DK572975A - Fremgangsmade til fremstilling af hidtil ukendte pyridylguanidiner - Google Patents
Fremgangsmade til fremstilling af hidtil ukendte pyridylguanidinerInfo
- Publication number
- DK572975A DK572975A DK572975A DK572975A DK572975A DK 572975 A DK572975 A DK 572975A DK 572975 A DK572975 A DK 572975A DK 572975 A DK572975 A DK 572975A DK 572975 A DK572975 A DK 572975A
- Authority
- DK
- Denmark
- Prior art keywords
- guanidines
- pyridyl
- procedure
- preparing
- previous
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB55209/74A GB1489879A (en) | 1974-12-20 | 1974-12-20 | N'-cyano-n'-3-pyridylguanidines |
GB5520974 | 1974-12-20 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK572975A true DK572975A (da) | 1976-06-21 |
DK145341B DK145341B (da) | 1982-11-01 |
DK145341C DK145341C (da) | 1983-03-28 |
Family
ID=10473276
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK572975A DK145341C (da) | 1974-12-20 | 1975-12-17 | Analogifremgangsmaade til fremstilling af pyridylguanidiner |
Country Status (22)
Country | Link |
---|---|
US (2) | US4057636A (da) |
JP (1) | JPS6028819B2 (da) |
AT (1) | AT346357B (da) |
BE (1) | BE836885A (da) |
CA (1) | CA1067083A (da) |
CH (1) | CH618429A5 (da) |
DD (1) | DD122529A5 (da) |
DE (2) | DE2557438A1 (da) |
DK (1) | DK145341C (da) |
ES (1) | ES443725A1 (da) |
FI (1) | FI60560C (da) |
FR (1) | FR2294703A1 (da) |
GB (1) | GB1489879A (da) |
IE (1) | IE42141B1 (da) |
IT (1) | IT1062213B (da) |
LU (1) | LU74071A1 (da) |
NL (1) | NL184109C (da) |
PH (1) | PH12506A (da) |
SE (1) | SE424637B (da) |
SU (1) | SU683615A3 (da) |
YU (1) | YU39754B (da) |
ZA (1) | ZA757481B (da) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5562066A (en) * | 1978-11-03 | 1980-05-10 | Toshihiko Okamoto | N-(2-substituted-4-pyridyl)-urea and thio urea, their preparation and plant growth regulator |
US4490533A (en) * | 1980-12-22 | 1984-12-25 | Merck & Co., Inc. | Aminoalkyl pyridine derivatives |
IE52935B1 (en) * | 1981-04-15 | 1988-04-13 | Leo Pharm Prod Ltd | Pharmaceutical preparation |
IE54196B1 (en) * | 1981-09-10 | 1989-07-19 | Leo Pharm Prod Ltd | Chemical compounds |
DK58983D0 (da) * | 1983-02-11 | 1983-02-11 | Leo Pharm Prod Ltd | Farmaceutisk praeparat |
JPS604120A (ja) * | 1983-06-22 | 1985-01-10 | Shionogi & Co Ltd | 作用持続型ピナシジル製剤 |
US4617311A (en) * | 1985-05-17 | 1986-10-14 | Eli Lilly And Company | Antiasthmatic method |
EP0302595B1 (en) * | 1987-07-07 | 1994-02-02 | Beecham Group Plc | Pinacidil for treatment of pulmonary hypertension or right heart failure |
GB8800199D0 (en) * | 1988-01-06 | 1988-02-10 | Beecham Group Plc | Pharmaceutical preparation |
GB8801318D0 (en) * | 1988-01-21 | 1988-02-17 | Leo Pharm Prod Ltd | Pharmaceutical preparations |
US5244664A (en) * | 1988-01-21 | 1993-09-14 | Leo Pharmaceutical Products Ltd. | Topical preparation for treatment of alopecia |
WO1989010757A1 (en) * | 1988-05-10 | 1989-11-16 | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemis | New ophthalmic preparation for treating glaucoma |
US5011837A (en) * | 1988-08-09 | 1991-04-30 | E. R. Squibb & Sons, Inc. | Aryl cyanoguanidines: potassium channel activators and method of making same |
NZ229828A (en) * | 1988-08-09 | 1992-03-26 | Squibb & Sons Inc | Aryl cyanoguanidine derivatives and pharmaceutical compositions |
US5278169A (en) * | 1988-08-09 | 1994-01-11 | E. R. Squibb & Sons, Inc. | Method of treating or prevention of fibrillation of the heart |
JP2884412B2 (ja) * | 1988-10-21 | 1999-04-19 | 日本バイエルアグロケム株式会社 | 殺虫性シアノ化合物 |
EP0381504A3 (en) * | 1989-02-03 | 1991-09-04 | Eli Lilly And Company | Improvements in and relating to guanidine derivatives |
US5264445A (en) * | 1989-02-03 | 1993-11-23 | Eli Lilly And Company | (-)-N"-cyano-N-3-pyridyl-N'-1,2,2-trimethylpropylguanidine |
EP0407346A3 (en) * | 1989-07-07 | 1991-10-02 | Ciba-Geigy Ag | Aminopyridines |
US5006523A (en) * | 1989-10-26 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Antiarrhythmic agents: aryl cyanoguanidine potassium channel blockers |
US5217982A (en) * | 1990-09-25 | 1993-06-08 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having antihypertensive properties |
US5371086A (en) * | 1991-03-15 | 1994-12-06 | The Green Cross Corporation | Aminopyridine compounds |
JPH05294935A (ja) * | 1991-03-15 | 1993-11-09 | Green Cross Corp:The | アミノピリジン系化合物 |
FR2677019B1 (fr) * | 1991-05-27 | 1994-11-25 | Pf Medicament | Nouvelles piperidines disubstituees-1,4, leur preparation et leur application en therapeutique. |
US5593993A (en) * | 1991-08-02 | 1997-01-14 | Medivir Ab | Method for inhibition of HIV related viruses |
IL102548A (en) * | 1991-08-02 | 1998-08-16 | Medivir Ab | Use of painting derivatives in the preparation of drugs for VIH inhibition and treatment of SDIA and new compounds |
KR940703666A (ko) * | 1991-12-23 | 1994-12-12 | 로렌스 티. 웰츠 | 발기 부전증 치료에 효능있는 약제(a potent drug for treatment of erectile dysfunction) |
US5262419A (en) * | 1992-06-11 | 1993-11-16 | E. R. Squibb & Sons, Inc. | Method for the prophylaxis and/or treatment of ulcerative gastrointestinal conditions using a potassium channel activator |
AU4530693A (en) * | 1992-08-13 | 1994-03-15 | Upjohn Company, The | Cyanoguanidines as potassium channel blockers |
GB9219472D0 (en) * | 1992-09-15 | 1992-10-28 | Leo Pharm Prod Ltd | Chemical compounds |
JPH06228100A (ja) * | 1992-12-07 | 1994-08-16 | Green Cross Corp:The | 光学活性アミノピリジン誘導体およびその用途 |
ATE176905T1 (de) * | 1993-06-11 | 1999-03-15 | Upjohn Co | Pyrimidine-cyanoguanidine als kaliumkanalblocker |
US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
US5633374A (en) * | 1993-11-26 | 1997-05-27 | The Upjohn Company | Pyrimidine, cyanoguanidines as K-channel blockers |
WO1995020579A1 (en) * | 1994-01-28 | 1995-08-03 | Pharmacia & Upjohn Company | Cyanoguanidines as k-channel blockers |
US5525742A (en) * | 1994-06-10 | 1996-06-11 | The Upjohn Company | Azidophenylcyanoguanidines as photoaffinity probes |
US5856449A (en) * | 1994-11-17 | 1999-01-05 | Pharmacia & Upjohn Company | Protein affecting KATP channels |
WO1998006399A1 (en) * | 1996-08-15 | 1998-02-19 | Smithkline Beecham Corporation | Il-8 receptor antagonists |
US5972894A (en) * | 1997-08-07 | 1999-10-26 | Cytran, Inc. | Peptides having potassium channel opener activity |
US6013668A (en) * | 1997-08-13 | 2000-01-11 | Bristol-Myers Squibb Company | Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile |
US6458835B2 (en) | 1997-08-13 | 2002-10-01 | Bristol-Myers Squibb Company | Method of inhibiting or treating chemotherapy-induced hair loss |
AU9211098A (en) * | 1997-09-03 | 1999-03-22 | American Home Products Corporation | Thiourea for increasing hdl-cholesterol levels, which are useful as anti-atherosclerotic agents |
US6255323B1 (en) | 1999-04-09 | 2001-07-03 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
AU4841700A (en) | 1999-05-12 | 2000-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
US6645968B2 (en) | 1999-08-03 | 2003-11-11 | Abbott Laboratories | Potassium channel openers |
WO2004037789A2 (en) * | 2002-10-24 | 2004-05-06 | Merck Patent Gmbh | Methylene urea derivatives as raf-kinase inhibitors |
WO2007022964A2 (de) * | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
US20070250567A1 (en) * | 2006-04-20 | 2007-10-25 | Graham Philip R | System and method for controlling a telepresence system |
US20110009446A1 (en) * | 2008-01-11 | 2011-01-13 | Nektar Therapeutics | Oligomer-guanidine class conjugates |
WO2012077108A1 (en) * | 2010-12-09 | 2012-06-14 | Radikal Therapeutics Inc. | Multifunctional nitroxide derivatives and uses thereof |
WO2021044413A1 (en) * | 2019-09-03 | 2021-03-11 | Salzman Group Ltd. | Atp-regulated potassium channel openers comprising guanidine and uses thereof |
WO2023176554A1 (ja) * | 2022-03-14 | 2023-09-21 | 国立大学法人東北大学 | 認知機能改善剤 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3036083A (en) * | 1959-05-15 | 1962-05-22 | Ciba Geigy Corp | Certain 2-pyridyl lower alkyl guanidines |
GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
-
1974
- 1974-12-20 GB GB55209/74A patent/GB1489879A/en not_active Expired
-
1975
- 1975-11-24 IE IE2554/75A patent/IE42141B1/en unknown
- 1975-11-27 ZA ZA7481A patent/ZA757481B/xx unknown
- 1975-12-01 US US05/636,747 patent/US4057636A/en not_active Expired - Lifetime
- 1975-12-09 CA CA241,325A patent/CA1067083A/en not_active Expired
- 1975-12-10 AT AT936075A patent/AT346357B/de not_active IP Right Cessation
- 1975-12-12 PH PH17861A patent/PH12506A/en unknown
- 1975-12-12 FI FI753520A patent/FI60560C/fi not_active IP Right Cessation
- 1975-12-15 YU YU3162/75A patent/YU39754B/xx unknown
- 1975-12-15 FR FR7538285A patent/FR2294703A1/fr active Granted
- 1975-12-15 SE SE7514153A patent/SE424637B/xx not_active IP Right Cessation
- 1975-12-17 DK DK572975A patent/DK145341C/da not_active IP Right Cessation
- 1975-12-18 DD DD190290A patent/DD122529A5/xx unknown
- 1975-12-18 CH CH1644375A patent/CH618429A5/de not_active IP Right Cessation
- 1975-12-19 LU LU74071A patent/LU74071A1/xx unknown
- 1975-12-19 NL NLAANVRAGE7514852,A patent/NL184109C/xx not_active IP Right Cessation
- 1975-12-19 IT IT70152/75A patent/IT1062213B/it active
- 1975-12-19 SU SU752198560A patent/SU683615A3/ru active
- 1975-12-19 DE DE19752557438 patent/DE2557438A1/de active Granted
- 1975-12-19 ES ES443725A patent/ES443725A1/es not_active Expired
- 1975-12-19 JP JP50150732A patent/JPS6028819B2/ja not_active Expired
- 1975-12-19 DE DE2560633A patent/DE2560633C2/de not_active Expired
- 1975-12-19 BE BE162952A patent/BE836885A/xx not_active IP Right Cessation
-
1981
- 1981-10-22 US US06/314,023 patent/USRE31244E/en not_active Expired - Lifetime
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK572975A (da) | Fremgangsmade til fremstilling af hidtil ukendte pyridylguanidiner | |
DK487475A (da) | Fremgangsmade til fremstilling af vandkveldende polyalkylenoxid | |
DK392675A (da) | Fremgangsmade til fremstilling af substituerede puriner | |
DK150155C (da) | Analogifremgangsmaade til fremstilling af benzocycloamid-derivater | |
DK552377A (da) | Fremgangsmaade til fremstilling af alfa-beskyttede oxyimino-beta-oxo-gamma-halogen-smoersyrederivater | |
DK321875A (da) | Fremgangsmade til fremstilling af amidin-metal-komplekser | |
DK244875A (da) | Fremgangsmade til fremstilling af chromanderivater | |
DK222375A (da) | Fremgangsmade til fremstilling af alkyl-tert-butylethere | |
DK558975A (da) | Fremgangsmade til fremstilling af polycarbonater | |
DK292475A (da) | Fremgangsmade til fremstilling af derivater af 3-amino-2-hydroxy-1-phenoxy-propan | |
DK351875A (da) | Fremgangsmade til fremstilling af 7-methoxy-6-thiatetracyliner | |
DK223175A (da) | Fremgangsmade til fremstilling af pyridobenzodiazepinoner | |
DK247175A (da) | Fremgangsmade til fremstilling af decahydroisoquinolin-forbindelser | |
DK145877C (da) | Fremgangsmaade til fremstilling af alfa-6-desoxy-5-hydroxytetracyclin | |
DK442977A (da) | Fremgangsmade til fremstilling af gamma-l-glutamyltaurin | |
DK409575A (da) | Fremgangsmade til fremstilling af spanplader | |
DK154890C (da) | Fremgangsmaade til fremstilling af 7beta-acylamino-7alfa-alkoxycephalosporiner | |
DK547675A (da) | Fremgangsmade til fremstilling af 6-methyl-8beta-substituerede methylergoliner | |
DK344175A (da) | Fremgangsmade til fremstilling af chromanderivater | |
DK212875A (da) | Fremgangsmade til fremstilling af 5-phenyltetrazol-forbindelser | |
DK373475A (da) | Fremgangsmade til optrekning af daser | |
DK197575A (da) | Fremgangsmade til fremstilling af peptider | |
DK137539B (da) | Fremgangsmade til fremstilling af 11beta-fluor-4-androsten-3-oner | |
DK482675A (da) | Fremgangsmade til fremstilling af antibakterielt aktive forbindelser | |
DK159266C (da) | Fremgangsmaade til fremstilling af substituerede amidinforbindelser |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |