
FI753520A7 (enrdf_load_stackoverflow) 1976-06-21
NL7514852A (nl) 1976-06-22
DE2560633C2 (enrdf_load_stackoverflow) 1988-09-08
AT346357B (de) 1978-11-10
AU8712775A (en) 1977-06-09
SE424637B (sv) 1982-08-02
US4057636A (en) 1977-11-08
SU683615A3 (ru) 1979-08-30
DE2557438A1 (de) 1976-06-24
DE2557438C2 (enrdf_load_stackoverflow) 1989-01-05
YU316275A (en) 1982-02-28
NL184109B (nl) 1988-11-16
JPS6028819B2 (ja) 1985-07-06
JPS5186474A (enrdf_load_stackoverflow) 1976-07-29
FI60560B (fi) 1981-10-30
YU39754B (en) 1985-04-30
DK145341C (da) 1983-03-28
BE836885A (fr) 1976-06-21
IE42141L (en) 1976-06-20

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Legal Events

Date Code Title Description
TP Transmission of property